Details for: IL20

Gene ID: 50604

Symbol: IL20

Ensembl ID: ENSG00000162891

Description: interleukin 20

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 1.6627
    Cell Significance Index: 4.9500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.6754
    Cell Significance Index: 47.7700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.3156
    Cell Significance Index: 8.5900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1813
    Cell Significance Index: 80.1700
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.1092
    Cell Significance Index: 1.3800
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.0686
    Cell Significance Index: 0.8200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0417
    Cell Significance Index: 1.9600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0373
    Cell Significance Index: 2.7800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0030
    Cell Significance Index: 0.1400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0003
    Cell Significance Index: -0.0100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0024
    Cell Significance Index: -4.6000
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0026
    Cell Significance Index: -0.0500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0062
    Cell Significance Index: -4.7300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0062
    Cell Significance Index: -3.3600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0078
    Cell Significance Index: -5.8100
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.0081
    Cell Significance Index: -0.1000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0088
    Cell Significance Index: -4.9500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0099
    Cell Significance Index: -1.2800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0119
    Cell Significance Index: -0.3300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0124
    Cell Significance Index: -1.2700
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0149
    Cell Significance Index: -0.2300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0163
    Cell Significance Index: -0.4200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0165
    Cell Significance Index: -4.7500
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0173
    Cell Significance Index: -0.2100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0204
    Cell Significance Index: -3.6800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0227
    Cell Significance Index: -4.5500
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: -0.0239
    Cell Significance Index: -0.1200
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.0275
    Cell Significance Index: -0.3800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0279
    Cell Significance Index: -5.8800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0296
    Cell Significance Index: -3.6400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0298
    Cell Significance Index: -0.3400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0319
    Cell Significance Index: -4.3800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0331
    Cell Significance Index: -5.6600
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0369
    Cell Significance Index: -0.9200
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.0384
    Cell Significance Index: -0.3800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0395
    Cell Significance Index: -4.5300
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0531
    Cell Significance Index: -1.0500
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.0552
    Cell Significance Index: -0.3400
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: -0.0570
    Cell Significance Index: -0.9800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0663
    Cell Significance Index: -5.0900
  • Cell Name: immature NK T cell (CL0000914)
    Fold Change: -0.0687
    Cell Significance Index: -0.8800
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.0777
    Cell Significance Index: -0.8500
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: -0.0882
    Cell Significance Index: -1.1300
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: -0.0882
    Cell Significance Index: -1.0500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0926
    Cell Significance Index: -4.8100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0945
    Cell Significance Index: -4.9600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1068
    Cell Significance Index: -3.7100
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: -0.1123
    Cell Significance Index: -0.9100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1133
    Cell Significance Index: -2.9800
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.1191
    Cell Significance Index: -1.0000
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1205
    Cell Significance Index: -3.0100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1207
    Cell Significance Index: -4.4300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1210
    Cell Significance Index: -4.2400
  • Cell Name: Langerhans cell (CL0000453)
    Fold Change: -0.1280
    Cell Significance Index: -1.2200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1284
    Cell Significance Index: -4.2100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1327
    Cell Significance Index: -3.9100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1413
    Cell Significance Index: -4.5000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1829
    Cell Significance Index: -2.5000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1891
    Cell Significance Index: -5.4200
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1892
    Cell Significance Index: -4.8200
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1899
    Cell Significance Index: -4.6000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2028
    Cell Significance Index: -4.4400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2059
    Cell Significance Index: -4.3700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2060
    Cell Significance Index: -2.9500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2079
    Cell Significance Index: -5.5500
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.2119
    Cell Significance Index: -5.1700
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.2144
    Cell Significance Index: -4.2800
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.2156
    Cell Significance Index: -2.2900
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.2203
    Cell Significance Index: -2.8800
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.2205
    Cell Significance Index: -3.7700
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.2286
    Cell Significance Index: -5.2800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.2359
    Cell Significance Index: -4.3600
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.2378
    Cell Significance Index: -4.6500
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.2448
    Cell Significance Index: -4.9200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2569
    Cell Significance Index: -4.3000
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.2636
    Cell Significance Index: -4.4400
  • Cell Name: myoepithelial cell (CL0000185)
    Fold Change: -0.2671
    Cell Significance Index: -3.0300
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.2748
    Cell Significance Index: -4.4500
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: -0.2781
    Cell Significance Index: -5.8000
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.2825
    Cell Significance Index: -2.9800
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.2899
    Cell Significance Index: -3.4500
  • Cell Name: salivary gland cell (CL0009005)
    Fold Change: -0.2911
    Cell Significance Index: -3.6200
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: -0.2928
    Cell Significance Index: -3.0200
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.2929
    Cell Significance Index: -3.3700
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.3024
    Cell Significance Index: -4.3900
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.3038
    Cell Significance Index: -5.1600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.3049
    Cell Significance Index: -5.9500
  • Cell Name: ionocyte (CL0005006)
    Fold Change: -0.3070
    Cell Significance Index: -3.2100
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.3087
    Cell Significance Index: -3.9800
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.3114
    Cell Significance Index: -4.2700
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.3226
    Cell Significance Index: -5.7000
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: -0.3241
    Cell Significance Index: -5.2300
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.3245
    Cell Significance Index: -4.5000
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.3258
    Cell Significance Index: -4.3300
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: -0.3259
    Cell Significance Index: -4.0900
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: -0.3295
    Cell Significance Index: -3.9800
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.3308
    Cell Significance Index: -4.5000
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.3320
    Cell Significance Index: -4.1700
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.3325
    Cell Significance Index: -3.9100
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.3339
    Cell Significance Index: -4.9300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** IL-20 is a type II cytokine that belongs to the IL-10 family, which also includes IL-22, IL-24, and IL-26. It is produced by various cell types, including epithelial cells, immune cells, and neural cells, and plays a crucial role in regulating immune responses, tissue homeostasis, and cellular differentiation. IL-20 is characterized by its ability to bind to the IL-10 receptor, which triggers a signaling cascade that leads to the activation of downstream transcription factors, including STAT1 and STAT3. **Pathways and Functions:** IL-20 is involved in various immune-related pathways, including: 1. **Cytokine signaling in immune system**: IL-20 binds to its receptor, triggering the activation of STAT1 and STAT3, which in turn regulate the expression of genes involved in immune responses, such as cytokine production and cell proliferation. 2. **Extracellular space**: IL-20 is secreted by epithelial cells and immune cells, where it acts as a chemoattractant, recruiting immune cells to sites of inflammation. 3. **Osteoclast differentiation**: IL-20 promotes the differentiation of osteoclasts, the cells responsible for bone resorption, which is essential for bone homeostasis. 4. **Positive regulation of epidermal cell differentiation**: IL-20 regulates the differentiation of epithelial cells, particularly in the skin, where it promotes the development of epidermal cells. 5. **Regulation of inflammatory response**: IL-20 modulates the inflammatory response by regulating the production of cytokines and chemokines, which are essential for the recruitment of immune cells to sites of inflammation. **Clinical Significance:** IL-20 has been implicated in various diseases, including: 1. **Autoimmune disorders**: IL-20 has been shown to contribute to the pathogenesis of autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis, by promoting inflammation and tissue damage. 2. **Cancer**: IL-20 has been implicated in the development and progression of various cancers, including melanoma, lung cancer, and breast cancer, where it promotes tumor growth and metastasis. 3. **Neurological disorders**: IL-20 has been shown to play a role in the pathogenesis of neurological disorders, such as multiple sclerosis and Alzheimer's disease, where it modulates the immune response and promotes inflammation. 4. **Inflammatory bowel disease**: IL-20 has been implicated in the pathogenesis of inflammatory bowel disease, where it promotes inflammation and tissue damage in the gut. In conclusion, IL-20 is a multifunctional cytokine that plays a crucial role in regulating immune responses, tissue homeostasis, and cellular differentiation. Its dysregulation has been implicated in various diseases, highlighting the importance of understanding its mechanisms of action and its potential therapeutic applications.

