Details for: MAT1A

Gene ID: 4143

Symbol: MAT1A

Ensembl ID: ENSG00000151224

Description: methionine adenosyltransferase 1A

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 2.99
    Marker Score: 16,089
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 2.19
    Marker Score: 9,457
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 2.19
    Marker Score: 14,057
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.09
    Marker Score: 2,100
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 2.08
    Marker Score: 6,821
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.61
    Marker Score: 1,173
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 1.43
    Marker Score: 1,536
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.27
    Marker Score: 858
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: 1.23
    Marker Score: 383
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.18
    Marker Score: 489
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 1.16
    Marker Score: 795
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4,819
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 1.11
    Marker Score: 2,303
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.07
    Marker Score: 6,473
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,829
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,054
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 511
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 464
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,409
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,412
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.95
    Marker Score: 436
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5,341
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.94
    Marker Score: 375
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2,742
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 327
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.84
    Marker Score: 486
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,268
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 710
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.78
    Marker Score: 1,472
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.77
    Marker Score: 12,098
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.77
    Marker Score: 212
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 398
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.73
    Marker Score: 1,480
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.71
    Marker Score: 710
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.69
    Marker Score: 203
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.67
    Marker Score: 252
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.63
    Marker Score: 402
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.62
    Marker Score: 136
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.6
    Marker Score: 478
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.55
    Marker Score: 324
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 174
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.52
    Marker Score: 1,097
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.5
    Marker Score: 233
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 278
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.44
    Marker Score: 232
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.4
    Marker Score: 388
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.39
    Marker Score: 3,406
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.38
    Marker Score: 229
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.37
    Marker Score: 1,283
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.35
    Marker Score: 337
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.35
    Marker Score: 384
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.34
    Marker Score: 108
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.34
    Marker Score: 2,234
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.32
    Marker Score: 170
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.31
    Marker Score: 150
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.31
    Marker Score: 238
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.3
    Marker Score: 709
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.29
    Marker Score: 326
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.25
    Marker Score: 64
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.24
    Marker Score: 116
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.24
    Marker Score: 161
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.23
    Marker Score: 333
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.23
    Marker Score: 85
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 64
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.22
    Marker Score: 417
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 74
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.2
    Marker Score: 324
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.19
    Marker Score: 108
  • Cell Name: epithelial cell of exocrine pancreas (CL1001433)
    Fold Change: 0.19
    Marker Score: 109
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.19
    Marker Score: 804
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.19
    Marker Score: 84
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.18
    Marker Score: 77
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.18
    Marker Score: 63
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 43
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.16
    Marker Score: 144
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.16
    Marker Score: 71
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.15
    Marker Score: 62
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.15
    Marker Score: 150
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.13
    Marker Score: 42
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.13
    Marker Score: 48
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.13
    Marker Score: 1,222
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.12
    Marker Score: 108
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.12
    Marker Score: 80
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.12
    Marker Score: 164
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.12
    Marker Score: 100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.12
    Marker Score: 2,077
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.12
    Marker Score: 121
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.11
    Marker Score: 36
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.11
    Marker Score: 21
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.1
    Marker Score: 110
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.1
    Marker Score: 21
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.1
    Marker Score: 58
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.1
    Marker Score: 67
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.1
    Marker Score: 61
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.09
    Marker Score: 34
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.09
    Marker Score: 32
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.09
    Marker Score: 93
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.09
    Marker Score: 20
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.09
    Marker Score: 92
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.08
    Marker Score: 21

