Details for: ZNF691

Gene ID: 51058

Symbol: ZNF691

Ensembl ID: ENSG00000164011

Description: zinc finger protein 691

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 42.5600
    Cell Significance Index: -6.6200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 22.3542
    Cell Significance Index: -5.6700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 13.9371
    Cell Significance Index: -6.5800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 5.3611
    Cell Significance Index: -6.6100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 2.0979
    Cell Significance Index: -5.6200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 1.6827
    Cell Significance Index: -6.6400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.9898
    Cell Significance Index: 188.3600
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.6308
    Cell Significance Index: 10.1200
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.5334
    Cell Significance Index: 3.3000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4986
    Cell Significance Index: 450.1700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.4696
    Cell Significance Index: 29.6000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.4527
    Cell Significance Index: 27.1800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3787
    Cell Significance Index: 61.5900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.3155
    Cell Significance Index: 8.4600
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.2582
    Cell Significance Index: 3.7000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.2193
    Cell Significance Index: 3.6700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2152
    Cell Significance Index: 14.8900
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.2085
    Cell Significance Index: 2.6700
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.2005
    Cell Significance Index: 2.1800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.1660
    Cell Significance Index: 4.2400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.1312
    Cell Significance Index: 4.5600
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.1205
    Cell Significance Index: 0.9100
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.1159
    Cell Significance Index: 0.9300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1089
    Cell Significance Index: 21.6100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0910
    Cell Significance Index: 12.4900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0869
    Cell Significance Index: 8.6000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0849
    Cell Significance Index: 3.9600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0771
    Cell Significance Index: 1.6700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.0712
    Cell Significance Index: 1.4900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0680
    Cell Significance Index: 1.9600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0642
    Cell Significance Index: 12.8800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0589
    Cell Significance Index: 2.6700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0560
    Cell Significance Index: 6.5300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0498
    Cell Significance Index: 27.1800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0473
    Cell Significance Index: 6.0600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.0426
    Cell Significance Index: 1.1200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0405
    Cell Significance Index: 0.8400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0385
    Cell Significance Index: 0.8200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0347
    Cell Significance Index: 15.3300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0331
    Cell Significance Index: 5.9600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0308
    Cell Significance Index: 0.7700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0288
    Cell Significance Index: 0.7800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0286
    Cell Significance Index: 2.0200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0274
    Cell Significance Index: 3.2300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0268
    Cell Significance Index: 9.6200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0214
    Cell Significance Index: 1.1100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0160
    Cell Significance Index: 0.9000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0139
    Cell Significance Index: 0.4900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0091
    Cell Significance Index: 6.2900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0071
    Cell Significance Index: 0.5500
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 0.0017
    Cell Significance Index: 0.0100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0018
    Cell Significance Index: -3.3900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0020
    Cell Significance Index: -0.2400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0024
    Cell Significance Index: -1.8500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0025
    Cell Significance Index: -0.3700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0025
    Cell Significance Index: -0.0700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0031
    Cell Significance Index: -2.2700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0031
    Cell Significance Index: -5.7700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0031
    Cell Significance Index: -4.7000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0036
    Cell Significance Index: -0.2300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0042
    Cell Significance Index: -0.0500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0048
    Cell Significance Index: -3.0400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0050
    Cell Significance Index: -0.8600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0055
    Cell Significance Index: -7.4500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0072
    Cell Significance Index: -0.7400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0082
    Cell Significance Index: -6.0500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0099
    Cell Significance Index: -5.6100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0106
    Cell Significance Index: -4.8000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0135
    Cell Significance Index: -0.7100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0137
    Cell Significance Index: -8.5400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0153
    Cell Significance Index: -0.4900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0159
    Cell Significance Index: -2.0600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0164
    Cell Significance Index: -4.7200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0167
    Cell Significance Index: -0.7900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0209
    Cell Significance Index: -1.2800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0279
    Cell Significance Index: -0.8200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0313
    Cell Significance Index: -3.5900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0355
    Cell Significance Index: -7.4700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0358
    Cell Significance Index: -2.6700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0438
    Cell Significance Index: -1.1700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0461
    Cell Significance Index: -1.0100
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.0529
    Cell Significance Index: -0.4500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0613
    Cell Significance Index: -4.1200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0632
    Cell Significance Index: -6.5800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0645
    Cell Significance Index: -0.8800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0669
    Cell Significance Index: -1.7900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0680
    Cell Significance Index: -4.1800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0683
    Cell Significance Index: -5.4100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0938
    Cell Significance Index: -4.1500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0953
    Cell Significance Index: -1.3700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1063
    Cell Significance Index: -3.1300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1101
    Cell Significance Index: -4.1700
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.1112
    Cell Significance Index: -1.5600
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1327
    Cell Significance Index: -2.0000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1433
    Cell Significance Index: -5.0200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1513
    Cell Significance Index: -4.8200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1517
    Cell Significance Index: -3.9000
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1531
    Cell Significance Index: -1.5900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1565
    Cell Significance Index: -5.1300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1624
    Cell Significance Index: -5.9600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Transcriptional Regulation:** ZNF691 is a transcription factor that regulates the expression of target genes through binding to specific DNA sequences. It is involved in the regulation of gene expression by RNA polymerase II, a key enzyme responsible for transcribing DNA into RNA. 2. **Cellular Expression:** This gene is expressed in a wide range of cell types, including polychromatophilic erythroblasts, hematopoietic oligopotent progenitor cells, smooth muscle fibers of the ileum, and CD8-alpha-beta-positive, alpha-beta intraepithelial T cells. Its expression is also observed in stromal cells of bone marrow, enteroendocrine cells of the colon, decidual cells, and pulmonary interstitial fibroblasts. 3. **Zinc Binding:** ZNF691 contains a zinc finger domain, which is essential for its DNA-binding activity. This domain allows the protein to specifically bind to metal ions, facilitating its interaction with DNA. **Pathways and Functions:** 1. **DNA-Binding Transcription Factor Activity:** ZNF691 regulates gene expression by binding to specific DNA sequences, thereby influencing the transcription of target genes. 2. **Generic Transcription Pathway:** This gene is involved in the regulation of gene expression through the generic transcription pathway, which is responsible for the transcription of DNA into RNA. 3. **Metal Ion Binding:** The zinc finger domain of ZNF691 is responsible for its metal ion-binding activity, which is essential for its DNA-binding function. **Clinical Significance:** 1. **Hematopoietic Disorders:** Abnormal expression of ZNF691 has been observed in various hematopoietic disorders, including leukemia and lymphoma. This suggests that ZNF691 may play a role in the regulation of cell proliferation and differentiation in hematopoietic cells. 2. **Immunological Disorders:** The expression of ZNF691 in immune cells, such as CD8-alpha-beta-positive, alpha-beta intraepithelial T cells, suggests that this gene may be involved in the regulation of immune responses. 3. **Cancer Research:** The expression of ZNF691 in various cancer cell types, including colon cancer, suggests that this gene may be involved in the regulation of cell proliferation and differentiation in cancer cells. 4. **Regulation of Transcription by RNA Polymerase II:** ZNF691 is a member of the RNA polymerase II cis-regulatory region sequence-specific DNA binding protein family, which regulates the transcription of genes by RNA polymerase II. In conclusion, ZNF691 is a transcription factor gene that plays a crucial role in various cellular processes, including cell differentiation, proliferation, and survival. Its expression in various cell types and its involvement in the regulation of gene expression by RNA polymerase II make it an important gene for further study. Further research is needed to fully understand the functions and clinical significance of ZNF691.

