Details for: MAN2A2

Gene ID: 4122

Symbol: MAN2A2

Ensembl ID: ENSG00000196547

Description: mannosidase alpha class 2A member 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 100.9353
    Cell Significance Index: -15.7000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 64.2635
    Cell Significance Index: -16.3000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 40.3931
    Cell Significance Index: -16.4100
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 37.0831
    Cell Significance Index: -19.0800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 17.1983
    Cell Significance Index: -16.4200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 14.5991
    Cell Significance Index: -18.0000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 7.1635
    Cell Significance Index: -19.1900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 5.2418
    Cell Significance Index: -16.1000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.8225
    Cell Significance Index: -19.0300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 2.1612
    Cell Significance Index: -4.7300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.2026
    Cell Significance Index: 75.8000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.9609
    Cell Significance Index: 867.6500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.8610
    Cell Significance Index: 172.7100
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.7330
    Cell Significance Index: 5.6500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6750
    Cell Significance Index: 109.7900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6556
    Cell Significance Index: 64.8500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.6136
    Cell Significance Index: 66.7500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.5364
    Cell Significance Index: 15.4600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.5112
    Cell Significance Index: 39.2300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4765
    Cell Significance Index: 21.6000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.4402
    Cell Significance Index: 26.4300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3851
    Cell Significance Index: 138.1300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.3750
    Cell Significance Index: 259.3700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3508
    Cell Significance Index: 7.6000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.2958
    Cell Significance Index: 18.1800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2911
    Cell Significance Index: 20.1300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.2788
    Cell Significance Index: 6.1100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2786
    Cell Significance Index: 55.2800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.2541
    Cell Significance Index: 11.2400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.2214
    Cell Significance Index: 5.9300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.2210
    Cell Significance Index: 8.3700
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.2169
    Cell Significance Index: 2.6900
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.2064
    Cell Significance Index: 3.1100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2027
    Cell Significance Index: 9.4500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1807
    Cell Significance Index: 11.6600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1788
    Cell Significance Index: 32.2400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1688
    Cell Significance Index: 4.2200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1553
    Cell Significance Index: 4.3400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0886
    Cell Significance Index: 4.6500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0874
    Cell Significance Index: 14.9300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0865
    Cell Significance Index: 3.0400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0822
    Cell Significance Index: 5.5300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0798
    Cell Significance Index: 10.2300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0779
    Cell Significance Index: 42.5300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0706
    Cell Significance Index: 13.4400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0565
    Cell Significance Index: 7.7600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0397
    Cell Significance Index: 4.8800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0344
    Cell Significance Index: 64.8500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.0309
    Cell Significance Index: 0.7400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0308
    Cell Significance Index: 13.6000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0214
    Cell Significance Index: 1.2000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0112
    Cell Significance Index: 7.1400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0097
    Cell Significance Index: 14.9800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0062
    Cell Significance Index: 11.5200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0050
    Cell Significance Index: -3.7300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0066
    Cell Significance Index: -4.1200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0069
    Cell Significance Index: -9.3400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0122
    Cell Significance Index: -5.5500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0161
    Cell Significance Index: -11.7900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0173
    Cell Significance Index: -13.1300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0201
    Cell Significance Index: -0.2400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0205
    Cell Significance Index: -2.9800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0231
    Cell Significance Index: -13.0300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0236
    Cell Significance Index: -0.6300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0459
    Cell Significance Index: -9.6700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0471
    Cell Significance Index: -13.5600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0482
    Cell Significance Index: -4.9200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0572
    Cell Significance Index: -2.9700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0734
    Cell Significance Index: -8.6600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0777
    Cell Significance Index: -9.0500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0875
    Cell Significance Index: -1.5000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0883
    Cell Significance Index: -1.8800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0887
    Cell Significance Index: -6.2700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0900
    Cell Significance Index: -10.3200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0909
    Cell Significance Index: -11.7400
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0985
    Cell Significance Index: -1.6600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1052
    Cell Significance Index: -4.9400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1084
    Cell Significance Index: -2.9000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1144
    Cell Significance Index: -5.9600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1489
    Cell Significance Index: -4.7700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1489
    Cell Significance Index: -15.5000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1508
    Cell Significance Index: -4.1100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1564
    Cell Significance Index: -17.8600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1763
    Cell Significance Index: -13.1400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1782
    Cell Significance Index: -4.5800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2263
    Cell Significance Index: -17.9200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2271
    Cell Significance Index: -6.4800
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.2443
    Cell Significance Index: -5.9600
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.2514
    Cell Significance Index: -3.7100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.2597
    Cell Significance Index: -4.8000
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.2655
    Cell Significance Index: -3.9200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2782
    Cell Significance Index: -8.8600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3013
    Cell Significance Index: -9.8700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.3034
    Cell Significance Index: -6.4400
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.3066
    Cell Significance Index: -6.1600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.3078
    Cell Significance Index: -4.2000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3135
    Cell Significance Index: -19.2200
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.3175
    Cell Significance Index: -6.8600
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.3368
    Cell Significance Index: -6.6600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3488
    Cell Significance Index: -8.9100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Alpha-mannosidase activity**: MAN2A2 exhibits alpha-mannosidase activity, which is essential for the removal of mannose residues from N-glycans, a crucial step in protein glycosylation. 2. **Asparagine n-linked glycosylation**: The enzyme participates in asparagine n-linked glycosylation, a process that involves the attachment of carbohydrate molecules to proteins. 3. **Golgi membrane localization**: MAN2A2 is primarily localized to the Golgi membrane, where it can interact with other glycosyltransferases and hydrolases to regulate protein glycosylation. 4. **Hydrolase activity**: The enzyme possesses hydrolase activity, which allows it to hydrolyze n-glycosyl compounds, further emphasizing its role in protein glycosylation. **Pathways and Functions:** 1. **Intra-golgi and retrograde Golgi-to-ER traffic**: MAN2A2 is involved in intra-golgi and retrograde Golgi-to-ER traffic, which is essential for the proper distribution and targeting of proteins within the cell. 2. **N-glycan processing**: The enzyme plays a critical role in N-glycan processing, including the removal of mannose residues and the elongation of N-glycan antennae. 3. **Protein deglycosylation**: MAN2A2 can participate in protein deglycosylation, a process that involves the removal of carbohydrate molecules from proteins. 4. **Cellular homeostasis**: The enzyme's involvement in glycosylation and protein modification suggests its potential role in maintaining cellular homeostasis and regulating protein function. **Clinical Significance:** 1. **Neurological disorders**: Alterations in MAN2A2 expression or function may contribute to neurological disorders, such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS). 2. **Cardiac muscle diseases**: MAN2A2's role in cardiac muscle cells suggests its potential involvement in cardiac muscle diseases, such as cardiomyopathy and heart failure. 3. **Cancer**: The enzyme's involvement in glycosylation and protein modification may also contribute to cancer development and progression. 4. **Neurodevelopmental disorders**: MAN2A2's expression in neurons and oligodendrocytes suggests its potential role in neurodevelopmental disorders, such as autism spectrum disorder and schizophrenia. In conclusion, MAN2A2 is a multifunctional enzyme that plays a crucial role in various cellular processes, including glycosylation, protein modification, and membrane trafficking. Its involvement in neurological disorders, cardiac muscle diseases, cancer, and neurodevelopmental disorders highlights the importance of further research into the functions and clinical significance of this gene.

