Details for: NPPC

Gene ID: 4880

Symbol: NPPC

Ensembl ID: ENSG00000163273

Description: natriuretic peptide C

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 49.6319
    Cell Significance Index: -7.7200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 30.5547
    Cell Significance Index: -7.7500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 6.2614
    Cell Significance Index: -7.7200
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 5.6639
    Cell Significance Index: 33.4400
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 2.4195
    Cell Significance Index: 36.4600
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.1339
    Cell Significance Index: 27.4700
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.8803
    Cell Significance Index: 9.1900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.6574
    Cell Significance Index: 13.7600
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.6191
    Cell Significance Index: 6.7300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.5482
    Cell Significance Index: 32.9100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.5235
    Cell Significance Index: 231.4400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.5132
    Cell Significance Index: 10.9300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.4696
    Cell Significance Index: 33.2200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4611
    Cell Significance Index: 20.9000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3959
    Cell Significance Index: 43.0600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3841
    Cell Significance Index: 38.0000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3712
    Cell Significance Index: 70.6500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3403
    Cell Significance Index: 307.3100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.3321
    Cell Significance Index: 9.0400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.3106
    Cell Significance Index: 6.8000
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.3085
    Cell Significance Index: 4.2800
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.3011
    Cell Significance Index: 2.4900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2853
    Cell Significance Index: 8.2200
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.2662
    Cell Significance Index: 3.7900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.2536
    Cell Significance Index: 7.2700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2293
    Cell Significance Index: 37.3000
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.1938
    Cell Significance Index: 3.0800
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: 0.1926
    Cell Significance Index: 1.1800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1602
    Cell Significance Index: 10.1000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.1454
    Cell Significance Index: 21.1300
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.1440
    Cell Significance Index: 1.8200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1348
    Cell Significance Index: 7.0100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1341
    Cell Significance Index: 9.2800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.1090
    Cell Significance Index: 12.7000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0992
    Cell Significance Index: 2.1500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0902
    Cell Significance Index: 2.8900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0670
    Cell Significance Index: 1.3900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0616
    Cell Significance Index: 0.8400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0612
    Cell Significance Index: 3.9500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0558
    Cell Significance Index: 1.9600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0354
    Cell Significance Index: 0.5100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0354
    Cell Significance Index: 0.9900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0325
    Cell Significance Index: 5.8500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.0320
    Cell Significance Index: 0.6800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0247
    Cell Significance Index: 17.0800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0210
    Cell Significance Index: 2.5800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0132
    Cell Significance Index: 7.1900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0084
    Cell Significance Index: 3.0200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.0054
    Cell Significance Index: 0.3300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0028
    Cell Significance Index: 5.2000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0015
    Cell Significance Index: 0.1100
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: 0.0012
    Cell Significance Index: 0.0200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0034
    Cell Significance Index: -4.6900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0040
    Cell Significance Index: -0.1000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0049
    Cell Significance Index: -0.6300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0051
    Cell Significance Index: -9.3300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0059
    Cell Significance Index: -9.1100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0088
    Cell Significance Index: -5.5600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0098
    Cell Significance Index: -0.3400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0100
    Cell Significance Index: -7.5400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0104
    Cell Significance Index: -7.7100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0104
    Cell Significance Index: -7.6400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0136
    Cell Significance Index: -7.6600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0148
    Cell Significance Index: -9.2200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0153
    Cell Significance Index: -6.9500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0174
    Cell Significance Index: -5.0100
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0220
    Cell Significance Index: -0.3400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0271
    Cell Significance Index: -5.3800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0284
    Cell Significance Index: -3.9000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0309
    Cell Significance Index: -3.9900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0335
    Cell Significance Index: -0.5600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0340
    Cell Significance Index: -6.8200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0361
    Cell Significance Index: -0.4300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0384
    Cell Significance Index: -6.5600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0410
    Cell Significance Index: -8.6400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0437
    Cell Significance Index: -5.1500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0522
    Cell Significance Index: -4.0100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0567
    Cell Significance Index: -6.5000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0568
    Cell Significance Index: -5.8000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0568
    Cell Significance Index: -2.6700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0606
    Cell Significance Index: -3.1800
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.0607
    Cell Significance Index: -1.0000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0742
    Cell Significance Index: -7.7300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0833
    Cell Significance Index: -2.1900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0883
    Cell Significance Index: -4.6000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0971
    Cell Significance Index: -5.9700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1000
    Cell Significance Index: -6.7200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1076
    Cell Significance Index: -6.0400
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.1085
    Cell Significance Index: -1.7400
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.1153
    Cell Significance Index: -0.9800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1260
    Cell Significance Index: -3.3700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1274
    Cell Significance Index: -3.2800
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1321
    Cell Significance Index: -3.3000
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1479
    Cell Significance Index: -2.9700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1574
    Cell Significance Index: -7.3400
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1604
    Cell Significance Index: -3.4700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1618
    Cell Significance Index: -4.7700
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1655
    Cell Significance Index: -3.9700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1743
    Cell Significance Index: -7.7100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1760
    Cell Significance Index: -6.4600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Gene Structure:** The NPPC gene is located on chromosome 1q31.1 and consists of 6 exons, which encode a 22-amino acid C-type natriuretic peptide (CNP). 2. **Protein Structure:** CNP is a small, secreted peptide that acts as a potent vasodilator and natriuretic factor, binding to guanylyl cyclase receptors. 3. **Cellular Expression:** NPPC is widely expressed in various tissues, including the heart, lungs, kidneys, and gastrointestinal tract, where it regulates blood pressure, vascular tone, and cellular proliferation. **Pathways and Functions:** 1. **C-Di-GMP Signaling:** CNP activates guanylyl cyclase receptors, leading to the production of cyclic guanosine monophosphate (cGMP), a key second messenger involved in various cellular processes, including vasodilation and cellular proliferation. 2. **Cardiac Conduction:** NPPC regulates cardiac conduction by modulating the expression of ion channels and transporters involved in the heart's electrical activity. 3. **Angiogenesis and Vascular Remodeling:** CNP promotes angiogenesis and vascular remodeling by regulating the expression of angiogenic factors and vascular smooth muscle cell proliferation. 4. **Cellular Response to Glycoproteins:** NPPC modulates cellular responses to glycoproteins, such as fibronectin and laminin, involved in cell adhesion, migration, and proliferation. **Clinical Significance:** 1. **Cardiovascular Diseases:** NPPC has been implicated in various cardiovascular diseases, including hypertension, heart failure, and atherosclerosis, where CNP levels are often elevated. 2. **Respiratory Diseases:** CNP has been shown to regulate lung function and is involved in the pathogenesis of respiratory diseases, such as chronic obstructive pulmonary disease (COPD). 3. **Neurological Disorders:** NPPC has been implicated in neurological disorders, including Parkinson's disease, where CNP levels are often reduced. 4. **Cancer and Osteoporosis:** CNP has been shown to regulate cellular proliferation and differentiation in cancer and osteoporosis, where CNP levels are often altered. In conclusion, the NPPC gene plays a crucial role in maintaining cardiovascular homeostasis and regulating various cellular processes. Further research is needed to elucidate the complex mechanisms by which NPPC modulates cellular responses and to explore its therapeutic potential in various diseases.

