Details for: MMP19

Gene ID: 4327

Symbol: MMP19

Ensembl ID: ENSG00000123342

Description: matrix metallopeptidase 19

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 69.6903
    Cell Significance Index: -10.8400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 43.0920
    Cell Significance Index: -10.9300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 22.2929
    Cell Significance Index: -10.5300
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 15.8229
    Cell Significance Index: -10.6200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 9.4947
    Cell Significance Index: -9.0700
  • Cell Name: subcutaneous adipocyte (CL0002521)
    Fold Change: 4.5472
    Cell Significance Index: 19.8000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 2.7242
    Cell Significance Index: -10.7500
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 2.6151
    Cell Significance Index: 40.4600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.6476
    Cell Significance Index: 12.6400
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: 0.5582
    Cell Significance Index: 9.5900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.4985
    Cell Significance Index: 14.2900
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: 0.3478
    Cell Significance Index: 4.3800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.2843
    Cell Significance Index: 7.5900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.2268
    Cell Significance Index: 11.4600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2007
    Cell Significance Index: 38.2000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1851
    Cell Significance Index: 25.4200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1100
    Cell Significance Index: 14.1000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1065
    Cell Significance Index: 96.1500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0682
    Cell Significance Index: 6.7500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0539
    Cell Significance Index: 10.7000
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.0417
    Cell Significance Index: 0.3400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0287
    Cell Significance Index: 4.6700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0178
    Cell Significance Index: 2.0800
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.0125
    Cell Significance Index: 0.1800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0045
    Cell Significance Index: 0.8200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0026
    Cell Significance Index: -4.8100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0028
    Cell Significance Index: -4.2400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0032
    Cell Significance Index: -5.9400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0033
    Cell Significance Index: -0.2000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0036
    Cell Significance Index: -1.5700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0060
    Cell Significance Index: -0.2100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0099
    Cell Significance Index: -13.5200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0116
    Cell Significance Index: -8.7800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0125
    Cell Significance Index: -0.3600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0133
    Cell Significance Index: -9.7200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0136
    Cell Significance Index: -8.6200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0142
    Cell Significance Index: -1.7500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0152
    Cell Significance Index: -8.3200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0176
    Cell Significance Index: -0.4400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0178
    Cell Significance Index: -13.1600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0214
    Cell Significance Index: -13.3600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0226
    Cell Significance Index: -1.0300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0233
    Cell Significance Index: -8.3700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0234
    Cell Significance Index: -13.1800
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: -0.0251
    Cell Significance Index: -0.1500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0262
    Cell Significance Index: -11.8700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.0291
    Cell Significance Index: -3.1700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0352
    Cell Significance Index: -7.0600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0372
    Cell Significance Index: -10.6900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0473
    Cell Significance Index: -6.8700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0521
    Cell Significance Index: -5.3300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0582
    Cell Significance Index: -4.0300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0632
    Cell Significance Index: -13.3100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0794
    Cell Significance Index: -13.5500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0798
    Cell Significance Index: -10.3200
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: -0.0843
    Cell Significance Index: -0.5300
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: -0.0869
    Cell Significance Index: -0.7600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0946
    Cell Significance Index: -6.6900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0958
    Cell Significance Index: -11.3000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1074
    Cell Significance Index: -11.1900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.1091
    Cell Significance Index: -6.5500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1170
    Cell Significance Index: -13.4100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1172
    Cell Significance Index: -6.0900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1274
    Cell Significance Index: -2.7600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1343
    Cell Significance Index: -10.0100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1521
    Cell Significance Index: -7.1500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1537
    Cell Significance Index: -2.8400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1540
    Cell Significance Index: -11.8200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1564
    Cell Significance Index: -10.0900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1576
    Cell Significance Index: -9.9300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1585
    Cell Significance Index: -8.2600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1587
    Cell Significance Index: -10.6700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1599
    Cell Significance Index: -4.4700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1619
    Cell Significance Index: -7.5500
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.1674
    Cell Significance Index: -1.0400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1705
    Cell Significance Index: -10.4800
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1741
    Cell Significance Index: -7.5700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1827
    Cell Significance Index: -10.2500
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.1867
    Cell Significance Index: -1.6500
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.1929
    Cell Significance Index: -1.8600
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.1936
    Cell Significance Index: -2.4000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1976
    Cell Significance Index: -5.2900
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2359
    Cell Significance Index: -3.5600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2617
    Cell Significance Index: -13.7400
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.2653
    Cell Significance Index: -2.5200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2849
    Cell Significance Index: -9.9000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2879
    Cell Significance Index: -7.4000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3117
    Cell Significance Index: -10.9200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3119
    Cell Significance Index: -5.2200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.3134
    Cell Significance Index: -6.5600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3142
    Cell Significance Index: -13.9000
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.3151
    Cell Significance Index: -4.5800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.3154
    Cell Significance Index: -8.4500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3244
    Cell Significance Index: -11.9100
  • Cell Name: osteoclast (CL0000092)
    Fold Change: -0.3252
    Cell Significance Index: -3.3200
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.3290
    Cell Significance Index: -5.2200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3378
    Cell Significance Index: -10.7600
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: -0.3398
    Cell Significance Index: -3.1100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.3430
    Cell Significance Index: -7.3100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3515
    Cell Significance Index: -11.5100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** MMP19 is a serine-type endopeptidase that belongs to the MMP family, which is characterized by its zinc-dependent catalytic activity and the ability to degrade a wide range of ECM components, including collagens, proteoglycans, and elastin. MMP19 is a relatively small MMP, consisting of 220 amino acids, and is encoded by the MMP19 gene (ENSG00000123342). The gene is highly expressed in various cell types, including elicited macrophages, alveolar macrophages, and intestinal crypt stem cells, suggesting its involvement in immune responses, tissue repair, and development. **Pathways and Functions** MMP19 is involved in various cellular processes, including: 1. **Extracellular matrix degradation**: MMP19 degrades ECM components, such as collagens and proteoglycans, which is essential for tissue remodeling, wound healing, and cellular migration. 2. **Angiogenesis**: MMP19 has been shown to regulate angiogenesis, the process of new blood vessel formation, which is critical for tissue growth and development. 3. **Cell differentiation**: MMP19 has been implicated in the regulation of cell differentiation, particularly in the context of immune cell development and function. 4. **Proteolysis**: MMP19's catalytic activity allows it to degrade a wide range of substrates, including peptides, proteins, and ECM components. **Clinical Significance** MMP19 has been implicated in various diseases, including: 1. **Cancer**: MMP19 has been shown to be overexpressed in various types of cancer, including breast, lung, and colon cancer, where it contributes to tumor growth, invasion, and metastasis. 2. **Inflammatory diseases**: MMP19 has been implicated in inflammatory diseases, such as atherosclerosis, where it contributes to the degradation of the ECM and the promotion of vascular inflammation. 3. **Neurological disorders**: MMP19 has been shown to play a role in neurological disorders, such as Alzheimer's disease, where it contributes to the degradation of the blood-brain barrier and the promotion of neuroinflammation. 4. **Wound healing**: MMP19 has been implicated in wound healing, where it contributes to the degradation of the ECM and the promotion of tissue remodeling. In conclusion, MMP19 is a multifunctional enzyme that plays a critical role in various physiological and pathological processes. Its involvement in ECM degradation, angiogenesis, cell differentiation, and proteolysis makes it an important player in tissue remodeling, wound healing, and disease progression. Elucidating the specific mechanisms by which MMP19 contributes to these processes will be essential for the development of novel therapeutic strategies for diseases where MMP19 is implicated.