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** MAT1A is a homotetramer composed of four identical subunits, which are encoded by the same gene. The enzyme catalyzes the transfer of an adenosyl group from S-adenosylhomocysteine (SAH) to methionine, resulting in the formation of SAMe. SAMe is a vital cofactor in numerous biochemical reactions, including DNA methylation, histone modification, and protein methylation. MAT1A is highly expressed in various tissues, including the liver, colon, and small intestine, where it plays a crucial role in maintaining SAMe homeostasis. **Pathways and Functions:** MAT1A is involved in several key pathways, including: 1. **One-carbon metabolism**: MAT1A is a critical enzyme in the one-carbon metabolic pathway, which is essential for the synthesis of SAMe, thymidine, and other biomolecules. 2. **Methylation**: SAMe is a key methyl donor in various biochemical reactions, including DNA methylation, histone modification, and protein methylation. 3. **Amino acid metabolism**: MAT1A is involved in the metabolism of methionine and homocysteine, which are essential amino acids and intermediates in the one-carbon metabolic pathway. 4. **Homocysteine metabolism**: MAT1A helps to regulate homocysteine levels by converting it into SAMe. **Clinical Significance:** Dysregulation of MAT1A has been implicated in various human diseases, including: 1. **Homocystinuria**: A genetic disorder characterized by elevated homocysteine levels, which can lead to cardiovascular disease and neurological disorders. 2. **Methylmalonic acidemia**: A metabolic disorder caused by mutations in the MTHFR gene, which affects MAT1A activity and leads to elevated methylmalonic acid levels. 3. **Cancer**: Alterations in MAT1A expression have been observed in various types of cancer, including colorectal and breast cancer, suggesting a potential role in tumorigenesis. 4. **Neurological disorders**: MAT1A has been implicated in the pathogenesis of neurological disorders, such as Alzheimer's disease and Parkinson's disease, where SAMe levels are often decreased. In conclusion, MAT1A plays a vital role in human metabolism and disease, and its dysregulation can have significant consequences for human health. Further research is needed to fully understand the mechanisms underlying MAT1A function and its role in disease, which may lead to the development of novel therapeutic strategies for the treatment of these disorders.

Genular Protein ID: 851710343

Symbol: METK1_HUMAN

Name: S-adenosylmethionine synthase isoform type-1

UniProtKB Accession Codes:

Q00266 D3DWD5 Q5QP09

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChEBI 22 ChEMBL 1 ChiTaRS 1 ComplexPortal 2 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 4 EC 1 EMBL 6 EPD 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 10 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HAMAP 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 3 PIR 1 PIRSF 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 4 RefSeq 2 Rhea 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniPathway 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8393662

Title: Characterization of a full-length cDNA encoding human liver S-adenosylmethionine synthetase: tissue-specific gene expression and mRNA levels in hepatopathies.

PubMed ID: 8393662

DOI: 10.1042/bj2930481

PubMed ID: 1772450

Title: Molecular cloning and nucleotide sequence of cDNA encoding the human liver S-adenosylmethionine synthetase.

PubMed ID: 1772450

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 23425511

Title: Insight into S-adenosylmethionine biosynthesis from the crystal structures of the human methionine adenosyltransferase catalytic and regulatory subunits.

PubMed ID: 23425511

DOI: 10.1042/bj20121580

PubMed ID: 7560086

Title: Molecular mechanisms of an inborn error of methionine pathway. Methionine adenosyltransferase deficiency.

PubMed ID: 7560086

DOI: 10.1172/jci118240

PubMed ID: 8770875

Title: Demyelination of the brain is associated with methionine adenosyltransferase I/III deficiency.

PubMed ID: 8770875

DOI: 10.1172/jci118862

PubMed ID: 9042912

Title: Dominant inheritance of isolated hypermethioninemia is associated with a mutation in the human methionine adenosyltransferase 1A gene.

PubMed ID: 9042912

PubMed ID: 10677294

Title: Methionine adenosyltransferase I/III deficiency: novel mutations and clinical variations.

PubMed ID: 10677294

DOI: 10.1086/302752

Sequence Information:

  • Length: 395
  • Mass: 43648
  • Checksum: B3462A5670A5B0D4
  • Sequence:
    • MNGPVDGLCD HSLSEGVFMF TSESVGEGHP DKICDQISDA VLDAHLKQDP NAKVACETVC 
KTGMVLLCGE ITSMAMVDYQ RVVRDTIKHI GYDDSAKGFD FKTCNVLVAL EQQSPDIAQC 
VHLDRNEEDV GAGDQGLMFG YATDETEECM PLTIILAHKL NARMADLRRS GLLPWLRPDS 
KTQVTVQYMQ DNGAVIPVRI HTIVISVQHN EDITLEEMRR ALKEQVIRAV VPAKYLDEDT 
VYHLQPSGRF VIGGPQGDAG VTGRKIIVDT YGGWGAHGGG AFSGKDYTKV DRSAAYAARW 
VAKSLVKAGL CRRVLVQVSY AIGVAEPLSI SIFTYGTSQK TERELLDVVH KNFDLRPGVI 
VRDLDLKKPI YQKTACYGHF GRSEFPWEVP RKLVF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.