Details for: OCRL

Gene ID: 4952

Symbol: OCRL

Ensembl ID: ENSG00000122126

Description: OCRL inositol polyphosphate-5-phosphatase

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 120.8652
    Cell Significance Index: -18.8000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 73.7256
    Cell Significance Index: -18.7000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 40.7839
    Cell Significance Index: -19.2600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 17.1669
    Cell Significance Index: -16.3900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 15.3371
    Cell Significance Index: -18.9100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 5.4464
    Cell Significance Index: -11.9200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.8175
    Cell Significance Index: -19.0100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.9314
    Cell Significance Index: 186.8300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.8581
    Cell Significance Index: 93.3400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.8207
    Cell Significance Index: 49.2700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7648
    Cell Significance Index: 124.4000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.7319
    Cell Significance Index: 85.3000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.7058
    Cell Significance Index: 9.6300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.6397
    Cell Significance Index: 18.2600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5622
    Cell Significance Index: 507.6100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.5614
    Cell Significance Index: 111.4100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.5567
    Cell Significance Index: 12.0600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.5223
    Cell Significance Index: 27.1300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.5095
    Cell Significance Index: 34.2600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4486
    Cell Significance Index: 160.9000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4337
    Cell Significance Index: 29.9900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4146
    Cell Significance Index: 11.9500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3955
    Cell Significance Index: 71.2900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3909
    Cell Significance Index: 17.7200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.3529
    Cell Significance Index: 27.0800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1994
    Cell Significance Index: 37.9500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1928
    Cell Significance Index: 19.0700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1782
    Cell Significance Index: 123.2700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1748
    Cell Significance Index: 4.3700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.1664
    Cell Significance Index: 7.3600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.1640
    Cell Significance Index: 6.2100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.1317
    Cell Significance Index: 3.5300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1010
    Cell Significance Index: 12.4300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0949
    Cell Significance Index: 43.0800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0832
    Cell Significance Index: 3.8800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0753
    Cell Significance Index: 41.1100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0673
    Cell Significance Index: 126.7600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0637
    Cell Significance Index: 40.4800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0622
    Cell Significance Index: 10.6200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0572
    Cell Significance Index: 7.8500
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.0478
    Cell Significance Index: 0.6700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0456
    Cell Significance Index: 20.1500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0377
    Cell Significance Index: 0.9700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0268
    Cell Significance Index: 0.9400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0203
    Cell Significance Index: 31.1800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0154
    Cell Significance Index: 28.3600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0119
    Cell Significance Index: 16.1600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0106
    Cell Significance Index: 1.5400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0106
    Cell Significance Index: 0.6500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0071
    Cell Significance Index: -0.1900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0073
    Cell Significance Index: -5.4000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0121
    Cell Significance Index: -0.2500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0123
    Cell Significance Index: -7.6900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0171
    Cell Significance Index: -12.5400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0182
    Cell Significance Index: -13.8100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0191
    Cell Significance Index: -1.0700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0212
    Cell Significance Index: -2.4300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0224
    Cell Significance Index: -12.6600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0266
    Cell Significance Index: -3.0400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0362
    Cell Significance Index: -0.7700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0367
    Cell Significance Index: -4.7100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0383
