Details for: NFYA

Gene ID: 4800

Symbol: NFYA

Ensembl ID: ENSG00000001167

Description: nuclear transcription factor Y subunit alpha

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 79.2053
    Cell Significance Index: -12.3200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 48.1385
    Cell Significance Index: -12.2100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 28.1349
    Cell Significance Index: -11.4300
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 12.1394
    Cell Significance Index: -11.5900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 10.6898
    Cell Significance Index: -13.1800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 5.1589
    Cell Significance Index: -13.8200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.3831
    Cell Significance Index: -13.3500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.1925
    Cell Significance Index: 16.2700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.9320
    Cell Significance Index: 92.2000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7237
    Cell Significance Index: 653.4700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.6471
    Cell Significance Index: 128.4100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.6224
    Cell Significance Index: 32.4200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.5825
    Cell Significance Index: 30.2600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.5339
    Cell Significance Index: 14.3100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.5132
    Cell Significance Index: 23.2600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5122
    Cell Significance Index: 83.3100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3863
    Cell Significance Index: 23.1900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3436
    Cell Significance Index: 9.9000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.2803
    Cell Significance Index: 15.7300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.2344
    Cell Significance Index: 5.8600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2188
    Cell Significance Index: 4.7400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2160
    Cell Significance Index: 14.9400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2155
    Cell Significance Index: 26.5000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.2079
    Cell Significance Index: 5.6600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1906
    Cell Significance Index: 34.3600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1821
    Cell Significance Index: 36.5300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1398
    Cell Significance Index: 10.7300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1362
    Cell Significance Index: 74.3700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1302
    Cell Significance Index: 90.0300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1219
    Cell Significance Index: 7.8700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.1195
    Cell Significance Index: 3.1900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0855
    Cell Significance Index: 10.0900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0848
    Cell Significance Index: 30.4200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0754
    Cell Significance Index: 33.3200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0723
    Cell Significance Index: 2.5400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0686
    Cell Significance Index: 5.1100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0664
    Cell Significance Index: 125.0200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0644
    Cell Significance Index: 8.2500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0608
    Cell Significance Index: 8.3500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0532
    Cell Significance Index: 3.2700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0429
    Cell Significance Index: 1.2000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0245
    Cell Significance Index: 0.4100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0181
    Cell Significance Index: 3.4500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0145
    Cell Significance Index: 0.6800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0124
    Cell Significance Index: 5.6200
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.0083
    Cell Significance Index: 0.1400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0075
    Cell Significance Index: 0.3500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0014
    Cell Significance Index: 0.8900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0025
    Cell Significance Index: -4.5400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0039
    Cell Significance Index: -6.0500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0063
    Cell Significance Index: -0.1800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0094
    Cell Significance Index: -12.7400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0139
    Cell Significance Index: -10.5500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0147
    Cell Significance Index: -10.8100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0149
    Cell Significance Index: -2.1700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0168
    Cell Significance Index: -12.4600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0234
    Cell Significance Index: -0.4900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0235
    Cell Significance Index: -13.2600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0249
    Cell Significance Index: -15.5500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0252
    Cell Significance Index: -4.3000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0263
    Cell Significance Index: -0.5600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0322
    Cell Significance Index: -9.2700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0397
    Cell Significance Index: -4.0600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0413
    Cell Significance Index: -2.9200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0464
    Cell Significance Index: -1.2200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0487
    Cell Significance Index: -5.6700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0507
    Cell Significance Index: -6.5500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0557
    Cell Significance Index: -3.5100
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.0601
    Cell Significance Index: -0.3700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0704
    Cell Significance Index: -8.0700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0732
    Cell Significance Index: -15.4100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0904
    Cell Significance Index: -6.0800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1063
    Cell Significance Index: -11.0700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1109
    Cell Significance Index: -4.9100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1183
    Cell Significance Index: -3.7900
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.1361
    Cell Significance Index: -2.0400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1376
    Cell Significance Index: -1.9700
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -0.1393
    Cell Significance Index: -1.4800
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.1405
    Cell Significance Index: -2.0000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1537
    Cell Significance Index: -5.8200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1593
    Cell Significance Index: -12.6200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1704
    Cell Significance Index: -10.4500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1737
    Cell Significance Index: -3.3900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1742
    Cell Significance Index: -4.4500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1836
    Cell Significance Index: -6.3800
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.1883
    Cell Significance Index: -4.0300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1937
    Cell Significance Index: -3.3200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2008
    Cell Significance Index: -5.3700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2224
    Cell Significance Index: -4.8700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2244
    Cell Significance Index: -11.7800
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.2301
    Cell Significance Index: -3.3100
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.2429
    Cell Significance Index: -2.5200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.2472
    Cell Significance Index: -7.2600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.2476
    Cell Significance Index: -2.2800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.2689
    Cell Significance Index: -6.4500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2694
    Cell Significance Index: -8.8200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2824
    Cell Significance Index: -9.0000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2909
    Cell Significance Index: -10.6800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2917
    Cell Significance Index: -10.2200
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.2930
    Cell Significance Index: -4.9400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** NFYA is a subunit of the NFY transcription factor complex, which consists of three subunits: A, B, and C. NFYA is a DNA-binding subunit that interacts with other transcription factors to regulate gene expression. It is highly conserved across species and has been identified in various cell types, including immune cells, muscle cells, and epithelial cells. NFYA is also known to interact with other transcription factors, such as SREBP and ATF6, to regulate the expression of genes involved in lipid and cholesterol metabolism. **Pathways and Functions** NFYA plays a critical role in regulating gene expression in response to various cellular stimuli, including: 1. **Endoplasmic Reticulum Stress Response**: NFYA interacts with ATF6 to regulate the expression of chaperone genes and promote cell survival. 2. **Lipid and Cholesterol Metabolism**: NFYA interacts with SREBP and PPARα to regulate the expression of genes involved in lipid and cholesterol synthesis and degradation. 3. **Cellular Responses to Stimuli**: NFYA regulates the expression of genes involved in inflammation, immune responses, and cell survival in response to various stimuli. 4. **DNA-Binding Transcription Factor Activity**: NFYA interacts with RNA polymerase II to regulate the expression of genes involved in transcriptional regulation. **Clinical Significance** Dysregulation of NFYA has been implicated in various diseases, including: 1. **Metabolic Disorders**: NFYA dysfunction has been linked to metabolic disorders, such as obesity and insulin resistance. 2. **Cancer**: NFYA has been shown to play a role in cancer development and progression, particularly in immune cells and epithelial cells. 3. **Neurodegenerative Diseases**: NFYA has been implicated in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. 4. **Immune Disorders**: NFYA dysfunction has been linked to immune disorders, such as autoimmune diseases and immunodeficiency disorders. In conclusion, NFYA is a critical transcription factor that plays a vital role in regulating gene expression in response to various cellular stimuli. Its dysregulation has been implicated in various diseases, highlighting the importance of NFYA in maintaining cellular homeostasis and preventing disease. Further research is needed to fully understand the mechanisms by which NFYA regulates gene expression and its role in disease pathogenesis.