Genular Protein ID: 568902954

Symbol: MA2A2_HUMAN

Name: Alpha-mannosidase 2x

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 8524845

Title: Molecular cloning and expression of cDNAs encoding human alpha-mannosidase II and a previously unrecognized alpha-mannosidase IIx isozyme.

PubMed ID: 8524845

DOI: 10.1073/pnas.92.25.11766

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16572171

Title: Analysis of the DNA sequence and duplication history of human chromosome 15.

PubMed ID: 16572171

DOI: 10.1038/nature04601

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14759258

Title: An unappreciated role for RNA surveillance.

PubMed ID: 14759258

DOI: 10.1186/gb-2004-5-2-r8

Sequence Information:

  • Length: 1150
  • Mass: 130539
  • Checksum: BFB3D763A6A55444
  • Sequence:
  • MKLKKQVTVC GAAIFCVAVF SLYLMLDRVQ HDPTRHQNGG NFPRSQISVL QNRIEQLEQL 
    LEENHEIISH IKDSVLELTA NAEGPPAMLP YYTVNGSWVV PPEPRPSFFS ISPQDCQFAL 
    GGRGQKPELQ MLTVSEELPF DNVDGGVWRQ GFDISYDPHD WDAEDLQVFV VPHSHNDPGW 
    IKTFDKYYTE QTQHILNSMV SKLQEDPRRR FLWAEVSFFA KWWDNINVQK RAAVRRLVGN 
    GQLEIATGGW VMPDEANSHY FALIDQLIEG HQWLERNLGA TPRSGWAVDP FGYSSTMPYL 
    LRRANLTSML IQRVHYAIKK HFAATHSLEF MWRQTWDSDS STDIFCHMMP FYSYDVPHTC 
    GPDPKICCQF DFKRLPGGRI NCPWKVPPRA ITEANVAERA ALLLDQYRKK SQLFRSNVLL 
    VPLGDDFRYD KPQEWDAQFF NYQRLFDFFN SRPNLHVQAQ FGTLSDYFDA LYKRTGVEPG 
    ARPPGFPVLS GDFFSYADRE DHYWTGYYTS RPFYKSLDRV LEAHLRGAEV LYSLAAAHAR 
    RSGLAGRYPL SDFTLLTEAR RTLGLFQHHD AITGTAKEAV VVDYGVRLLR SLVNLKQVII 
    HAAHYLVLGD KETYHFDPEA PFLQVDDTRL SHDALPERTV IQLDSSPRFV VLFNPLEQER 
    FSMVSLLVNS PRVRVLSEEG QPLAVQISAH WSSATEAVPD VYQVSVPVRL PALGLGVLQL 
    QLGLDGHRTL PSSVRIYLHG RQLSVSRHEA FPLRVIDSGT SDFALSNRYM QVWFSGLTGL 
    LKSIRRVDEE HEQQVDMQVL VYGTRTSKDK SGAYLFLPDG EAKPYVPKEP PVLRVTEGPF 
    FSEVVAYYEH IHQAVRLYNL PGVEGLSLDI SSLVDIRDYV NKELALHIHT DIDSQGIFFT 
    DLNGFQVQPR RYLKKLPLQA NFYPMPVMAY IQDAQKRLTL HTAQALGVSS LKDGQLEVIL 
    DRRLMQDDNR GLGQGLKDNK RTCNRFRLLL ERRTVGSEVQ DSHSTSYPSL LSHLTSMYLN 
    APALALPVAR MQLPGPGLRS FHPLASSLPC DFHLLNLRTL QAEEDTLPSA ETALILHRKG 
    FDCGLEAKNL GFNCTTSQGK VALGSLFHGL DVVFLQPTSL TLLYPLASPS NSTDVYLEPM 
    EIATFRLRLG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.