Details for: NTF4

Gene ID: 4909

Symbol: NTF4

Ensembl ID: ENSG00000225950

Description: neurotrophin 4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.6396
    Cell Significance Index: 22.3700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.4365
    Cell Significance Index: 74.6200
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.2176
    Cell Significance Index: 10.0700
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 1.1970
    Cell Significance Index: 15.1500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.6775
    Cell Significance Index: 18.4400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.5987
    Cell Significance Index: 16.7300
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.5813
    Cell Significance Index: 14.0800
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.3537
    Cell Significance Index: 3.1400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.3475
    Cell Significance Index: 24.5800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2842
    Cell Significance Index: 51.2300
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.2564
    Cell Significance Index: 3.6500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2418
    Cell Significance Index: 29.7300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2293
    Cell Significance Index: 101.3800
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.0427
    Cell Significance Index: 0.4400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0055
    Cell Significance Index: 0.1400
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.0007
    Cell Significance Index: 0.0300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0021
    Cell Significance Index: -0.1100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0074
    Cell Significance Index: -5.6300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0088
    Cell Significance Index: -6.5100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0090
    Cell Significance Index: -4.9300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0112
    Cell Significance Index: -6.3100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0188
    Cell Significance Index: -6.7500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0315
    Cell Significance Index: -6.6300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0320
    Cell Significance Index: -4.1300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0350
    Cell Significance Index: -5.9800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0370
    Cell Significance Index: -4.3100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0370
    Cell Significance Index: -7.4300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0485
    Cell Significance Index: -6.6600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0533
    Cell Significance Index: -6.1100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0553
    Cell Significance Index: -5.6500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0564
    Cell Significance Index: -1.1800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0597
    Cell Significance Index: -2.8100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0648
    Cell Significance Index: -1.7300
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0723
    Cell Significance Index: -0.8200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0741
    Cell Significance Index: -5.5200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0881
    Cell Significance Index: -4.5900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1013
    Cell Significance Index: -7.7700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1046
    Cell Significance Index: -1.7500
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.1070
    Cell Significance Index: -0.7100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1077
    Cell Significance Index: -2.8900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1250
    Cell Significance Index: -5.8300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1296
    Cell Significance Index: -4.5100
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: -0.1478
    Cell Significance Index: -0.9200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1680
    Cell Significance Index: -9.4300
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: -0.1729
    Cell Significance Index: -1.3800
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: -0.1777
    Cell Significance Index: -1.6100
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: -0.1897
    Cell Significance Index: -0.4300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2012
    Cell Significance Index: -7.0500
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.2018
    Cell Significance Index: -5.0400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2030
    Cell Significance Index: -5.8200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.2034
    Cell Significance Index: -3.9700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2071
    Cell Significance Index: -9.1600
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.2073
    Cell Significance Index: -5.1700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2103
    Cell Significance Index: -7.7200
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: -0.2124
    Cell Significance Index: -1.6700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2156
    Cell Significance Index: -7.0600
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.2235
    Cell Significance Index: -1.9000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2271
    Cell Significance Index: -6.6900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2358
    Cell Significance Index: -7.5100
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.2407
    Cell Significance Index: -3.4200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2416
    Cell Significance Index: -9.1500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2544
    Cell Significance Index: -5.5700
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: -0.2627
    Cell Significance Index: -2.7100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.2705
    Cell Significance Index: -5.0000
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: -0.2736
    Cell Significance Index: -3.1800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2746
    Cell Significance Index: -7.2200
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.2747
    Cell Significance Index: -4.7400
  • Cell Name: tendon cell (CL0000388)
    Fold Change: -0.2809
    Cell Significance Index: -3.8200
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.2867
    Cell Significance Index: -4.8300
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.2877
    Cell Significance Index: -7.3300
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.2890
    Cell Significance Index: -7.2100
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.2941
    Cell Significance Index: -3.5000
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.2987
    Cell Significance Index: -4.4100
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: -0.2992
    Cell Significance Index: -3.5600
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: -0.3145
    Cell Significance Index: -2.8900
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.3167
    Cell Significance Index: -6.6100
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.3279
    Cell Significance Index: -4.8400
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.3322
    Cell Significance Index: -5.8700
  • Cell Name: osteoblast (CL0000062)
    Fold Change: -0.3350
    Cell Significance Index: -3.2500
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.3404
    Cell Significance Index: -7.3600
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.3427
    Cell Significance Index: -3.8800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.3454
    Cell Significance Index: -7.3300
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.3480
    Cell Significance Index: -6.9400
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.3495
    Cell Significance Index: -3.8000
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.3503
    Cell Significance Index: -4.6700
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.3514
    Cell Significance Index: -5.7900
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.3516
    Cell Significance Index: -6.9200
  • Cell Name: pulmonary capillary endothelial cell (CL4028001)
    Fold Change: -0.3516
    Cell Significance Index: -4.8200
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: -0.3567
    Cell Significance Index: -3.8200
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.3572
    Cell Significance Index: -5.7900
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.3601
    Cell Significance Index: -7.0400
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.3615
    Cell Significance Index: -6.0800
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.3623
    Cell Significance Index: -8.3700
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.3741
    Cell Significance Index: -7.5100
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: -0.3743
    Cell Significance Index: -4.7400
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.3798
    Cell Significance Index: -7.5100
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.3820
    Cell Significance Index: -6.0600
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.3859
    Cell Significance Index: -4.9700
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.3894
    Cell Significance Index: -4.8700
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.3901
    Cell Significance Index: -4.7100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** NTF4 is a secreted protein that belongs to the neurotrophin family, which consists of five members: NTF (nerve growth factor), NT-3, NT-4, NT-5, and brain-derived neurotrophic factor (BDNF). NTF4 is a dimeric protein composed of two identical subunits, each containing an extracellular domain, a transmembrane domain, and an intracellular domain. The extracellular domain is responsible for binding to its high-affinity receptor, tropomyosin receptor kinase B (TrkB). **Pathways and Functions:** NTF4 activates TrkB signaling pathways through various mechanisms, including: 1. **Activated TrkB signals through Frs2 and Frs3**: NTF4 binding to TrkB triggers the recruitment of Frs2 and Frs3, two adaptor proteins that facilitate the activation of downstream signaling pathways. 2. **Activated TrkB signals through PI3K**: NTF4 binding to TrkB activates the PI3K (phosphatidylinositol 3-kinase) pathway, which regulates cell survival, growth, and differentiation. 3. **Activated TrkB signals through PLCG1**: NTF4 binding to TrkB activates PLCG1 (phospholipase C gamma 1), an enzyme that regulates cell signaling and membrane trafficking. 4. **Activated TrkB signals through Ras**: NTF4 binding to TrkB activates the Ras (Rat Sarcoma) pathway, which regulates cell growth, differentiation, and survival. NTF4 plays a crucial role in various neural processes, including: 1. **Neuron development**: NTF4 regulates the development and differentiation of neurons, including the specification of neural cell types and the formation of neural connections. 2. **Neuronal survival**: NTF4 promotes neuronal survival by activating anti-apoptotic signaling pathways and inhibiting pro-apoptotic signaling pathways. 3. **Neuroplasticity**: NTF4 regulates neuroplasticity, the brain's ability to reorganize and adapt in response to changing experiences. 4. **Synaptic transmission**: NTF4 modulates synaptic transmission, the process by which neurons communicate with each other through chemical signals. **Clinical Significance:** Dysregulation of NTF4 signaling has been implicated in various neurological disorders, including: 1. **Alzheimer's disease**: Decreased NTF4 expression has been observed in Alzheimer's disease, suggesting that NTF4 plays a role in the pathogenesis of this disease. 2. **Parkinson's disease**: NTF4 has been shown to regulate dopamine signaling, which is disrupted in Parkinson's disease. 3. **Stroke**: NTF4 has been implicated in the regulation of neuronal survival and plasticity after stroke, suggesting that it may be a potential therapeutic target for stroke treatment. 4. **Neurodevelopmental disorders**: NTF4 has been shown to play a role in the development of neurodevelopmental disorders, such as autism spectrum disorder and schizophrenia. In conclusion, NTF4 is a multifunctional protein that plays a critical role in the development and maintenance of the nervous system. Its dysregulation has been implicated in various neurological disorders, highlighting the need for further research into the mechanisms of NTF4 signaling and its potential therapeutic applications.

