Details for: MAT1A

Gene ID: 4143

Symbol: MAT1A

Ensembl ID: ENSG00000151224

Description: methionine adenosyltransferase 1A

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: liver dendritic cell (CL2000055)
    Fold Change: 29.3182
    Cell Significance Index: 77.3400
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 26.3378
    Cell Significance Index: 244.4300
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 13.9738
    Cell Significance Index: 235.0300
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 8.5751
    Cell Significance Index: 144.4500
  • Cell Name: epithelial cell of exocrine pancreas (CL1001433)
    Fold Change: 3.7235
    Cell Significance Index: 1.8700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 3.0218
    Cell Significance Index: -2.8900
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 1.5284
    Cell Significance Index: 13.0200
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 1.4214
    Cell Significance Index: 21.4200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.3136
    Cell Significance Index: 260.6900
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.2331
    Cell Significance Index: 18.2000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.8082
    Cell Significance Index: 21.6600
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: 0.7574
    Cell Significance Index: 5.8200
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.7476
    Cell Significance Index: 4.3100
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.7115
    Cell Significance Index: 7.0200
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.5361
    Cell Significance Index: 1.8700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.5021
    Cell Significance Index: 12.5500
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 0.4461
    Cell Significance Index: 1.2000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.3536
    Cell Significance Index: 7.5300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3350
    Cell Significance Index: 20.1100
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.2470
    Cell Significance Index: 1.9500
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.1777
    Cell Significance Index: 2.5300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1646
    Cell Significance Index: 31.3300
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: 0.1593
    Cell Significance Index: 0.6000
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.1515
    Cell Significance Index: 1.4400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1487
    Cell Significance Index: 16.1700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1301
    Cell Significance Index: 82.6100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0661
    Cell Significance Index: 9.6100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0628
    Cell Significance Index: 6.2100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0623
    Cell Significance Index: 0.8500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.0494
    Cell Significance Index: 3.0300
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.0470
    Cell Significance Index: 0.4300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0454
    Cell Significance Index: 7.7500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0451
    Cell Significance Index: 3.1200
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.0339
    Cell Significance Index: 0.3500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0293
    Cell Significance Index: 4.7700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0121
    Cell Significance Index: 22.6900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0077
    Cell Significance Index: 4.2000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0065
    Cell Significance Index: 0.7600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0051
    Cell Significance Index: 0.1100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0033
    Cell Significance Index: 2.2600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0028
    Cell Significance Index: 0.0400
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.0002
    Cell Significance Index: 0.0100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0008
    Cell Significance Index: -1.4400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0011
    Cell Significance Index: -1.6600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0014
    Cell Significance Index: -1.0400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0015
    Cell Significance Index: -2.0200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0023
    Cell Significance Index: -1.7200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0023
    Cell Significance Index: -1.7500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0024
    Cell Significance Index: -1.3400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0042
    Cell Significance Index: -1.5100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0043
    Cell Significance Index: -1.9400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0048
    Cell Significance Index: -0.1700
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0048
    Cell Significance Index: -0.1200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0049
    Cell Significance Index: -0.2500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0051
    Cell Significance Index: -0.2100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0074
    Cell Significance Index: -2.1300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0077
    Cell Significance Index: -1.5400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0080
    Cell Significance Index: -0.2300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0087
    Cell Significance Index: -1.8400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0104
    Cell Significance Index: -1.1900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0118
    Cell Significance Index: -1.6200
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0123
    Cell Significance Index: -0.1700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0126
    Cell Significance Index: -2.2800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0137
    Cell Significance Index: -0.6200
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0141
    Cell Significance Index: -0.2000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0142
    Cell Significance Index: -0.7400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0172
    Cell Significance Index: -2.2200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0183
    Cell Significance Index: -0.3800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0186
    Cell Significance Index: -0.4900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0192
    Cell Significance Index: -2.0000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0202
    Cell Significance Index: -0.5500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0210
    Cell Significance Index: -0.9800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0210
    Cell Significance Index: -0.5900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0221
    Cell Significance Index: -2.7200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0222
    Cell Significance Index: -0.7100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0233
    Cell Significance Index: -2.3800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0271
    Cell Significance Index: -1.2000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0276
    Cell Significance Index: -2.0600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0280
    Cell Significance Index: -0.7200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0305
    Cell Significance Index: -2.0500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0309
    Cell Significance Index: -1.1700
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0316
    Cell Significance Index: -0.7900
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0317
    Cell Significance Index: -0.4000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0321
    Cell Significance Index: -1.9700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0323
    Cell Significance Index: -2.5600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0358
    Cell Significance Index: -1.8800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0412
    Cell Significance Index: -2.3100
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0437
    Cell Significance Index: -0.5700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0451
    Cell Significance Index: -2.1200
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0477
    Cell Significance Index: -1.1900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0493
    Cell Significance Index: -1.8100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0528
    Cell Significance Index: -1.8500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0556
    Cell Significance Index: -1.8200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0584
    Cell Significance Index: -1.0800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0589
    Cell Significance Index: -3.0700
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: -0.0596
    Cell Significance Index: -0.5900
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0616
    Cell Significance Index: -0.7800
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0617
    Cell Significance Index: -1.9500
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0620
    Cell Significance Index: -1.5800
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.0633
    Cell Significance Index: -0.6900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** MAT1A is a homotetramer composed of four identical subunits, which are encoded by the same gene. The enzyme catalyzes the transfer of an adenosyl group from S-adenosylhomocysteine (SAH) to methionine, resulting in the formation of SAMe. SAMe is a vital cofactor in numerous biochemical reactions, including DNA methylation, histone modification, and protein methylation. MAT1A is highly expressed in various tissues, including the liver, colon, and small intestine, where it plays a crucial role in maintaining SAMe homeostasis. **Pathways and Functions:** MAT1A is involved in several key pathways, including: 1. **One-carbon metabolism**: MAT1A is a critical enzyme in the one-carbon metabolic pathway, which is essential for the synthesis of SAMe, thymidine, and other biomolecules. 2. **Methylation**: SAMe is a key methyl donor in various biochemical reactions, including DNA methylation, histone modification, and protein methylation. 3. **Amino acid metabolism**: MAT1A is involved in the metabolism of methionine and homocysteine, which are essential amino acids and intermediates in the one-carbon metabolic pathway. 4. **Homocysteine metabolism**: MAT1A helps to regulate homocysteine levels by converting it into SAMe. **Clinical Significance:** Dysregulation of MAT1A has been implicated in various human diseases, including: 1. **Homocystinuria**: A genetic disorder characterized by elevated homocysteine levels, which can lead to cardiovascular disease and neurological disorders. 2. **Methylmalonic acidemia**: A metabolic disorder caused by mutations in the MTHFR gene, which affects MAT1A activity and leads to elevated methylmalonic acid levels. 3. **Cancer**: Alterations in MAT1A expression have been observed in various types of cancer, including colorectal and breast cancer, suggesting a potential role in tumorigenesis. 4. **Neurological disorders**: MAT1A has been implicated in the pathogenesis of neurological disorders, such as Alzheimer's disease and Parkinson's disease, where SAMe levels are often decreased. In conclusion, MAT1A plays a vital role in human metabolism and disease, and its dysregulation can have significant consequences for human health. Further research is needed to fully understand the mechanisms underlying MAT1A function and its role in disease, which may lead to the development of novel therapeutic strategies for the treatment of these disorders.

