Details for: P2RX1

Gene ID: 5023

Symbol: P2RX1

Ensembl ID: ENSG00000108405

Description: purinergic receptor P2X 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 23.5301
    Cell Significance Index: -3.6600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 10.5844
    Cell Significance Index: -4.3000
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 10.0897
    Cell Significance Index: -5.1900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 9.2349
    Cell Significance Index: -4.3600
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: 3.3333
    Cell Significance Index: 38.3900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 3.0253
    Cell Significance Index: -3.7300
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 2.6689
    Cell Significance Index: 33.8000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 2.4588
    Cell Significance Index: 150.7500
  • Cell Name: brush cell (CL0002204)
    Fold Change: 2.0027
    Cell Significance Index: 18.3600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.6770
    Cell Significance Index: 108.1900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 1.5376
    Cell Significance Index: -0.3900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.3817
    Cell Significance Index: 29.9400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 1.3488
    Cell Significance Index: 36.0800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.3317
    Cell Significance Index: 34.0200
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.2604
    Cell Significance Index: 19.5000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 0.9985
    Cell Significance Index: -3.9400
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.8833
    Cell Significance Index: 5.8600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.6771
    Cell Significance Index: 128.8500
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.6576
    Cell Significance Index: 9.9100
  • Cell Name: megakaryocyte progenitor cell (CL0000553)
    Fold Change: 0.5412
    Cell Significance Index: 3.8900
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 0.4887
    Cell Significance Index: 3.1200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4853
    Cell Significance Index: 48.0100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4018
    Cell Significance Index: 362.8100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.3576
    Cell Significance Index: 6.6100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.2925
    Cell Significance Index: 6.2300
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.2703
    Cell Significance Index: 6.7400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2538
    Cell Significance Index: 41.2900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2272
    Cell Significance Index: 24.7200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.2238
    Cell Significance Index: 38.2100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1239
    Cell Significance Index: 8.5700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1148
    Cell Significance Index: 6.8900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0624
    Cell Significance Index: 1.0700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0555
    Cell Significance Index: 1.9500
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.0435
    Cell Significance Index: 0.5500
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.0273
    Cell Significance Index: 0.4500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.0171
    Cell Significance Index: 1.7800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0165
    Cell Significance Index: 1.9500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0076
    Cell Significance Index: 0.1900
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0024
    Cell Significance Index: 0.0300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0004
    Cell Significance Index: 0.0900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0000
    Cell Significance Index: -0.0100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0002
    Cell Significance Index: -0.0100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0003
    Cell Significance Index: -0.0300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0014
    Cell Significance Index: -2.1800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0016
    Cell Significance Index: -2.9000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0024
    Cell Significance Index: -3.2800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0053
    Cell Significance Index: -4.0300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0057
    Cell Significance Index: -4.2200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0064
    Cell Significance Index: -1.8300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0066
    Cell Significance Index: -4.1800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0067
    Cell Significance Index: -4.9400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0067
    Cell Significance Index: -3.6800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0070
    Cell Significance Index: -3.9700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0073
    Cell Significance Index: -4.5800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0077
    Cell Significance Index: -1.5300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0084
    Cell Significance Index: -3.8100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0087
    Cell Significance Index: -0.2500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0089
    Cell Significance Index: -3.2000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0096
    Cell Significance Index: -1.7300
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.0133
    Cell Significance Index: -0.1900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0158
    Cell Significance Index: -1.2100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0175
    Cell Significance Index: -2.0100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0196
