Details for: ARSD

Gene ID: 414

Symbol: ARSD

Ensembl ID: ENSG00000006756

Description: arylsulfatase D

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 108.8429
    Cell Significance Index: -16.9300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 55.6293
    Cell Significance Index: -14.1100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 37.9316
    Cell Significance Index: -15.4100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 16.1719
    Cell Significance Index: -15.4400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 13.7312
    Cell Significance Index: -16.9300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 6.0735
    Cell Significance Index: -16.2700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.3233
    Cell Significance Index: -17.0600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.8204
    Cell Significance Index: 38.4800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 2.3760
    Cell Significance Index: -5.2000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.9833
    Cell Significance Index: 103.0300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.9017
    Cell Significance Index: 114.1700
  • Cell Name: peg cell (CL4033014)
    Fold Change: 1.8616
    Cell Significance Index: 43.0100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.6229
    Cell Significance Index: 35.1600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.5891
    Cell Significance Index: 185.1900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.5098
    Cell Significance Index: 164.2200
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 1.3877
    Cell Significance Index: 8.5400
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: 1.1021
    Cell Significance Index: 4.2200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.0238
    Cell Significance Index: 166.5200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.0089
    Cell Significance Index: 45.7300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.9784
    Cell Significance Index: 9.0100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.9782
    Cell Significance Index: 176.3300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.8453
    Cell Significance Index: 39.4100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.8318
    Cell Significance Index: 57.5200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.8021
    Cell Significance Index: 51.7500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7131
    Cell Significance Index: 20.5500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.6626
    Cell Significance Index: 81.4800
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 0.6212
    Cell Significance Index: 6.6000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.5862
    Cell Significance Index: 320.1500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.5677
    Cell Significance Index: 42.3100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.5461
    Cell Significance Index: 13.6500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5190
    Cell Significance Index: 51.3400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.5157
    Cell Significance Index: 13.5600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.4477
    Cell Significance Index: 12.1900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.4336
    Cell Significance Index: 74.0500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3957
    Cell Significance Index: 54.3400
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.3921
    Cell Significance Index: 5.4400
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.3744
    Cell Significance Index: 5.6100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.3700
    Cell Significance Index: 10.3400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3455
    Cell Significance Index: 68.5600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.2925
    Cell Significance Index: 6.2300
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.2860
    Cell Significance Index: 2.9500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.2656
    Cell Significance Index: 5.5100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2552
    Cell Significance Index: 176.5100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2379
    Cell Significance Index: 30.5000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2138
    Cell Significance Index: 40.7000
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.1972
    Cell Significance Index: 2.5400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1879
    Cell Significance Index: 83.0700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1155
    Cell Significance Index: 8.1700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0988
    Cell Significance Index: 72.4100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.0947
    Cell Significance Index: 1.7500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0889
    Cell Significance Index: 11.4800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0847
    Cell Significance Index: 3.9800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0845
    Cell Significance Index: 4.7400
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.0844
    Cell Significance Index: 0.5500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.0748
    Cell Significance Index: 0.8500
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.0653
    Cell Significance Index: 1.1000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0446
    Cell Significance Index: 3.4300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0389
    Cell Significance Index: 1.2500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0209
    Cell Significance Index: 39.2700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0139
    Cell Significance Index: 10.5400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0120
    Cell Significance Index: 4.3100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0068
    Cell Significance Index: 0.2400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0068
    Cell Significance Index: 10.5400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0066
    Cell Significance Index: 12.2400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0057
    Cell Significance Index: 3.6300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0004
    Cell Significance Index: 0.0100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0013
    Cell Significance Index: -0.9500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0015
    Cell Significance Index: -0.9500
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0048
    Cell Significance Index: -0.0500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0130
    Cell Significance Index: -1.8900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0130
    Cell Significance Index: -17.6600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0131
    Cell Significance Index: -1.3400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0184
    Cell Significance Index: -8.3500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0195
    Cell Significance Index: -11.0200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0205
    Cell Significance Index: -4.1200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0289
    Cell Significance Index: -3.3100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0344
    Cell Significance Index: -7.2500
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0452
    Cell Significance Index: -5.1600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0506
    Cell Significance Index: -14.5500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0650
    Cell Significance Index: -1.7400
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.1106
    Cell Significance Index: -0.9400
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.1150
    Cell Significance Index: -1.1900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1174
    Cell Significance Index: -4.0800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1278
    Cell Significance Index: -3.4300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1356
    Cell Significance Index: -2.9700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1386
    Cell Significance Index: -16.3400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1484
    Cell Significance Index: -11.7500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1535
    Cell Significance Index: -15.9800
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.1768
    Cell Significance Index: -2.6100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1840
    Cell Significance Index: -11.3100
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.1841
    Cell Significance Index: -2.6200
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.1872
    Cell Significance Index: -1.5000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2016
    Cell Significance Index: -12.3600
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: -0.2185
    Cell Significance Index: -2.5400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2194
    Cell Significance Index: -11.4300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2507
    Cell Significance Index: -15.8000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.2605
    Cell Significance Index: -13.1600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2693
    Cell Significance Index: -18.1100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2947
    Cell Significance Index: -8.6800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2955
    Cell Significance Index: -7.5500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

Key Characteristics:

ARSD is a type II transmembrane glycoprotein consisting of a large extracellular domain, a transmembrane domain, and a lysosomal catalytic domain. The enzyme’s substrate specificity is characterized by its ability to hydrolyze arylsulfates, a class of sulfated compounds found in glycosphingolipids. The optimal pH for ARSD activity ranges from 4.5 to 5.5, and the enzyme’s kinetic parameters suggest a relatively low Km value, indicating its high affinity for substrates.

