Details for: MGAT3

Gene ID: 4248

Symbol: MGAT3

Ensembl ID: ENSG00000128268

Description: beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 102.6711
    Cell Significance Index: -15.9700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 67.3781
    Cell Significance Index: -17.0900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 35.4145
    Cell Significance Index: -16.7200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 13.6339
    Cell Significance Index: -16.8100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 6.3423
    Cell Significance Index: -16.9900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.3639
    Cell Significance Index: -17.2200
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 3.6287
    Cell Significance Index: 52.0000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.2994
    Cell Significance Index: 260.6600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.1639
    Cell Significance Index: 15.8800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 1.0235
    Cell Significance Index: -2.2400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.9376
    Cell Significance Index: 20.5300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.8270
    Cell Significance Index: 23.6000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.7720
    Cell Significance Index: 276.9200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.7242
    Cell Significance Index: 15.6900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.6753
    Cell Significance Index: 29.8700
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.6572
    Cell Significance Index: 15.9200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.6561
    Cell Significance Index: 76.4600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.5985
    Cell Significance Index: 22.6700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.5567
    Cell Significance Index: 37.4300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.5257
    Cell Significance Index: 15.1500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.5194
    Cell Significance Index: 31.1800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4505
    Cell Significance Index: 406.7500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.3374
    Cell Significance Index: 233.3900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3366
    Cell Significance Index: 33.3000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3147
    Cell Significance Index: 34.2300
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.2431
    Cell Significance Index: 3.0200
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.2141
    Cell Significance Index: 1.6500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2046
    Cell Significance Index: 38.9400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2017
    Cell Significance Index: 32.8100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1946
    Cell Significance Index: 13.4600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1400
    Cell Significance Index: 3.5000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1352
    Cell Significance Index: 8.3100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.1243
    Cell Significance Index: 2.1300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1174
    Cell Significance Index: 64.1000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0777
    Cell Significance Index: 2.7300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0541
    Cell Significance Index: 2.4500
  • Cell Name: subcutaneous adipocyte (CL0002521)
    Fold Change: 0.0459
    Cell Significance Index: 0.2000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0431
    Cell Significance Index: 1.1500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.0246
    Cell Significance Index: 0.5900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0090
    Cell Significance Index: 0.5000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0042
    Cell Significance Index: 0.8300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0007
    Cell Significance Index: -1.2200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0048
    Cell Significance Index: -7.3300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0068
    Cell Significance Index: -12.8600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0103
    Cell Significance Index: -1.8500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0125
    Cell Significance Index: -16.9700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0174
    Cell Significance Index: -2.3900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0213
    Cell Significance Index: -15.6400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0226
    Cell Significance Index: -17.1100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0232
    Cell Significance Index: -17.1900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0234
    Cell Significance Index: -14.8700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0236
    Cell Significance Index: -10.7100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0300
    Cell Significance Index: -18.7200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0311
    Cell Significance Index: -17.5600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0313
    Cell Significance Index: -13.8500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0320
    Cell Significance Index: -3.2700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0453
    Cell Significance Index: -13.0300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0554
    Cell Significance Index: -2.9100
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.0578
    Cell Significance Index: -0.7500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0656
    Cell Significance Index: -7.7400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0732
    Cell Significance Index: -9.3800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0845
    Cell Significance Index: -4.3900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0850
    Cell Significance Index: -17.9000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0864
    Cell Significance Index: -14.7600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0873
    Cell Significance Index: -12.7000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0938
    Cell Significance Index: -11.5300
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0964
    Cell Significance Index: -1.3800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1071
    Cell Significance Index: -6.5700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1292
    Cell Significance Index: -16.6900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1334
    Cell Significance Index: -3.4300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1410
    Cell Significance Index: -3.9400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1559
    Cell Significance Index: -17.8600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1566
    Cell Significance Index: -9.8700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1634
    Cell Significance Index: -17.0200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1648
    Cell Significance Index: -3.5100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1786
    Cell Significance Index: -3.7900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1912
    Cell Significance Index: -14.6800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1975
    Cell Significance Index: -15.6400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2282
    Cell Significance Index: -16.1400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2284
    Cell Significance Index: -17.0200
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2336
    Cell Significance Index: -3.5200
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.2417
    Cell Significance Index: -2.9300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2433
    Cell Significance Index: -7.7500
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.2529
    Cell Significance Index: -5.0000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2547
    Cell Significance Index: -8.3400
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.2551
    Cell Significance Index: -11.0900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2592
    Cell Significance Index: -16.7300
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2597
    Cell Significance Index: -5.6100
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.2650
    Cell Significance Index: -5.3200
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.2976
    Cell Significance Index: -4.7800
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.3176
    Cell Significance Index: -3.4600
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.3200
    Cell Significance Index: -3.0500
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.3235
    Cell Significance Index: -2.6700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.3273
    Cell Significance Index: -15.3900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3379
    Cell Significance Index: -10.8200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3612
    Cell Significance Index: -12.6500
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.3617
    Cell Significance Index: -4.5100
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.3632
    Cell Significance Index: -3.7600
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.3816
    Cell Significance Index: -9.5200
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.3913
    Cell Significance Index: -4.5700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** MGAT3 is a member of the glycosyltransferase family, which is responsible for the transfer of carbohydrate molecules to proteins. The enzyme specifically catalyzes the transfer of N-acetylglucosamine (GlcNAc) from UDP-GlcNAc to the growing N-glycan chain. This reaction is crucial for the formation of complex N-glycans, which play significant roles in protein function, cell signaling, and immune responses. MGAT3 has a unique substrate specificity, recognizing and transferring GlcNAc to mannose residues, which are essential for the formation of hybrid N-glycans. **Pathways and Functions** MGAT3 is involved in several key pathways, including: 1. **N-glycan antennae elongation**: MGAT3 catalyzes the transfer of GlcNAc to mannose residues, elongating the N-glycan antennae in the medial/trans-Golgi network. 2. **Hybrid N-glycan synthesis**: MGAT3 is involved in the synthesis of hybrid N-glycans, which are formed by the combination of different N-glycan structures. 3. **Cellular response to oxidative stress**: MGAT3 has been implicated in the regulation of cellular response to oxidative stress, which is essential for maintaining cellular homeostasis. 4. **Protein localization and trafficking**: MGAT3 influences the localization and trafficking of proteins within the cell, which is critical for maintaining cellular homeostasis and regulating cellular responses to stimuli. **Clinical Significance** Dysregulation of MGAT3 has been implicated in various neurological and metabolic disorders, including: 1. **Alzheimer's disease**: MGAT3 has been shown to be involved in the regulation of amyloid-beta metabolism, which is a hallmark of Alzheimer's disease. 2. **Neuropathic pain**: MGAT3 has been implicated in the regulation of pain signaling pathways, which are dysregulated in neuropathic pain. 3. **Metabolic disorders**: MGAT3 has been shown to influence glucose metabolism and insulin signaling, which are critical for maintaining metabolic homeostasis. In summary, MGAT3 is a crucial enzyme involved in N-glycosylation, which plays significant roles in protein function, cell signaling, and immune responses. Its dysregulation has been implicated in various neurological and metabolic disorders, highlighting the importance of this enzyme in maintaining cellular homeostasis and regulating cellular responses to stimuli.

