Details for: NINJ2

Gene ID: 4815

Symbol: NINJ2

Ensembl ID: ENSG00000171840

Description: ninjurin 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 54.5822
    Cell Significance Index: -8.4900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 32.5654
    Cell Significance Index: -8.2600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 20.3350
    Cell Significance Index: -10.4600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 7.3563
    Cell Significance Index: -9.0700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 3.5776
    Cell Significance Index: -7.8300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 3.5314
    Cell Significance Index: -9.4600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 3.2818
    Cell Significance Index: -10.0800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 2.8205
    Cell Significance Index: -11.1300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.6925
    Cell Significance Index: 322.0900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.2096
    Cell Significance Index: 25.7600
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 1.1888
    Cell Significance Index: 8.0600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.1278
    Cell Significance Index: 23.4000
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.8374
    Cell Significance Index: 17.9000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.7529
    Cell Significance Index: 74.4800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.7369
    Cell Significance Index: 56.5500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.6803
    Cell Significance Index: 34.3800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5973
    Cell Significance Index: 539.3600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.5295
    Cell Significance Index: 31.7900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.5123
    Cell Significance Index: 18.0000
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.4923
    Cell Significance Index: 7.0800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4830
    Cell Significance Index: 52.5400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.4786
    Cell Significance Index: 9.3400
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.4150
    Cell Significance Index: 6.9800
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.4033
    Cell Significance Index: 9.8400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3797
    Cell Significance Index: 61.7600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3279
    Cell Significance Index: 65.0800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2434
    Cell Significance Index: 16.8400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.2281
    Cell Significance Index: 6.7000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2098
    Cell Significance Index: 24.7500
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.1709
    Cell Significance Index: 2.5800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1707
    Cell Significance Index: 4.7700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.1381
    Cell Significance Index: 3.7000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1380
    Cell Significance Index: 9.7600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1354
    Cell Significance Index: 8.7400
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.1313
    Cell Significance Index: 2.3200
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.1086
    Cell Significance Index: 1.5600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0916
    Cell Significance Index: 2.2900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0767
    Cell Significance Index: 15.3900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0700
    Cell Significance Index: 30.9400
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.0405
    Cell Significance Index: 0.3300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0347
    Cell Significance Index: 53.4600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0244
    Cell Significance Index: 45.0200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0212
    Cell Significance Index: 16.0300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0105
    Cell Significance Index: 7.2400
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 0.0093
    Cell Significance Index: 0.1500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0080
    Cell Significance Index: 15.1500
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.0046
    Cell Significance Index: 0.1400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0006
    Cell Significance Index: 0.3500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0001
    Cell Significance Index: 0.0200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0003
    Cell Significance Index: -0.0400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0029
    Cell Significance Index: -3.8800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0039
    Cell Significance Index: -1.3900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0056
    Cell Significance Index: -0.1600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0108
    Cell Significance Index: -6.8400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0134
    Cell Significance Index: -9.8300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0162
    Cell Significance Index: -12.0000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0178
    Cell Significance Index: -8.0800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0185
    Cell Significance Index: -11.5600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0188
    Cell Significance Index: -0.8500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0219
    Cell Significance Index: -12.3700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0243
    Cell Significance Index: -0.4500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0260
    Cell Significance Index: -3.2000
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0261
    Cell Significance Index: -0.2800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0282
    Cell Significance Index: -8.1100
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.0380
    Cell Significance Index: -0.6100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0404
    Cell Significance Index: -5.1800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0421
    Cell Significance Index: -4.3000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0477
    Cell Significance Index: -6.5600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0489
    Cell Significance Index: -1.2500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0544
    Cell Significance Index: -11.4600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0647
    Cell Significance Index: -11.0500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0708
    Cell Significance Index: -9.1500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0746
    Cell Significance Index: -8.6900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0909
    Cell Significance Index: -1.9700
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.1016
    Cell Significance Index: -1.5000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1022
    Cell Significance Index: -10.6500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1060
    Cell Significance Index: -12.1400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1107
    Cell Significance Index: -5.1600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1166
    Cell Significance Index: -1.6700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1177
    Cell Significance Index: -5.5300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1200
    Cell Significance Index: -7.3600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1258
    Cell Significance Index: -8.4600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1336
    Cell Significance Index: -9.9600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1411
    Cell Significance Index: -4.5200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1447
    Cell Significance Index: -2.4800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1482
    Cell Significance Index: -3.8100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1639
    Cell Significance Index: -9.2000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1646
    Cell Significance Index: -10.1200
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.1656
    Cell Significance Index: -2.7900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1723
    Cell Significance Index: -10.8600
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -0.1779
    Cell Significance Index: -2.2400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1944
    Cell Significance Index: -8.6000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1964
    Cell Significance Index: -10.2000
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.2051
    Cell Significance Index: -8.9200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2097
    Cell Significance Index: -11.0100
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.2137
    Cell Significance Index: -2.7400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2155
    Cell Significance Index: -7.5500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2170
    Cell Significance Index: -6.9100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2281
    Cell Significance Index: -6.5400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2397
    Cell Significance Index: -8.8000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** NINJ2 is a relatively conserved gene across species, with high expression levels in cells involved in the nervous system, such as retinal bipolar neurons, oligodendrocytes, and cardiac muscle myoblasts. The gene is also expressed in other cell types, including mononuclear cells, kidney capillary endothelial cells, and enterocytes. NINJ2 is primarily associated with plasma membrane proteins and exhibits significant binding affinity for various proteins, including those involved in cell-cell adhesion. **Pathways and Functions:** NINJ2 is implicated in several key cellular pathways, including: 1. **Cell adhesion:** NINJ2 is involved in the regulation of cell-cell adhesion, particularly in the nervous system. It interacts with other adhesion molecules to maintain tissue integrity and promote neuronal communication. 2. **Nervous system development:** NINJ2 plays a crucial role in the development and maturation of neurons, particularly in the retina. It is involved in the regulation of neuronal migration, differentiation, and synaptogenesis. 3. **Tissue regeneration:** NINJ2 is also implicated in tissue regeneration, particularly in the context of nerve injury. It is involved in the regulation of cellular responses to injury, including proliferation, differentiation, and migration of cells involved in tissue repair. **Functions:** The functions of NINJ2 can be summarized as follows: 1. **Regulation of cell-cell adhesion:** NINJ2 interacts with other adhesion molecules to regulate cell-cell adhesion, maintaining tissue integrity and promoting neuronal communication. 2. **Nervous system development and maintenance:** NINJ2 is involved in the regulation of neuronal development, migration, differentiation, and synaptogenesis, ensuring proper nervous system function. 3. **Tissue regeneration:** NINJ2 is involved in the regulation of cellular responses to injury, including proliferation, differentiation, and migration of cells involved in tissue repair. **Clinical Significance:** The clinical significance of NINJ2 is multifaceted: 1. **Neurological disorders:** Alterations in NINJ2 expression have been linked to various neurological disorders, including Alzheimer's disease, Parkinson's disease, and multiple sclerosis. 2. **Cancer:** NINJ2 is overexpressed in certain types of cancer, including breast cancer and lung cancer, suggesting its potential role in tumorigenesis and metastasis. 3. **Regenerative medicine:** NINJ2's role in tissue regeneration makes it a potential target for the development of regenerative therapies, particularly in the context of nerve injury and tissue repair. In conclusion, NINJ2 is a critical gene involved in various cellular processes, including cell adhesion, nervous system development, and tissue regeneration. Its dysregulation has been implicated in various disease states, including neurological disorders and cancer. Further research is needed to fully elucidate the molecular mechanisms underlying NINJ2's functions and to explore its therapeutic potential.

