Details for: TNFRSF11B

Gene ID: 4982

Symbol: TNFRSF11B

Ensembl ID: ENSG00000164761

Description: TNF receptor superfamily member 11b

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 34.2213
    Cell Significance Index: -8.6800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 8.9134
    Cell Significance Index: -8.5100
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 5.9314
    Cell Significance Index: 63.0200
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 3.7580
    Cell Significance Index: 16.1600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 3.7105
    Cell Significance Index: -9.9400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 2.1642
    Cell Significance Index: -8.5400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.4009
    Cell Significance Index: 138.5800
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 1.0194
    Cell Significance Index: 25.4200
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.9838
    Cell Significance Index: 21.0300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.6601
    Cell Significance Index: 31.0300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6320
    Cell Significance Index: 570.6100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.5528
    Cell Significance Index: 33.1900
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: 0.5350
    Cell Significance Index: 2.4700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5091
    Cell Significance Index: 55.3800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4109
    Cell Significance Index: 66.8300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.3993
    Cell Significance Index: 46.5300
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.3748
    Cell Significance Index: 2.8700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.3710
    Cell Significance Index: 27.6500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.3101
    Cell Significance Index: 23.8000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2427
    Cell Significance Index: 11.0000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2347
    Cell Significance Index: 44.6600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.1499
    Cell Significance Index: 93.6100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1428
    Cell Significance Index: 28.3400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1199
    Cell Significance Index: 15.5000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1109
    Cell Significance Index: 5.1700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0757
    Cell Significance Index: 2.6600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0618
    Cell Significance Index: 1.7800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.0616
    Cell Significance Index: 0.7000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0548
    Cell Significance Index: 37.9300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0291
    Cell Significance Index: 18.4600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0184
    Cell Significance Index: 2.1100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0132
    Cell Significance Index: 0.3300
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0111
    Cell Significance Index: 0.1200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0042
    Cell Significance Index: 0.0900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0020
    Cell Significance Index: -1.4500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0033
    Cell Significance Index: -2.4500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0035
    Cell Significance Index: -6.5500
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.0036
    Cell Significance Index: -0.0300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0049
    Cell Significance Index: -2.7800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0059
    Cell Significance Index: -10.9200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0070
    Cell Significance Index: -3.8400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0078
    Cell Significance Index: -12.0000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0094
    Cell Significance Index: -1.8800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0097
    Cell Significance Index: -13.1500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0112
    Cell Significance Index: -8.4600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0131
    Cell Significance Index: -0.4200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0132
    Cell Significance Index: -5.8300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0138
    Cell Significance Index: -0.7200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0189
    Cell Significance Index: -3.9800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0213
    Cell Significance Index: -3.8500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0215
    Cell Significance Index: -9.7700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0220
    Cell Significance Index: -7.8800
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.0240
    Cell Significance Index: -0.3800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0249
    Cell Significance Index: -0.5300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0267
    Cell Significance Index: -7.6900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0296
    Cell Significance Index: -3.8000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0300
    Cell Significance Index: -5.1300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0325
    Cell Significance Index: -1.9900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0361
    Cell Significance Index: -0.9700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0371
    Cell Significance Index: -3.7900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0416
    Cell Significance Index: -2.1000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0443
    Cell Significance Index: -6.0800
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.0448
    Cell Significance Index: -0.4900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0450
    Cell Significance Index: -5.5300
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0454
    Cell Significance Index: -5.1800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0538
    Cell Significance Index: -7.8200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0554
    Cell Significance Index: -1.1500
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0764
    Cell Significance Index: -1.8500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0819
    Cell Significance Index: -3.3600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0823
    Cell Significance Index: -9.7100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0849
    Cell Significance Index: -8.8400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1099
    Cell Significance Index: -1.5000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1124
    Cell Significance Index: -8.9000
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -0.1126
    Cell Significance Index: -1.0200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1234
    Cell Significance Index: -7.7800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1288
    Cell Significance Index: -8.6600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1331
    Cell Significance Index: -3.7200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1586
    Cell Significance Index: -8.9000
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.1590
    Cell Significance Index: -2.4600
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1646
    Cell Significance Index: -2.4800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1713
    Cell Significance Index: -10.5300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1740
    Cell Significance Index: -9.0400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1832
    Cell Significance Index: -8.1100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1832
    Cell Significance Index: -9.6200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2039
    Cell Significance Index: -5.2400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2107
    Cell Significance Index: -6.2100
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.2130
    Cell Significance Index: -3.5100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2135
    Cell Significance Index: -5.7200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2150
    Cell Significance Index: -8.1400
  • Cell Name: osteoblast (CL0000062)
    Fold Change: -0.2381
    Cell Significance Index: -2.3100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2449
    Cell Significance Index: -8.5800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2498
    Cell Significance Index: -6.6700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2499
    Cell Significance Index: -5.2300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2585
    Cell Significance Index: -9.4900
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: -0.2642
    Cell Significance Index: -1.0000
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.2680
    Cell Significance Index: -4.5200
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.2690
    Cell Significance Index: -3.9700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2706
    Cell Significance Index: -8.8600
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.2709
    Cell Significance Index: -11.7800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2797
    Cell Significance Index: -9.7200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TNFRSF11B is a type II transmembrane protein that belongs to the TNF receptor superfamily. It is primarily expressed in cells involved in immune responses, bone metabolism, and development. The receptor is activated by its ligand, RANK, which is expressed on the surface of osteoclasts, T-cells, and other immune cells. Upon binding, RANKL induces the activation of NF-κB signaling, leading to the expression of genes involved in immune responses, bone resorption, and development. **Pathways and Functions:** TNFRSF11B is involved in several key pathways, including: 1. **Apoptotic Process:** TNFRSF11B is involved in regulating apoptosis in various cell types, including immune cells and osteoclasts. 2. **Cytokine Activity:** TNFRSF11B modulates cytokine signaling, influencing the production of pro-inflammatory and anti-inflammatory cytokines. 3. **Immune System Regulation:** TNFRSF11B plays a crucial role in regulating immune responses, including the activation of T-cells and the production of cytokines. 4. **Bone Resorption:** TNFRSF11B is involved in regulating bone resorption by inducing the activation of osteoclasts. 5. **Skeletal System Development:** TNFRSF11B is essential for the development and maintenance of the skeletal system, particularly during embryonic development. **Clinical Significance:** Dysregulation of TNFRSF11B has been implicated in various diseases, including: 1. **Rickets and Osteomalacia:** Defects in TNFRSF11B have been linked to rickets and osteomalacia, highlighting its importance in bone metabolism. 2. **Multiple Myeloma:** Abnormal expression of TNFRSF11B has been observed in multiple myeloma, suggesting its potential as a therapeutic target. 3. **Autoimmune Diseases:** TNFRSF11B dysregulation has been implicated in various autoimmune diseases, including rheumatoid arthritis and lupus. 4. **Cancer:** TNFRSF11B has been implicated in cancer progression, with its expression altered in various types of cancer. In conclusion, TNFRSF11B is a complex protein that plays a multifaceted role in regulating immune responses, bone metabolism, and development. Its dysregulation has been implicated in various diseases, highlighting its potential as a therapeutic target. Further research is necessary to fully elucidate the mechanisms underlying TNFRSF11B function and to explore its therapeutic applications.

