Details for: MLXIPL

Gene ID: 51085

Symbol: MLXIPL

Ensembl ID: ENSG00000009950

Description: MLX interacting protein like

Associated with

  • Ampk inhibits chrebp transcriptional activation activity
    (R-HSA-163680)
  • Chrebp activates metabolic gene expression
    (R-HSA-163765)
  • Integration of energy metabolism
    (R-HSA-163685)
  • Metabolism
    (R-HSA-1430728)
  • Pka-mediated phosphorylation of key metabolic factors
    (R-HSA-163358)
  • Pp2a-mediated dephosphorylation of key metabolic factors
    (R-HSA-163767)
  • Anatomical structure morphogenesis
    (GO:0009653)
  • Carbohydrate response element binding
    (GO:0035538)
  • Chromatin
    (GO:0000785)
  • Cytoplasm
    (GO:0005737)
  • Cytosol
    (GO:0005829)
  • Dna-binding transcription activator activity
    (GO:0001216)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna-binding transcription factor binding
    (GO:0140297)
  • Dna-binding transcription repressor activity, rna polymerase ii-specific
    (GO:0001227)
  • Dna binding
    (GO:0003677)
  • Energy homeostasis
    (GO:0097009)
  • Fatty acid homeostasis
    (GO:0055089)
  • Glucose homeostasis
    (GO:0042593)
  • Glucose mediated signaling pathway
    (GO:0010255)
  • Lipid biosynthetic process
    (GO:0008610)
  • Negative regulation of dna-templated transcription
    (GO:0045892)
  • Negative regulation of oxidative phosphorylation
    (GO:0090324)
  • Negative regulation of peptidyl-serine phosphorylation
    (GO:0033137)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Nucleoplasm
    (GO:0005654)
  • Nucleus
    (GO:0005634)
  • Positive regulation of cell population proliferation
    (GO:0008284)
  • Positive regulation of dna-templated transcription
    (GO:0045893)
  • Positive regulation of fatty acid biosynthetic process
    (GO:0045723)
  • Positive regulation of glycolytic process
    (GO:0045821)
  • Positive regulation of lipid biosynthetic process
    (GO:0046889)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Positive regulation of transcription from rna polymerase ii promoter by glucose
    (GO:0000432)
  • Protein heterodimerization activity
    (GO:0046982)
  • Protein homodimerization activity
    (GO:0042803)
  • Regulation of dna-templated transcription
    (GO:0006355)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii-specific dna-binding transcription factor binding
    (GO:0061629)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Transcription regulator complex
    (GO:0005667)
  • Triglyceride homeostasis
    (GO:0070328)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 100.6781
    Cell Significance Index: -15.6600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 62.4105
    Cell Significance Index: -15.8300
  • Cell Name: subcutaneous adipocyte (CL0002521)
    Fold Change: 28.5492
    Cell Significance Index: 124.2800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 7.0758
    Cell Significance Index: -18.9600
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 7.0341
    Cell Significance Index: 118.4900
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: 3.8139
    Cell Significance Index: 48.0300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.9102
    Cell Significance Index: 577.5500
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 2.9052
    Cell Significance Index: 22.0300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.9009
    Cell Significance Index: 1716.3900
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 1.3386
    Cell Significance Index: 32.6600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.3383
    Cell Significance Index: 268.4700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.3025
    Cell Significance Index: 141.6800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.2475
    Cell Significance Index: 202.8900
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.1313
    Cell Significance Index: 6.5200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.1269
    Cell Significance Index: 67.6500
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.0982
    Cell Significance Index: 16.2100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.7466
    Cell Significance Index: 51.6300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.7205
    Cell Significance Index: 258.4200
  • Cell Name: liver dendritic cell (CL2000055)
    Fold Change: 0.7136
    Cell Significance Index: 1.8800
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.6287
    Cell Significance Index: 4.2600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6057
    Cell Significance Index: 59.9200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.6035
    Cell Significance Index: 13.0800
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.5824
    Cell Significance Index: 6.0800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.5372
    Cell Significance Index: 36.1200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.4794
    Cell Significance Index: 25.1700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3708
    Cell Significance Index: 70.5700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.3479
    Cell Significance Index: 7.4100
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.3310
    Cell Significance Index: 4.1100
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.3013
    Cell Significance Index: 4.9700
  • Cell Name: helper T cell (CL0000912)
    Fold Change: 0.2386
    Cell Significance Index: 3.3900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1790
    Cell Significance Index: 6.2900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1522
    Cell Significance Index: 6.9000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1293
    Cell Significance Index: 89.4600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0888
    Cell Significance Index: 48.5200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.0881
    Cell Significance Index: 1.7200
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.0545
    Cell Significance Index: 6.2200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0541
    Cell Significance Index: 1.5600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0443
    Cell Significance Index: 5.0800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0377
    Cell Significance Index: 6.4300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0064
    Cell Significance Index: 9.8900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0004
    Cell Significance Index: -0.3100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0009
    Cell Significance Index: -0.6000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0032
    Cell Significance Index: -5.9700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0076
    Cell Significance Index: -4.7600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0079
    Cell Significance Index: -14.5900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0103
    Cell Significance Index: -5.8100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0137
    Cell Significance Index: -10.3700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0144
    Cell Significance Index: -19.5400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0159
    Cell Significance Index: -1.8500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0160
