Gene LYL1 - ENSG00000104903 | NCBI Gene ID: 4066

Details for: LYL1

Gene ID: 4066

Symbol: LYL1

Ensembl ID: ENSG00000104903

Description: LYL1 basic helix-loop-helix family member

Associated with

Ngf-stimulated transcription
(R-HSA-9031628)
Nuclear events (kinase and transcription factor activation)
(R-HSA-198725)
Signaling by ntrk1 (trka)
(R-HSA-187037)
Signaling by ntrks
(R-HSA-166520)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signal transduction
(R-HSA-162582)
B cell differentiation
(GO:0030183)
Blood vessel maturation
(GO:0001955)
Chromatin
(GO:0000785)
Definitive hemopoiesis
(GO:0060216)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Dna binding
(GO:0003677)
Nucleoplasm
(GO:0005654)
Positive regulation of dna-templated transcription
(GO:0045893)
Protein binding
(GO:0005515)
Protein dimerization activity
(GO:0046983)
Regulation of dna-templated transcription
(GO:0006355)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: pro-T cell (CL0000827)
Fold Change: 2.05
Marker Score: 8397
Cell Name: early pro-B cell (CL0002046)
Fold Change: 1.53
Marker Score: 15545
Cell Name: Hofbauer cell (CL3000001)
Fold Change: 1.51
Marker Score: 831
Cell Name: proerythroblast (CL0000547)
Fold Change: 1.4
Marker Score: 946.5
Cell Name: hematopoietic precursor cell (CL0008001)
Fold Change: 1.35
Marker Score: 472
Cell Name: germinal center B cell (CL0000844)
Fold Change: 1.35
Marker Score: 820
Cell Name: erythroid progenitor cell, mammalian (CL0001066)
Fold Change: 1.31
Marker Score: 419
Cell Name: basophil (CL0000767)
Fold Change: 1.27
Marker Score: 603
Cell Name: naive B cell (CL0000788)
Fold Change: 1.17
Marker Score: 1044
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 1.14
Marker Score: 4778
Cell Name: common lymphoid progenitor (CL0000051)
Fold Change: 1.13
Marker Score: 768
Cell Name: type EC enteroendocrine cell (CL0000577)
Fold Change: 1.12
Marker Score: 1057
Cell Name: endothelial cell of uterus (CL0009095)
Fold Change: 1.1
Marker Score: 2190
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 1.1
Marker Score: 2227.5
Cell Name: IgG memory B cell (CL0000979)
Fold Change: 1.08
Marker Score: 652
Cell Name: promyelocyte (CL0000836)
Fold Change: 1.08
Marker Score: 532
Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
Fold Change: 1.03
Marker Score: 749
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71788
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48013
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30404
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.96
Marker Score: 493.5
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 0.95
Marker Score: 604
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.95
Marker Score: 448
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2407
Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
Fold Change: 0.94
Marker Score: 1355
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.92
Marker Score: 5249
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2726
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.91
Marker Score: 613
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.9
Marker Score: 361
Cell Name: IgG-negative class switched memory B cell (CL0002117)
Fold Change: 0.9
Marker Score: 885
Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
Fold Change: 0.88
Marker Score: 430
Cell Name: memory B cell (CL0000787)
Fold Change: 0.88
Marker Score: 664
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.87
Marker Score: 314
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 0.87
Marker Score: 48799
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5280
Cell Name: lung macrophage (CL1001603)
Fold Change: 0.87
Marker Score: 990
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 0.86
Marker Score: 867
Cell Name: transitional stage B cell (CL0000818)
Fold Change: 0.84
Marker Score: 297
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: 0.82
Marker Score: 2033
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.8
Marker Score: 2362
Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 0.77
Marker Score: 242
Cell Name: class switched memory B cell (CL0000972)
Fold Change: 0.77
Marker Score: 721
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.76
Marker Score: 1241
Cell Name: mononuclear cell (CL0000842)
Fold Change: 0.75
Marker Score: 243
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.74
