Details for: MAT1A
Associated with
Cells (max top 100)
(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: 2.99
Marker Score: 16,089 - Cell Name: midzonal region hepatocyte (CL0019028)
Fold Change: 2.19
Marker Score: 9,457 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 2.19
Marker Score: 14,057 - Cell Name: blood vessel endothelial cell (CL0000071)
Fold Change: 2.09
Marker Score: 2,100 - Cell Name: hepatoblast (CL0005026)
Fold Change: 2.08
Marker Score: 6,821 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.61
Marker Score: 1,173 - Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
Fold Change: 1.43
Marker Score: 1,536 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 1.27
Marker Score: 858 - Cell Name: inflammatory macrophage (CL0000863)
Fold Change: 1.23
Marker Score: 383 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 1.18
Marker Score: 489 - Cell Name: hepatocyte (CL0000182)
Fold Change: 1.16
Marker Score: 795 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 1.15
Marker Score: 4,819 - Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
Fold Change: 1.11
Marker Score: 2,303 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 1.07
Marker Score: 6,473 - Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71,829 - Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48,054 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.99
Marker Score: 511 - Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.98
Marker Score: 464 - Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30,409 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2,412 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.95
Marker Score: 436 - Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.94
Marker Score: 5,341 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.94
Marker Score: 375 - Cell Name: abnormal cell (CL0001061)
Fold Change: 0.92
Marker Score: 2,742 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.91
Marker Score: 327 - Cell Name: mast cell (CL0000097)
Fold Change: 0.84
Marker Score: 486 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1,268 - Cell Name: brush cell (CL0002204)
Fold Change: 0.78
Marker Score: 710 - Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 0.78
Marker Score: 1,472 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.77
Marker Score: 12,098 - Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
Fold Change: 0.77
Marker Score: 212 - Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.77
Marker Score: 398 - Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 0.73
Marker Score: 1,480 - Cell Name: Kupffer cell (CL0000091)
Fold Change: 0.71
Marker Score: 710 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.69
Marker Score: 203 - Cell Name: hepatic stellate cell (CL0000632)
Fold Change: 0.67
Marker Score: 252 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.63
Marker Score: 402 - Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
Fold Change: 0.62
Marker Score: 136 - Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.6
Marker Score: 478 - Cell Name: pericyte (CL0000669)
Fold Change: 0.55
Marker Score: 324 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 0.55
Marker Score: 174 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.52
Marker Score: 1,097 - Cell Name: mature NK T cell (CL0000814)
Fold Change: 0.5
Marker Score: 233 - Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 0.47
Marker Score: 278 - Cell Name: renal alpha-intercalated cell (CL0005011)
Fold Change: 0.44
Marker Score: 232 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: 0.4
Marker Score: 388 - Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
Fold Change: 0.39
Marker Score: 3,406 - Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.38
Marker Score: 229 - Cell Name: ciliated cell (CL0000064)
Fold Change: 0.37
Marker Score: 1,283 - Cell Name: B cell (CL0000236)
Fold Change: 0.35
Marker Score: 337 - Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 0.35
Marker Score: 384 - Cell Name: renal beta-intercalated cell (CL0002201)
Fold Change: 0.34
Marker Score: 108 - Cell Name: goblet cell (CL0000160)
Fold Change: 0.34
Marker Score: 2,234 - Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: 0.32
Marker Score: 170 - Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.31
Marker Score: 150 - Cell Name: alpha-beta T cell (CL0000789)
Fold Change: 0.31
Marker Score: 238 - Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 0.3
Marker Score: 709 - Cell Name: plasma cell (CL0000786)
Fold Change: 0.29
Marker Score: 326 - Cell Name: connective tissue cell (CL0002320)
Fold Change: 0.25
Marker Score: 64 - Cell Name: lung ciliated cell (CL1000271)
Fold Change: 0.24
Marker Score: 116 - Cell Name: precursor B cell (CL0000817)
Fold Change: 0.24
Marker Score: 161 - Cell Name: respiratory basal cell (CL0002633)
Fold Change: 0.23
Marker Score: 333 - Cell Name: cholangiocyte (CL1000488)
Fold Change: 0.23
Marker Score: 85 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.22
