Details for: MAT1A
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: liver dendritic cell (CL2000055)
Fold Change: 29.3182
Cell Significance Index: 77.3400 - Cell Name: plasmablast (CL0000980)
Fold Change: 26.3378
Cell Significance Index: 244.4300 - Cell Name: hepatoblast (CL0005026)
Fold Change: 13.9738
Cell Significance Index: 235.0300 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 8.5751
Cell Significance Index: 144.4500 - Cell Name: epithelial cell of exocrine pancreas (CL1001433)
Fold Change: 3.7235
Cell Significance Index: 1.8700 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 3.0218
Cell Significance Index: -2.8900 - Cell Name: alpha-beta T cell (CL0000789)
Fold Change: 1.5284
Cell Significance Index: 13.0200 - Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: 1.4214
Cell Significance Index: 21.4200 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 1.3136
Cell Significance Index: 260.6900 - Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: 1.2331
Cell Significance Index: 18.2000 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 0.8082
Cell Significance Index: 21.6600 - Cell Name: inflammatory macrophage (CL0000863)
Fold Change: 0.7574
Cell Significance Index: 5.8200 - Cell Name: midzonal region hepatocyte (CL0019028)
Fold Change: 0.7476
Cell Significance Index: 4.3100 - Cell Name: cholangiocyte (CL1000488)
Fold Change: 0.7115
Cell Significance Index: 7.0200 - Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
Fold Change: 0.5361
Cell Significance Index: 1.8700 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.5021
Cell Significance Index: 12.5500 - Cell Name: hepatic pit cell (CL2000054)
Fold Change: 0.4461
Cell Significance Index: 1.2000 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.3536
Cell Significance Index: 7.5300 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.3350
Cell Significance Index: 20.1100 - Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
Fold Change: 0.2470
Cell Significance Index: 1.9500 - Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 0.1777
Cell Significance Index: 2.5300 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.1646
Cell Significance Index: 31.3300 - Cell Name: intrahepatic cholangiocyte (CL0002538)
Fold Change: 0.1593
Cell Significance Index: 0.6000 - Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
Fold Change: 0.1515
Cell Significance Index: 1.4400 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.1487
Cell Significance Index: 16.1700 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.1301
Cell Significance Index: 82.6100 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: 0.0661
Cell Significance Index: 9.6100 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.0628
Cell Significance Index: 6.2100 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.0623
Cell Significance Index: 0.8500 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 0.0494
Cell Significance Index: 3.0300 - Cell Name: Kupffer cell (CL0000091)
Fold Change: 0.0470
Cell Significance Index: 0.4300 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.0454
Cell Significance Index: 7.7500 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.0451
Cell Significance Index: 3.1200 - Cell Name: hepatic stellate cell (CL0000632)
Fold Change: 0.0339
Cell Significance Index: 0.3500 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.0293
Cell Significance Index: 4.7700 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0121
Cell Significance Index: 22.6900 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.0077
Cell Significance Index: 4.2000 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 0.0065
Cell Significance Index: 0.7600 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.0051
Cell Significance Index: 0.1100 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.0033
Cell Significance Index: 2.2600 - Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: 0.0028
Cell Significance Index: 0.0400 - Cell Name: eukaryotic cell (CL0000255)
Fold Change: 0.0002
Cell Significance Index: 0.0100 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0008
Cell Significance Index: -1.4400 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0011
Cell Significance Index: -1.6600 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0014
Cell Significance Index: -1.0400 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0015
Cell Significance Index: -2.0200 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0023
Cell Significance Index: -1.7200 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0023
Cell Significance Index: -1.7500 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0024
Cell Significance Index: -1.3400 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0042
Cell Significance Index: -1.5100 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0043
Cell Significance Index: -1.9400 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.0048
Cell Significance Index: -0.1700 - Cell Name: keratinocyte (CL0000312)
Fold Change: -0.0048
Cell Significance Index: -0.1200 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.0049
Cell Significance Index: -0.2500 - Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.0051
Cell Significance Index: -0.2100 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0074
Cell Significance Index: -2.1300 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.0077
Cell Significance Index: -1.5400 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.0080
Cell Significance Index: -0.2300 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0087
Cell Significance Index: -1.8400 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0104
Cell Significance Index: -1.1900 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0118
Cell Significance Index: -1.6200 - Cell Name: hepatocyte (CL0000182)
