Details for: NMB

Gene ID: 4828

Symbol: NMB

Ensembl ID: ENSG00000197696

Description: neuromedin B

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 95.9849
    Cell Significance Index: -14.9300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 54.7028
    Cell Significance Index: -13.8800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 28.9226
    Cell Significance Index: -11.7500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 12.4117
    Cell Significance Index: -11.8500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 12.1416
    Cell Significance Index: -14.9700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 4.8771
    Cell Significance Index: -13.0700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.7366
    Cell Significance Index: -14.7500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 3.1505
    Cell Significance Index: 90.3100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 3.0246
    Cell Significance Index: -9.2900
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 2.7478
    Cell Significance Index: 45.2800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.6022
    Cell Significance Index: 135.1800
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 1.4118
    Cell Significance Index: 15.0000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.1712
    Cell Significance Index: 15.9800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.9664
    Cell Significance Index: 95.6000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.7785
    Cell Significance Index: 55.0600
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.7733
    Cell Significance Index: 13.6700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.7491
    Cell Significance Index: 44.9700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.7136
    Cell Significance Index: 33.5400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.6485
    Cell Significance Index: 70.5400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6434
    Cell Significance Index: 580.9900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.5544
    Cell Significance Index: 5.1100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.5257
    Cell Significance Index: 24.5100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5024
    Cell Significance Index: 81.7100
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.4054
    Cell Significance Index: 5.6300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3280
    Cell Significance Index: 179.1400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3076
    Cell Significance Index: 58.5300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.3035
    Cell Significance Index: 38.9100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2967
    Cell Significance Index: 20.5200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.2726
    Cell Significance Index: 7.4200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2513
    Cell Significance Index: 111.1100
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.1957
    Cell Significance Index: 3.1400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1894
    Cell Significance Index: 26.0100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1883
    Cell Significance Index: 33.9400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1874
    Cell Significance Index: 4.0600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1802
    Cell Significance Index: 23.2800
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.1719
    Cell Significance Index: 2.6600
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.1688
    Cell Significance Index: 3.9000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1501
    Cell Significance Index: 18.4600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1476
    Cell Significance Index: 6.6900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.1336
    Cell Significance Index: 9.9600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.1150
    Cell Significance Index: 6.0400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0694
    Cell Significance Index: 11.8500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.0625
    Cell Significance Index: 0.7100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0619
    Cell Significance Index: 3.9000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.0536
    Cell Significance Index: 1.4100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0348
    Cell Significance Index: 0.8700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.0219
    Cell Significance Index: 0.7600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0193
    Cell Significance Index: 3.8300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0151
    Cell Significance Index: 0.4100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.0007
    Cell Significance Index: 0.5300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0009
    Cell Significance Index: -0.6300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0062
    Cell Significance Index: -11.6500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0064
    Cell Significance Index: -4.0100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0066
    Cell Significance Index: -5.0100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0077
    Cell Significance Index: -2.2100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0088
    Cell Significance Index: -16.3200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0092
    Cell Significance Index: -14.2300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0117
    Cell Significance Index: -15.9600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0118
    Cell Significance Index: -1.2100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0137
    Cell Significance Index: -7.7100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0140
    Cell Significance Index: -1.6000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0159
    Cell Significance Index: -10.1200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0228
    Cell Significance Index: -8.1800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0240
    Cell Significance Index: -2.7500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0246
    Cell Significance Index: -1.2400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0289
    Cell Significance Index: -6.0800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0301
    Cell Significance Index: -0.6400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0306
    Cell Significance Index: -13.8700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0357
    Cell Significance Index: -7.1600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0373
    Cell Significance Index: -4.4000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0402
    Cell Significance Index: -4.6800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0564
    Cell Significance Index: -1.5800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0572
    Cell Significance Index: -2.0100
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0603
    Cell Significance Index: -2.4700
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.0643
    Cell Significance Index: -1.0200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0696
    Cell Significance Index: -10.1100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0779
    Cell Significance Index: -1.6200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1040
    Cell Significance Index: -1.7400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1114
    Cell Significance Index: -7.1900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1204
    Cell Significance Index: -7.3800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1223
    Cell Significance Index: -6.3700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1405
    Cell Significance Index: -2.9400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1437
    Cell Significance Index: -11.3800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1439
    Cell Significance Index: -14.9800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2038
    Cell Significance Index: -15.6400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2278
    Cell Significance Index: -6.7100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2439
    Cell Significance Index: -5.3400
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.2563
    Cell Significance Index: -3.8400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2563
    Cell Significance Index: -14.3800
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2668
    Cell Significance Index: -4.0200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2724
    Cell Significance Index: -10.0000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2743
    Cell Significance Index: -7.0500
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.2766
    Cell Significance Index: -1.7000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2795
    Cell Significance Index: -7.1400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.2816
    Cell Significance Index: -8.2700
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.3247
    Cell Significance Index: -2.2000
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: -0.3359
    Cell Significance Index: -4.2300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.3414
    Cell Significance Index: -9.1200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3420
    Cell Significance Index: -10.9600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3450
    Cell Significance Index: -15.2600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** NMB is a 26-amino acid peptide hormone that belongs to the tachykinin family of neuropeptides. It is primarily expressed in the central nervous system, particularly in the cerebral cortex, forebrain, and spinal cord, where it functions as a neurotransmitter and neuromodulator. NMB interacts with its receptor, NMBR, which is a G protein-coupled receptor (GPCR) that activates various signaling pathways, including Gq signaling events, protein kinase C activation, and phospholipase C activation. **Pathways and Functions:** NMB's signaling pathways are multifaceted and involve various cellular processes, including: 1. **Antiviral Innate Immune Response:** NMB has been shown to modulate the antiviral innate immune response by regulating the production of interferon-alpha and other cytokines. 2. **Neuroprotection:** NMB has neuroprotective effects, particularly in the context of neuroinflammation and neurodegenerative diseases. 3. **Hormone Regulation:** NMB regulates hormone secretion, including testosterone and osteoclast proliferation. 4. **Pain Modulation:** NMB has been implicated in pain modulation, particularly in the context of itch perception and sensory processing. 5. **Inflammation:** NMB has anti-inflammatory properties, particularly in the context of respiratory diseases. **Clinical Significance:** NMB's dysregulation has been implicated in various diseases, including: 1. **Respiratory Diseases:** NMB's anti-inflammatory properties make it a potential therapeutic target for respiratory diseases, such as chronic obstructive pulmonary disease (COPD) and asthma. 2. **Neurodegenerative Diseases:** NMB's neuroprotective effects make it a potential therapeutic target for neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. 3. **Cancer:** NMB's role in hormone regulation and inflammation makes it a potential therapeutic target for cancer treatment. 4. **Pain Management:** NMB's involvement in pain modulation makes it a potential therapeutic target for pain management. **Significantly Expressed Cells:** NMB is expressed in various cell types, including: 1. **Respiratory Basal Cell:** NMB is expressed in respiratory basal cells, which are responsible for maintaining the integrity of the respiratory epithelium. 2. **Fibroblast of Mammary Gland:** NMB is expressed in fibroblasts of the mammary gland, which are involved in milk production and secretion. 3. **Bladder Urothelial Cell:** NMB is expressed in bladder urothelial cells, which are involved in bladder function and inflammation. 4. **Neural Progenitor Cell:** NMB is expressed in neural progenitor cells, which are involved in neural development and plasticity. In conclusion, NMB is a multifaceted gene that plays a crucial role in various physiological and pathological processes. Its dysregulation has been implicated in various diseases, making it a potential therapeutic target for treatment. Further research is needed to fully understand the mechanisms of NMB's action and its implications in different disease models.