Genular Protein ID: 3595262631

Symbol: ZN691_HUMAN

Name: Zinc finger protein 691

UniProtKB Accession Codes:

Q5VV52 A8MXP6 B4DJR7 O95878 Q9NWE8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 EMBL 8 Ensembl 5 ExpressionAtlas 1 GO 5 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 4 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

Sequence Information:

  • Length: 315
  • Mass: 35810
  • Checksum: 5EDA193FDA237383
  • Sequence:
    • MSLCSPTHSA EMSLFLQGPE EMLPLSSEGS EMGSEKEQSP EPHLPEEGEG GKPWRVDDSE 
GSWIPPGEKE HGQESLSDEL QETHPKKPWQ KVTVRARELG DPIAHPRHEA DEKPFICAQC 
GKTFNNTSNL RTHQRIHTGE KPYKCSECGK SFSRSSNRIR HERIHLEEKH YKCPKCQESF 
RRRSDLTTHQ QDHLGKRPYR CDICGKSFSQ SATLAVHHRT HLEPAPYICC ECGKSFSNSS 
SFGVHHRTHT GERPYECTEC GRTFSDISNF GAHQRTHRGE KPYRCTVCGK HFSRSSNLIR 
HQKTHLGEQA GKDSS

Genular Protein ID: 873975366

Symbol: Q5VV50_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q5VV50

Database IDs:

ARBA 3 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 1 Ensembl 3 GO 1 Gene3D 1 GeneTree 1 HGNC 1 InterPro 3 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 3 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 2 Proteomes 2 ProteomicsDB 2 RefSeq 2 SAM 1 SMART 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

Sequence Information:

  • Length: 306
  • Mass: 34653
  • Checksum: B006645191FFD5D5
  • Sequence:
    • MAQISSGGGG QSRCLLFALG SEMGSEKEQS PEPHLPEEGE GGKPWRVDDS EGSWIPPGEK 
EHGQESLSDE LQETHPKKPW QKVTVRAREL GDPIAHPRHE ADEKPFICAQ CGKTFNNTSN 
LRTHQRIHTG EKPYKCSECG KSFSRSSNRI RHERIHLEEK HYKCPKCQES FRRRSDLTTH 
QQDHLGKRPY RCDICGKSFS QSATLAVHHR THLEPAPYIC CECGKSFSNS SSFGVHHRTH 
TGERPYECTE CGRTFSDISN FGAHQRTHRG EKPYRCTVCG KHFSRSSNLI RHQKTHLGEQ 
AGKDSS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.