Pathways and Functions:

ARSD is involved in the lysosomal catabolism of glycosphingolipids, which are essential components of cellular membranes. The enzyme’s primary function is to hydrolyze glycosphingolipids, releasing arylsulfates and other metabolites. These metabolites can then be further processed by other enzymes, such as arylsulfatase A, to produce glucose and sulfate. ARSD’s activity is tightly regulated, and its dysregulation has been linked to various diseases, including lysosomal storage disorders.

Clinical Significance:

Dysregulation of ARSD has been implicated in several diseases, including:

  1. Lysosomal storage disorders: ARSD’s deficiency has been linked to lysosomal storage disorders, such as I-cell disease and Hurler syndrome, which are characterized by the accumulation of glycosphingolipids in lysosomes.
  2. Neurodegenerative diseases: ARSD’s dysregulation has been implicated in neurodegenerative diseases, such as Alzheimer’s disease and Parkinson’s disease, which are characterized by the accumulation of glycosphingolipids in the brain.
  3. Cancer: ARSD’s overexpression has been observed in certain types of cancer, including breast and lung cancer, suggesting its potential role in tumor progression and metastasis.

In conclusion, ARSD is a crucial enzyme involved in the lysosomal catabolism of glycosphingolipids. Its dysregulation has been linked to various diseases, highlighting the importance of its functional understanding. Further research is needed to elucidate the molecular mechanisms underlying ARSD’s role in disease and to develop novel therapeutic strategies for its dysregulation.

Recommendations for Future Research:

  1. Structural studies: Further structural studies are needed to elucidate the binding mechanism of ARSD’s substrate and to understand the enzyme’s conformational dynamics.
  2. Kinetic studies: Kinetic studies are necessary to elucidate the enzyme’s kinetic parameters and to understand its substrate specificity.
  3. Functional studies: Functional studies are required to elucidate the enzyme’s role in disease and to understand its interactions with other proteins and lipids.

By addressing these knowledge gaps, we can gain a deeper understanding of ARSD’s molecular mechanisms and develop novel therapeutic strategies for its dysregulation.

Genular Protein ID: 2418391087

Symbol: ARSD_HUMAN

Name: Arylsulfatase D

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 7720070

Title: A cluster of sulfatase genes on Xp22.3: mutations in chondrodysplasia punctata (CDPX) and implications for warfarin embryopathy.

PubMed ID: 7720070

DOI: 10.1016/0092-8674(95)90367-4

PubMed ID: 11177574

Title: Arylsulfatase D gene in Xp22.3 encodes two protein isoforms.

PubMed ID: 11177574

DOI: 10.1089/104454900750058125

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

Sequence Information:

  • Length: 593
  • Mass: 64860
  • Checksum: 982B29D0FCEF9D34
  • Sequence:
  • MRSAARRGRA APAARDSLPV LLFLCLLLKT CEPKTANAFK PNILLIMADD LGTGDLGCYG 
    NNTLRTPNID QLAEEGVRLT QHLAAAPLCT PSRAAFLTGR HSFRSGMDAS NGYRALQWNA 
    GSGGLPENET TFARILQQHG YATGLIGKWH QGVNCASRGD HCHHPLNHGF DYFYGMPFTL 
    TNDCDPGRPP EVDAALRAQL WGYTQFLALG ILTLAAGQTC GFFSVSARAV TGMAGVGCLF 
    FISWYSSFGF VRRWNCILMR NHDVTEQPMV LEKTASLMLK EAVSYIERHK HGPFLLFLSL 
    LHVHIPLVTT SAFLGKSQHG LYGDNVEEMD WLIGKVLNAI EDNGLKNSTF TYFTSDHGGH 
    LEARDGHSQL GGWNGIYKGG KGMGGWEGGI RVPGIFHWPG VLPAGRVIGE PTSLMDVFPT 
    VVQLVGGEVP QDRVIDGHSL VPLLQGAEAR SAHEFLFHYC GQHLHAARWH QKDSGSVWKV 
    HYTTPQFHPE GAGACYGRGV CPCSGEGVTH HRPPLLFDLS RDPSEARPLT PDSEPLYHAV 
    IARVGAAVSE HRQTLSPVPQ QFSMSNILWK PWLQPCCGHF PFCSCHEDGD GTP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.