Details for: SOST

Gene ID: 50964

Symbol: SOST

Ensembl ID: ENSG00000167941

Description: sclerostin

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: glomerular capillary endothelial cell (CL1001005)
    Fold Change: 19.7909
    Cell Significance Index: 73.7600
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 4.1118
    Cell Significance Index: 32.8300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.7754
    Cell Significance Index: 20.3900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.2429
    Cell Significance Index: 8.4400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.2402
    Cell Significance Index: 3.4400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.1833
    Cell Significance Index: 5.4000
  • Cell Name: vasa recta descending limb cell (CL1001285)
    Fold Change: 0.1819
    Cell Significance Index: 1.3200
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.1803
    Cell Significance Index: 2.0200
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.0584
    Cell Significance Index: 0.8400
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.0455
    Cell Significance Index: 0.6600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0087
    Cell Significance Index: 1.1100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0021
    Cell Significance Index: -0.9100
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.0025
    Cell Significance Index: -0.0300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0026
    Cell Significance Index: -4.8100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0043
    Cell Significance Index: -0.7300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0054
    Cell Significance Index: -3.9900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0062
    Cell Significance Index: -0.7200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0063
    Cell Significance Index: -4.0000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0063
    Cell Significance Index: -11.6900
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.0071
    Cell Significance Index: -0.0600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0075
    Cell Significance Index: -11.5400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0076
    Cell Significance Index: -4.3100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0080
    Cell Significance Index: -0.4000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0084
    Cell Significance Index: -4.5800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0086
    Cell Significance Index: -11.6900
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0095
    Cell Significance Index: -0.3900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0109
    Cell Significance Index: -1.9700
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0122
    Cell Significance Index: -0.5300
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0123
    Cell Significance Index: -0.1900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0123
    Cell Significance Index: -0.8700
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0186
    Cell Significance Index: -0.3700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0198
    Cell Significance Index: -0.5400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0203
    Cell Significance Index: -4.0800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0231
    Cell Significance Index: -4.5800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0239
    Cell Significance Index: -2.9400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0255
    Cell Significance Index: -7.3300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0273
    Cell Significance Index: -3.9700
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0314
    Cell Significance Index: -0.5400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0327
    Cell Significance Index: -4.4900
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.0333
    Cell Significance Index: -0.3400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0364
    Cell Significance Index: -3.7200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0368
    Cell Significance Index: -4.2200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0387
    Cell Significance Index: -0.8100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0506
    Cell Significance Index: -4.0100
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.0512
    Cell Significance Index: -0.5300
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: -0.0562
    Cell Significance Index: -0.6100
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: -0.0586
    Cell Significance Index: -0.5900
  • Cell Name: ionocyte (CL0005006)
    Fold Change: -0.0603
    Cell Significance Index: -0.6300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0670
    Cell Significance Index: -4.3200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0736
    Cell Significance Index: -4.9500
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.0739
    Cell Significance Index: -0.6200
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -0.0766
    Cell Significance Index: -0.5500
  • Cell Name: myoepithelial cell (CL0000185)
    Fold Change: -0.0767
    Cell Significance Index: -0.8700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0788
    Cell Significance Index: -3.5700
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: -0.0836
    Cell Significance Index: -1.0500
  • Cell Name: glomerular endothelial cell (CL0002188)
    Fold Change: -0.0878
    Cell Significance Index: -0.6100
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: -0.0918
    Cell Significance Index: -0.5700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0929
    Cell Significance Index: -4.3300
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.0929
    Cell Significance Index: -1.0100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0996
    Cell Significance Index: -5.5900
  • Cell Name: myoblast (CL0000056)
    Fold Change: -0.1038
    Cell Significance Index: -1.0200
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.1041
    Cell Significance Index: -1.2300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1078
    Cell Significance Index: -5.6600
  • Cell Name: Schwann cell precursor (CL0002375)
    Fold Change: -0.1108
    Cell Significance Index: -0.8800
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.1150
    Cell Significance Index: -1.5900
  • Cell Name: pancreatic epsilon cell (CL0005019)
    Fold Change: -0.1152
    Cell Significance Index: -1.0700
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.1219
    Cell Significance Index: -1.3400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1220
    Cell Significance Index: -5.7400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1268
    Cell Significance Index: -4.0600
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.1271
    Cell Significance Index: -3.1700
  • Cell Name: urothelial cell (CL0000731)
    Fold Change: -0.1276
    Cell Significance Index: -0.8900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1296
    Cell Significance Index: -4.5400
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.1373
    Cell Significance Index: -1.5800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1405
    Cell Significance Index: -1.6000
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.1411
    Cell Significance Index: -1.3400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1460
    Cell Significance Index: -4.6500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1498
    Cell Significance Index: -7.7800
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: -0.1518
    Cell Significance Index: -1.2300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1530
    Cell Significance Index: -5.0100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1566
    Cell Significance Index: -4.1900
  • Cell Name: chondroblast (CL0000058)
    Fold Change: -0.1601
    Cell Significance Index: -0.9400
  • Cell Name: peridermal cell (CL0000078)
    Fold Change: -0.1652
    Cell Significance Index: -1.0300
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.1693
    Cell Significance Index: -2.8800
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: -0.1698
    Cell Significance Index: -1.0400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1717
    Cell Significance Index: -4.6000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1728
    Cell Significance Index: -4.9300
  • Cell Name: osteoblast (CL0000062)
    Fold Change: -0.1732
    Cell Significance Index: -1.6800
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.1740
    Cell Significance Index: -2.7600
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1800
    Cell Significance Index: -4.3600
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1888
    Cell Significance Index: -4.7100
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1904
    Cell Significance Index: -4.8500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1968
    Cell Significance Index: -4.3100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1986
    Cell Significance Index: -3.6700
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2152
    Cell Significance Index: -4.6500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.2189
    Cell Significance Index: -5.2500
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.2214
    Cell Significance Index: -4.6200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2295
    Cell Significance Index: -4.8700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2336
    Cell Significance Index: -3.9100
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.2358
    Cell Significance Index: -4.6100
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: -0.2362
    Cell Significance Index: -2.2300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** The SOST gene is a single-copy gene located on the X chromosome, with a single transcript variant. It encodes a protein that belongs to the sclerostin family, characterized by its ability to bind to the Wnt/β-catenin signaling pathway. The SOST protein is expressed in various tissues, including bone, kidney, and reproductive organs, and is highly regulated by mechanical stimuli and parathyroid hormone. **Pathways and Functions** The SOST gene plays a pivotal role in regulating bone homeostasis by inhibiting the Wnt/β-catenin signaling pathway. This pathway is involved in the regulation of osteoclastogenesis, and SOST acts as a negative regulator by binding to the Wnt ligands and preventing their interaction with the Frizzled receptors. This binding inhibits the activation of β-catenin and subsequently suppresses the expression of genes involved in osteoclastogenesis. In addition to its role in bone metabolism, SOST has been implicated in other biological processes, including: * Regulation of kidney function: SOST is expressed in renal cells and has been shown to play a role in maintaining glomerular filtration rate. * Reproductive function: SOST is expressed in granulosa cells and has been implicated in the regulation of follicular development. * Cancer: SOST has been shown to be overexpressed in various cancers, including breast and prostate cancer, and may play a role in tumor progression. **Clinical Significance** Dysregulation of the SOST gene has been implicated in various diseases, including: * Osteoporosis: SOST has been shown to be overexpressed in osteoporotic patients, leading to increased bone resorption and decreased bone density. * Kidney disease: SOST has been implicated in the regulation of kidney function, and its dysregulation may contribute to the development of kidney disease. * Cancer: SOST has been shown to be overexpressed in various cancers, and its role in tumor progression and metastasis is still being explored. In conclusion, the SOST gene is a critical regulator of bone homeostasis, but its role extends beyond the bone tissue. Further research is needed to fully understand the mechanisms by which SOST regulates other biological processes and to explore its potential as a therapeutic target for various diseases. **Key Takeaways** * SOST is a negative regulator of the Wnt/β-catenin signaling pathway. * SOST plays a critical role in regulating bone homeostasis and is overexpressed in osteoporotic patients. * SOST is also expressed in other tissues, including kidney and reproductive organs, and may play a role in regulating these functions. * Dysregulation of the SOST gene has been implicated in various diseases, including osteoporosis, kidney disease, and cancer. **Future Directions** * Further research is needed to fully understand the mechanisms by which SOST regulates other biological processes. * The role of SOST in regulating kidney function and reproductive function requires further investigation. * The potential of SOST as a therapeutic target for various diseases, including osteoporosis and cancer, requires further exploration.