Genular Protein ID: 707020002

Symbol: MGAT3_HUMAN

Name: N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase III

UniProtKB Accession Codes:

Q09327 A6NGD0 Q14CK5 Q6IC49 Q9UH32

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CAZy 1 CCDS 1 CTD 1 ChEBI 5 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 7 Ensembl 1 ExpressionAtlas 1 GO 13 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 14 Rhea 3 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8370666

Title: cDNA cloning, expression, and chromosomal localization of human N-acetylglucosaminyltransferase III (GnT-III).

PubMed ID: 8370666

DOI: 10.1093/oxfordjournals.jbchem.a124105

PubMed ID: 15461802

Title: A genome annotation-driven approach to cloning the human ORFeome.

PubMed ID: 15461802

DOI: 10.1186/gb-2004-5-10-r84

PubMed ID: 10591208

Title: The DNA sequence of human chromosome 22.

PubMed ID: 10591208

DOI: 10.1038/990031

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19403558

Title: The role of N-acetylglucosaminyltransferase III and V in the post-transcriptional modifications of E-cadherin.

PubMed ID: 19403558

DOI: 10.1093/hmg/ddp194

PubMed ID: 26801611

Title: Expression of N-Acetylglucosaminyltransferase III Suppresses alpha2,3-Sialylation, and Its Distinctive Functions in Cell Migration Are Attributed to alpha2,6-Sialylation Levels.

PubMed ID: 26801611

DOI: 10.1074/jbc.m115.712836

Sequence Information:

  • Length: 533
  • Mass: 61313
  • Checksum: 11F56C44A6B173AB
  • Sequence:
    • MKMRRYKLFL MFCMAGLCLI SFLHFFKTLS YVTFPRELAS LSPNLVSSFF WNNAPVTPQA 
SPEPGGPDLL RTPLYSHSPL LQPLPPSKAA EELHRVDLVL PEDTTEYFVR TKAGGVCFKP 
GTKMLERPPP GRPEEKPEGA NGSSARRPPR YLLSARERTG GRGARRKWVE CVCLPGWHGP 
SCGVPTVVQY SNLPTKERLV PREVPRRVIN AINVNHEFDL LDVRFHELGD VVDAFVVCES 
NFTAYGEPRP LKFREMLTNG TFEYIRHKVL YVFLDHFPPG GRQDGWIADD YLRTFLTQDG 
VSRLRNLRPD DVFIIDDADE IPARDGVLFL KLYDGWTEPF AFHMRKSLYG FFWKQPGTLE 
VVSGCTVDML QAVYGLDGIR LRRRQYYTMP NFRQYENRTG HILVQWSLGS PLHFAGWHCS 
WCFTPEGIYF KLVSAQNGDF PRWGDYEDKR DLNYIRGLIR TGGWFDGTQQ EYPPADPSEH 
MYAPKYLLKN YDRFHYLLDN PYQEPRSTAA GGWRHRGPEG RPPARGKLDE AEV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.