    Cell Significance Index: -0.3400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0168
    Cell Significance Index: -12.3000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0201
    Cell Significance Index: -4.2400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0263
    Cell Significance Index: -11.6200
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0269
    Cell Significance Index: -0.5400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0361
    Cell Significance Index: -1.0300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0381
    Cell Significance Index: -17.2900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0463
    Cell Significance Index: -1.1900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0469
    Cell Significance Index: -1.3100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0531
    Cell Significance Index: -9.5800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0589
    Cell Significance Index: -8.5600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0619
    Cell Significance Index: -1.0600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0626
    Cell Significance Index: -18.0100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0719
    Cell Significance Index: -7.3400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0865
    Cell Significance Index: -10.6400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0922
    Cell Significance Index: -5.6500
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.0975
    Cell Significance Index: -0.7500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1014
    Cell Significance Index: -7.7800
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.1029
    Cell Significance Index: -1.7300
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1103
    Cell Significance Index: -2.1800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1211
    Cell Significance Index: -3.8800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1212
    Cell Significance Index: -16.6500
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.1242
    Cell Significance Index: -2.6600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1252
    Cell Significance Index: -16.1800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1253
    Cell Significance Index: -3.9900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1292
    Cell Significance Index: -1.8500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1319
    Cell Significance Index: -16.9100
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1381
    Cell Significance Index: -1.4300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1506
    Cell Significance Index: -9.4900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1586
    Cell Significance Index: -16.5200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1600
    Cell Significance Index: -4.0000
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1725
    Cell Significance Index: -2.6000
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1852
    Cell Significance Index: -4.6200
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1879
    Cell Significance Index: -8.1700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1925
    Cell Significance Index: -9.7300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1953
    Cell Significance Index: -13.8100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2003
    Cell Significance Index: -9.3400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2061
    Cell Significance Index: -5.4200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2139
    Cell Significance Index: -8.1000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2195
    Cell Significance Index: -16.3600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2258
    Cell Significance Index: -17.8800
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.2302
    Cell Significance Index: -2.1900
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.2401
    Cell Significance Index: -3.3300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2406
    Cell Significance Index: -8.4300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2433
    Cell Significance Index: -3.3200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2444
    Cell Significance Index: -10.8100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2782
    Cell Significance Index: -14.4500
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.2800
    Cell Significance Index: -2.3800
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: -0.2868
    Cell Significance Index: -1.0800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2918
    Cell Significance Index: -16.3800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2962
    Cell Significance Index: -13.9200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Transcription Factor Activity**: MLXIPL is a transcription factor that regulates the expression of genes involved in metabolism, energy homeostasis, and cell proliferation. 2. **Cell-Specific Expression**: MLXIPL is significantly expressed in various cell types, including hematopoietic oligopotent progenitor cells, subcutaneous adipocytes, and neoplastic cells. 3. **Regulation of Metabolic Pathways**: MLXIPL regulates the expression of genes involved in carbohydrate homeostasis, fatty acid homeostasis, and glucose homeostasis, suggesting its role in maintaining metabolic balance. 4. **Interactions with Other Proteins**: MLXIPL interacts with other proteins, such as AMPK and PKA, to regulate metabolic processes and energy homeostasis. **Pathways and Functions:** 1. **AMPK-MLXIPL Signaling Pathway**: The AMPK-MLXIPL pathway is involved in regulating glucose and fatty acid homeostasis, promoting energy balance and metabolic health. 2. **GLUT4 Regulation**: MLXIPL regulates the expression of GLUT4, a glucose transporter essential for glucose homeostasis and insulin sensitivity. 3. **Fatty Acid Synthesis**: MLXIPL regulates the expression of genes involved in fatty acid synthesis, influencing lipid homeostasis and energy balance. 4. **Cell Proliferation and Differentiation**: MLXIPL regulates the expression of genes involved in cell proliferation and differentiation, influencing the development and maintenance of various cell types. **Clinical Significance:** 1. **Metabolic Disorders**: Dysregulation of MLXIPL has been implicated in various metabolic disorders, including type 2 diabetes, obesity, and fatty liver disease. 2. **Cancer**: MLXIPL has been shown to promote cell proliferation and tumorigenesis in certain cancer types, including breast and colon cancer. 3. **Neurological Disorders**: MLXIPL may play a role in the development and progression of neurological disorders, such as Alzheimer's disease and Parkinson's disease. 4. **Immunological Disorders**: MLXIPL has been implicated in the regulation of immune cell function and the development of autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. In conclusion, MLXIPL is a transcription factor that plays a crucial role in regulating metabolic processes, energy homeostasis, and cell proliferation. Its dysregulation has been implicated in various human diseases, highlighting the importance of further research into the biological significance of MLXIPL.