    Cell Significance Index: -1.0700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0492
    Cell Significance Index: -10.3700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0552
    Cell Significance Index: -15.8900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0687
    Cell Significance Index: -4.3300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0690
    Cell Significance Index: -7.0500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0694
    Cell Significance Index: -7.2300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1012
    Cell Significance Index: -2.6600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1090
    Cell Significance Index: -14.0800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1325
    Cell Significance Index: -9.3700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1406
    Cell Significance Index: -2.4100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1421
    Cell Significance Index: -16.7600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1530
    Cell Significance Index: -4.9000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1552
    Cell Significance Index: -3.0300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1669
    Cell Significance Index: -12.4400
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.1722
    Cell Significance Index: -2.9000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1819
    Cell Significance Index: -9.5500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1859
    Cell Significance Index: -4.0700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1927
    Cell Significance Index: -5.2500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1949
    Cell Significance Index: -9.1600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2000
    Cell Significance Index: -10.4200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2154
    Cell Significance Index: -17.0600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2161
    Cell Significance Index: -13.2500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2227
    Cell Significance Index: -14.3700
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.2406
    Cell Significance Index: -5.7700
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.2552
    Cell Significance Index: -5.4600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2756
    Cell Significance Index: -5.8500
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.3022
    Cell Significance Index: -4.4600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3256
    Cell Significance Index: -10.3700
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.3259
    Cell Significance Index: -5.1700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.3300
    Cell Significance Index: -16.6800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3311
    Cell Significance Index: -10.8400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3448
    Cell Significance Index: -11.9800
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.3448
    Cell Significance Index: -5.0900
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.3584
    Cell Significance Index: -5.3700
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.3598
    Cell Significance Index: -5.1800
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.3707
    Cell Significance Index: -8.0100
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.3864
    Cell Significance Index: -7.6400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3900
    Cell Significance Index: -11.1800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.4111
    Cell Significance Index: -14.4000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** OCRL is a phosphoinositide phosphatase enzyme that catalyzes the hydrolysis of inositol polyphosphates, including phosphatidylinositol-4,5-bisphosphate (PIP2), phosphatidylinositol-3,4,5-trisphosphate (PIP3), and phosphatidylinositol-3-phosphate (PIP). These phosphoinositides are critical components of cell signaling pathways, influencing various cellular processes, including motility, endocytosis, and lipid metabolism. OCRL is specifically localized to the Golgi apparatus and endosomes, where it regulates the levels of phosphoinositides by dephosphorylating them. **Pathways and Functions** OCRL is involved in several key signaling pathways, including: 1. **Cilium assembly and motility**: OCRL regulates the assembly and maintenance of cilia, which are essential for sensory perception and motility in various cell types. 2. **Endocytosis and vesicle trafficking**: OCRL modulates the activity of clathrin-coated pits and vesicles, influencing the internalization of receptors and ligands. 3. **Lipid metabolism**: OCRL regulates the synthesis and degradation of phosphoinositides, which are critical components of cell membranes and signaling pathways. 4. **Signaling by GTPases**: OCRL interacts with GTPases, including Rho, Rac, and Rab, to modulate their activity and influence cellular processes. **Clinical Significance** Mutations in the OCRL gene have been associated with several neurodevelopmental disorders, including: 1. **Ube3D-related disorders**: These disorders are characterized by intellectual disability, epilepsy, and other neurological abnormalities. 2. **Bardet-Biedl syndrome**: This disorder is characterized by obesity, polydactyly, and renal abnormalities. 3. **Other disorders**: OCRL mutations have also been associated with other neurodevelopmental disorders, including intellectual disability and autism spectrum disorder. In conclusion, OCRL is a critical regulator of phosphoinositide metabolism, influencing various cellular processes, including cilium assembly, endocytosis, and lipid metabolism. Mutations in the OCRL gene have been associated with several neurodevelopmental disorders, highlighting the importance of this gene in maintaining normal cellular function and development.

