Details for: ARSD

Gene ID: 414

Symbol: ARSD

Ensembl ID: ENSG00000006756

Description: arylsulfatase D

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 2.36
    Marker Score: 6774
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.57
    Marker Score: 3956
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.54
    Marker Score: 4130
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.49
    Marker Score: 1552
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168444
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.4
    Marker Score: 2065
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 1.32
    Marker Score: 553
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.3
    Marker Score: 375
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.29
    Marker Score: 864
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.28
    Marker Score: 2706
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 1.27
    Marker Score: 1098
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 1.26
    Marker Score: 4343
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.24
    Marker Score: 1319
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.24
    Marker Score: 10737
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.22
    Marker Score: 2771
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 1.2
    Marker Score: 1989
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.17
    Marker Score: 1660
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 1.12
    Marker Score: 5878
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.1
    Marker Score: 2507
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 1.09
    Marker Score: 14667
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 1.05
    Marker Score: 4370
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 1.04
    Marker Score: 389
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1
    Marker Score: 468
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71760
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1
    Marker Score: 7424
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47983
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.99
    Marker Score: 1888.5
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.99
    Marker Score: 574
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30402
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.98
    Marker Score: 33964
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 0.97
    Marker Score: 1368
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.96
    Marker Score: 971
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.96
    Marker Score: 493
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2406
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.95
    Marker Score: 447
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.91
    Marker Score: 2163
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2722
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.89
    Marker Score: 1450
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.89
    Marker Score: 220
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.88
    Marker Score: 877
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.88
    Marker Score: 1396
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.88
    Marker Score: 433
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.88
    Marker Score: 3380
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.88
    Marker Score: 315
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5262
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.86
    Marker Score: 4932
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.86
    Marker Score: 8691
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.85
    Marker Score: 319
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.83
    Marker Score: 1470
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.83
    Marker Score: 194
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.83
    Marker Score: 870
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.82
    Marker Score: 454
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.82
    Marker Score: 804
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.82
    Marker Score: 884
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.82
    Marker Score: 3928
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.81
    Marker Score: 3503
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 0.79
    Marker Score: 1268
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.78
    Marker Score: 5113
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 0.78
    Marker Score: 248
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.78
    Marker Score: 1843
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 0.78
    Marker Score: 749
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.78
    Marker Score: 595
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.77
    Marker Score: 308
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.77
    Marker Score: 1397
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.74
    Marker Score: 2633
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.74
    Marker Score: 383
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.74
    Marker Score: 149
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.73
    Marker Score: 378
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.72
    Marker Score: 490
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.71
    Marker Score: 503
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.71
    Marker Score: 369
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.69
    Marker Score: 1211
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.69
    Marker Score: 628
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.69
    Marker Score: 631
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.69
    Marker Score: 4372
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.68
    Marker Score: 256
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.68
    Marker Score: 720
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.68
    Marker Score: 2852.5
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 174
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.68
    Marker Score: 1377
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.67
    Marker Score: 4324
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.67
    Marker Score: 6716
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.66
    Marker Score: 509
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.66
    Marker Score: 440
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.64
    Marker Score: 35907
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.64
    Marker Score: 403
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.63
    Marker Score: 700
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.63
    Marker Score: 153
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.63
    Marker Score: 401
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 0.63
    Marker Score: 436
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 0.62
    Marker Score: 215
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.62
    Marker Score: 321
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.62
    Marker Score: 293
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.62
    Marker Score: 276
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.61
    Marker Score: 707
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.6
    Marker Score: 398
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.6
    Marker Score: 1636
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.6
    Marker Score: 636
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.59
    Marker Score: 405
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.58
    Marker Score: 307

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Other Information

## Summary ARSD is an enzyme that catalyzes the removal of an aryl group from argininosuccinic acid, a precursor of the amino acid argininosine. This enzyme is expressed in a variety of cell types, including retinal cone cells, kidney cells, and pancreatic cells. ## Key characteristics * ARSD is a transmembrane protein with a molecular weight of approximately 120 kDa. * It is localized to the endoplasmic reticulum lumen. * It is a member of the arylsulfatase family of enzymes. * It is involved in the metabolism of argininosine and its derivatives. ## Pathways and functions * ARSD is involved in the degradation of argininosine and its derivatives. * It is also involved in the metabolism of glycosphingolipids, a class of lipids that are involved in cell signaling and membrane trafficking. * It is involved in the regulation of bile secretion by the liver. ## Clinical significance Mutations in ARSD have been linked to several human diseases, including albinism, which is caused by a deficiency of argininosine. ARSD is also a potential therapeutic target for diseases such as cancer and liver disease. ## Additional information * ARSD is a highly conserved enzyme, with a similar protein found in other mammals. * It is regulated by a variety of factors, including the hormones glucagon and epinephrine. * It is a substrate for the enzyme arginase A.

Genular Protein ID: 2418391087

Symbol: ARSD_HUMAN

Name: Arylsulfatase D

UniProtKB Accession Codes:

P51689 Q9UHJ8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 6 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 4 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 4 Gene3D 3 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 Reactome 2 RefSeq 2 SMR 1 STRING 1 SUPFAM 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7720070

Title: A cluster of sulfatase genes on Xp22.3: mutations in chondrodysplasia punctata (CDPX) and implications for warfarin embryopathy.

PubMed ID: 7720070

DOI: 10.1016/0092-8674(95)90367-4

PubMed ID: 11177574

Title: Arylsulfatase D gene in Xp22.3 encodes two protein isoforms.

PubMed ID: 11177574

DOI: 10.1089/104454900750058125

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

Sequence Information:

  • Length: 593
  • Mass: 64860
  • Checksum: 982B29D0FCEF9D34
  • Sequence:
    • MRSAARRGRA APAARDSLPV LLFLCLLLKT CEPKTANAFK PNILLIMADD LGTGDLGCYG 
NNTLRTPNID QLAEEGVRLT QHLAAAPLCT PSRAAFLTGR HSFRSGMDAS NGYRALQWNA 
GSGGLPENET TFARILQQHG YATGLIGKWH QGVNCASRGD HCHHPLNHGF DYFYGMPFTL 
TNDCDPGRPP EVDAALRAQL WGYTQFLALG ILTLAAGQTC GFFSVSARAV TGMAGVGCLF 
FISWYSSFGF VRRWNCILMR NHDVTEQPMV LEKTASLMLK EAVSYIERHK HGPFLLFLSL 
LHVHIPLVTT SAFLGKSQHG LYGDNVEEMD WLIGKVLNAI EDNGLKNSTF TYFTSDHGGH 
LEARDGHSQL GGWNGIYKGG KGMGGWEGGI RVPGIFHWPG VLPAGRVIGE PTSLMDVFPT 
VVQLVGGEVP QDRVIDGHSL VPLLQGAEAR SAHEFLFHYC GQHLHAARWH QKDSGSVWKV 
HYTTPQFHPE GAGACYGRGV CPCSGEGVTH HRPPLLFDLS RDPSEARPLT PDSEPLYHAV 
IARVGAAVSE HRQTLSPVPQ QFSMSNILWK PWLQPCCGHF PFCSCHEDGD GTP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.