Details for: PCDH8

Gene ID: 5100

Symbol: PCDH8

Ensembl ID: ENSG00000136099

Description: protocadherin 8

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 52.3175
    Cell Significance Index: -13.2700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 33.0763
    Cell Significance Index: -13.4400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 3.9665
    Cell Significance Index: 243.1900
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 1.8567
    Cell Significance Index: 27.9800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.5654
    Cell Significance Index: 297.9100
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 1.0016
    Cell Significance Index: 7.7200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.7044
    Cell Significance Index: 20.1000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6898
    Cell Significance Index: 68.2400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6101
    Cell Significance Index: 550.8700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.5986
    Cell Significance Index: 214.6900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.5888
    Cell Significance Index: 39.5900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4091
    Cell Significance Index: 44.5000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.3792
    Cell Significance Index: 23.3100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3641
    Cell Significance Index: 59.2200
  • Cell Name: chandelier cell (CL4023083)
    Fold Change: 0.3332
    Cell Significance Index: 2.6900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3325
    Cell Significance Index: 19.9600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.2935
    Cell Significance Index: 183.3100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2891
    Cell Significance Index: 8.3300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1769
    Cell Significance Index: 35.4900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1705
    Cell Significance Index: 11.7900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.1593
    Cell Significance Index: 3.8200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1580
    Cell Significance Index: 7.1600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1230
    Cell Significance Index: 85.0400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0929
    Cell Significance Index: 2.0400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0319
    Cell Significance Index: 1.1200
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0026
    Cell Significance Index: -0.1100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0046
    Cell Significance Index: -3.4300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0074
    Cell Significance Index: -13.8500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0103
    Cell Significance Index: -5.8100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0111
    Cell Significance Index: -2.3400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0125
    Cell Significance Index: -0.2600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0189
    Cell Significance Index: -0.4100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0190
    Cell Significance Index: -2.3400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0212
    Cell Significance Index: -13.4500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0216
    Cell Significance Index: -9.5700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0234
    Cell Significance Index: -12.7700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0278
    Cell Significance Index: -4.7600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0292
    Cell Significance Index: -13.2600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0315
    Cell Significance Index: -9.0700
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0329
    Cell Significance Index: -0.6600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0337
    Cell Significance Index: -1.8900
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.0339
    Cell Significance Index: -0.4400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0393
    Cell Significance Index: -7.0900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0430
    Cell Significance Index: -1.6300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0439
    Cell Significance Index: -6.3900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0653
    Cell Significance Index: -1.3900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0701
    Cell Significance Index: -3.1000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0824
    Cell Significance Index: -9.4100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0888
    Cell Significance Index: -11.4700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0902
    Cell Significance Index: -2.8900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0936
    Cell Significance Index: -12.8500
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0960
    Cell Significance Index: -1.1200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0970
    Cell Significance Index: -11.3000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1065
    Cell Significance Index: -6.7100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1106
    Cell Significance Index: -12.6700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1448
    Cell Significance Index: -7.6000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1542
    Cell Significance Index: -7.1900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1593
    Cell Significance Index: -11.8700
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.1711
    Cell Significance Index: -3.5700
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.1900
    Cell Significance Index: -2.0700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1959
    Cell Significance Index: -12.6400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2161
    Cell Significance Index: -3.1000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2436
    Cell Significance Index: -11.4500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2475
    Cell Significance Index: -5.1800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2559
    Cell Significance Index: -13.3000
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.2741
    Cell Significance Index: -5.4200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2769
    Cell Significance Index: -9.7000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2856
    Cell Significance Index: -7.5100
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.3091
    Cell Significance Index: -2.9300
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.3308
    Cell Significance Index: -7.0200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.3364
    Cell Significance Index: -8.4100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3454
    Cell Significance Index: -12.6800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3546
    Cell Significance Index: -11.6100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3689
    Cell Significance Index: -11.7500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3690
    Cell Significance Index: -6.1800
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.3757
    Cell Significance Index: -7.4000
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.3851
    Cell Significance Index: -7.6800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3960
    Cell Significance Index: -13.7600
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.4004
    Cell Significance Index: -3.8100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.4054
    Cell Significance Index: -11.6200
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.4079
    Cell Significance Index: -4.9500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.4151
    Cell Significance Index: -11.3000
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.4258
    Cell Significance Index: -9.2000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.4317
    Cell Significance Index: -5.8900
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.4410
    Cell Significance Index: -6.1900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.4416
    Cell Significance Index: -12.9700
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.4419
    Cell Significance Index: -5.8900
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.4440
    Cell Significance Index: -11.0900
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.4511
    Cell Significance Index: -6.4100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.4626
    Cell Significance Index: -12.4000
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.4647
    Cell Significance Index: -11.8400
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.4656
    Cell Significance Index: -11.3600
  • Cell Name: osteoblast (CL0000062)
    Fold Change: -0.4680
    Cell Significance Index: -4.5400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.4693
    Cell Significance Index: -12.5300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4702
    Cell Significance Index: -13.8500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.4718
    Cell Significance Index: -12.6200
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.4747
    Cell Significance Index: -11.8400
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: -0.4808
    Cell Significance Index: -4.9600
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.5135
    Cell Significance Index: -12.8100
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.5297
    Cell Significance Index: -3.5900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** PCDH8 is a small, secreted protein that belongs to the cadherin superfamily. It is characterized by its ability to bind calcium ions, which is essential for its function in cell-cell adhesion. PCDH8 is primarily expressed in the nervous system, particularly in the brain, where it plays a crucial role in synaptic transmission and neuronal development. Its homophilic binding properties allow it to interact with other PCDH8 molecules, facilitating cell-cell adhesion and synaptic plasticity. **Pathways and Functions:** PCDH8 is involved in several key pathways, including: 1. **Cell-cell signaling:** PCDH8 mediates cell-cell communication through its homophilic binding properties, influencing various cellular processes such as morphogenesis, differentiation, and survival. 2. **Chemical synaptic transmission:** PCDH8 is expressed at the postsynaptic membrane, where it regulates synaptic adhesion and transmission, modulating the strength of synaptic connections. 3. **Calcium ion binding:** PCDH8 binds calcium ions, which is essential for its function in cell-cell adhesion and synaptic transmission. 4. **Morphogenesis:** PCDH8 is involved in the morphogenesis of embryonic epithelium, where it plays a crucial role in the formation of epithelial tissues. **Clinical Significance:** PCDH8 has been implicated in various diseases, including: 1. **Neurological disorders:** PCDH8 has been associated with neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, where it is thought to play a role in synaptic transmission and neuronal survival. 2. **Cancer:** PCDH8 has been found to be overexpressed in some types of cancer, including colon cancer, where it may contribute to tumor progression and metastasis. 3. **Immune system disorders:** PCDH8 is expressed in various immune cells, including plasma cells and conventional dendritic cells, where it may play a role in immune response regulation. In conclusion, PCDH8 is a crucial protein involved in cell-cell adhesion, synaptic transmission, and morphogenesis. Its expression in various cell types and tissues highlights its broad functional range, and its implication in various diseases underscores its importance in human health and disease. Further research is needed to fully elucidate the mechanisms by which PCDH8 regulates cellular processes and to explore its therapeutic potential.