Marker Score: 383
Cell Name: follicular B cell (CL0000843)
Fold Change: 0.73
Marker Score: 795
Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
Fold Change: 0.73
Marker Score: 1428
Cell Name: Kupffer cell (CL0000091)
Fold Change: 0.73
Marker Score: 731
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.73
Marker Score: 555.5
Cell Name: brush cell (CL0002204)
Fold Change: 0.72
Marker Score: 660
Cell Name: B-1b B cell (CL0000821)
Fold Change: 0.72
Marker Score: 166
Cell Name: non-classical monocyte (CL0000875)
Fold Change: 0.72
Marker Score: 1738
Cell Name: primitive red blood cell (CL0002355)
Fold Change: 0.68
Marker Score: 513
Cell Name: vein endothelial cell (CL0002543)
Fold Change: 0.68
Marker Score: 615
Cell Name: alveolar macrophage (CL0000583)
Fold Change: 0.68
Marker Score: 17350
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.67
Marker Score: 171
Cell Name: multi-ciliated epithelial cell (CL0005012)
Fold Change: 0.62
Marker Score: 1184
Cell Name: early lymphoid progenitor (CL0000936)
Fold Change: 0.61
Marker Score: 300
Cell Name: myeloid cell (CL0000763)
Fold Change: 0.6
Marker Score: 959
Cell Name: blood vessel endothelial cell (CL0000071)
Fold Change: 0.6
Marker Score: 602
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.59
Marker Score: 9291
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 0.59
Marker Score: 995
Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
Fold Change: 0.58
Marker Score: 1479
Cell Name: lung microvascular endothelial cell (CL2000016)
Fold Change: 0.57
Marker Score: 121
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.56
Marker Score: 361
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.56
Marker Score: 148
Cell Name: capillary endothelial cell (CL0002144)
Fold Change: 0.56
Marker Score: 600
Cell Name: endothelial cell (CL0000115)
Fold Change: 0.55
Marker Score: 495
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.55
Marker Score: 440
Cell Name: elicited macrophage (CL0000861)
Fold Change: 0.55
Marker Score: 3312
Cell Name: dendritic cell, human (CL0001056)
Fold Change: 0.54
Marker Score: 555
Cell Name: central nervous system macrophage (CL0000878)
Fold Change: 0.54
Marker Score: 270
Cell Name: common dendritic progenitor (CL0001029)
Fold Change: 0.54
Marker Score: 186
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.53
Marker Score: 221
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.53
Marker Score: 320
Cell Name: B cell (CL0000236)
Fold Change: 0.53
Marker Score: 500
Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
Fold Change: 0.52
Marker Score: 1356
Cell Name: erythroblast (CL0000765)
Fold Change: 0.52
Marker Score: 322
Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: 0.51
Marker Score: 534
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 0.51
Marker Score: 212
Cell Name: B-1a B cell (CL0000820)
Fold Change: 0.5
Marker Score: 120
Cell Name: large pre-B-II cell (CL0000957)
Fold Change: 0.49
Marker Score: 1345.5
Cell Name: mast cell (CL0000097)
Fold Change: 0.49
Marker Score: 286
Cell Name: pro-B cell (CL0000826)
Fold Change: 0.49
Marker Score: 473
Cell Name: endocardial cell (CL0002350)
Fold Change: 0.49
Marker Score: 277
Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: 0.49
Marker Score: 258
Cell Name: immature B cell (CL0000816)
Fold Change: 0.49
Marker Score: 323
Cell Name: conventional dendritic cell (CL0000990)
Fold Change: 0.48
Marker Score: 334
Cell Name: B-1 B cell (CL0000819)
Fold Change: 0.48
Marker Score: 838
Cell Name: retinal blood vessel endothelial cell (CL0002585)
Fold Change: 0.48
Marker Score: 115
Cell Name: erythrocyte (CL0000232)
Fold Change: 0.47
Marker Score: 260
Cell Name: hematopoietic cell (CL0000988)
Fold Change: 0.45
Marker Score: 301
Cell Name: granulocyte (CL0000094)
Fold Change: 0.45
Marker Score: 202
Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
Fold Change: 0.45
Marker Score: 3868
Cell Name: pulmonary artery endothelial cell (CL1001568)
Fold Change: 0.44
Marker Score: 382
Cell Name: endothelial cell of artery (CL1000413)
Fold Change: 0.44
Marker Score: 183
Cell Name: myeloid leukocyte (CL0000766)
Fold Change: 0.44
Marker Score: 526
Cell Name: alternatively activated macrophage (CL0000890)
Fold Change: 0.43
Marker Score: 180
Cell Name: mature B cell (CL0000785)
Fold Change: 0.43
Marker Score: 314
Cell Name: centroblast (CL0009112)
Fold Change: 0.43
Marker Score: 210

