Details for: CHST11

Gene ID: 50515

Symbol: CHST11

Ensembl ID: ENSG00000171310

Description: carbohydrate sulfotransferase 11

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 314.5066
    Cell Significance Index: -48.9200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 184.2350
    Cell Significance Index: -46.7300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 107.6166
    Cell Significance Index: -43.7200
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 96.8340
    Cell Significance Index: -49.8100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 46.5270
    Cell Significance Index: 6763.2400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 41.7290
    Cell Significance Index: -51.4500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 18.5527
    Cell Significance Index: -49.7000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 15.9273
    Cell Significance Index: -48.9200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 14.2923
    Cell Significance Index: -31.2800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 13.3222
    Cell Significance Index: -52.5700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 6.0012
    Cell Significance Index: 131.4100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 3.1859
    Cell Significance Index: 140.9200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 3.0616
    Cell Significance Index: 187.7000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 3.0495
    Cell Significance Index: 1093.8200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 3.0435
    Cell Significance Index: 115.2500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 2.9871
    Cell Significance Index: 183.6000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 2.8266
    Cell Significance Index: 67.7900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 2.2736
    Cell Significance Index: 79.8900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.7096
    Cell Significance Index: 3218.9300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.6260
    Cell Significance Index: 1032.6800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 1.4856
    Cell Significance Index: 99.8900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.4291
    Cell Significance Index: 286.6700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 1.3933
    Cell Significance Index: 39.7600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.3077
    Cell Significance Index: 41.8900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.0031
    Cell Significance Index: 693.7600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.8850
    Cell Significance Index: 67.9100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.8820
    Cell Significance Index: 167.8500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.8502
    Cell Significance Index: 1308.8300
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.7773
    Cell Significance Index: 6.9000
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.7467
    Cell Significance Index: 15.9600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.7085
    Cell Significance Index: 19.8000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.6663
    Cell Significance Index: 42.9900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.6472
    Cell Significance Index: 128.4400
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: 0.6257
    Cell Significance Index: 8.7500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.5797
    Cell Significance Index: 788.2600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4756
    Cell Significance Index: 429.4500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3622
    Cell Significance Index: 35.8300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1558
    Cell Significance Index: 25.3400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1333
    Cell Significance Index: 3.8400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.1290
    Cell Significance Index: 7.2400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1196
    Cell Significance Index: 2.9900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0090
    Cell Significance Index: 16.5600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0018
    Cell Significance Index: -0.8000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0037
    Cell Significance Index: -0.1000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0302
    Cell Significance Index: -16.5200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.0604
    Cell Significance Index: -6.5700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0637
    Cell Significance Index: -48.2100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0652
    Cell Significance Index: -28.8400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0655
    Cell Significance Index: -48.0400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0659
    Cell Significance Index: -9.0500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0717
    Cell Significance Index: -53.1000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1041
    Cell Significance Index: -58.7300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1046
    Cell Significance Index: -65.3100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.1474
    Cell Significance Index: -26.5800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1503
    Cell Significance Index: -15.6500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1520
    Cell Significance Index: -43.7400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1838
    Cell Significance Index: -21.6700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.2188
    Cell Significance Index: -37.3600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.2222
    Cell Significance Index: -10.0700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2462
    Cell Significance Index: -25.1500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.2714
    Cell Significance Index: -33.3700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2922
    Cell Significance Index: -61.5500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.3170
    Cell Significance Index: -21.9300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.3745
    Cell Significance Index: -48.0100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.3907
    Cell Significance Index: -50.4700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.4090
    Cell Significance Index: -47.6600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.4391
    Cell Significance Index: -8.5700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.4438
    Cell Significance Index: -9.6100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.4794
    Cell Significance Index: -28.7800
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.4797
    Cell Significance Index: -8.3000
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.4896
    Cell Significance Index: -6.3500
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.5419
    Cell Significance Index: -10.8800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.5499
    Cell Significance Index: -63.0000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.5552
    Cell Significance Index: -14.8500
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.5915
    Cell Significance Index: -12.7800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.6103
    Cell Significance Index: -12.6600
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: -0.6638
    Cell Significance Index: -7.2500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.6799
    Cell Significance Index: -50.6700
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.7084
    Cell Significance Index: -4.2800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.7087
    Cell Significance Index: -12.1500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.7104
    Cell Significance Index: -23.2600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.7302
    Cell Significance Index: -34.3200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.7792
    Cell Significance Index: -40.5900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.7920
    Cell Significance Index: -23.2600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.8673
    Cell Significance Index: -12.4200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.8705
    Cell Significance Index: -16.0900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.8719
    Cell Significance Index: -45.7800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.9285
    Cell Significance Index: -48.2400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.9582
    Cell Significance Index: -24.4800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.9775
    Cell Significance Index: -34.2500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -1.0277
    Cell Significance Index: -29.4600
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -1.0479
    Cell Significance Index: -20.7200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -1.0660
    Cell Significance Index: -33.9500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -1.2069
    Cell Significance Index: -25.6200
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -1.2260
    Cell Significance Index: -18.1000
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: -1.2286
    Cell Significance Index: -12.7300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -1.2730
    Cell Significance Index: -44.2400
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -1.2768
    Cell Significance Index: -31.8500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -1.3457
    Cell Significance Index: -49.4000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -1.3637
    Cell Significance Index: -63.5800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** CHST11 is a member of the sulfotransferase family, which catalyzes the transfer of sulfate groups to specific substrates. In the case of CHST11, the enzyme specifically targets N-acetylgalactosamine residues, converting them into 4-sulfate derivatives. This sulfation event is critical for the proper functioning of GAGs, as it enables them to interact with other molecules, such as growth factors, cytokines, and cell surface receptors, thereby influencing cell proliferation, migration, and differentiation. The expression of CHST11 is tissue-specific, with highest levels detected in hematopoietic cells, epithelial cells, and immune cells. This suggests that CHST11 plays a crucial role in maintaining the integrity and function of these cell types. Notably, CHST11 is also expressed in the developing embryo, where it is involved in the regulation of chondrocyte development and embryonic viscerocranium morphogenesis. **Pathways and Functions** CHST11 is involved in several key biological pathways, including: 1. **Glycosaminoglycan metabolism**: CHST11 is responsible for the sulfation of N-acetylgalactosamine residues in GAGs, which is essential for their proper functioning and interactions with other molecules. 2. **Apoptotic process**: CHST11 has been shown to regulate the apoptotic process by modulating the activity of pro-apoptotic and anti-apoptotic proteins. 3. **Chondrocyte development**: CHST11 is involved in the regulation of chondrocyte development and maturation, which is critical for the formation of cartilage and bone tissue. 4. **Immune cell development**: CHST11 is expressed in hematopoietic cells and immune cells, where it plays a crucial role in the development and function of these cells. **Clinical Significance** Dysregulation of CHST11 has been implicated in various diseases, including: 1. **Chondrodysplasias**: CHST11 mutations have been associated with several types of chondrodysplasias, a group of disorders characterized by abnormal bone and cartilage development. 2. **Immune disorders**: CHST11 has been shown to play a role in the development and function of immune cells, and dysregulation of CHST11 has been implicated in autoimmune and inflammatory disorders. 3. **Cancer**: CHST11 has been found to be overexpressed in certain types of cancer, including colorectal and breast cancer, where it may contribute to tumor progression and metastasis. In conclusion, CHST11 is a critical enzyme involved in the biosynthesis and metabolism of glycosaminoglycans, with significant implications for various biological processes, including apoptosis, chondrocyte development, and immune cell function. Dysregulation of CHST11 has been implicated in various diseases, highlighting the need for further research into the role of this enzyme in human health and disease.