Genular Protein ID: 1612153933

Symbol: PCDH8_HUMAN

Name: Protocadherin-8

UniProtKB Accession Codes:

O95206 B4DMV7 Q5TAN1 Q5TAN2 Q8IYE9 Q96SF1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 2 ExpressionAtlas 1 GO 15 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 2 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9787079

Title: Characterization of two novel protocadherins (PCDH8 and PCDH9) localized on human chromosome 13 and mouse chromosome 14.

PubMed ID: 9787079

DOI: 10.1006/geno.1998.5467

PubMed ID: 11230163

Title: Comparative DNA sequence analysis of mouse and human protocadherin gene clusters.

PubMed ID: 11230163

DOI: 10.1101/gr.167301

PubMed ID: 15057823

Title: The DNA sequence and analysis of human chromosome 13.

PubMed ID: 15057823

DOI: 10.1038/nature02379

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12884975

Title: Screening the human protocadherin 8 (PCDH8) gene in schizophrenia.

PubMed ID: 12884975

DOI: 10.1034/j.1601-183x.2002.10307.x

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 1070
  • Mass: 113019
  • Checksum: CBCCE3C43C0E02D8
  • Sequence:
    • MSPVRRWGSP CLFPLQLFSL CWVLSVAQSK TVRYSTFEED APGTVIGTLA EDLHMKVSGD 
TSFRLMKQFN SSLLRVREGD GQLTVGDAGL DRERLCGQAP QCVLAFDVVS FSQEQFRLVH 
VEVEVRDVND HAPRFPRAQI PVEVSEGAAV GTRIPLEVPV DEDVGANGLQ TVRLAEPHSP 
FRVELQTRAD GAQCADLVLL QELDRESQAA YSLELVAQDG GRPPRSATAA LSVRVLDAND 
HSPAFPQGAV AEVELAEDAP VGSLLLDLDA ADPDEGPNGD VVFAFGARTP PEARRLFRLD 
PRSGRLTLAG PVDYERQDTY ELDVRAQDRG PGPRAATCKV IVRIRDVNDN APDIAITPLA 
APGAPATSPF AAAAAAAALG GADASSPAGA GTPEAGATSL VPEGAARESL VALVSTSDRD 
SGANGQVRCA LYGHEHFRLQ PAYAGSYLVV TAASLDRERI AEYNLTLVAE DRGAPPLRTV 
RPYTVRVGDE NDNAPLFTRP VYEVSVRENN PPGAYLATVA ARDRDLGRNG QVTYRLLEAE 
VGRAGGAVST YVSVDPATGA IYALRSFDYE TLRQLDVRIQ ASDGGSPQLS SSALVQVRVL 
DQNDHAPVLV HPAPANGSLE VAVPGRTAKD TVVARVQARD ADEGANGELA FELQQQEPRE 
AFAIGRRTGE ILLTGDLSQE PPGRVFRALL VISDGGRPPL TTTATVSFVV TAGGGRGPAA 
PASAGSPERS RPPGSRLGVS GSVLQWDTPL IVIIVLAGSC TLLLAAIIAI ATTCNRRKKE 
VRKGGALREE RPGAAGGGAS APGSPEEAAR GAGPRPNMFD VLTFPGTGKA PFGSPAADAP 
PPAVAAAEVP GSEGGSATGE SACHFEGQQR LRGAHAEPYG ASPGFGKEPA PPVAVWKGHS 
FNTISGREAE KFSGKDSGKG DSDFNDSDSD ISGDALKKDL INHMQSGLWA CTAECKILGH 
SDRCWSPSCS GPNAHPSPHP PAQMSTFCKS TSLPRDPLRR DNYYQAQLPK TVGLQSVYEK 
VLHRDYDRTV TLLSPPRPGR LPDLQEIGVP LYQSPPGRYL SPKKGANENV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.