Details for: MYO1A

Gene ID: 4640

Symbol: MYO1A

Ensembl ID: ENSG00000166866

Description: myosin IA

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 48.9270
    Cell Significance Index: -12.4100
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 11.2165
    Cell Significance Index: 85.0600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 6.4068
    Cell Significance Index: 290.4000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 5.6216
    Cell Significance Index: 121.7900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 5.6069
    Cell Significance Index: -15.0200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 2.0637
    Cell Significance Index: 224.4700
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 2.0200
    Cell Significance Index: 30.4400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.9430
    Cell Significance Index: 41.3800
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.9311
    Cell Significance Index: 28.9400
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 1.7827
    Cell Significance Index: 19.3200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.0544
    Cell Significance Index: 63.3000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.9438
    Cell Significance Index: 852.1800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.9191
    Cell Significance Index: 32.3000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.8442
    Cell Significance Index: 27.0400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.8146
    Cell Significance Index: 132.4800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.6837
    Cell Significance Index: 17.0900
  • Cell Name: helper T cell (CL0000912)
    Fold Change: 0.6425
    Cell Significance Index: 9.1300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.6173
    Cell Significance Index: 12.8100
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 0.5789
    Cell Significance Index: 5.8400
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.3290
    Cell Significance Index: 2.1500
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.2338
    Cell Significance Index: 2.4200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2240
    Cell Significance Index: 42.6200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1945
    Cell Significance Index: 19.2400
  • Cell Name: colonocyte (CL1000347)
    Fold Change: 0.1545
    Cell Significance Index: 0.9600
  • Cell Name: urothelial cell (CL0000731)
    Fold Change: 0.1183
    Cell Significance Index: 0.8300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0276
    Cell Significance Index: 0.8000
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.0014
    Cell Significance Index: 0.0100
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.0016
    Cell Significance Index: -0.0100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0016
    Cell Significance Index: -1.1400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0018
    Cell Significance Index: -0.7900
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0037
    Cell Significance Index: -0.1600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0061
    Cell Significance Index: -11.5000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0098
    Cell Significance Index: -7.2800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0100
    Cell Significance Index: -0.5100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0144
    Cell Significance Index: -1.0000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0155
    Cell Significance Index: -1.1000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0158
    Cell Significance Index: -11.9700
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0160
    Cell Significance Index: -0.6500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0171
    Cell Significance Index: -9.6500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0176
    Cell Significance Index: -11.1900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0178
    Cell Significance Index: -32.8700
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.0182
    Cell Significance Index: -0.2000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0211
    Cell Significance Index: -32.5100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0218
    Cell Significance Index: -11.8800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0242
    Cell Significance Index: -32.8700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0244
    Cell Significance Index: -4.8400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0253
    Cell Significance Index: -0.7100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0270
    Cell Significance Index: -9.6900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0277
    Cell Significance Index: -4.9900
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.0305
    Cell Significance Index: -0.2900
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0336
    Cell Significance Index: -0.5800
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: -0.0357
    Cell Significance Index: -0.1700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0369
    Cell Significance Index: -4.3000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0370
    Cell Significance Index: -0.9500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0387
    Cell Significance Index: -17.5800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0440
    Cell Significance Index: -5.0400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0474
    Cell Significance Index: -2.2100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0479
    Cell Significance Index: -0.8200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0480
    Cell Significance Index: -10.1200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0506
    Cell Significance Index: -1.0600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0539
    Cell Significance Index: -15.5200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0548
    Cell Significance Index: -11.0000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0593