Hover over a box to see details here...

**Key characteristics:** * LYL1 is a transcription factor that is highly expressed in hematopoietic cells. * It is a key regulator of blood vessel maturation and the development of the immune system. * LYL1 is involved in the regulation of the expression of many genes involved in blood cell development and function. **Pathways and functions:** * LYL1 is involved in the regulation of B cell differentiation. It is expressed in high levels in pro-T cells and early pro-B cells, and its expression is downregulated in mature B cells. * LYL1 is also involved in the regulation of the development of the immune system. It is expressed in hematopoietic precursor cells and germinal center B cells, where it promotes the differentiation of these cells into mature B cells. * In addition to its role in B cell development, LYL1 is also involved in the regulation of vascular development. It is expressed in endothelial cells, where it promotes the formation of new blood vessels. **Clinical significance:** Mutations in the LYL1 gene have been linked to several human diseases, including leukemia, lymphoma, and vascular disorders. These diseases are characterized by the abnormal development of blood cells, and LYL1 is a key regulator of blood cell development. **Conclusion:** The LYL1 gene is a critical regulator of blood cell development and function. Its expression is highly expressed in hematopoietic cells, and it plays a key role in the regulation of B cell differentiation, vascular development, and the development of the immune system. Mutations in the LYL1 gene have been linked to several human diseases, highlighting its importance in human health.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Protein lyl-1

Genular Protein ID: 569010545

Symbol: LYL1_HUMAN

Name: Protein lyl-1

UniProtKB Accession Codes:

P12980 O76102

Database IDs:

Citations:

PubMed ID: 2752424

Title: lyl-1, a novel gene altered by chromosomal translocation in T cell leukemia, codes for a protein with a helix-loop-helix DNA binding motif.

PubMed ID: 2752424

DOI: 10.1016/0092-8674(89)90404-2

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

Sequence Information:

Length: 280
Mass: 29938
Checksum: 4A9D795FF74C59F8
Sequence:

MCPPQAQAEV GPTMTEKAEM VCAPSPAPAP PPKPASPGPP QVEEVGHRGG SSPPRLPPGV 
PVISLGHSRP PGVAMPTTEL GTLRPPLLQL STLGTAPPTL ALHYHPHPFL NSVYIGPAGP 
FSIFPSSRLK RRPSHCELDL AEGHQPQKVA RRVFTNSRER WRQQNVNGAF AELRKLLPTH 
PPDRKLSKNE VLRLAMKYIG FLVRLLRDQA AALAAGPTPP GPRKRPVHRV PDDGARRGSG 
RRAEAAARSQ PAPPADPDGS PGGAARPIKM EQTALSPEVR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: LYL1

Associated with

Cells (max top 100)

Other Information

lyl-1, a novel gene altered by chromosomal translocation in T cell leukemia, codes for a protein with a helix-loop-helix DNA binding motif. PubMed ID: 2752424

The DNA sequence and biology of human chromosome 19. PubMed ID: 15057824

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

Database document:

PubMed ID: 2752424

PubMed ID: 15057824

PubMed ID: 15489334

PubMed ID: 23186163