Genular Protein ID: 161556438

Symbol: OCRL_HUMAN

Name: Inositol polyphosphate 5-phosphatase OCRL-1

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 1321346

Title: The Lowe's oculocerebrorenal syndrome gene encodes a protein highly homologous to inositol polyphosphate-5-phosphatase.

PubMed ID: 1321346

DOI: 10.1038/358239a0

PubMed ID: 9048911

Title: Physical mapping and genomic structure of the Lowe syndrome gene OCRL1.

PubMed ID: 9048911

DOI: 10.1007/s004390050329

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8504307

Title: Nonsense mutations in the OCRL-1 gene in patients with the oculocerebrorenal syndrome of Lowe.

PubMed ID: 8504307

DOI: 10.1093/hmg/2.4.461

PubMed ID: 7761412

Title: The protein deficient in Lowe syndrome is a phosphatidylinositol-4,5-bisphosphate 5-phosphatase.

PubMed ID: 7761412

DOI: 10.1073/pnas.92.11.4853

PubMed ID: 9430698

Title: Cell lines from kidney proximal tubules of a patient with Lowe syndrome lack OCRL inositol polyphosphate 5-phosphatase and accumulate phosphatidylinositol 4,5-bisphosphate.

PubMed ID: 9430698

DOI: 10.1074/jbc.273.3.1574

PubMed ID: 10764818

Title: The isolation and characterization of a cDNA encoding phospholipid-specific inositol polyphosphate 5-phosphatase.

PubMed ID: 10764818

DOI: 10.1074/jbc.m910119199

PubMed ID: 15474001

Title: Type II phosphoinositide 5-phosphatases have unique sensitivities towards fatty acid composition and head group phosphorylation.

PubMed ID: 15474001

DOI: 10.1016/j.febslet.2004.08.052

PubMed ID: 20133602

Title: Two closely related endocytic proteins that share a common OCRL-binding motif with APPL1.

PubMed ID: 20133602

DOI: 10.1073/pnas.0914658107

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21971085

Title: OCRL controls trafficking through early endosomes via PtdIns4,5P(2)-dependent regulation of endosomal actin.

PubMed ID: 21971085

DOI: 10.1038/emboj.2011.354

PubMed ID: 21233288

Title: The PH domain proteins IPIP27A and B link OCRL1 to receptor recycling in the endocytic pathway.

PubMed ID: 21233288

DOI: 10.1091/mbc.e10-08-0730

PubMed ID: 22543976

Title: OCRL localizes to the primary cilium: a new role for cilia in Lowe syndrome.

PubMed ID: 22543976

DOI: 10.1093/hmg/dds163

PubMed ID: 22228094

Title: The Lowe syndrome protein OCRL1 is involved in primary cilia assembly.

PubMed ID: 22228094

DOI: 10.1093/hmg/ddr615

PubMed ID: 22072788

Title: Recruitment of OCRL and Inpp5B to phagosomes by Rab5 and APPL1 depletes phosphoinositides and attenuates Akt signaling.

PubMed ID: 22072788

DOI: 10.1091/mbc.e11-06-0489

PubMed ID: 22381590

Title: Inositol 5-phosphatases: insights from the Lowe syndrome protein OCRL.

PubMed ID: 22381590

DOI: 10.1016/j.tibs.2012.01.002

PubMed ID: 25869668

Title: Sac2/INPP5F is an inositol 4-phosphatase that functions in the endocytic pathway.

PubMed ID: 25869668

DOI: 10.1083/jcb.201409064

PubMed ID: 19536138

Title: A PH domain within OCRL bridges clathrin-mediated membrane trafficking to phosphoinositide metabolism.

PubMed ID: 19536138

DOI: 10.1038/emboj.2009.155

PubMed ID: 21378754

Title: A structural basis for Lowe syndrome caused by mutations in the Rab-binding domain of OCRL1.

PubMed ID: 21378754

DOI: 10.1038/emboj.2011.60

PubMed ID: 17765681

Title: A role of the Lowe syndrome protein OCRL in early steps of the endocytic pathway.

PubMed ID: 17765681

DOI: 10.1016/j.devcel.2007.08.004

PubMed ID: 21666675

Title: Recognition of the F&H motif by the Lowe syndrome protein OCRL.

PubMed ID: 21666675

DOI: 10.1038/nsmb.2071

PubMed ID: 9199559

Title: Spectrum of mutations in the OCRL1 gene in the Lowe oculocerebrorenal syndrome.

PubMed ID: 9199559

DOI: 10.1086/515471

PubMed ID: 9682219

Title: Mutations are not uniformly distributed throughout the OCRL1 gene in Lowe syndrome patients.

PubMed ID: 9682219

DOI: 10.1006/mgme.1998.2687

PubMed ID: 9632163

Title: Oculocerebrorenal syndrome of Lowe: three mutations in the OCRL1 gene derived from three patients with different phenotypes.

PubMed ID: 9632163

DOI: 10.1002/(sici)1096-8628(19980605)77:5<348::aid-ajmg2>3.3.co;2-h

PubMed ID: 9788721

Title: Identification of two novel mutations in the OCRL1 gene in Japanese families with Lowe syndrome.

PubMed ID: 9788721

DOI: 10.1111/j.1399-0004.1998.tb04284.x

PubMed ID: 10923037

Title: OCRL1 mutation analysis in French Lowe syndrome patients: implications for molecular diagnosis strategy and genetic counseling.

