Details for: LYL1

Gene ID: 4066

Symbol: LYL1

Ensembl ID: ENSG00000104903

Description: LYL1 basic helix-loop-helix family member

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 23.2857
    Cell Significance Index: -9.4600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 20.4710
    Cell Significance Index: -10.5300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 20.1007
    Cell Significance Index: -9.4900
  • Cell Name: basophilic erythroblast (CL0000549)
    Fold Change: 15.4148
    Cell Significance Index: 7.0200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 2.8494
    Cell Significance Index: 76.2200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 2.0856
    Cell Significance Index: -8.2300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.8832
    Cell Significance Index: 358.3900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.8466
    Cell Significance Index: 119.1400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 1.7600
    Cell Significance Index: -2.1700
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 1.2500
    Cell Significance Index: 7.3800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.0131
    Cell Significance Index: 100.2200
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.9797
    Cell Significance Index: 11.1300
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.9216
    Cell Significance Index: 15.5000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.9004
    Cell Significance Index: 813.0300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.6602
    Cell Significance Index: 14.0600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.5648
    Cell Significance Index: 66.6100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5401
    Cell Significance Index: 87.8400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5187
    Cell Significance Index: 56.4200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.4399
    Cell Significance Index: 8.1300
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.3277
    Cell Significance Index: 5.7900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3178
    Cell Significance Index: 19.0800
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.2967
    Cell Significance Index: 4.7600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2905
    Cell Significance Index: 20.0900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1501
    Cell Significance Index: 103.8100
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 0.1129
    Cell Significance Index: 0.5100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0605
    Cell Significance Index: 7.7500
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.0397
    Cell Significance Index: 0.2400
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 0.0172
    Cell Significance Index: 0.1100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.0023
    Cell Significance Index: 0.1400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0008
    Cell Significance Index: -0.0200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0014
    Cell Significance Index: -0.0400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0018
    Cell Significance Index: -0.0400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0026
    Cell Significance Index: -0.0900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0026
    Cell Significance Index: -0.3600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0037
    Cell Significance Index: -7.0000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0046
    Cell Significance Index: -8.5000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0054
    Cell Significance Index: -8.3500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0070
    Cell Significance Index: -9.5700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0072
    Cell Significance Index: -1.3000
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: -0.0096
    Cell Significance Index: -0.0600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0097
    Cell Significance Index: -4.3000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0106
    Cell Significance Index: -3.0400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0109
    Cell Significance Index: -8.2400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0111
    Cell Significance Index: -6.0900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0122
    Cell Significance Index: -2.4500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0134
    Cell Significance Index: -9.8900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0138
    Cell Significance Index: -10.0900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0152
    Cell Significance Index: -9.6300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0152
    Cell Significance Index: -9.5100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0162
    Cell Significance Index: -5.8100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0169
    Cell Significance Index: -9.5500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0205
    Cell Significance Index: -9.3200
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.0206
    Cell Significance Index: -0.2600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0247
    Cell Significance Index: -4.9100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0289
    Cell Significance Index: -1.3100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0344
    Cell Significance Index: -3.5100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0366
    Cell Significance Index: -4.2700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0422
    Cell Significance Index: -5.1900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0459
    Cell Significance Index: -9.6700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0468
    Cell Significance Index: -2.4400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0490
    Cell Significance Index: -2.4800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0556
    Cell Significance Index: -9.4900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0630
    Cell Significance Index: -9.1600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0732
    Cell Significance Index: -5.6200
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0736
    Cell Significance Index: -3.2000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0758
    Cell Significance Index: -7.8900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0770
    Cell Significance Index: -9.9500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0784
    Cell Significance Index: -1.9600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0800
    Cell Significance Index: -1.6600
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: -0.0809
    Cell Significance Index: -0.6600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0809
    Cell Significance Index: -9.2700
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.0954
    Cell Significance Index: -1.0800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0954
    Cell Significance Index: -4.4500
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: -0.0980
    Cell Significance Index: -0.6500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1036
    Cell Significance Index: -4.2500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1138
    Cell Significance Index: -5.3500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1170
    Cell Significance Index: -6.0800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1261
    Cell Significance Index: -9.9900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1264
    Cell Significance Index: -4.0500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1319
    Cell Significance Index: -9.8300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1415
    Cell Significance Index: -7.4300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1418
    Cell Significance Index: -9.5400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1422
    Cell Significance Index: -8.7400
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.1521
    Cell Significance Index: -2.1800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1553
    Cell Significance Index: -8.7100
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.1610
    Cell Significance Index: -2.3600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1984
    Cell Significance Index: -6.9500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2002
    Cell Significance Index: -7.3500
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.2036
    Cell Significance Index: -3.5100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2065
    Cell Significance Index: -9.1400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2135
    Cell Significance Index: -6.9900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2138
    Cell Significance Index: -6.8100
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2276
    Cell Significance Index: -3.4300
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: -0.2299
    Cell Significance Index: -1.1500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2301
    Cell Significance Index: -6.4300
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.2337
    Cell Significance Index: -3.2800
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.2367
    Cell Significance Index: -1.9300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.2370
    Cell Significance Index: -6.9600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2422
    Cell Significance Index: -9.1700
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.2566
    Cell Significance Index: -3.6900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** LYL1 is a transcription factor that belongs to the bHLH family, which is a class of proteins that regulate gene expression by interacting with other transcription factors. The LYL1 protein is highly expressed in various immune cells, including pro-T cells, early pro-B cells, and germinal center B cells. Its expression is also observed in other cell types, such as Hofbauer cells and enterocytes. The LYL1 protein is characterized by its ability to dimerize with other transcription factors, such as NTRK1 (trka), and regulate gene expression through DNA binding and transcriptional activation. **Pathways and Functions:** LYL1 is involved in various signaling pathways that regulate immune cell development and function. Some of the key pathways include: 1. **B cell differentiation:** LYL1 plays a crucial role in the development of B cells by regulating the expression of genes involved in B cell differentiation and maturation. 2. **Blood vessel maturation:** LYL1 is involved in the regulation of blood vessel maturation, which is essential for the proper functioning of the immune system. 3. **Chromatin regulation:** LYL1 regulates chromatin structure and function, which is essential for the proper expression of genes involved in immune cell development and function. 4. **NTRK1 signaling:** LYL1 interacts with NTRK1 to regulate signaling pathways that are involved in immune cell development and function. **Clinical Significance:** The dysregulation of LYL1 has been implicated in various immune-related disorders, including: 1. **Autoimmune diseases:** LYL1 has been shown to play a role in the development of autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. 2. **Cancer:** LYL1 has been implicated in the development of certain types of cancer, such as lymphoma and leukemia. 3. **Immune deficiency disorders:** LYL1 has been shown to play a role in the development of immune deficiency disorders, such as X-linked agammaglobulinemia. In conclusion, LYL1 is a critical transcription factor that plays a significant role in immune cell development and function. Its dysregulation has been implicated in various immune-related disorders, highlighting the importance of LYL1 in maintaining immune homeostasis. Further research is needed to fully understand the mechanisms by which LYL1 regulates immune cell development and function, and to explore its potential as a therapeutic target for immune-related disorders.