Genular Protein ID: 650511922

Symbol: CHSTB_HUMAN

Name: Carbohydrate sulfotransferase 11

UniProtKB Accession Codes:

Q9NPF2 A8K4F8 Q9NXY6 Q9NY36

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChEBI 7 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 2 EMBL 7 Ensembl 2 ExpressionAtlas 1 GO 23 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 1 RefSeq 2 Rhea 3 STRING 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 11056388

Title: Molecular cloning, expression, and chromosomal mapping of human chondroitin 4-sulfotransferase, whose expression pattern in human tissues is different from that of chondroitin 6-sulfotransferase.

PubMed ID: 11056388

DOI: 10.1093/oxfordjournals.jbchem.a022813

PubMed ID: 10781601

Title: Molecular cloning and expression of two distinct human chondroitin 4-O-sulfotransferases that belong to the HNK-1 sulfotransferase gene family.

PubMed ID: 10781601

DOI: 10.1074/jbc.m002443200

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12847091

Title: Specificities of three distinct human chondroitin/dermatan N-acetylgalactosamine 4-O-sulfotransferases demonstrated using partially desulfated dermatan sulfate as an acceptor. Implication of differential roles in dermatan sulfate biosynthesis.

PubMed ID: 12847091

DOI: 10.1074/jbc.m306044200

PubMed ID: 15273723

Title: Deregulation of the carbohydrate (chondroitin 4) sulfotransferase 11 (CHST11) gene in a B-cell chronic lymphocytic leukemia with a t(12;14)(q23;q32).

PubMed ID: 15273723

DOI: 10.1038/sj.onc.1207934

PubMed ID: 15628971

Title: N-linked oligosaccharides are required to produce and stabilize the active form of chondroitin 4-sulphotransferase-1.

PubMed ID: 15628971

DOI: 10.1042/bj20041573

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 29514872

Title: Homozygous CHST11 mutation in chondrodysplasia, brachydactyly, overriding digits, clino-symphalangism and synpolydactyly.

PubMed ID: 29514872

DOI: 10.1136/jmedgenet-2017-105003

Sequence Information:

  • Length: 352
  • Mass: 41555
  • Checksum: 55DF1D29D6703307
  • Sequence:
    • MKPALLEVMR MNRICRMVLA TCLGSFILVI FYFQSMLHPV MRRNPFGVDI CCRKGSRSPL 
QELYNPIQLE LSNTAVLHQM RRDQVTDTCR ANSATSRKRR VLTPNDLKHL VVDEDHELIY 
CYVPKVACTN WKRLMMVLTG RGKYSDPMEI PANEAHVSAN LKTLNQYSIP EINHRLKSYM 
KFLFVREPFE RLVSAYRNKF TQKYNISFHK RYGTKIIKRQ RKNATQEALR KGDDVKFEEF 
VAYLIDPHTQ REEPFNEHWQ TVYSLCHPCH IHYDLVGKYE TLEEDSNYVL QLAGVGSYLK 
FPTYAKSTRT TDEMTTEFFQ NISSEHQTQL YEVYKLDFLM FNYSVPSYLK LE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.