    Cell Significance Index: -10.1300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0630
    Cell Significance Index: -7.7500
  • Cell Name: CD141-positive myeloid dendritic cell (CL0002394)
    Fold Change: -0.0657
    Cell Significance Index: -0.7100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0713
    Cell Significance Index: -1.9400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0736
    Cell Significance Index: -10.7000
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: -0.0814
    Cell Significance Index: -0.8200
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: -0.0821
    Cell Significance Index: -0.4300
  • Cell Name: stromal cell of endometrium (CL0002255)
    Fold Change: -0.0851
    Cell Significance Index: -1.2100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0879
    Cell Significance Index: -12.0700
  • Cell Name: myoepithelial cell (CL0000185)
    Fold Change: -0.0899
    Cell Significance Index: -1.0200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0910
    Cell Significance Index: -5.5800
  • Cell Name: immature NK T cell (CL0000914)
    Fold Change: -0.0945
    Cell Significance Index: -1.2100
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.0957
    Cell Significance Index: -1.0400
  • Cell Name: osteoblast (CL0000062)
    Fold Change: -0.1072
    Cell Significance Index: -1.0400
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: -0.1131
    Cell Significance Index: -0.7000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1153
    Cell Significance Index: -2.2500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1198
    Cell Significance Index: -12.2400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1231
    Cell Significance Index: -12.8200
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.1457
    Cell Significance Index: -0.9900
  • Cell Name: parietal cell (CL0000162)
    Fold Change: -0.1491
    Cell Significance Index: -1.4100
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.1657
    Cell Significance Index: -1.1000
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: -0.1671
    Cell Significance Index: -1.7900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1770
    Cell Significance Index: -11.9000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1858
    Cell Significance Index: -9.6800
  • Cell Name: pulmonary capillary endothelial cell (CL4028001)
    Fold Change: -0.1877
    Cell Significance Index: -2.5700
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: -0.1898
    Cell Significance Index: -0.7200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1975
    Cell Significance Index: -12.7400
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.2082
    Cell Significance Index: -2.1600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2156
    Cell Significance Index: -13.2500
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: -0.2246
    Cell Significance Index: -2.6000
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: -0.2308
    Cell Significance Index: -2.2600
  • Cell Name: embryonic fibroblast (CL2000042)
    Fold Change: -0.2425
    Cell Significance Index: -1.1600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2506
    Cell Significance Index: -19.2300
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: -0.2556
    Cell Significance Index: -0.5900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2609
    Cell Significance Index: -11.5400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2723
    Cell Significance Index: -32.1100
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.2787
    Cell Significance Index: -2.9100
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.2920
    Cell Significance Index: -3.0800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** MYO1A is a cytoplasmic protein with a motor domain that interacts with actin filaments, facilitating their movement and organization. It is characterized by its ability to bind calmodulin, a calcium-binding protein that regulates its activity. MYO1A is also involved in the assembly and disassembly of microvilli, which are critical structures involved in absorptive functions in enterocytes. Its expression is highly restricted to enterocytes, colon epithelial cells, and other cells involved in epithelial functions, highlighting its specific role in these cell types. **Pathways and Functions:** MYO1A is involved in several cellular pathways, including: 1. **Actin Cytoskeleton Organization:** MYO1A regulates the organization of actin filaments, which is essential for maintaining cell shape, motility, and intracellular signaling. 2. **Endocytosis:** MYO1A facilitates the internalization of receptors and cargo through the formation of actin-based endocytic structures. 3. **Vesicle Localization:** MYO1A regulates the movement and localization of vesicles, which is critical for maintaining cellular homeostasis and regulating signaling pathways. 4. **Microvillus Assembly and Disassembly:** MYO1A is involved in the assembly and disassembly of microvilli, which is essential for regulating absorptive functions in enterocytes. **Clinical Significance:** Dysregulation of MYO1A has been implicated in various diseases, including: 1. **Gastrointestinal Disorders:** Mutations in MYO1A have been associated with gastrointestinal disorders, such as celiac disease and inflammatory bowel disease. 2. **Cardiovascular Conditions:** MYO1A has been implicated in cardiovascular conditions, such as atherosclerosis and cardiac hypertrophy. 3. **Neurological Disorders:** MYO1A has also been implicated in neurological disorders, such as autism spectrum disorder and schizophrenia. In conclusion, MYO1A plays a critical role in maintaining cellular homeostasis and regulating various cellular processes, including actin cytoskeleton organization, endocytosis, and vesicle localization. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the mechanisms underlying MYO1A function and its role in human disease.