Genular Protein ID: 2581333707

Symbol: TR11B_HUMAN

Name: Tumor necrosis factor receptor superfamily member 11B

UniProtKB Accession Codes:

O00300 B2R9A8 O60236 Q53FX6 Q9UHP4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 ChiTaRS 1 ComplexPortal 1 DNASU 1 DisGeNET 1 EMBL 10 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 21 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIRSF 1 PRINTS 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9108485

Title: Osteoprotegerin: a novel secreted protein involved in the regulation of bone density.

PubMed ID: 9108485

DOI: 10.1016/s0092-8674(00)80209-3

PubMed ID: 9492069

Title: Identity of osteoclastogenesis inhibitory factor (OCIF) and osteoprotegerin (OPG): a mechanism by which OPG/OCIF inhibits osteoclastogenesis in vitro.

PubMed ID: 9492069

DOI: 10.1210/endo.139.3.5837

PubMed ID: 9688283

Title: Cloning and characterization of the gene encoding human osteoprotegerin/osteoclastogenesis-inhibitory factor.

PubMed ID: 9688283

DOI: 10.1046/j.1432-1327.1998.2540685.x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9571159

Title: Characterization of monomeric and homodimeric forms of osteoclastogenesis inhibitory factor.

PubMed ID: 9571159

DOI: 10.1006/bbrc.1998.8443

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

PubMed ID: 12110935

Title: Cloning and expression of a novel mutated osteoprogerin/osteoclastogenesis inhibitory factor gene.

PubMed ID: 12110935

PubMed ID: 9168977

Title: Isolation of a novel cytokine from human fibroblasts that specifically inhibits osteoclastogenesis.

PubMed ID: 9168977

DOI: 10.1006/bbrc.1997.6603

PubMed ID: 9603945

Title: Osteoprotegerin is a receptor for the cytotoxic ligand TRAIL.

PubMed ID: 9603945

DOI: 10.1074/jbc.273.23.14363

PubMed ID: 9478964

Title: Characterization of structural domains of human osteoclastogenesis inhibitory factor.

PubMed ID: 9478964

DOI: 10.1074/jbc.273.9.5117

PubMed ID: 11505389

Title: Receptor activator of nuclear factor-kappaB ligand and osteoprotegerin: potential implications for the pathogenesis and treatment of malignant bone diseases.

PubMed ID: 11505389

DOI: 10.1002/1097-0142(20010801)92:3<460::aid-cncr1344>3.0.co;2-d

PubMed ID: 22664871

Title: Crystal structure of human RANKL complexed with its decoy receptor osteoprotegerin.

PubMed ID: 22664871

DOI: 10.4049/jimmunol.1103387

PubMed ID: 12189164

Title: A mutation in the gene TNFRSF11B encoding osteoprotegerin causes an idiopathic hyperphosphatasia phenotype.

PubMed ID: 12189164

DOI: 10.1093/hmg/11.18.2119

Sequence Information:

  • Length: 401
  • Mass: 46026
  • Checksum: 2A23AC07BFA1E2DE
  • Sequence:
    • MNNLLCCALV FLDISIKWTT QETFPPKYLH YDEETSHQLL CDKCPPGTYL KQHCTAKWKT 
VCAPCPDHYY TDSWHTSDEC LYCSPVCKEL QYVKQECNRT HNRVCECKEG RYLEIEFCLK 
HRSCPPGFGV VQAGTPERNT VCKRCPDGFF SNETSSKAPC RKHTNCSVFG LLLTQKGNAT 
HDNICSGNSE STQKCGIDVT LCEEAFFRFA VPTKFTPNWL SVLVDNLPGT KVNAESVERI 
KRQHSSQEQT FQLLKLWKHQ NKDQDIVKKI IQDIDLCENS VQRHIGHANL TFEQLRSLME 
SLPGKKVGAE DIEKTIKACK PSDQILKLLS LWRIKNGDQD TLKGLMHALK HSKTYHFPKT 
VTQSLKKTIR FLHSFTMYKL YQKLFLEMIG NQVQSVKISC L

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.