Genular Protein ID: 3254646150

Symbol: IL20_HUMAN

Name: Interleukin-20

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11163236

Title: Interleukin 20: discovery, receptor identification, and role in epidermal function.

PubMed ID: 11163236

DOI: 10.1016/s0092-8674(01)00187-8

PubMed ID: 16511554

Title: Interleukin-20 promotes angiogenesis in a direct and indirect manner.

PubMed ID: 16511554

DOI: 10.1038/sj.gene.6364291

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

PubMed ID: 11564763

Title: STAT activation by IL-19, IL-20 and mda-7 through IL-20 receptor complexes of two types.

PubMed ID: 11564763

DOI: 10.4049/jimmunol.167.7.3545

PubMed ID: 11706020

Title: Interleukin 24 (MDA-7/MOB-5) signals through two heterodimeric receptors, IL-22R1/IL-20R2 and IL-20R1/IL-20R2.

PubMed ID: 11706020

DOI: 10.1074/jbc.m106043200

PubMed ID: 16908179

Title: Tissue microarray analysis of interleukin-20 expression.

PubMed ID: 16908179

DOI: 10.1016/j.cyto.2006.07.006

PubMed ID: 16709143

Title: Ultraviolet B light stimulates interleukin-20 expression by human epithelial keratinocytes.

PubMed ID: 16709143

DOI: 10.1562/2005-08-31-ra-668

PubMed ID: 17277128

Title: The effects of IL-20 subfamily cytokines on reconstituted human epidermis suggest potential roles in cutaneous innate defense and pathogenic adaptive immunity in psoriasis.

PubMed ID: 17277128

DOI: 10.4049/jimmunol.178.4.2229

PubMed ID: 23614738

Title: Studies of Jak/STAT3 expression and signalling in psoriasis identifies STAT3-Ser727 phosphorylation as a modulator of transcriptional activity.

PubMed ID: 23614738

DOI: 10.1111/exd.12128

PubMed ID: 28424238

Title: IL-20 Signaling in Activated Human Neutrophils Inhibits Neutrophil Migration and Function.

PubMed ID: 28424238

DOI: 10.4049/jimmunol.1700253

PubMed ID: 34403503

Title: IL-20 is involved in obesity by modulation of adipogenesis and macrophage dysregulation.

PubMed ID: 34403503

DOI: 10.1111/imm.13403

PubMed ID: 22802649

Title: Structural basis for receptor sharing and activation by interleukin-20 receptor-2 (IL-20R2) binding cytokines.

PubMed ID: 22802649

DOI: 10.1073/pnas.1117551109

Sequence Information:

  • Length: 176
  • Mass: 20072
  • Checksum: 8385992500B6C447
  • Sequence:
  • MKASSLAFSL LSAAFYLLWT PSTGLKTLNL GSCVIATNLQ EIRNGFSEIR GSVQAKDGNI 
    DIRILRRTES LQDTKPANRC CLLRHLLRLY LDRVFKNYQT PDHYTLRKIS SLANSFLTIK 
    KDLRLCHAHM TCHCGEEAMK KYSQILSHFE KLEPQAAVVK ALGELDILLQ WMEETE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.