Genular Protein ID: 1323900039

Symbol: MLXPL_HUMAN

Name: Carbohydrate-responsive element-binding protein

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 10780788

Title: WBSCR14, a putative transcription factor gene deleted in Williams-Beuren syndrome: complete characterisation of the human gene and the mouse ortholog.

PubMed ID: 10780788

DOI: 10.1038/sj.ejhg.5200435

PubMed ID: 11230181

Title: WBSCR14, a gene mapping to the Williams-Beuren syndrome deleted region, is a new member of the Mlx transcription factor network.

PubMed ID: 11230181

DOI: 10.1093/hmg/10.6.617

PubMed ID: 9860302

Title: Complete physical map of the common deletion region in Williams syndrome and identification and characterization of three novel genes.

PubMed ID: 9860302

DOI: 10.1007/s004390050874

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14759258

Title: An unappreciated role for RNA surveillance.

PubMed ID: 14759258

DOI: 10.1186/gb-2004-5-2-r8

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 852
  • Mass: 93073
  • Checksum: D49E5C3D7C0A72EC
  • Sequence:
  • MAGALAGLAA GLQVPRVAPS PDSDSDTDSE DPSLRRSAGG LLRSQVIHSG HFMVSSPHSD 
    SLPRRRDQEG SVGPSDFGPR SIDPTLTRLF ECLSLAYSGK LVSPKWKNFK GLKLLCRDKI 
    RLNNAIWRAW YIQYVKRRKS PVCGFVTPLQ GPEADAHRKP EAVVLEGNYW KRRIEVVMRE 
    YHKWRIYYKK RLRKPSREDD LLAPKQAEGR WPPPEQWCKQ LFSSVVPVLL GDPEEEPGGR 
    QLLDLNCFLS DISDTLFTMT QSGPSPLQLP PEDAYVGNAD MIQPDLTPLQ PSLDDFMDIS 
    DFFTNSRLPQ PPMPSNFPEP PSFSPVVDSL FSSGTLGPEV PPASSAMTHL SGHSRLQARN 
    SCPGPLDSSA FLSSDFLLPE DPKPRLPPPP VPPPLLHYPP PAKVPGLEPC PPPPFPPMAP 
    PTALLQEEPL FSPRFPFPTV PPAPGVSPLP APAAFPPTPQ SVPSPAPTPF PIELLPLGYS 
    EPAFGPCFSM PRGKPPAPSP RGQKASPPTL APATASPPTT AGSNNPCLTQ LLTAAKPEQA 
    LEPPLVSSTL LRSPGSPQET VPEFPCTFLP PTPAPTPPRP PPGPATLAPS RPLLVPKAER 
    LSPPAPSGSE RRLSGDLSSM PGPGTLSVRV SPPQPILSRG RPDSNKTENR RITHISAEQK 
    RRFNIKLGFD TLHGLVSTLS AQPSLKVSKA TTLQKTAEYI LMLQQERAGL QEEAQQLRDE 
    IEELNAAINL CQQQLPATGV PITHQRFDQM RDMFDDYVRT RTLHNWKFWV FSILIRPLFE 
    SFNGMVSTAS VHTLRQTSLA WLDQYCSLPA LRPTVLNSLR QLGTSTSILT DPGRIPEQAT 
    RAVTEGTLGK PL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.