Details for: MFAP3

Gene ID: 4238

Symbol: MFAP3

Ensembl ID: ENSG00000037749

Description: microfibril associated protein 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 109.2287
    Cell Significance Index: -16.9900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 67.1809
    Cell Significance Index: -17.0400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 35.9871
    Cell Significance Index: -14.6200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 15.4073
    Cell Significance Index: -14.7100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 13.8610
    Cell Significance Index: -17.0900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 6.5140
    Cell Significance Index: -17.4500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.1625
    Cell Significance Index: -9.1100
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.2032
    Cell Significance Index: 17.3100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.9863
    Cell Significance Index: 197.8600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.9288
    Cell Significance Index: 176.7500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.8936
    Cell Significance Index: 33.8400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.8143
    Cell Significance Index: 36.0200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.7520
    Cell Significance Index: 269.7300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.6704
    Cell Significance Index: 133.0500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.6563
    Cell Significance Index: 18.7300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.6214
    Cell Significance Index: 32.3700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.5719
    Cell Significance Index: 15.3300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5492
    Cell Significance Index: 54.3300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4718
    Cell Significance Index: 426.0100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.4685
    Cell Significance Index: 35.9600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.4311
    Cell Significance Index: 24.1900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.3473
    Cell Significance Index: 50.4800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2888
    Cell Significance Index: 8.3200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2883
    Cell Significance Index: 46.9000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.2802
    Cell Significance Index: 18.8400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2785
    Cell Significance Index: 30.2900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.2637
    Cell Significance Index: 16.2100
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.2435
    Cell Significance Index: 3.6700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.2418
    Cell Significance Index: 4.7200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2054
    Cell Significance Index: 12.3300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1999
    Cell Significance Index: 9.0600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.1814
    Cell Significance Index: 4.3500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1428
    Cell Significance Index: 3.5700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.1295
    Cell Significance Index: 2.8400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1211
    Cell Significance Index: 8.3800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.1085
    Cell Significance Index: 2.7900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0889
    Cell Significance Index: 16.0200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0734
    Cell Significance Index: 1.5900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0700
    Cell Significance Index: 8.6100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0652
    Cell Significance Index: 45.0900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0451
    Cell Significance Index: 0.6200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0432
    Cell Significance Index: 0.7400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0387
    Cell Significance Index: 1.3600
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.0381
    Cell Significance Index: 0.2300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0310
    Cell Significance Index: 19.7100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0302
    Cell Significance Index: 56.8600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0195
    Cell Significance Index: 10.6600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0094
    Cell Significance Index: 14.5000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0048
    Cell Significance Index: 6.5500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0015
    Cell Significance Index: 2.7600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0022
    Cell Significance Index: -0.0600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0051
    Cell Significance Index: -3.2000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0073
    Cell Significance Index: -3.3200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0085
    Cell Significance Index: -3.7800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0104
    Cell Significance Index: -7.6800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0170
    Cell Significance Index: -1.0700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0178
    Cell Significance Index: -10.0600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0179
    Cell Significance Index: -2.4600
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.0198
    Cell Significance Index: -0.2800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0204
    Cell Significance Index: -14.9600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0231
    Cell Significance Index: -17.4700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0254
    Cell Significance Index: -4.3300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0335
    Cell Significance Index: -7.0600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0473
    Cell Significance Index: -13.6100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0475
    Cell Significance Index: -0.6800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0477
    Cell Significance Index: -5.4500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0641
    Cell Significance Index: -7.5600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0728
    Cell Significance Index: -3.7800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0743
    Cell Significance Index: -8.6600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0775
    Cell Significance Index: -9.9400
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0799
    Cell Significance Index: -1.1800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0827
    Cell Significance Index: -8.4500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0876
    Cell Significance Index: -10.0400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1032
    Cell Significance Index: -2.1900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1152
    Cell Significance Index: -2.3900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1155
    Cell Significance Index: -2.4600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1229
    Cell Significance Index: -5.7300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1246
    Cell Significance Index: -16.1000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1284
    Cell Significance Index: -7.8700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1292
    Cell Significance Index: -3.6100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1566
    Cell Significance Index: -16.3100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1627
    Cell Significance Index: -11.5100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1843
    Cell Significance Index: -3.0900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1873
    Cell Significance Index: -6.0000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1874
    Cell Significance Index: -6.1400
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.2008
    Cell Significance Index: -3.9700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2013
    Cell Significance Index: -15.9500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2068
    Cell Significance Index: -6.5900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2101
    Cell Significance Index: -15.6600
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.2217
    Cell Significance Index: -4.4500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2220
    Cell Significance Index: -14.3200
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.2224
    Cell Significance Index: -1.3200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2300
    Cell Significance Index: -10.8100
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2314
    Cell Significance Index: -5.0000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2496
    Cell Significance Index: -13.1100
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.2758
    Cell Significance Index: -6.7300
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.2935
    Cell Significance Index: -4.3900
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.3021
    Cell Significance Index: -4.0300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3111
    Cell Significance Index: -10.9000
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.3162
    Cell Significance Index: -4.1000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** MFAP3 is a transmembrane protein that is predominantly expressed in cerebral cortex endothelial cells, neurons, and mural cells. The gene is highly expressed in regions of the brain involved in cognitive functions, including the cerebral cortex, hippocampus, and basal ganglia. MFAP3 is also expressed in other cell types, such as L6b glutamatergic cortical neurons, corticothalamic-projecting glutamatergic cortical neurons, and dopaminergic neurons. The protein's structure consists of a transmembrane domain, a cytoplasmic domain, and a glycosylated extracellular domain. **Pathways and Functions:** MFAP3 plays a crucial role in various cellular processes, including: 1. **Elastic fibre formation**: MFAP3 is involved in the formation of elastic fibres, which are essential components of the extracellular matrix in tissues such as the skin, lungs, and blood vessels. 2. **Extracellular matrix organization**: MFAP3 helps to organize the extracellular matrix, regulating the deposition and remodeling of matrix components. 3. **Immune regulation**: MFAP3 interacts with immune cells, such as T cells and dendritic cells, regulating their activation, proliferation, and survival. 4. **Signaling pathways**: MFAP3 is involved in various signaling pathways, including the interleukin-15-mediated signaling pathway, which regulates immune responses and inflammation. 5. **Protein binding**: MFAP3 interacts with various proteins, including protein tyrosine kinases, which regulate signal transduction and cellular responses. **Clinical Significance:** MFAP3 has been implicated in several immune-related disorders, including: 1. **Autoimmune diseases**: MFAP3 has been associated with autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis, where it plays a role in regulating immune responses and inflammation. 2. **Neurological disorders**: MFAP3 has been implicated in neurological disorders, such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis, where it may contribute to the development of neurodegenerative symptoms. 3. **Cancer**: MFAP3 has been linked to cancer, where it may play a role in tumour progression and metastasis. In conclusion, MFAP3 is a multifunctional protein that plays a critical role in various cellular processes, including immune regulation, neural function, and extracellular matrix organization. Further research is needed to fully elucidate the mechanisms by which MFAP3 contributes to disease pathology and to explore its potential as a therapeutic target for immune-related disorders and neurological diseases.

