Details for: PAWR

Gene ID: 5074

Symbol: PAWR

Ensembl ID: ENSG00000177425

Description: pro-apoptotic WT1 regulator

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 292.7123
    Cell Significance Index: -45.5300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 165.8234
    Cell Significance Index: -42.0600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 92.5819
    Cell Significance Index: -43.7100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 91.7030
    Cell Significance Index: -37.2600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 39.0262
    Cell Significance Index: -37.2600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 36.9356
    Cell Significance Index: -45.5400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 16.2569
    Cell Significance Index: -43.5500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 11.5888
    Cell Significance Index: -45.7300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 9.4079
    Cell Significance Index: -20.5900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 7.9492
    Cell Significance Index: 216.3700
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 7.6257
    Cell Significance Index: 46.9300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 4.5982
    Cell Significance Index: 122.7800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 3.2196
    Cell Significance Index: 239.9600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2.5601
    Cell Significance Index: 116.0400
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 2.3532
    Cell Significance Index: 39.6400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.0864
    Cell Significance Index: 414.0600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.8852
    Cell Significance Index: 231.8100
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 1.6481
    Cell Significance Index: 14.6300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.6278
    Cell Significance Index: 46.9000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.6145
    Cell Significance Index: 45.1200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.4411
    Cell Significance Index: 41.3100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.3035
    Cell Significance Index: 28.2400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.2095
    Cell Significance Index: 660.5200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.1891
    Cell Significance Index: 84.1000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.1781
    Cell Significance Index: 61.2000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.1579
    Cell Significance Index: 54.4200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.1111
    Cell Significance Index: 200.3100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.9447
    Cell Significance Index: 122.0500
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 0.9261
    Cell Significance Index: 9.8400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.8969
    Cell Significance Index: 123.1700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.8583
    Cell Significance Index: 93.3600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.7989
    Cell Significance Index: 353.2100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.7786
    Cell Significance Index: 43.6900
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 0.6741
    Cell Significance Index: 6.8000
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.6112
    Cell Significance Index: 14.1200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.6044
    Cell Significance Index: 28.1800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4709
    Cell Significance Index: 46.5800
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.4692
    Cell Significance Index: 10.0300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.4299
    Cell Significance Index: 15.1100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.3371
    Cell Significance Index: 7.1800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3256
    Cell Significance Index: 293.9800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.2856
    Cell Significance Index: 181.3900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.2116
    Cell Significance Index: 36.1300
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.1955
    Cell Significance Index: 2.9300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.1937
    Cell Significance Index: 6.7300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1878
    Cell Significance Index: 353.6500
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.1786
    Cell Significance Index: 1.6500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1682
    Cell Significance Index: 21.5600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1479
    Cell Significance Index: 102.3000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1230
    Cell Significance Index: 14.5100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1212
    Cell Significance Index: 186.6600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.1160
    Cell Significance Index: 213.9100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.1084
    Cell Significance Index: 49.1800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0942
    Cell Significance Index: 1.9600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0927
    Cell Significance Index: 17.6400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.0416
    Cell Significance Index: 1.1000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0220
    Cell Significance Index: 29.9000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0165
    Cell Significance Index: 12.1000
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.0174
    Cell Significance Index: -0.1800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0223
    Cell Significance Index: -16.5400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0263
    Cell Significance Index: -16.4100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0318
    Cell Significance Index: -24.0700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0515
    Cell Significance Index: -10.3300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0549
    Cell Significance Index: -30.9700
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0657
    Cell Significance Index: -0.9700
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.0805
    Cell Significance Index: -0.5000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0812
    Cell Significance Index: -29.1400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0951
    Cell Significance Index: -6.5800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0999
    Cell Significance Index: -11.4500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1006
    Cell Significance Index: -28.9600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1051
    Cell Significance Index: -6.4600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1282
    Cell Significance Index: -14.9400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1290
    Cell Significance Index: -1.7600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1325
    Cell Significance Index: -19.2600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1547
    Cell Significance Index: -15.8000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1561
    Cell Significance Index: -32.8800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1644
    Cell Significance Index: -4.1100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2137
    Cell Significance Index: -16.4000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2355
    Cell Significance Index: -12.2700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.2521
    Cell Significance Index: -4.9200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3053
    Cell Significance Index: -31.7900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3166
    Cell Significance Index: -10.1400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3348
    Cell Significance Index: -38.2200
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: -0.3712
    Cell Significance Index: -2.2900
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.4095
    Cell Significance Index: -3.4400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4169
    Cell Significance Index: -33.0200
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.4425
    Cell Significance Index: -8.7500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.5302
    Cell Significance Index: -26.7900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.5688
    Cell Significance Index: -14.5300
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.6438
    Cell Significance Index: -9.2200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.6498
    Cell Significance Index: -43.6900
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.6514
    Cell Significance Index: -9.9100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.6637
    Cell Significance Index: -40.6900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.6647
    Cell Significance Index: -17.7800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.6668
    Cell Significance Index: -43.0200
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.7074
    Cell Significance Index: -10.0700
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: -0.7209
    Cell Significance Index: -2.7200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.7214
    Cell Significance Index: -45.4700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.7214
    Cell Significance Index: -15.1000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.7244
    Cell Significance Index: -18.6200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** PAWR is a protein-coding gene that belongs to the protein kinase C (PRKC) family. It is characterized by its ability to regulate apoptosis, cell proliferation, and gene expression through its interaction with the Wnt1 pathway. PAWR is specifically expressed in certain cell types, including myoepithelial cells of the mammary gland, renal interstitial pericytes, and basal cells of the prostate epithelium. Its expression is also detected in other tissues, such as the kidney, cornea, and conjunctiva. **Pathways and Functions** PAWR plays a crucial role in regulating apoptosis and cell proliferation through its interaction with the Wnt1 pathway. The Wnt1 pathway is a key signaling pathway involved in the regulation of cell growth, differentiation, and survival. PAWR acts as a negative regulator of this pathway, inhibiting the activation of downstream targets that promote cell proliferation and survival. Instead, PAWR promotes apoptosis and cell cycle arrest, thereby regulating cell growth and proliferation. PAWR's regulatory functions extend beyond the Wnt1 pathway. It also interacts with other signaling pathways, including the PI3K/AKT and MAPK/ERK pathways, to modulate gene expression and cell behavior. PAWR's role in regulating gene expression is mediated through its interaction with transcription factors, such as p53 and NF-κB, which are key regulators of cellular responses to stress and damage. **Clinical Significance** Dysregulation of PAWR has been implicated in several diseases, including cancer. Overexpression of PAWR has been observed in various types of cancer, including breast, prostate, and kidney cancer. This overexpression is associated with increased cell proliferation, apoptosis resistance, and poor prognosis. PAWR's role in regulating cell proliferation and apoptosis also makes it a potential therapeutic target for cancer treatment. Inhibiting PAWR's activity could lead to the induction of apoptosis and cell cycle arrest, thereby reducing tumor growth and progression. Additionally, PAWR's involvement in the Wnt1 pathway makes it a potential target for the treatment of diseases associated with Wnt1 dysregulation, such as certain types of cancer and bone disorders. In conclusion, PAWR is a critical regulator of apoptosis and cell proliferation that plays a significant role in maintaining tissue homeostasis. Its dysregulation has been implicated in several diseases, including cancer, and makes it a potential therapeutic target for cancer treatment and other diseases associated with Wnt1 dysregulation.