    Cell Significance Index: -0.2800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0216
    Cell Significance Index: -2.7700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0217
    Cell Significance Index: -4.5800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0247
    Cell Significance Index: -3.5900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0260
    Cell Significance Index: -0.5400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0267
    Cell Significance Index: -3.6700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0291
    Cell Significance Index: -0.7800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0300
    Cell Significance Index: -0.9600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0316
    Cell Significance Index: -3.8900
  • Cell Name: basophil mast progenitor cell (CL0002028)
    Fold Change: -0.0367
    Cell Significance Index: -0.3100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0395
    Cell Significance Index: -5.1100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0396
    Cell Significance Index: -4.0500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0525
    Cell Significance Index: -1.3800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0619
    Cell Significance Index: -4.1600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0620
    Cell Significance Index: -3.4800
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0656
    Cell Significance Index: -0.9600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0661
    Cell Significance Index: -3.0800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0664
    Cell Significance Index: -3.4500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0686
    Cell Significance Index: -5.1200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0732
    Cell Significance Index: -4.5000
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0748
    Cell Significance Index: -0.6100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0754
    Cell Significance Index: -3.9600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0779
    Cell Significance Index: -4.0600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0805
    Cell Significance Index: -2.8200
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0813
    Cell Significance Index: -1.0300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0814
    Cell Significance Index: -3.6000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0831
    Cell Significance Index: -2.7200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0856
    Cell Significance Index: -2.7300
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.0865
    Cell Significance Index: -1.0700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0889
    Cell Significance Index: -4.1800
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0921
    Cell Significance Index: -1.3600
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.0928
    Cell Significance Index: -1.0500
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.0933
    Cell Significance Index: -1.3100
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0946
    Cell Significance Index: -1.8500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0953
    Cell Significance Index: -3.6100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1037
    Cell Significance Index: -5.2400
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1044
    Cell Significance Index: -2.5300
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1044
    Cell Significance Index: -4.5400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Structure:** The P2X1 receptor is a hexameric ion channel composed of six subunits, each consisting of three transmembrane domains and a pore-forming region. 2. **Ligand-Binding:** The receptor is activated by extracellular ATP, which binds to specific binding sites on the receptor subunits, leading to the opening of the ion channel. 3. **Ion Channel Function:** The P2X1 receptor forms a pore that allows the influx of calcium ions into the cell, regulating various cellular processes. 4. **Expression:** The P2RX1 gene is widely expressed in various cell types, including immune cells, neurons, and epithelial cells. **Pathways and Functions:** 1. **Immune Response:** The P2X1 receptor plays a crucial role in the regulation of immune responses, including neutrophil degranulation, platelet activation, and hemostasis. 2. **Neurotransmission:** The receptor is involved in the regulation of synaptic transmission, particularly in glutamatergic synapses, and the modulation of neuronal action potentials. 3. **Cell Signaling:** The P2X1 receptor is a key component of various signaling pathways, including the regulation of blood pressure, vascular smooth muscle contraction, and the secretion of serotonin by platelets. 4. **Cell Death:** The receptor has been implicated in the regulation of apoptosis, particularly in the context of immune cell activation and regulation. **Clinical Significance:** 1. **Inflammatory Diseases:** The P2X1 receptor has been implicated in the pathogenesis of various inflammatory diseases, including rheumatoid arthritis, multiple sclerosis, and inflammatory bowel disease. 2. **Neurological Disorders:** The receptor has been linked to neurological disorders, such as Alzheimer's disease, Parkinson's disease, and stroke. 3. **Cancer:** The P2X1 receptor has been found to be overexpressed in various types of cancer, including breast cancer, lung cancer, and colon cancer. 4. **Cardiovascular Disease:** The receptor has been implicated in the regulation of blood pressure and the pathogenesis of cardiovascular disease. In conclusion, the P2RX1 gene and its encoded receptor, P2X1, play a complex and multifaceted role in various physiological and pathological processes. Further research is needed to fully elucidate the mechanisms by which this receptor regulates immune and non-immune cell function, and to explore its potential as a therapeutic target for the treatment of various diseases.