PubMed ID: 10923037

DOI: 10.1002/1098-1004(200008)16:2<157::aid-humu8>3.0.co;2-9

PubMed ID: 10767176

Title: Carrier assessment in families with Lowe oculocerebrorenal syndrome: novel mutations in the OCRL1 gene and correlation of direct DNA diagnosis with ocular examination.

PubMed ID: 10767176

DOI: 10.1006/mgme.1999.2955

PubMed ID: 15627218

Title: Dent disease with mutations in OCRL1.

PubMed ID: 15627218

DOI: 10.1086/427887

PubMed ID: 17384968

Title: OCRL1 mutations in patients with Dent disease phenotype in Japan.

PubMed ID: 17384968

DOI: 10.1007/s00467-007-0454-x

PubMed ID: 19168822

Title: Magnetic resonance imaging, magnetic resonance spectroscopy, and facial dysmorphism in a case of Lowe syndrome with novel OCRL1 gene mutation.

PubMed ID: 19168822

DOI: 10.1177/0883073808321047

PubMed ID: 21031565

Title: From Lowe syndrome to Dent disease: correlations between mutations of the OCRL1 gene and clinical and biochemical phenotypes.

PubMed ID: 21031565

DOI: 10.1002/humu.21391

Sequence Information:

  • Length: 901
  • Mass: 104205
  • Checksum: 476BFCCC3655C1FE
  • Sequence:
  • MEPPLPVGAQ PLATVEGMEM KGPLREPCAL TLAQRNGQYE LIIQLHEKEQ HVQDIIPINS 
    HFRCVQEAEE TLLIDIASNS GCKIRVQGDW IRERRFEIPD EEHCLKFLSA VLAAQKAQSQ 
    LLVPEQKDSS SWYQKLDTKD KPSVFSGLLG FEDNFSSMNL DKKINSQNQP TGIHREPPPP 
    PFSVNKMLPR EKEASNKEQP KVTNTMRKLF VPNTQSGQRE GLIKHILAKR EKEYVNIQTF 
    RFFVGTWNVN GQSPDSGLEP WLNCDPNPPD IYCIGFQELD LSTEAFFYFE SVKEQEWSMA 
    VERGLHSKAK YKKVQLVRLV GMMLLIFARK DQCRYIRDIA TETVGTGIMG KMGNKGGVAV 
    RFVFHNTTFC IVNSHLAAHV EDFERRNQDY KDICARMSFV VPNQTLPQLN IMKHEVVIWL 
    GDLNYRLCMP DANEVKSLIN KKDLQRLLKF DQLNIQRTQK KAFVDFNEGE IKFIPTYKYD 
    SKTDRWDSSG KCRVPAWCDR ILWRGTNVNQ LNYRSHMELK TSDHKPVSAL FHIGVKVVDE 
    RRYRKVFEDS VRIMDRMEND FLPSLELSRR EFVFENVKFR QLQKEKFQIS NNGQVPCHFS 
    FIPKLNDSQY CKPWLRAEPF EGYLEPNETV DISLDVYVSK DSVTILNSGE DKIEDILVLH 
    LDRGKDYFLT ISGNYLPSCF GTSLEALCRM KRPIREVPVT KLIDLEEDSF LEKEKSLLQM 
    VPLDEGASER PLQVPKEIWL LVDHLFKYAC HQEDLFQTPG MQEELQQIID CLDTSIPETI 
    PGSNHSVAEA LLIFLEALPE PVICYELYQR CLDSAYDPRI CRQVISQLPR CHRNVFRYLM 
    AFLRELLKFS EYNSVNANMI ATLFTSLLLR PPPNLMARQT PSDRQRAIQF LLGFLLGSEE 
    D