Genular Protein ID: 3190712109

Symbol: NTF4_HUMAN

Name: Neurotrophin-4

UniProtKB Accession Codes:

P34130 Q6FH56

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 7 EvolutionaryTrace 1 ExpressionAtlas 1 GO 23 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PIR 1 PIRSF 1 PRINTS 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 8 RefSeq 5 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 1742028

Title: Neurotrophin-5: a novel neurotrophic factor that activates trk and trkB.

PubMed ID: 1742028

DOI: 10.1016/0896-6273(91)90287-a

PubMed ID: 1313578

Title: Mammalian neurotrophin-4: structure, chromosomal localization, tissue distribution, and receptor specificity.

PubMed ID: 1313578

DOI: 10.1073/pnas.89.7.3060

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10631974

Title: The structures of the neurotrophin 4 homodimer and the brain-derived neurotrophic factor/neurotrophin 4 heterodimer reveal a common Trk-binding site.

PubMed ID: 10631974

DOI: 10.1110/ps.8.12.2589

PubMed ID: 19765683

Title: Heterozygous NTF4 mutations impairing neurotrophin-4 signaling in patients with primary open-angle glaucoma.

PubMed ID: 19765683

DOI: 10.1016/j.ajhg.2009.08.016

PubMed ID: 20215012

Title: No evidence of association of heterozygous NTF4 mutations in patients with primary open-angle glaucoma.

PubMed ID: 20215012

DOI: 10.1016/j.ajhg.2009.11.018

Sequence Information:

  • Length: 210
  • Mass: 22427
  • Checksum: DBC6A30195E139AD
  • Sequence:
    • MLPLPSCSLP ILLLFLLPSV PIESQPPPST LPPFLAPEWD LLSPRVVLSR GAPAGPPLLF 
LLEAGAFRES AGAPANRSRR GVSETAPASR RGELAVCDAV SGWVTDRRTA VDLRGREVEV 
LGEVPAAGGS PLRQYFFETR CKADNAEEGG PGAGGGGCRG VDRRHWVSEC KAKQSYVRAL 
TADAQGRVGW RWIRIDTACV CTLLSRTGRA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.