Genular Protein ID: 227393423

Symbol: PAWR_HUMAN

Name: PRKC apoptosis WT1 regulator protein

UniProtKB Accession Codes:

Q96IZ0 O75796 Q6FHY9 Q8N700

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 ELM 1 EMBL 5 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 24 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 3 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8943350

Title: A novel repressor, par-4, modulates transcription and growth suppression functions of the Wilms' tumor suppressor WT1.

PubMed ID: 8943350

DOI: 10.1128/mcb.16.12.6945

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12242017

Title: Structural and functional characterization of the upstream regulatory region of the human gene encoding prostate apoptosis response factor-4.

PubMed ID: 12242017

DOI: 10.1016/s0378-1119(02)00826-0

PubMed ID: 11585763

Title: Par-4 drives trafficking and activation of Fas and Fasl to induce prostate cancer cell apoptosis and tumor regression.

PubMed ID: 11585763

PubMed ID: 11755531

Title: p62 forms a ternary complex with PKCzeta and PAR-4 and antagonizes PAR-4-induced PKCzeta inhibition.

PubMed ID: 11755531

DOI: 10.1016/s0014-5793(01)03224-0

PubMed ID: 12717420

Title: THAP1 is a nuclear proapoptotic factor that links prostate-apoptosis-response-4 (Par-4) to PML nuclear bodies.

PubMed ID: 12717420

DOI: 10.1038/sj.onc.1206271

PubMed ID: 14627703

Title: AATF inhibits aberrant production of amyloid beta peptide 1-42 by interacting directly with Par-4.

PubMed ID: 14627703

DOI: 10.1074/jbc.m309811200

PubMed ID: 15671026

Title: PAR-4 is involved in regulation of beta-secretase cleavage of the Alzheimer amyloid precursor protein.

PubMed ID: 15671026

DOI: 10.1074/jbc.m411933200

PubMed ID: 17189197

Title: Structural basis for protein recognition by B30.2/SPRY domains.

PubMed ID: 17189197

DOI: 10.1016/j.molcel.2006.11.009

PubMed ID: 12565819

Title: Apoptosis by Par-4 in cancer and neurodegenerative diseases.

PubMed ID: 12565819

DOI: 10.1016/s0014-4827(02)00016-2

PubMed ID: 14755681

Title: Par-4 inducible apoptosis in prostate cancer cells.

PubMed ID: 14755681

DOI: 10.1002/jcb.20000

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 20561531

Title: Structural basis for Par-4 recognition by the SPRY domain- and SOCS box-containing proteins SPSB1, SPSB2, and SPSB4.

PubMed ID: 20561531

DOI: 10.1016/j.jmb.2010.06.017

Sequence Information:

  • Length: 340
  • Mass: 36568
  • Checksum: 7E7515455402DBF8
  • Sequence:
    • MATGGYRTSS GLGGSTTDFL EEWKAKREKM RAKQNPPGPA PPGGGSSDAA GKPPAGALGT 
PAAAAANELN NNLPGGAPAA PAVPGPGGVN CAVGSAMLTR AAPGPRRSED EPPAASASAA 
PPPQRDEEEP DGVPEKGKSS GPSARKGKGQ IEKRKLREKR RSTGVVNIPA AECLDEYEDD 
EAGQKERKRE DAITQQNTIQ NEAVNLLDPG SSYLLQEPPR TVSGRYKSTT SVSEEDVSSR 
YSRTDRSGFP RYNRDANVSG TLVSSSTLEK KIEDLEKEVV RERQENLRLV RLMQDKEEMI 
GKLKEEIDLL NRDLDDIEDE NEQLKQENKT LLKVVGQLTR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.