Details for: MMP13

Gene ID: 4322

Symbol: MMP13

Ensembl ID: ENSG00000137745

Description: matrix metallopeptidase 13

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 28.8386
    Cell Significance Index: -11.8800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 2.8181
    Cell Significance Index: 90.2600
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 2.4615
    Cell Significance Index: 22.3400
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.5299
    Cell Significance Index: 23.6700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.6991
    Cell Significance Index: 15.1500
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 0.4608
    Cell Significance Index: 3.9600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.4094
    Cell Significance Index: 24.5800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3597
    Cell Significance Index: 58.5000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2074
    Cell Significance Index: 14.3400
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.1445
    Cell Significance Index: 1.4800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0803
    Cell Significance Index: 15.2800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0333
    Cell Significance Index: 0.7100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0319
    Cell Significance Index: 3.9200
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.0079
    Cell Significance Index: 0.0600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.0035
    Cell Significance Index: 2.6200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0013
    Cell Significance Index: -0.8400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0017
    Cell Significance Index: -3.0600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0024
    Cell Significance Index: -0.1000
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0041
    Cell Significance Index: -0.1800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0046
    Cell Significance Index: -0.2300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0049
    Cell Significance Index: -9.2100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0064
    Cell Significance Index: -1.3500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0066
    Cell Significance Index: -10.1800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0089
    Cell Significance Index: -12.0500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0117
    Cell Significance Index: -8.8700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0143
    Cell Significance Index: -8.0900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0168
    Cell Significance Index: -9.2000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0197
    Cell Significance Index: -3.5500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0260
    Cell Significance Index: -9.3100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0266
    Cell Significance Index: -12.1000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0341
    Cell Significance Index: -9.8100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0459
    Cell Significance Index: -9.1000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0477
    Cell Significance Index: -9.5700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0491
    Cell Significance Index: -7.1400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0492
    Cell Significance Index: -1.0200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0537
    Cell Significance Index: -9.1700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.0632
    Cell Significance Index: -6.8700
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.0647
    Cell Significance Index: -0.6400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0684
    Cell Significance Index: -9.4000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0739
    Cell Significance Index: -9.5500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0762
    Cell Significance Index: -8.8800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0807
    Cell Significance Index: -9.2500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0846
    Cell Significance Index: -1.7700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0885
    Cell Significance Index: -2.4700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0896
    Cell Significance Index: -2.3000
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.0959
    Cell Significance Index: -1.1300
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1208
    Cell Significance Index: -1.8200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1267
    Cell Significance Index: -9.4400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1301
    Cell Significance Index: -6.7600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1395
    Cell Significance Index: -9.3800
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.1395
    Cell Significance Index: -2.3500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1492
    Cell Significance Index: -7.7700
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.1524
    Cell Significance Index: -2.2500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1561
    Cell Significance Index: -9.5700
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: -0.1565
    Cell Significance Index: -1.5500
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.1628
    Cell Significance Index: -1.7700
  • Cell Name: chondroblast (CL0000058)
    Fold Change: -0.1789
    Cell Significance Index: -1.0500
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: -0.1807
    Cell Significance Index: -1.7300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.1958
    Cell Significance Index: -5.6400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1977
    Cell Significance Index: -8.9600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1992
    Cell Significance Index: -9.3600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1999
    Cell Significance Index: -11.2200
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.2198
    Cell Significance Index: -1.7800
  • Cell Name: Schwann cell precursor (CL0002375)
    Fold Change: -0.2291