Genular Protein ID: 521611972

Symbol: MMP19_HUMAN

Name: Matrix metalloproteinase-19

UniProtKB Accession Codes:

Q99542 B4E030 O15278 O95606 Q99580

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CTD 1 ChEBI 6 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EC 1 EMBL 10 Ensembl 3 ExpressionAtlas 1 GO 12 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 10 KEGG 1 MANE-Select 1 MEROPS 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 1 PIRSF 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 Reactome 2 RefSeq 2 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8920941

Title: Identification of MMP-18, a putative novel human matrix metalloproteinase.

PubMed ID: 8920941

DOI: 10.1006/bbrc.1996.1688

PubMed ID: 9020145

Title: Identification and characterization of a novel human matrix metalloproteinase with unique structural characteristics, chromosomal location and tissue distribution.

PubMed ID: 9020145

DOI: 10.1074/jbc.272.7.4281

PubMed ID: 9232430

Title: The matrix metalloproteinase RASI-1 is expressed in synovial blood vessels of a rheumatoid arthritis patient.

PubMed ID: 9232430

DOI: 10.1016/s0165-2478(97)00057-6

PubMed ID: 9562866

Title: Matrix metalloproteinase MMP-19 (RASI-1) is expressed on the surface of activated peripheral blood mononuclear cells and is detected as an autoantigen in rheumatoid arthritis.

PubMed ID: 9562866

DOI: 10.1016/s0171-2985(98)80049-1

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10809722

Title: Biochemical characterization of the catalytic domain of human matrix metalloproteinase 19. Evidence for a role as a potent basement membrane degrading enzyme.

PubMed ID: 10809722

DOI: 10.1074/jbc.275.20.14809

PubMed ID: 10922468

Title: Matrix metalloproteinases 19 and 20 cleave aggrecan and cartilage oligomeric matrix protein (COMP).

PubMed ID: 10922468

DOI: 10.1016/s0014-5793(00)01819-6

PubMed ID: 25171405

Title: A secreted tyrosine kinase acts in the extracellular environment.

PubMed ID: 25171405

DOI: 10.1016/j.cell.2014.06.048

PubMed ID: 25581579

Title: Heterozygous triplication of upstream regulatory sequences leads to dysregulation of matrix metalloproteinase 19 in patients with cavitary optic disc anomaly.

PubMed ID: 25581579

DOI: 10.1002/humu.22754

Sequence Information:

  • Length: 508
  • Mass: 57357
  • Checksum: BA480549AA9A8972
  • Sequence:
    • MNCQQLWLGF LLPMTVSGRV LGLAEVAPVD YLSQYGYLQK PLEGSNNFKP EDITEALRAF 
QEASELPVSG QLDDATRARM RQPRCGLEDP FNQKTLKYLL LGRWRKKHLT FRILNLPSTL 
PPHTARAALR QAFQDWSNVA PLTFQEVQAG AADIRLSFHG RQSSYCSNTF DGPGRVLAHA 
DIPELGSVHF DEDEFWTEGT YRGVNLRIIA AHEVGHALGL GHSRYSQALM APVYEGYRPH 
FKLHPDDVAG IQALYGKKSP VIRDEEEEET ELPTVPPVPT EPSPMPDPCS SELDAMMLGP 
RGKTYAFKGD YVWTVSDSGP GPLFRVSALW EGLPGNLDAA VYSPRTQWIH FFKGDKVWRY 
INFKMSPGFP KKLNRVEPNL DAALYWPLNQ KVFLFKGSGY WQWDELARTD FSSYPKPIKG 
LFTGVPNQPS AAMSWQDGRV YFFKGKVYWR LNQQLRVEKG YPRNISHNWM HCRPRTIDTT 
PSGGNTTPSG TGITLDTTLS ATETTFEY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.