Genular Protein ID: 3361788152

Symbol: ANFC_HUMAN

Name: C-type natriuretic peptide

UniProtKB Accession Codes:

P23582 Q4ZG41

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 2 EvolutionaryTrace 1 GO 42 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2018508

Title: Gene and precursor structures of human C-type natriuretic peptide.

PubMed ID: 2018508

DOI: 10.1016/0006-291x(91)91614-i

PubMed ID: 1339402

Title: Human C-type natriuretic peptide. Characterization of the gene and peptide.

PubMed ID: 1339402

DOI: 10.1161/01.hyp.19.6.809

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1472040

Title: Isolation and identification of C-type natriuretic peptide in human monocytic cell line, THP-1.

PubMed ID: 1472040

DOI: 10.1016/0006-291x(92)92257-x

PubMed ID: 1672777

Title: Selective activation of the B natriuretic peptide receptor by C-type natriuretic peptide (CNP).

PubMed ID: 1672777

DOI: 10.1126/science.1672777

PubMed ID: 9794555

Title: The renal natriuretic peptide urodilatin is present in human kidney.

PubMed ID: 9794555

DOI: 10.1093/ndt/13.10.2529

PubMed ID: 21098034

Title: Insulin-degrading enzyme modulates the natriuretic peptide-mediated signaling response.

PubMed ID: 21098034

DOI: 10.1074/jbc.m110.173252

PubMed ID: 29941213

Title: Natriuretic peptide based therapeutics for heart failure: cenderitide: a novel first-in-class designer natriuretic peptide.

PubMed ID: 29941213

DOI: 10.1016/j.ijcard.2018.06.002

PubMed ID: 11533490

Title: Allosteric activation of a spring-loaded natriuretic peptide receptor dimer by hormone.

PubMed ID: 11533490

DOI: 10.1126/science.1062246

Sequence Information:

  • Length: 126
  • Mass: 13246
  • Checksum: 58F6E657868F9A2D
  • Sequence:
    • MHLSQLLACA LLLTLLSLRP SEAKPGAPPK VPRTPPAEEL AEPQAAGGGQ KKGDKAPGGG 
GANLKGDRSR LLRDLRVDTK SRAAWARLLQ EHPNARKYKG ANKKGLSKGC FGLKLDRIGS 
MSGLGC

Genular Protein ID: 4035501597

Symbol: E5LCN7_HUMAN

Name: N/A

UniProtKB Accession Codes:

E5LCN7

Database IDs:

ARBA 6 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 4 GO 5 InterPro 3 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 2 PROSITE 1 PeptideAtlas 1 Pfam 1 RefSeq 1 RuleBase 1 SMART 1

Citations:

PubMed ID: 23542429

Title: Characterization of novel 3'untranslated regions and related polymorphisms of the gene NPPC, encoding for the C-type natriuretic peptide.

PubMed ID: 23542429

Sequence Information:

  • Length: 61
  • Mass: 6758
  • Checksum: 675D82FD403DDC17
  • Sequence:
    • GDRSRLLRDL RVDTKSRAAW ARLLQEHPNA RKYKGANKKG LSKGCFGLKL DRIGSMSGLG 
C

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.