Details for: MATN1

Gene ID: 4146

Symbol: MATN1

Ensembl ID: ENSG00000162510

Description: matrilin 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 9.6198
    Cell Significance Index: -2.4400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.4271
    Cell Significance Index: 8.8600
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.2521
    Cell Significance Index: 3.1900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.2508
    Cell Significance Index: 5.2500
  • Cell Name: chondroblast (CL0000058)
    Fold Change: 0.2027
    Cell Significance Index: 1.1900
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.1708
    Cell Significance Index: 2.3700
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.1532
    Cell Significance Index: 1.6700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1333
    Cell Significance Index: 6.0400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1229
    Cell Significance Index: 22.1600
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.0552
    Cell Significance Index: 0.7800
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.0551
    Cell Significance Index: 0.7900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0514
    Cell Significance Index: 3.2400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.0467
    Cell Significance Index: 0.4300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0339
    Cell Significance Index: 6.8100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0230
    Cell Significance Index: 2.8300
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.0221
    Cell Significance Index: 0.2500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0200
    Cell Significance Index: 0.5800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0157
    Cell Significance Index: 1.8300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0092
    Cell Significance Index: 3.3100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0073
    Cell Significance Index: 0.9400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0070
    Cell Significance Index: 0.1000
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.0056
    Cell Significance Index: 0.0700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.0035
    Cell Significance Index: 0.1000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0025
    Cell Significance Index: 0.4900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0024
    Cell Significance Index: 1.2900
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.0005
    Cell Significance Index: 0.0200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0000
    Cell Significance Index: -0.0800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0006
    Cell Significance Index: -1.2200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0007
    Cell Significance Index: -0.0200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0008
    Cell Significance Index: -1.2300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0014
    Cell Significance Index: -1.9500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0023
    Cell Significance Index: -1.0300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0026
    Cell Significance Index: -1.6800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0032
    Cell Significance Index: -2.3900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0032
    Cell Significance Index: -2.4100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0039
    Cell Significance Index: -1.1300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0040
    Cell Significance Index: -1.8100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0041
    Cell Significance Index: -2.3400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0059
    Cell Significance Index: -0.1300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0059
    Cell Significance Index: -0.0800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0084
    Cell Significance Index: -0.9900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0087
    Cell Significance Index: -1.2700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0087
    Cell Significance Index: -1.2000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0092
    Cell Significance Index: -1.5700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0121
    Cell Significance Index: -2.5500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0124
    Cell Significance Index: -1.2700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0136
    Cell Significance Index: -0.8800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0140
    Cell Significance Index: -1.8100
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.0148
    Cell Significance Index: -0.2400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0176
    Cell Significance Index: -2.0200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0198
    Cell Significance Index: -1.0300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0225
    Cell Significance Index: -1.1800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0228
    Cell Significance Index: -2.3700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0235
    Cell Significance Index: -0.6400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0237
    Cell Significance Index: -1.1200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0242
    Cell Significance Index: -1.1300
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0249
    Cell Significance Index: -0.6200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0279
    Cell Significance Index: -2.0800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0281
    Cell Significance Index: -1.8900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0304
    Cell Significance Index: -2.3400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0315
    Cell Significance Index: -1.7700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0317
    Cell Significance Index: -1.9500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0338
    Cell Significance Index: -2.0700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0342
    Cell Significance Index: -1.0900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0377
    Cell Significance Index: -1.3200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0403
    Cell Significance Index: -1.2900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0405
    Cell Significance Index: -1.1600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0406
    Cell Significance Index: -1.3300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0418
    Cell Significance Index: -0.7000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0422
    Cell Significance Index: -1.5500
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0472
    Cell Significance Index: -1.0900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0481
    Cell Significance Index: -1.2700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0500
    Cell Significance Index: -2.5300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0515
    Cell Significance Index: -2.2800
  • Cell Name: myoblast (CL0000056)
    Fold Change: -0.0529
    Cell Significance Index: -0.5200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0535
    Cell Significance Index: -1.8800
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.0546
    Cell Significance Index: -0.5400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0562
    Cell Significance Index: -1.5000
  • Cell Name: tendon cell (CL0000388)
    Fold Change: -0.0566
    Cell Significance Index: -0.7700
  • Cell Name: articular chondrocyte (CL1001607)
    Fold Change: -0.0590
    Cell Significance Index: -0.3200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0599
    Cell Significance Index: -2.2700
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: -0.0604
    Cell Significance Index: -0.3700
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0609
    Cell Significance Index: -1.5200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0631
    Cell Significance Index: -1.8600
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0644
    Cell Significance Index: -1.3100
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0663
    Cell Significance Index: -2.7200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0668
    Cell Significance Index: -1.6700
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0688
    Cell Significance Index: -1.6700
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0707
    Cell Significance Index: -0.6700
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0734
    Cell Significance Index: -1.8700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0740
    Cell Significance Index: -1.5700
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0741
    Cell Significance Index: -1.6000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0744
    Cell Significance Index: -1.9900
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: -0.0749
    Cell Significance Index: -0.9100
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.0767
    Cell Significance Index: -1.2300
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0769
    Cell Significance Index: -1.5200
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0800
    Cell Significance Index: -2.5300
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0808
    Cell Significance Index: -1.2500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0814
    Cell Significance Index: -2.3900
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0815
    Cell Significance Index: -1.3700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** MATN1 is a type II transmembrane protein that belongs to the matrilin family of ECM proteins. It is characterized by its ability to bind to collagen, proteoglycans, and other ECM components, thereby contributing to the stability and organization of the ECM. MATN1 is also known to interact with various signaling pathways, including those involved in cell growth, differentiation, and survival. Its expression is widespread, with significant levels detected in kidney proximal convoluted tubule epithelial cells, cardiac endothelial cells, and immune cells. **Pathways and Functions:** MATN1 plays a critical role in various biological processes, including: 1. **Extracellular matrix organization:** MATN1 interacts with collagen and proteoglycans to maintain the structure and organization of the ECM, ensuring proper tissue function and integrity. 2. **Cell growth and differentiation:** MATN1 regulates cell growth and differentiation by interacting with signaling pathways, such as the Wnt/β-catenin pathway, which is involved in the development and maintenance of tissue homeostasis. 3. **Immune function:** MATN1 is expressed in immune cells, including immature innate lymphoid cells and lymphoid lineage-restricted progenitor cells, suggesting its involvement in immune regulation and function. 4. **Bone mineralization:** MATN1 is expressed in chondrocytes and osteoblasts, indicating its role in regulating bone mineralization and density. **Clinical Significance:** Dysregulation of MATN1 has been implicated in various diseases, including: 1. **Osteoarthritis:** Abnormal expression of MATN1 has been linked to osteoarthritis, a degenerative joint disease characterized by ECM degradation and cartilage loss. 2. **Immune disorders:** MATN1 has been implicated in autoimmune diseases, such as rheumatoid arthritis, where it may contribute to ECM damage and inflammation. 3. **Cancer:** MATN1 has been shown to be overexpressed in certain types of cancer, including breast and lung cancer, where it may promote tumor progression and metastasis. In conclusion, MATN1 is a multifunctional protein that plays a critical role in the structure and organization of the ECM, as well as immune function and bone mineralization. Further studies are needed to fully elucidate the mechanisms by which MATN1 regulates these processes and to explore its potential as a therapeutic target for various diseases.