Genular Protein ID: 851710343

Symbol: METK1_HUMAN

Name: S-adenosylmethionine synthase isoform type-1

UniProtKB Accession Codes:

Q00266 D3DWD5 Q5QP09

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChEBI 22 ChEMBL 1 ChiTaRS 1 ComplexPortal 2 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 4 EC 1 EMBL 6 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 10 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HAMAP 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PIR 1 PIRSF 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 4 RefSeq 2 Rhea 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8393662

Title: Characterization of a full-length cDNA encoding human liver S-adenosylmethionine synthetase: tissue-specific gene expression and mRNA levels in hepatopathies.

PubMed ID: 8393662

DOI: 10.1042/bj2930481

PubMed ID: 1772450

Title: Molecular cloning and nucleotide sequence of cDNA encoding the human liver S-adenosylmethionine synthetase.

PubMed ID: 1772450

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 23425511

Title: Insight into S-adenosylmethionine biosynthesis from the crystal structures of the human methionine adenosyltransferase catalytic and regulatory subunits.

PubMed ID: 23425511

DOI: 10.1042/bj20121580

PubMed ID: 7560086

Title: Molecular mechanisms of an inborn error of methionine pathway. Methionine adenosyltransferase deficiency.

PubMed ID: 7560086

DOI: 10.1172/jci118240

PubMed ID: 8770875

Title: Demyelination of the brain is associated with methionine adenosyltransferase I/III deficiency.

PubMed ID: 8770875

DOI: 10.1172/jci118862

PubMed ID: 9042912

Title: Dominant inheritance of isolated hypermethioninemia is associated with a mutation in the human methionine adenosyltransferase 1A gene.

PubMed ID: 9042912

PubMed ID: 10677294

Title: Methionine adenosyltransferase I/III deficiency: novel mutations and clinical variations.

PubMed ID: 10677294

DOI: 10.1086/302752

Sequence Information:

  • Length: 395
  • Mass: 43648
  • Checksum: B3462A5670A5B0D4
  • Sequence:
    • MNGPVDGLCD HSLSEGVFMF TSESVGEGHP DKICDQISDA VLDAHLKQDP NAKVACETVC 
KTGMVLLCGE ITSMAMVDYQ RVVRDTIKHI GYDDSAKGFD FKTCNVLVAL EQQSPDIAQC 
VHLDRNEEDV GAGDQGLMFG YATDETEECM PLTIILAHKL NARMADLRRS GLLPWLRPDS 
KTQVTVQYMQ DNGAVIPVRI HTIVISVQHN EDITLEEMRR ALKEQVIRAV VPAKYLDEDT 
VYHLQPSGRF VIGGPQGDAG VTGRKIIVDT YGGWGAHGGG AFSGKDYTKV DRSAAYAARW 
VAKSLVKAGL CRRVLVQVSY AIGVAEPLSI SIFTYGTSQK TERELLDVVH KNFDLRPGVI 
VRDLDLKKPI YQKTACYGHF GRSEFPWEVP RKLVF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.