Fold Change: -0.0123
Cell Significance Index: -0.1700 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.0126
Cell Significance Index: -2.2800 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.0137
Cell Significance Index: -0.6200 - Cell Name: helper T cell (CL0000912)
Fold Change: -0.0141
Cell Significance Index: -0.2000 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.0142
Cell Significance Index: -0.7400 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.0172
Cell Significance Index: -2.2200 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.0183
Cell Significance Index: -0.3800 - Cell Name: granulosa cell (CL0000501)
Fold Change: -0.0186
Cell Significance Index: -0.4900 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.0192
Cell Significance Index: -2.0000 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.0202
Cell Significance Index: -0.5500 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.0210
Cell Significance Index: -0.9800 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.0210
Cell Significance Index: -0.5900 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0221
Cell Significance Index: -2.7200 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.0222
Cell Significance Index: -0.7100 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0233
Cell Significance Index: -2.3800 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.0271
Cell Significance Index: -1.2000 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.0276
Cell Significance Index: -2.0600 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.0280
Cell Significance Index: -0.7200 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.0305
Cell Significance Index: -2.0500 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.0309
Cell Significance Index: -1.1700 - Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: -0.0316
Cell Significance Index: -0.7900 - Cell Name: thymocyte (CL0000893)
Fold Change: -0.0317
Cell Significance Index: -0.4000 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.0321
Cell Significance Index: -1.9700 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.0323
Cell Significance Index: -2.5600 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.0358
Cell Significance Index: -1.8800 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.0412
Cell Significance Index: -2.3100 - Cell Name: precursor B cell (CL0000817)
Fold Change: -0.0437
Cell Significance Index: -0.5700 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.0451
Cell Significance Index: -2.1200 - Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: -0.0477
Cell Significance Index: -1.1900 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.0493
Cell Significance Index: -1.8100 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.0528
Cell Significance Index: -1.8500 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.0556
Cell Significance Index: -1.8200 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.0584
Cell Significance Index: -1.0800 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.0589
Cell Significance Index: -3.0700 - Cell Name: ciliated epithelial cell (CL0000067)
Fold Change: -0.0596
Cell Significance Index: -0.5900 - Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: -0.0616
Cell Significance Index: -0.7800 - Cell Name: lens fiber cell (CL0011004)
Fold Change: -0.0617
Cell Significance Index: -1.9500 - Cell Name: erythrocyte (CL0000232)
Fold Change: -0.0620
Cell Significance Index: -1.5800 - Cell Name: ciliated cell (CL0000064)
Fold Change: -0.0633
Cell Significance Index: -0.6900
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 851710343
Symbol: METK1_HUMAN
Name: S-adenosylmethionine synthase isoform type-1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8393662
Title: Characterization of a full-length cDNA encoding human liver S-adenosylmethionine synthetase: tissue-specific gene expression and mRNA levels in hepatopathies.
PubMed ID: 8393662
DOI: 10.1042/bj2930481
PubMed ID: 1772450
Title: Molecular cloning and nucleotide sequence of cDNA encoding the human liver S-adenosylmethionine synthetase.
PubMed ID: 1772450
PubMed ID: 15164054
Title: The DNA sequence and comparative analysis of human chromosome 10.
PubMed ID: 15164054
DOI: 10.1038/nature02462
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 23425511
Title: Insight into S-adenosylmethionine biosynthesis from the crystal structures of the human methionine adenosyltransferase catalytic and regulatory subunits.
PubMed ID: 23425511
DOI: 10.1042/bj20121580
PubMed ID: 7560086
Title: Molecular mechanisms of an inborn error of methionine pathway. Methionine adenosyltransferase deficiency.
PubMed ID: 7560086
DOI: 10.1172/jci118240
PubMed ID: 8770875
Title: Demyelination of the brain is associated with methionine adenosyltransferase I/III deficiency.
PubMed ID: 8770875
DOI: 10.1172/jci118862
PubMed ID: 9042912
Title: Dominant inheritance of isolated hypermethioninemia is associated with a mutation in the human methionine adenosyltransferase 1A gene.
PubMed ID: 9042912
PubMed ID: 10677294
Title: Methionine adenosyltransferase I/III deficiency: novel mutations and clinical variations.
PubMed ID: 10677294
DOI: 10.1086/302752
Sequence Information:
- Length: 395
- Mass: 43648
- Checksum: B3462A5670A5B0D4
- Sequence:
MNGPVDGLCD HSLSEGVFMF TSESVGEGHP DKICDQISDA VLDAHLKQDP NAKVACETVC KTGMVLLCGE ITSMAMVDYQ RVVRDTIKHI GYDDSAKGFD FKTCNVLVAL EQQSPDIAQC VHLDRNEEDV GAGDQGLMFG YATDETEECM PLTIILAHKL NARMADLRRS GLLPWLRPDS KTQVTVQYMQ DNGAVIPVRI HTIVISVQHN EDITLEEMRR ALKEQVIRAV VPAKYLDEDT VYHLQPSGRF VIGGPQGDAG VTGRKIIVDT YGGWGAHGGG AFSGKDYTKV DRSAAYAARW VAKSLVKAGL CRRVLVQVSY AIGVAEPLSI SIFTYGTSQK TERELLDVVH KNFDLRPGVI VRDLDLKKPI YQKTACYGHF GRSEFPWEVP RKLVF
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.