Genular Protein ID: 3405211329

Symbol: NMB_HUMAN

Name: Neuromedin-B

UniProtKB Accession Codes:

P08949 Q96A06 Q96HH5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 4 EvolutionaryTrace 1 GO 22 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 2 RefSeq 2 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 2458345

Title: Molecular cloning of cDNAs encoding the human bombesin-like peptide neuromedin B. Chromosomal localization and comparison to cDNAs encoding its amphibian homolog ranatensin.

PubMed ID: 2458345

DOI: 10.1016/s0021-9258(18)37707-x

PubMed ID: 16572171

Title: Analysis of the DNA sequence and duplication history of human chromosome 15.

PubMed ID: 16572171

DOI: 10.1038/nature04601

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 31601264

Title: Role of neuromedin B and its receptor in the innate immune responses against influenza A virus infection in vitro and in vivo.

PubMed ID: 31601264

DOI: 10.1186/s13567-019-0695-2

PubMed ID: 10544247

Title: Solution structure of neuromedin B by (1)H nuclear magnetic resonance spectroscopy.

PubMed ID: 10544247

DOI: 10.1016/s0014-5793(99)01346-0

Sequence Information:

  • Length: 121
  • Mass: 13252
  • Checksum: 10E16BA4886F03FB
  • Sequence:
    • MARRAGGARM FGSLLLFALL AAGVAPLSWD LPEPRSRASK IRVHSRGNLW ATGHFMGKKS 
LEPSSPSPLG TAPHTSLRDQ RLQLSHDLLG ILLLKKALGV SLSRPAPQIQ YRRLLVQILQ 
K

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.