Genular Protein ID: 4100354710

Symbol: MFAP3_HUMAN

Name: Microfibril-associated glycoprotein 3

UniProtKB Accession Codes:

P55082 B2RDK0 B4DKA1 Q9NXA7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 10 Ensembl 3 ExpressionAtlas 1 GO 8 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 3 SMART 2 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7782085

Title: Molecular cloning of the microfibrillar protein MFAP3 and assignment of the gene to human chromosome 5q32-q33.2.

PubMed ID: 7782085

DOI: 10.1016/0888-7543(95)80081-v

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 23033978

Title: Diagnostic exome sequencing in persons with severe intellectual disability.

PubMed ID: 23033978

DOI: 10.1056/nejmoa1206524

Sequence Information:

  • Length: 362
  • Mass: 40165
  • Checksum: B99B176F1EC78785
  • Sequence:
    • MKLHCCLFTL VASIIVPAAF VLEDVDFDQM VSLEANRSSY NASFPSSFEL SASSHSDDDV 
IIAKEGTSVS IECLLTASHY EDVHWHNSKG QQLDGRSRGG KWLVSDNFLN ITNVAFDDRG 
LYTCFVTSPI RASYSVTLRV IFTSGDMSVY YMIVCLIAFT ITLILNVTRL CMMSSHLRKT 
EKAINEFFRT EGAEKLQKAF EIAKRIPIIT SAKTLELAKV TQFKTMEFAR YIEELARSVP 
LPPLILNCRA FVEEMFEAVR VDDPDDLGER IKERPALNAQ GGIYVINPEM GRSNSPGGDS 
DDGSLNEQGQ EIAVQVSVHL QSETKSIDTE SQGSSHFSPP DDIGSAESNC NYKDGAYENC 
QL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.