Genular Protein ID: 3809070295

Symbol: MATN1_HUMAN

Name: Cartilage matrix protein

UniProtKB Accession Codes:

P21941 B2R7E3 Q5TBB9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ComplexPortal 2 DMDM 1 DNASU 1 DisGeNET 1 EMBL 10 Ensembl 1 GO 10 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SMART 4 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 2246248

Title: Structure and chromosomal location of the human gene encoding cartilage matrix protein.

PubMed ID: 2246248

DOI: 10.1016/s0021-9258(17)45417-2

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15075323

Title: Interactions between the cartilage oligomeric matrix protein and matrilins. Implications for matrix assembly and the pathogenesis of chondrodysplasias.

PubMed ID: 15075323

DOI: 10.1074/jbc.m403778200

Sequence Information:

  • Length: 496
  • Mass: 53701
  • Checksum: 2D880A8114C7940F
  • Sequence:
    • MRVLSGTSLM LCSLLLLLQA LCSPGLAPQS RGHLCRTRPT DLVFVVDSSR SVRPVEFEKV 
KVFLSQVIES LDVGPNATRV GMVNYASTVK QEFSLRAHVS KAALLQAVRR IQPLSTGTMT 
GLAIQFAITK AFGDAEGGRS RSPDISKVVI VVTDGRPQDS VQDVSARARA SGVELFAIGV 
GSVDKATLRQ IASEPQDEHV DYVESYSVIE KLSRKFQEAF CVVSDLCATG DHDCEQVCIS 
SPGSYTCACH EGFTLNSDGK TCNVCSGGGG SSATDLVFLI DGSKSVRPEN FELVKKFISQ 
IVDTLDVSDK LAQVGLVQYS SSVRQEFPLG RFHTKKDIKA AVRNMSYMEK GTMTGAALKY 
LIDNSFTVSS GARPGAQKVG IVFTDGRSQD YINDAAKKAK DLGFKMFAVG VGNAVEDELR 
EIASEPVAEH YFYTADFKTI NQIGKKLQKK ICVEEDPCAC ESLVKFQAKV EGLLQALTRK 
LEAVSKRLAI LENTVV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.