Genular Protein ID: 551460523

Symbol: NINJ2_HUMAN

Name: Nerve injury-induced protein 2

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 10627596

Title: Ninjurin2, a novel homophilic adhesion molecule, is expressed in mature sensory and enteric neurons and promotes neurite outgrowth.

PubMed ID: 10627596

DOI: 10.1523/jneurosci.20-01-00187.2000

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 33472215

Title: NINJ1 mediates plasma membrane rupture during lytic cell death.

PubMed ID: 33472215

DOI: 10.1038/s41586-021-03218-7

PubMed ID: 38614101

Title: NINJ1 mediates plasma membrane rupture by cutting and releasing membrane disks.

PubMed ID: 38614101

DOI: 10.1016/j.cell.2024.03.008

Sequence Information:

  • Length: 142
  • Mass: 15680
  • Checksum: B00A92F5EAFF6BD9
  • Sequence:
  • MESARENIDL QPGSSDPRSQ PINLNHYATK KSVAESMLDV ALFMSNAMRL KAVLEQGPSS 
    HYYTTLVTLI SLSLLLQVVI GVLLVVIARL NLNEVEKQWR LNQLNNAATI LVFFTVVINV 
    FITAFGAHKT GFLAARASRN PL

Genular Protein ID: 704666047

Symbol: A0A590UJR9_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

Sequence Information:

  • Length: 188
  • Mass: 20430
  • Checksum: 1CE3F4A16E9F156A
  • Sequence:
  • MAGLSRQLCA LSHPKKAAET QTAEPGGAHA VCSRHPVRVK GLEGSEMESA RENIDLQPGS 
    SDPRSQPINL NHYATKKSVA ESMLDVALFM SNAMRLKAVL EQGPSSHYYT TLVTLISLSL 
    LLQVVIGVLL VVIARLNLNE VEKQWRLNQL NNAATILVFF TVVINVFITA FGAHKTGFLA 
    ARASRNPL

Genular Protein ID: 3688223608

Symbol: F8WBZ3_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

Sequence Information:

  • Length: 135
  • Mass: 14950
  • Checksum: 8C139BEBE5687861
  • Sequence:
  • MMYMPGSSDP RSQPINLNHY ATKKSVAESM LDVALFMSNA MRLKAVLEQG PSSHYYTTLV 
    TLISLSLLLQ VVIGVLLVVI ARLNLNEVEK QWRLNQLNNA ATILVFFTVV INVFITAFGA 
    HKTGFLAARA SRNPL

Genular Protein ID: 2491704255

Symbol: F5H3L1_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

Sequence Information:

  • Length: 106
  • Mass: 11727
  • Checksum: A4EE9C9AEC1B448F
  • Sequence:
  • MLDVALFMSN AMRLKAVLEQ GPSSHYYTTL VTLISLSLLL QVVIGVLLVV IARLNLNEVE 
    KQWRLNQLNN AATILVFFTV VINVFITAFG AHKTGFLAAR ASRNPL

Genular Protein ID: 2744628309

Symbol: B4DJC1_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 172
  • Mass: 18454
  • Checksum: 0E6425956FDCE597
  • Sequence:
  • MAGLSRQLCA LSHPKKAAET QTAEPGGAHA VCSRHPVRVK GLEGSEMESA RENIDLQPGS 
    SDPRSQPINL NHYATKKSVA ESMLDVALFM SNAMRLKAVL EQGPSSHYYT TLVTLISLSL 
    LLQVVIGVLL VVIGEEPSLQ SDLLPRHPWL AERPHVSPGP PCIGTGSFAT TR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.