Genular Protein ID: 848747059

Symbol: SOST_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9BQB4 Q495N9

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEMBL 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 DrugBank 1 DrugCentral 1 ELM 1 EMBL 10 Ensembl 1 EvolutionaryTrace 1 GO 20 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 2 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 7 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 3 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 11181578

Title: Increased bone density in sclerosteosis is due to the deficiency of a novel secreted protein (SOST).

PubMed ID: 11181578

DOI: 10.1093/hmg/10.5.537

PubMed ID: 11179006

Title: Bone dysplasia sclerosteosis results from loss of the SOST gene product, a novel cystine knot-containing protein.

PubMed ID: 11179006

DOI: 10.1086/318811

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

PubMed ID: 11836356

Title: Identification of a 52 kb deletion downstream of the SOST gene in patients with van Buchem disease.

PubMed ID: 11836356

DOI: 10.1136/jmg.39.2.91

PubMed ID: 15908424

Title: SOST is a ligand for LRP5/LRP6 and a Wnt signaling inhibitor.

PubMed ID: 15908424

DOI: 10.1074/jbc.m504308200

PubMed ID: 20551380

Title: Proteomics characterization of extracellular space components in the human aorta.

PubMed ID: 20551380

DOI: 10.1074/mcp.m110.001693

PubMed ID: 21221996

Title: Identification of signal peptide domain SOST mutations in autosomal dominant craniodiaphyseal dysplasia.

PubMed ID: 21221996

DOI: 10.1007/s00439-011-0947-3

PubMed ID: 21471202

Title: Bone overgrowth-associated mutations in the LRP4 gene impair sclerostin facilitator function.

PubMed ID: 21471202

DOI: 10.1074/jbc.m110.190330

PubMed ID: 19208630

Title: Characterization of the structural features and interactions of sclerostin: molecular insight into a key regulator of Wnt-mediated bone formation.

PubMed ID: 19208630

DOI: 10.1074/jbc.m807994200

PubMed ID: 20583295

Title: First missense mutation in the SOST gene causing sclerosteosis by loss of sclerostin function.

PubMed ID: 20583295

DOI: 10.1002/humu.21274

Sequence Information:

  • Length: 213
  • Mass: 24031
  • Checksum: 30DBD55CE73D5BB2
  • Sequence:
    • MQLPLALCLV CLLVHTAFRV VEGQGWQAFK NDATEIIPEL GEYPEPPPEL ENNKTMNRAE 
NGGRPPHHPF ETKDVSEYSC RELHFTRYVT DGPCRSAKPV TELVCSGQCG PARLLPNAIG 
RGKWWRPSGP DFRCIPDRYR AQRVQLLCPG GEAPRARKVR LVASCKCKRL TRFHNQSELK 
DFGTEAARPQ KGRKPRPRAR SAKANQAELE NAY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.