Genular Protein ID: 1011353205

Symbol: A0A2X0TVZ9_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 893
  • Mass: 103227
  • Checksum: E61E59C6AD0AC650
  • Sequence:
  • MEPPLPVGAQ PLATVEGMEM KGPLREPCAL TLAQRNGQYE LIIQLHEKEQ HVQDIIPINS 
    HFRCVQEAEE TLLIDIASNS GCKIRVQGDW IRERRFEIPD EEHCLKFLSA VLAAQKAQSQ 
    LLVPEQKDSS SWYQKLDTKD KPSVFSGLLG FEDNFSSMNL DKKINSQNQP TGIHREPPPP 
    PFSVNKMLPR EKEASNKEQP KVTNTMRKLF VPNTQSGQRE GLIKHILAKR EKEYVNIQTF 
    RFFVGTWNVN GQSPDSGLEP WLNCDPNPPD IYCIGFQELD LSTEAFFYFE SVKEQEWSMA 
    VERGLHSKAK YKKVQLVRLV GMMLLIFARK DQCRYIRDIA TETVGTGIMG KMGNKGGVAV 
    RFVFHNTTFC IVNSHLAAHV EDFERRNQDY KDICARMSFV VPNQTLPQLN IMKHEVVIWL 
    GDLNYRLCMP DANEVKSLIN KKDLQRLLKF DQLNIQRTQK KAFVDFNEGE IKFIPTYKYD 
    SKTDRWDSSG KCRVPAWCDR ILWRGTNVNQ LNYRSHMELK TSDHKPVSAL FHIGVKVVDE 
    RRYRKVFEDS VRIMDRMEND FLPSLELSRR EFVFENVKFR QLQKEKFQIS NNGQVPCHFS 
    FIPKLNDSQY CKPWLRAEPF EGYLEPNETV DISLDVYVSK DSVTILNSGE DKIEDILVLH 
    LDRGKDYFLT ISGNYLPSCF GTSLEALCRM KRPIREVPVT KLIDLEKSLL QMVPLDEGAS 
    ERPLQVPKEI WLLVDHLFKY ACHQEDLFQT PGMQEELQQI IDCLDTSIPE TIPGSNHSVA 
    EALLIFLEAL PEPVICYELY QRCLDSAYDP RICRQVISQL PRCHRNVFRY LMAFLRELLK 
    FSEYNSVNAN MIATLFTSLL LRPPPNLMAR QTPSDRQRAI QFLLGFLLGS EED

Genular Protein ID: 652428974

Symbol: Q504W7_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 893
  • Mass: 103181
  • Checksum: 1EF7E1812E182B79
  • Sequence:
  • MEPPLPVGAQ PLATVEGMEM KGPLREPCAL TLAQRNGQYE LIIQLHEKEQ HVQDIIPINS 
    HFRCVQEAEE TLLIDIASNS GCKIRVQGDW IRERRFEIPD EEHCLKFLSA VLAAQKAQSQ 
    LLVPEQKDSS SWYQKLDTKD KPSVFSGLLG FEDNFSSMNL DKKINSQNQP TGIHREPPPP 
    PFSVNKMLPR EKEASNKEQP KVTNTMRKLF VPNTQSGQRE GLIKHILAKR EKEYVNIQTF 
    RFFVGTWNVN GQSPDSGLEP WLNCDPNPPD IYCIGFQELD LSTEAFFYFE SVKEQEWSMA 
    VERGLHSKAK YKKVQLVRLV GMMLLIFARK DQCRYIRDIA TETVGTGIMG KMGNKGGVAV 
    RFVFHNTTFC IVNSHLAAHV EDFERRNQDY KDICARMSFV VPNQTLPQLN IMKHEVVIWL 
    GDLNYRLGMP DANEVKSLIN KKDLQRLLKF DQLNIQRTQK KAFVDFNEGE IKFIPTYKYD 
    SKTDRWDSSG KCRVPAWCDR ILWRGTNVNQ LNYRSHMELK TSDHKPVSAL FHIGVKVVDE 
    RRYRKVFEDS VRIMDRMEND FLPSLELSRR EFVFENVKFR QLQKEKFQIS NNGQVPCHFS 
    FIPKLNDSQY CKPWLRAEPF EGYLEPNETV DISLDVYVSK DSVTILNSGE DKIEDILVLH 
    LDRGKDYFLT ISGNYLPSCF GTSLEALCRM KRPIREVPVT KLIDLEKSLL QMVPLDEGAS 
    ERPLQVPKEI WLLVDHLFKY ACHQEDLFQT PGMQEELQQI IDCLDTSIPE TIPGSNHSVA 
    EALLIFLEAL PEPVICYELY QRCLDSAYDP RICRQVISQL PRCHRNVFRY LMAFLRELLK 
    FSEYNSVNAN MIATLFTSLL LRPPPNLMAR QTPSDRQRAI QFLLGFLLGS EED

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.