Genular Protein ID: 3498526183

Symbol: MYO1A_HUMAN

Name: Unconventional myosin-Ia

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 10653589

Title: Brush border myosin I (BBMI): a basally localized transcript in human jejunal enterocytes.

PubMed ID: 10653589

DOI: 10.1177/002215540004800109

PubMed ID: 9858156

Title: Human brush border myosin-I and myosin-Ic expression in human intestine and Caco-2BBe cells.

PubMed ID: 9858156

DOI: 10.1002/(sici)1097-0169(1998)41:4<308::aid-cm4>3.0.co;2-j

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15883161

Title: Alpha-kinase 1, a new component in apical protein transport.

PubMed ID: 15883161

DOI: 10.1074/jbc.m502265200

PubMed ID: 12736868

Title: Multiple mutations of MYO1A, a cochlear-expressed gene, in sensorineural hearing loss.

PubMed ID: 12736868

DOI: 10.1086/375654

PubMed ID: 24616153

Title: Targeted and genomewide NGS data disqualify mutations in MYO1A, the 'DFNA48 gene', as a cause of deafness.

PubMed ID: 24616153

DOI: 10.1002/humu.22532

Sequence Information:

  • Length: 1043
  • Mass: 118401
  • Checksum: EE5D79D9D6E085DC
  • Sequence:
  • MPLLEGSVGV EDLVLLEPLV EESLLKNLQL RYENKEIYTY IGNVVISVNP YQQLPIYGPE 
    FIAKYQDYTF YELKPHIYAL ANVAYQSLRD RDRDQCILIT GESGSGKTEA SKLVMSYVAA 
    VCGKGEQVNS VKEQLLQSNP VLEAFGNAKT IRNNNSSRFG KYMDIEFDFK GSPLGGVITN 
    YLLEKSRLVK QLKGERNFHI FYQLLAGADE QLLKALKLER DTTGYAYLNH EVSRVDGMDD 
    ASSFRAVQSA MAVIGFSEEE IRQVLEVTSM VLKLGNVLVA DEFQASGIPA SGIRDGRGVR 
    EIGEMVGLNS EEVERALCSR TMETAKEKVV TALNVMQAQY ARDALAKNIY SRLFDWIVNR 
    INESIKVGIG EKKKVMGVLD IYGFEILEDN SFEQFVINYC NEKLQQVFIE MTLKEEQEEY 
    KREGIPWTKV DYFDNGIICK LIEHNQRGIL AMLDEECLRP GVVSDSTFLA KLNQLFSKHG 
    HYESKVTQNA QRQYDHTMGL SCFRICHYAG KVTYNVTSFI DKNNDLLFRD LLQAMWKAQH 
    PLLRSLFPEG NPKQASLKRP PTAGAQFKSS VAILMKNLYS KSPNYIRCIK PNEHQQRGQF 
    SSDLVATQAR YLGLLENVRV RRAGYAHRQG YGPFLERYRL LSRSTWPHWN GGDREGVEKV 
    LGELSMSSGE LAFGKTKIFI RSPKTLFYLE EQRRLRLQQL ATLIQKIYRG WRCRTHYQLM 
    RKSQILISSW FRGNMQKKCY GKIKASVLLI QAFVRGWKAR KNYRKYFRSE AALTLADFIY 
    KSMVQKFLLG LKNNLPSTNV LDKTWPAAPY KCLSTANQEL QQLFYQWKCK RFRDQLSPKQ 
    VEILREKLCA SELFKGKKAS YPQSVPIPFC GDYIGLQGNP KLQKLKGGEE GPVLMAEAVK 
    KVNRGNGKTS SRILLLTKGH VILTDTKKSQ AKIVIGLDNV AGVSVTSLKD GLFSLHLSEM 
    SSVGSKGDFL LVSEHVIELL TKMYRAVLDA TQRQLTVTVT EKFSVRFKEN SVAVKVVQGP 
    AGGDNSKLRY KKKGSHCLEV TVQ

Genular Protein ID: 3312136376

Symbol: B2R643_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 1043
  • Mass: 118415
  • Checksum: DE3AB8A030AAF671
  • Sequence:
  • MPLLEGSVGV EDLVLLEPLV EESLLKNLQL RYENKEIYTY IGNVVISVNP YQQLPIYGPE 
    FIAKYQDYTF YELKPHIYAL ANVAYQSLRD RDRDQCILIT GESGSGKTEA SKLVMSYVAA 
    VCGKGEQVNS VKEQLLQSNP VLEAFGNAKT IRNNNSSRFG KYMDIEFDFK GSPLGGVITN 
    YLLEKSRLVK QLKGERNFHI FYQLLAGADE QLLKALKLER DTTGYAYLNH EVSRLDGMDD 
    ASSFRAVQSA MAVIGFSEEE IRQVLEVTSM VLKLGNVLVA DEFQASGIPA SGIRDGRGVR 
    EIGEMVGLNS EEVERALCSR TMETAKEKVV TALNVMQAQY ARDALAKNIY SRLFDWIVNR 
    INESIKVGIG EKKKVMGVLD IYGFEILEDN SFEQFVINYC NEKLQQVFIE MTLKEEQEEY 
    KREGIPWTKV DYFDNGIICK LIEHNQRGIL AMLDEECLRP GVVSDSTFLA KLNQLFSKHG 
    HYESKVTQNA QRQYDHTMGL SCFRICHYAG KVTYNVTSFI DKNNDLLFRD LLQAMWKAQH 
    PLLRSLFPEG NPKQASLKRP PTAGAQFKSS VAILMKNLYS KSPNYIRCIK PNEHQQRGQF 
    SSDLVATQAR YLGLLENVRV RRAGYAHRQG YGPFLERYRL LSRSTWPHWN GGDREGVEKV 
    LGELSMSSGE LAFGKTKIFI RSPKTLFYLE EQRRLRLQQL ATLIQKIYRG WRCRTHYQLM 
    RKSQILISSW FRGNMQKKCY GKIKASVLLI QAFVRGWKAR KNYRKYFRSE AALTLADFIY 
    KSMVQKFLLG LKNNLPSTNV LDKTWPAAPY KCLSTANQEL QQLFYQWKCK RFRDQLSPKQ 
    VEILREKLCA SELFKGKKAS YPQSVPIPFC GDYIGLQGNP KLQKLKGGEE GPVLMAEAVK 
    KVNRGNGKTS SRILLLTKGH VILTDTKKSQ AKIVIGLDNV AGVSVTSLKD GLFSLHLSEM 
    SSVGSKGDFL LVSEHVIELL TKMYRAVLDA TQRQLTVTVT EKFSVRFKEN SVAVKVVQGP 
    AGGDNSKLRY KKKGSHCLEV TVQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.