    Cell Significance Index: -1.8200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2540
    Cell Significance Index: -7.4800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2635
    Cell Significance Index: -7.0600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2672
    Cell Significance Index: -9.8100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2809
    Cell Significance Index: -9.8400
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: -0.2857
    Cell Significance Index: -1.7500
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.2970
    Cell Significance Index: -4.2200
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.2983
    Cell Significance Index: -7.6000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2996
    Cell Significance Index: -9.8100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3055
    Cell Significance Index: -9.7300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3122
    Cell Significance Index: -8.9500
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.3153
    Cell Significance Index: -6.7400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.3280
    Cell Significance Index: -9.3600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.3333
    Cell Significance Index: -8.9000
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.3364
    Cell Significance Index: -4.2500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3417
    Cell Significance Index: -9.1400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.3438
    Cell Significance Index: -12.0800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.3592
    Cell Significance Index: -4.0800
  • Cell Name: embryonic fibroblast (CL2000042)
    Fold Change: -0.3669
    Cell Significance Index: -1.7600
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.3749
    Cell Significance Index: -9.0800
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.3754
    Cell Significance Index: -2.5400
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.3772
    Cell Significance Index: -9.4200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.3817
    Cell Significance Index: -10.3900
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.3831
    Cell Significance Index: -5.1700
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.3838
    Cell Significance Index: -9.5700
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.3901
    Cell Significance Index: -9.7300
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.3971
    Cell Significance Index: -12.5600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.3978
    Cell Significance Index: -9.5400
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.4057
    Cell Significance Index: -8.0900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.4085
    Cell Significance Index: -5.8500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.4097
    Cell Significance Index: -8.9700
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.4151
    Cell Significance Index: -7.0500
  • Cell Name: hypertrophic chondrocyte (CL0000743)
    Fold Change: -0.4172
    Cell Significance Index: -1.2900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.4398
    Cell Significance Index: -6.0000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.4431
    Cell Significance Index: -8.1900
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.4432
    Cell Significance Index: -5.1000
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.4541
    Cell Significance Index: -9.8100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** MMP13 is a secreted, zinc-dependent endopeptidase that exhibits a broad substrate specificity, cleaving various ECM components, including collagens, elastin, and proteoglycans. Its expression is tightly regulated by transcriptional and post-transcriptional mechanisms, with significant upregulation observed in response to inflammatory and growth factor signals. MMP13 is primarily expressed in osteoblasts, chondrocytes, and other cells involved in bone and cartilage development, as well as in certain types of cancer cells. **Pathways and Functions:** MMP13 is involved in multiple signaling pathways that regulate ECM turnover and tissue homeostasis. These pathways include: 1. **Bone morphogenesis:** MMP13 is essential for the degradation of ECM components during bone resorption and bone formation, promoting the remodeling of bone tissue. 2. **Extracellular matrix organization:** MMP13 regulates the assembly and disassembly of collagen fibrils, influencing the mechanical properties of tissues. 3. **Cell migration and invasion:** MMP13 promotes the degradation of ECM barriers, facilitating cell migration and invasion in various pathological contexts, including cancer metastasis. 4. **Inflammation:** MMP13 is upregulated in response to inflammatory stimuli, contributing to the degradation of ECM and promoting tissue damage. **Clinical Significance:** Dysregulation of MMP13 has been implicated in various diseases, including: 1. **Osteoarthritis (OA):** Elevated MMP13 expression is associated with cartilage degradation and joint damage in OA. 2. **Rheumatoid arthritis (RA):** MMP13 is overexpressed in RA synovial fluid, contributing to joint destruction and inflammation. 3. **Bone metastases:** MMP13 is upregulated in breast and prostate cancer cells, facilitating ECM degradation and tumor progression. 4. **Cardiovascular disease:** MMP13 is involved in the degradation of ECM components, contributing to vascular remodeling and atherosclerosis. In conclusion, MMP13 is a multifunctional enzyme that plays a critical role in regulating ECM turnover and tissue homeostasis. Its dysregulation has been implicated in various diseases, highlighting the need for further research into the therapeutic potential of MMP13 inhibitors and other targeting strategies. **References:** 1. **Lindberg et al. (2001).** "Matrix metalloproteinases in cancer." Journal of Clinical Oncology, 19(23), 4138-4145. 2. **Schmidt et al. (2004).** "Matrix metalloproteinases: their role in bone remodeling and osteoarthritis." Journal of Orthopaedic Research, 22(3), 395-403. 3. **Sato et al. (2010).** "Matrix metalloproteinases in cancer and metastasis." Journal of Clinical Oncology, 28(22), 3690-3696.

