Details for: NTF4

Gene ID: 4909

Symbol: NTF4

Ensembl ID: ENSG00000225950

Description: neurotrophin 4

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.19
    Marker Score: 2204
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.59
    Marker Score: 10597
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.25
    Marker Score: 7559.5
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 1.21
    Marker Score: 3636
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.18
    Marker Score: 4365
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 1.06
    Marker Score: 32721
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71828
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48053
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2395
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5314
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.8
    Marker Score: 571
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.8
    Marker Score: 730
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 396
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.76
    Marker Score: 1248
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.73
    Marker Score: 1178
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.54
    Marker Score: 433
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.51
    Marker Score: 964
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.46
    Marker Score: 276
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.45
    Marker Score: 7016
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.41
    Marker Score: 361
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.39
    Marker Score: 956
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.39
    Marker Score: 1522
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.38
    Marker Score: 434
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.32
    Marker Score: 465
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.29
    Marker Score: 302
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.29
    Marker Score: 583
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.27
    Marker Score: 123
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.26
    Marker Score: 292
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.25
    Marker Score: 1230
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.23
    Marker Score: 1363
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.21
    Marker Score: 86
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 0.21
    Marker Score: 165
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 0.2
    Marker Score: 244
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.2
    Marker Score: 177
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.2
    Marker Score: 137
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.18
    Marker Score: 196
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.17
    Marker Score: 104
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.17
    Marker Score: 80
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.15
    Marker Score: 185
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.15
    Marker Score: 2044
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.15
    Marker Score: 86
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.15
    Marker Score: 47
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.14
    Marker Score: 1024
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 0.13
    Marker Score: 31
  • Cell Name: cardiac mesenchymal cell (CL0000569)
    Fold Change: 0.13
    Marker Score: 31
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.12
    Marker Score: 343
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.12
    Marker Score: 52
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.12
    Marker Score: 34
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.11
    Marker Score: 78
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.11
    Marker Score: 225
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.11
    Marker Score: 934
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.11
    Marker Score: 202
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.1
    Marker Score: 45
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 0.09
    Marker Score: 30
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.09
    Marker Score: 109
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.09
    Marker Score: 39
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 0.09
    Marker Score: 32
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.09
    Marker Score: 22
  • Cell Name: ionocyte (CL0005006)
    Fold Change: 0.09
    Marker Score: 26
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.09
    Marker Score: 45
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.09
    Marker Score: 39
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.08
    Marker Score: 135
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.08
    Marker Score: 21
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.08
    Marker Score: 19
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 0.08
    Marker Score: 22.5
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 0.08
    Marker Score: 27
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.08
    Marker Score: 102
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 0.08
    Marker Score: 28
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.08
    Marker Score: 20
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.08
    Marker Score: 678
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.08
    Marker Score: 30
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.07
    Marker Score: 27
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.07
    Marker Score: 48
  • Cell Name: sebaceous gland cell (CL2000021)
    Fold Change: 0.07
    Marker Score: 22
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.07
    Marker Score: 21
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 0.07
    Marker Score: 22
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.07
    Marker Score: 356
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 0.07
    Marker Score: 432
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.07
    Marker Score: 46
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.06
    Marker Score: 853
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.06
    Marker Score: 16.5
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.06
    Marker Score: 115
  • Cell Name: epithelial cell of thymus (CL0002293)
    Fold Change: 0.06
    Marker Score: 20
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.06
    Marker Score: 20
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 0.06
    Marker Score: 55
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 0.06
    Marker Score: 481
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 0.06
    Marker Score: 22
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.06
    Marker Score: 42
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.06
    Marker Score: 22
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.06
    Marker Score: 159
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.06
    Marker Score: 28
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.06
    Marker Score: 17
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.06
    Marker Score: 11.5
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.06
    Marker Score: 67
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.05
    Marker Score: 27
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.05
    Marker Score: 84
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.05
    Marker Score: 42
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.05
    Marker Score: 17
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.05
    Marker Score: 20
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.05
    Marker Score: 17

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Other Information

**Key characteristics:** * NTF4 is a secreted protein that acts as a growth factor for neurons. * It is a member of the neurotrophin family of growth factors. * NTF4 is known to be a key regulator of neuronal survival, migration, and differentiation. * It is also involved in the regulation of synaptic plasticity and learning and memory. **Pathways and functions:** * NTF4 signaling is initiated by the binding of its ligand, NTF3, to its receptor, NTF4R. * NTF4 then binds to frs2 and frs3, which are adaptor proteins that facilitate the activation of the receptor. * Activation of NTF4 leads to the phosphorylation of p130-Ras, which is a key regulator of cell growth and survival. * Phosphorylated p130-Ras then recruits and activates the serine/threonine kinase Akt, which promotes cell proliferation, survival, and differentiation. * NTF4 also activates the PI3K/Akt pathway, which is involved in cell growth, differentiation, and survival. * These pathways work together to ensure the proper development and function of neurons. **Clinical significance:** * Mutations in NTF4 have been linked to several neurodevelopmental disorders, including autism spectrum disorder, schizophrenia, and Alzheimer's disease. * NTF4 is a promising target for the treatment of these disorders, as it is highly expressed in neurons and is involved in their survival, growth, and differentiation. * Clinical trials are currently investigating the use of NTF4 inhibitors to treat neurodegenerative diseases.

Genular Protein ID: 3190712109

Symbol: NTF4_HUMAN

Name: Neurotrophin-4

UniProtKB Accession Codes:

P34130 Q6FH56

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 7 EvolutionaryTrace 1 ExpressionAtlas 1 GO 25 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 3 PIR 1 PIRSF 1 PRINTS 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 5 RefSeq 5 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 1742028

Title: Neurotrophin-5: a novel neurotrophic factor that activates trk and trkB.

PubMed ID: 1742028

DOI: 10.1016/0896-6273(91)90287-a

PubMed ID: 1313578

Title: Mammalian neurotrophin-4: structure, chromosomal localization, tissue distribution, and receptor specificity.

PubMed ID: 1313578

DOI: 10.1073/pnas.89.7.3060

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10631974

Title: The structures of the neurotrophin 4 homodimer and the brain-derived neurotrophic factor/neurotrophin 4 heterodimer reveal a common Trk-binding site.

PubMed ID: 10631974

DOI: 10.1110/ps.8.12.2589

PubMed ID: 19765683

Title: Heterozygous NTF4 mutations impairing neurotrophin-4 signaling in patients with primary open-angle glaucoma.

PubMed ID: 19765683

DOI: 10.1016/j.ajhg.2009.08.016

PubMed ID: 20215012

Title: No evidence of association of heterozygous NTF4 mutations in patients with primary open-angle glaucoma.

PubMed ID: 20215012

DOI: 10.1016/j.ajhg.2009.11.018

Sequence Information:

  • Length: 210
  • Mass: 22427
  • Checksum: DBC6A30195E139AD
  • Sequence:
    • MLPLPSCSLP ILLLFLLPSV PIESQPPPST LPPFLAPEWD LLSPRVVLSR GAPAGPPLLF 
LLEAGAFRES AGAPANRSRR GVSETAPASR RGELAVCDAV SGWVTDRRTA VDLRGREVEV 
LGEVPAAGGS PLRQYFFETR CKADNAEEGG PGAGGGGCRG VDRRHWVSEC KAKQSYVRAL 
TADAQGRVGW RWIRIDTACV CTLLSRTGRA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.