Marker Score: 64 - Cell Name: multi-ciliated epithelial cell (CL0005012)
Fold Change: 0.22
Marker Score: 417 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.22
Marker Score: 74 - Cell Name: myeloid cell (CL0000763)
Fold Change: 0.2
Marker Score: 324 - Cell Name: erythrocyte (CL0000232)
Fold Change: 0.19
Marker Score: 108 - Cell Name: epithelial cell of exocrine pancreas (CL1001433)
Fold Change: 0.19
Marker Score: 109 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.19
Marker Score: 804 - Cell Name: neuronal receptor cell (CL0000006)
Fold Change: 0.19
Marker Score: 84 - Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 0.18
Marker Score: 77 - Cell Name: innate lymphoid cell (CL0001065)
Fold Change: 0.18
Marker Score: 63 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.17
Marker Score: 43 - Cell Name: choroid plexus epithelial cell (CL0000706)
Fold Change: 0.16
Marker Score: 144 - Cell Name: ciliated epithelial cell (CL0000067)
Fold Change: 0.16
Marker Score: 71 - Cell Name: type A enteroendocrine cell (CL0002067)
Fold Change: 0.15
Marker Score: 62 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.15
Marker Score: 150 - Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 0.13
Marker Score: 42 - Cell Name: parietal epithelial cell (CL1000452)
Fold Change: 0.13
Marker Score: 48 - Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: 0.13
Marker Score: 1,222 - Cell Name: endothelial cell (CL0000115)
Fold Change: 0.12
Marker Score: 108 - Cell Name: gamma-delta T cell (CL0000798)
Fold Change: 0.12
Marker Score: 80 - Cell Name: double negative thymocyte (CL0002489)
Fold Change: 0.12
Marker Score: 164 - Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
Fold Change: 0.12
Marker Score: 100 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 0.12
Marker Score: 2,077 - Cell Name: thymocyte (CL0000893)
Fold Change: 0.12
Marker Score: 121 - Cell Name: mononuclear cell (CL0000842)
Fold Change: 0.11
Marker Score: 36 - Cell Name: kidney collecting duct cell (CL1001225)
Fold Change: 0.11
Marker Score: 21 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.1
Marker Score: 110 - Cell Name: papillary tips cell (CL1000597)
Fold Change: 0.1
Marker Score: 21 - Cell Name: megakaryocyte (CL0000556)
Fold Change: 0.1
Marker Score: 58 - Cell Name: smooth muscle cell (CL0000192)
Fold Change: 0.1
Marker Score: 67 - Cell Name: erythroblast (CL0000765)
Fold Change: 0.1
Marker Score: 61 - Cell Name: podocyte (CL0000653)
Fold Change: 0.09
Marker Score: 34 - Cell Name: ependymal cell (CL0000065)
Fold Change: 0.09
Marker Score: 32 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 0.09
Marker Score: 93 - Cell Name: PP cell (CL0000696)
Fold Change: 0.09
Marker Score: 20 - Cell Name: Leydig cell (CL0000178)
Fold Change: 0.09
Marker Score: 92 - Cell Name: oocyte (CL0000023)
Fold Change: 0.08
Marker Score: 21
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 851710343
Symbol: METK1_HUMAN
Name: S-adenosylmethionine synthase isoform type-1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8393662
Title: Characterization of a full-length cDNA encoding human liver S-adenosylmethionine synthetase: tissue-specific gene expression and mRNA levels in hepatopathies.
PubMed ID: 8393662
DOI: 10.1042/bj2930481
PubMed ID: 1772450
Title: Molecular cloning and nucleotide sequence of cDNA encoding the human liver S-adenosylmethionine synthetase.
PubMed ID: 1772450
PubMed ID: 15164054
Title: The DNA sequence and comparative analysis of human chromosome 10.
PubMed ID: 15164054
DOI: 10.1038/nature02462
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 23425511
Title: Insight into S-adenosylmethionine biosynthesis from the crystal structures of the human methionine adenosyltransferase catalytic and regulatory subunits.
PubMed ID: 23425511
DOI: 10.1042/bj20121580
PubMed ID: 7560086
Title: Molecular mechanisms of an inborn error of methionine pathway. Methionine adenosyltransferase deficiency.
PubMed ID: 7560086
DOI: 10.1172/jci118240
PubMed ID: 8770875
Title: Demyelination of the brain is associated with methionine adenosyltransferase I/III deficiency.
PubMed ID: 8770875
DOI: 10.1172/jci118862
PubMed ID: 9042912
Title: Dominant inheritance of isolated hypermethioninemia is associated with a mutation in the human methionine adenosyltransferase 1A gene.
PubMed ID: 9042912
PubMed ID: 10677294
Title: Methionine adenosyltransferase I/III deficiency: novel mutations and clinical variations.
PubMed ID: 10677294
DOI: 10.1086/302752
Sequence Information:
- Length: 395
- Mass: 43648
- Checksum: B3462A5670A5B0D4
- Sequence:
MNGPVDGLCD HSLSEGVFMF TSESVGEGHP DKICDQISDA VLDAHLKQDP NAKVACETVC KTGMVLLCGE ITSMAMVDYQ RVVRDTIKHI GYDDSAKGFD FKTCNVLVAL EQQSPDIAQC VHLDRNEEDV GAGDQGLMFG YATDETEECM PLTIILAHKL NARMADLRRS GLLPWLRPDS KTQVTVQYMQ DNGAVIPVRI HTIVISVQHN EDITLEEMRR ALKEQVIRAV VPAKYLDEDT VYHLQPSGRF VIGGPQGDAG VTGRKIIVDT YGGWGAHGGG AFSGKDYTKV DRSAAYAARW VAKSLVKAGL CRRVLVQVSY AIGVAEPLSI SIFTYGTSQK TERELLDVVH KNFDLRPGVI VRDLDLKKPI YQKTACYGHF GRSEFPWEVP RKLVF
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.