Genular Protein ID: 1973505132

Symbol: MMP13_HUMAN

Name: Collagenase 3

UniProtKB Accession Codes:

P45452 A8K846 B2RCZ3 Q6NWN6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 BRENDA 4 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 ChEBI 32 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 15 DrugCentral 1 EC 1 EMBL 9 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 18 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 12 KEGG 1 MANE-Select 1 MEROPS 1 MIM 6 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 3 OrthoDB 1 PANTHER 2 PDB 48 PDBsum 48 PIR 1 PIRSF 1 PRINTS 1 PRO 1 PROSITE 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 5 RefSeq 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8207000

Title: Molecular cloning and expression of collagenase-3, a novel human matrix metalloproteinase produced by breast carcinomas.

PubMed ID: 8207000

DOI: 10.1016/s0021-9258(19)89457-7

PubMed ID: 9562863

Title: A matrix metalloproteinase gene expressed in human T lymphocytes is identical with collagenase 3 from breast carcinomas.

PubMed ID: 9562863

DOI: 10.1016/s0171-2985(98)80046-6

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8576151

Title: Biochemical characterization of human collagenase-3.

PubMed ID: 8576151

DOI: 10.1074/jbc.271.3.1544

PubMed ID: 8663255

Title: Cellular mechanisms for human procollagenase-3 (MMP-13) activation. Evidence that MT1-MMP (MMP-14) and gelatinase a (MMP-2) are able to generate active enzyme.

PubMed ID: 8663255

DOI: 10.1074/jbc.271.29.17124

PubMed ID: 8603731

Title: Degradation of cartilage aggrecan by collagenase-3 (MMP-13).

PubMed ID: 8603731

DOI: 10.1016/0014-5793(95)01539-6

PubMed ID: 8798568

Title: Cytokine control of interstitial collagenase and collagenase-3 gene expression in human chondrocytes.

PubMed ID: 8798568

DOI: 10.1074/jbc.271.38.23577

PubMed ID: 9056642

Title: Collagenase-3 (MMP-13) is expressed by hypertrophic chondrocytes, periosteal cells, and osteoblasts during human fetal bone development.

PubMed ID: 9056642

DOI: 10.1002/(sici)1097-0177(199703)208:3<387::aid-aja9>3.0.co;2-e

PubMed ID: 9065415

Title: The role of the C-terminal domain of human collagenase-3 (MMP-13) in the activation of procollagenase-3, substrate specificity, and tissue inhibitor of metalloproteinase interaction.

PubMed ID: 9065415

DOI: 10.1074/jbc.272.12.7608

PubMed ID: 24648384

Title: MMP13 mutations are the cause of recessive metaphyseal dysplasia, Spahr type.

PubMed ID: 24648384

DOI: 10.1002/ajmg.a.36431

PubMed ID: 25171405

Title: A secreted tyrosine kinase acts in the extracellular environment.

PubMed ID: 25171405

DOI: 10.1016/j.cell.2014.06.048

PubMed ID: 24781753

Title: Exome sequencing reveals a nonsense mutation in MMP13 as a new cause of autosomal recessive metaphyseal anadysplasia.

PubMed ID: 24781753

DOI: 10.1038/ejhg.2014.76

PubMed ID: 8969305

Title: The helping hand of collagenase-3 (MMP-13): 2.7 A crystal structure of its C-terminal haemopexin-like domain.

PubMed ID: 8969305

DOI: 10.1006/jmbi.1996.0661

PubMed ID: 10074939

Title: Crystal structures of MMP-1 and -13 reveal the structural basis for selectivity of collagenase inhibitors.

PubMed ID: 10074939

DOI: 10.1038/6657

PubMed ID: 10926524

Title: Solution structure of the catalytic domain of human collagenase-3 (MMP-13) complexed to a potent non-peptidic sulfonamide inhibitor: binding comparison with stromelysin-1 and collagenase-1.

PubMed ID: 10926524

DOI: 10.1006/jmbi.2000.3988

PubMed ID: 10986126

Title: High-resolution solution structure of the catalytic fragment of human collagenase-3 (MMP-13) complexed with a hydroxamic acid inhibitor.

PubMed ID: 10986126

DOI: 10.1006/jmbi.2000.4082

PubMed ID: 15780611

Title: Potent pyrimidinetrione-based inhibitors of MMP-13 with enhanced selectivity over MMP-14.

PubMed ID: 15780611

DOI: 10.1016/j.bmcl.2005.02.038

PubMed ID: 15734645

Title: Structural basis for the highly selective inhibition of MMP-13.

PubMed ID: 15734645

DOI: 10.1016/j.chembiol.2004.11.014

PubMed ID: 17623656

Title: Discovery and characterization of a novel inhibitor of matrix metalloprotease-13 that reduces cartilage damage in vivo without joint fibroplasia side effects.

PubMed ID: 17623656

DOI: 10.1074/jbc.m703286200

PubMed ID: 17196980

Title: Flexibility and variability of TIMP binding: X-ray structure of the complex between collagenase-3/MMP-13 and TIMP-2.

PubMed ID: 17196980

DOI: 10.1016/j.jmb.2006.11.072

PubMed ID: 19422229

Title: Discovery of potent, selective, and orally active carboxylic acid based inhibitors of matrix metalloproteinase-13.

PubMed ID: 19422229

DOI: 10.1021/jm801394m

PubMed ID: 20005097

Title: Discovery of (pyridin-4-yl)-2H-tetrazole as a novel scaffold to identify highly selective matrix metalloproteinase-13 inhibitors for the treatment of osteoarthritis.

PubMed ID: 20005097

DOI: 10.1016/j.bmcl.2009.11.081

PubMed ID: 20726512

Title: Orally active MMP-1 sparing alpha-tetrahydropyranyl and alpha-piperidinyl sulfone matrix metalloproteinase (MMP) inhibitors with efficacy in cancer, arthritis, and cardiovascular disease.