Genular Protein ID: 2181477428

Symbol: P2RX1_HUMAN

Name: P2X purinoceptor 1

UniProtKB Accession Codes:

P51575 Q9UK84

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 17 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 DrugCentral 1 EMBL 6 Ensembl 1 ExpressionAtlas 1 GO 33 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PIRSF 1 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 3 RefSeq 1 Rhea 3 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8834001

Title: Characterization and chromosomal localization of a human P2X receptor from the urinary bladder.

PubMed ID: 8834001

PubMed ID: 8809107

Title: The human P2x1 receptor: molecular cloning, tissue distribution, and localization to chromosome 17.

PubMed ID: 8809107

DOI: 10.1016/0167-4781(96)00112-1

PubMed ID: 9565569

Title: P2X1 purinoceptor in human platelets. Molecular cloning and functional characterization after heterologous expression.

PubMed ID: 9565569

DOI: 10.1074/jbc.273.19.11544

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8961184

Title: Ionic permeability of, and divalent cation effects on, two ATP-gated cation channels (P2X receptors) expressed in mammalian cells.

PubMed ID: 8961184

DOI: 10.1113/jphysiol.1996.sp021777

PubMed ID: 10440098

Title: Pharmacological characterization of recombinant human and rat P2X receptor subtypes.

PubMed ID: 10440098

DOI: 10.1016/s0014-2999(99)00350-7

PubMed ID: 11809854

Title: Conserved cysteine residues in the extracellular loop of the human P2X(1) receptor form disulfide bonds and are involved in receptor trafficking to the cell surface.

PubMed ID: 11809854

DOI: 10.1124/mol.61.2.303

PubMed ID: 14699168

Title: ATP binding at human P2X1 receptors. Contribution of aromatic and basic amino acids revealed using mutagenesis and partial agonists.

PubMed ID: 14699168

DOI: 10.1074/jbc.m308964200

PubMed ID: 15056721

Title: Contribution of calcium ions to P2X channel responses.

PubMed ID: 15056721

DOI: 10.1523/jneurosci.5429-03.2004

PubMed ID: 19635923

Title: P2X1 ion channels promote neutrophil chemotaxis through Rho kinase activation.

PubMed ID: 19635923

DOI: 10.4049/jimmunol.0804007

PubMed ID: 20699225

Title: Lipid raft association and cholesterol sensitivity of P2X1-4 receptors for ATP: chimeras and point mutants identify intracellular amino-terminal residues involved in lipid regulation of P2X1 receptors.

PubMed ID: 20699225

DOI: 10.1074/jbc.m110.148940

PubMed ID: 22971236

Title: Mass spectrometry analysis of human P2X1 receptors; insight into phosphorylation, modelling and conformational changes.

PubMed ID: 22971236

DOI: 10.1111/jnc.12012

PubMed ID: 10816552

Title: A natural dominant negative P2X1 receptor due to deletion of a single amino acid residue.

PubMed ID: 10816552

DOI: 10.1074/jbc.c000305200

Sequence Information:

  • Length: 399
  • Mass: 44980
  • Checksum: 8365466665522BF8
  • Sequence:
    • MARRFQEELA AFLFEYDTPR MVLVRNKKVG VIFRLIQLVV LVYVIGWVFL YEKGYQTSSG 
LISSVSVKLK GLAVTQLPGL GPQVWDVADY VFPAQGDNSF VVMTNFIVTP KQTQGYCAEH 
PEGGICKEDS GCTPGKAKRK AQGIRTGKCV AFNDTVKTCE IFGWCPVEVD DDIPRPALLR 
EAENFTLFIK NSISFPRFKV NRRNLVEEVN AAHMKTCLFH KTLHPLCPVF QLGYVVQESG 
QNFSTLAEKG GVVGITIDWH CDLDWHVRHC RPIYEFHGLY EEKNLSPGFN FRFARHFVEN 
GTNYRHLFKV FGIRFDILVD GKAGKFDIIP TMTTIGSGIG IFGVATVLCD LLLLHILPKR 
HYYKQKKFKY AEDMGPGAAE RDLAATSSTL GLQENMRTS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.