Genular Protein ID: 737489625

Symbol: NFYA_HUMAN

Name: Nuclear transcription factor Y subunit alpha

UniProtKB Accession Codes:

P23511 Q8IXU0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 16 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 7 PDBsum 7 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 5 RefSeq 2 SASBDB 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1549471

Title: Evolutionary variation of the CCAAT-binding transcription factor NF-Y.

PubMed ID: 1549471

DOI: 10.1093/nar/20.5.1087

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2000400

Title: A cDNA encoding a human CCAAT-binding protein cloned by functional complementation in yeast.

PubMed ID: 2000400

DOI: 10.1073/pnas.88.5.1968

PubMed ID: 10441475

Title: Human ZHX1: cloning, chromosomal location, and interaction with transcription factor NF-Y.

PubMed ID: 10441475

DOI: 10.1006/bbrc.1999.1087

PubMed ID: 10571058

Title: Identification of proteins that interact with NF-YA.

PubMed ID: 10571058

DOI: 10.1016/s0014-5793(99)01311-3

PubMed ID: 12659632

Title: Analysis of zinc-fingers and homeoboxes (ZHX)-1-interacting proteins: molecular cloning and characterization of a member of the ZHX family, ZHX3.

PubMed ID: 12659632

DOI: 10.1042/bj20021866

PubMed ID: 12741956

Title: Zinc-fingers and homeoboxes (ZHX) 2, a novel member of the ZHX family, functions as a transcriptional repressor.

PubMed ID: 12741956

DOI: 10.1042/bj20030171

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19302979

Title: O-GlcNAcylation of Sp1 interrupts Sp1 interaction with NF-Y.

PubMed ID: 19302979

DOI: 10.1016/j.bbrc.2009.03.075

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 23332751

Title: Sequence-specific transcription factor NF-Y displays histone-like DNA binding and H2B-like ubiquitination.

PubMed ID: 23332751

DOI: 10.1016/j.cell.2012.11.047

Sequence Information:

  • Length: 347
  • Mass: 36877
  • Checksum: D00BE17041EB1A9E
  • Sequence:
    • MEQYTANSNS STEQIVVQAG QIQQQQQGGV TAVQLQTEAQ VASASGQQVQ TLQVVQGQPL 
MVQVSGGQLI TSTGQPIMVQ AVPGGQGQTI MQVPVSGTQG LQQIQLVPPG QIQIQGGQAV 
QVQGQQGQTQ QIIIQQPQTA VTAGQTQTQQ QIAVQGQQVA QTAEGQTIVY QPVNADGTIL 
QQVTVPVSGM ITIPAASLAG AQIVQTGANT NTTSSGQGTV TVTLPVAGNV VNSGGMVMMV 
PGAGSVPAIQ RIPLPGAEML EEEPLYVNAK QYHRILKRRQ ARAKLEAEGK IPKERRKYLH 
ESRHRHAMAR KRGEGGRFFS PKEKDSPHMQ DPNQADEEAM TQIIRVS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.