Genular Protein ID: 569010545

Symbol: LYL1_HUMAN

Name: Protein lyl-1

UniProtKB Accession Codes:

P12980 O76102

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CPTAC 2 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 1 ExpressionAtlas 1 GO 12 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 2752424

Title: lyl-1, a novel gene altered by chromosomal translocation in T cell leukemia, codes for a protein with a helix-loop-helix DNA binding motif.

PubMed ID: 2752424

DOI: 10.1016/0092-8674(89)90404-2

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

Sequence Information:

  • Length: 280
  • Mass: 29938
  • Checksum: 4A9D795FF74C59F8
  • Sequence:
    • MCPPQAQAEV GPTMTEKAEM VCAPSPAPAP PPKPASPGPP QVEEVGHRGG SSPPRLPPGV 
PVISLGHSRP PGVAMPTTEL GTLRPPLLQL STLGTAPPTL ALHYHPHPFL NSVYIGPAGP 
FSIFPSSRLK RRPSHCELDL AEGHQPQKVA RRVFTNSRER WRQQNVNGAF AELRKLLPTH 
PPDRKLSKNE VLRLAMKYIG FLVRLLRDQA AALAAGPTPP GPRKRPVHRV PDDGARRGSG 
RRAEAAARSQ PAPPADPDGS PGGAARPIKM EQTALSPEVR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.