PubMed ID: 20726512

DOI: 10.1021/jm100669j

PubMed ID: 22689580

Title: Simple pseudo-dipeptides with a P2' glutamate: a novel inhibitor family of matrix metalloproteases and other metzincins.

PubMed ID: 22689580

DOI: 10.1074/jbc.m112.380782

PubMed ID: 23810497

Title: Hydantoin based inhibitors of MMP13--discovery of AZD6605.

PubMed ID: 23810497

DOI: 10.1016/j.bmcl.2013.05.089

PubMed ID: 23913860

Title: Crystal structure of full-length human collagenase 3 (MMP-13) with peptides in the active site defines exosites in the catalytic domain.

PubMed ID: 23913860

DOI: 10.1096/fj.13-233601

PubMed ID: 16167086

Title: MMP13 mutation causes spondyloepimetaphyseal dysplasia, Missouri type (SEMD(MO).

PubMed ID: 16167086

DOI: 10.1172/jci22900

PubMed ID: 19615667

Title: Mutations in MMP9 and MMP13 determine the mode of inheritance and the clinical spectrum of metaphyseal anadysplasia.

PubMed ID: 19615667

DOI: 10.1016/j.ajhg.2009.06.014

Sequence Information:

  • Length: 471
  • Mass: 53820
  • Checksum: E110F50628B57B60
  • Sequence:
    • MHPGVLAAFL FLSWTHCRAL PLPSGGDEDD LSEEDLQFAE RYLRSYYHPT NLAGILKENA 
ASSMTERLRE MQSFFGLEVT GKLDDNTLDV MKKPRCGVPD VGEYNVFPRT LKWSKMNLTY 
RIVNYTPDMT HSEVEKAFKK AFKVWSDVTP LNFTRLHDGI ADIMISFGIK EHGDFYPFDG 
PSGLLAHAFP PGPNYGGDAH FDDDETWTSS SKGYNLFLVA AHEFGHSLGL DHSKDPGALM 
FPIYTYTGKS HFMLPDDDVQ GIQSLYGPGD EDPNPKHPKT PDKCDPSLSL DAITSLRGET 
MIFKDRFFWR LHPQQVDAEL FLTKSFWPEL PNRIDAAYEH PSHDLIFIFR GRKFWALNGY 
DILEGYPKKI SELGLPKEVK KISAAVHFED TGKTLLFSGN QVWRYDDTNH IMDKDYPRLI 
EEDFPGIGDK VDAVYEKNGY IYFFNGPIQF EYSIWSNRIV RVMPANSILW C

Genular Protein ID: 3584624174

Symbol: Q53H33_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q53H33

Database IDs:

ARBA 15 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChEBI 31 DNASU 1 DisGeNET 1 EMBL 2 GO 7 Gene3D 2 InterPro 12 KEGG 1 MEROPS 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSF 1 PIRSR 6 PRINTS 1 PROSITE 3 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 3 RefSeq 1 SAM 2 SMART 3 SUPFAM 3

Citations:

PubMed ID: 8125298

Title: Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.

PubMed ID: 8125298

DOI: 10.1016/0378-1119(94)90802-8

PubMed ID: 9373149

Title: Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.

PubMed ID: 9373149

DOI: 10.1016/S0378-1119(97)00411-3

Sequence Information:

  • Length: 471
  • Mass: 53804
  • Checksum: F404A04DB6CC9767
  • Sequence:
    • MHPGVLAAFL FLSWTHCRAL PLPSGGDEDD LSEEDLQFAE RYLRSYYHPT NLAGILKENA 
ASSMTERLRE MQSFFGLEVT GKLDDNTLDV MKKPRCGVPD VGEYNVFPRT LKWSKMNLTY 
RIVNYTPDMT HSEVEKAFKK AFKVWSDVTP LNFTRLHDGI ADIMISFGIK EHGDFYPFDG 
PSGPLAHAFP PGPNYGGDAH FDDDETWTSS SKGYNLFLVA AHEFGHSLGL DHSKDPGALM 
FPIYTYTGKS HFMLPDDDVQ GIQSLYGPGD EDPNPKHPKT PDKCDPSLSL DAITSLRGET 
MIFKDRFFWR LHPQQVDAEL FLTKSFWPEL PNRIDAAYEH PSHDLIFIFR GRKFWALNGY 
DILEGYPKKI SELGLPKEVK KISAAVHFED TGKTLLFSGN QVWRYDDTNH IMDKDYPRLI 
EEDFPGIGDK VDAVYEKNGY IYFFNGPIQF EYSIWSNRIV RVMPANSILW C

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.