Details for: TNNI3K

Gene ID: 51086

Symbol: TNNI3K

Ensembl ID: ENSG00000116783

Description: TNNI3 interacting kinase

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 4.6694
    Cell Significance Index: 358.3200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.6415
    Cell Significance Index: 329.2900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.8775
    Cell Significance Index: 53.8000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.8549
    Cell Significance Index: 306.6300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.6409
    Cell Significance Index: 24.2700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.6102
    Cell Significance Index: 19.5500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.5383
    Cell Significance Index: 27.2100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.4307
    Cell Significance Index: 19.0500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3750
    Cell Significance Index: 71.3600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.1327
    Cell Significance Index: 2.7500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1246
    Cell Significance Index: 3.5900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1150
    Cell Significance Index: 103.8300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0905
    Cell Significance Index: 3.1800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0810
    Cell Significance Index: 4.9800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0555
    Cell Significance Index: 38.4000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0509
    Cell Significance Index: 5.0400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0348
    Cell Significance Index: 5.6600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.0165
    Cell Significance Index: 1.8000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0051
    Cell Significance Index: 0.9200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0021
    Cell Significance Index: -0.1200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.0023
    Cell Significance Index: -0.1400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0072
    Cell Significance Index: -0.1800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0094
    Cell Significance Index: -17.7000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0116
    Cell Significance Index: -21.4700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0140
    Cell Significance Index: -21.5400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0157
    Cell Significance Index: -21.4000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0178
    Cell Significance Index: -5.1400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0222
    Cell Significance Index: -16.4700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0237
    Cell Significance Index: -17.3600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0272
    Cell Significance Index: -17.2600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0304
    Cell Significance Index: -23.0200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0347
    Cell Significance Index: -18.9300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0365
    Cell Significance Index: -20.6000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0381
    Cell Significance Index: -17.3000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0405
    Cell Significance Index: -17.9200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0479
    Cell Significance Index: -2.1700
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0488
    Cell Significance Index: -1.1700
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.0601
    Cell Significance Index: -0.7500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0758
    Cell Significance Index: -5.2400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0797
    Cell Significance Index: -9.8000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0969
    Cell Significance Index: -2.1000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0969
    Cell Significance Index: -20.4200
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.1149
    Cell Significance Index: -1.4500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1187
    Cell Significance Index: -17.2600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1244
    Cell Significance Index: -17.0800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1275
    Cell Significance Index: -21.7700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1505
    Cell Significance Index: -19.4400
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.1619
    Cell Significance Index: -1.5400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1623
    Cell Significance Index: -16.5800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1631
    Cell Significance Index: -19.0100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1750
    Cell Significance Index: -22.4400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1778
    Cell Significance Index: -20.3700
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.1784
    Cell Significance Index: -2.2100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2176
    Cell Significance Index: -17.2400
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.2522
    Cell Significance Index: -4.3600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2552
    Cell Significance Index: -18.0500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2623
    Cell Significance Index: -19.5500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2847
    Cell Significance Index: -9.3200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2900
    Cell Significance Index: -18.2800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2901
    Cell Significance Index: -4.1600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2917
    Cell Significance Index: -18.8200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3064
    Cell Significance Index: -20.6000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.3240
    Cell Significance Index: -15.2300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3291
    Cell Significance Index: -17.2800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.3301
    Cell Significance Index: -7.0300
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.3336
    Cell Significance Index: -4.9300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3438
    Cell Significance Index: -10.9500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3979
    Cell Significance Index: -13.9400
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.4029
    Cell Significance Index: -4.7000
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.4031
    Cell Significance Index: -8.5600
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.4432
    Cell Significance Index: -9.2500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.4512
    Cell Significance Index: -23.4400
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.4560
    Cell Significance Index: -11.3800
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.4608
    Cell Significance Index: -5.0200
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.4759
    Cell Significance Index: -9.4100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.4892
    Cell Significance Index: -22.8100
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.5026
    Cell Significance Index: -10.0900
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.5077
    Cell Significance Index: -10.9700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.5153
    Cell Significance Index: -17.9100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.5418
    Cell Significance Index: -19.8900
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.5983
    Cell Significance Index: -5.9200
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.5995
    Cell Significance Index: -8.0900
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.6055
    Cell Significance Index: -7.4900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.6121
    Cell Significance Index: -18.0300
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.6173
    Cell Significance Index: -7.7900
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.6182
    Cell Significance Index: -7.2900
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.6297
    Cell Significance Index: -9.4900
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.6428
    Cell Significance Index: -16.0300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.6428
    Cell Significance Index: -17.1700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.6434
    Cell Significance Index: -17.2400
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.6488
    Cell Significance Index: -16.5300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.6520
    Cell Significance Index: -17.4400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.6544
    Cell Significance Index: -14.3300
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.6580
    Cell Significance Index: -16.0600
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.6641
    Cell Significance Index: -13.0700
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.6670
    Cell Significance Index: -16.6600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.6694
    Cell Significance Index: -19.1900
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.6746
    Cell Significance Index: -16.3400
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.6832
    Cell Significance Index: -21.6100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.6880
    Cell Significance Index: -18.0900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TNNI3K is a protein kinase that belongs to the TNNI3 family of proteins. It is characterized by its ability to interact with TNNI3, a protein involved in cardiac muscle contraction. The TNNI3K protein kinase has been shown to have multiple phosphorylation sites, which are essential for its activity. The gene has been significantly expressed in various cell types, including cardiac muscle myoblasts, neurons, and intestinal cells. The TNNI3K protein kinase has been found to be involved in multiple signaling pathways, including protein phosphorylation, protein kinase activity, and histone H2A1 kinase activity. **Pathways and Functions:** The TNNI3K protein kinase is involved in multiple signaling pathways, including: 1. **Protein Phosphorylation:** TNNI3K phosphorylates various proteins, including histones, which are essential for chromatin remodeling and gene expression regulation. 2. **Protein Kinase Activity:** TNNI3K has been shown to have protein kinase activity, which is essential for regulating various cellular processes, including cell growth and differentiation. 3. **Histone H2A1 Kinase Activity:** TNNI3K has been shown to have histone H2A1 kinase activity, which is essential for regulating chromatin remodeling and gene expression regulation. 4. **Regulation of Cardiac Conduction:** TNNI3K has been shown to play a crucial role in regulating cardiac conduction, including the regulation of Bundle of His cell to Purkinje myocyte communication. 5. **Regulation of Cardiac Muscle Contraction:** TNNI3K has been shown to play a crucial role in regulating cardiac muscle contraction, including the regulation of heart rate. **Clinical Significance:** The TNNI3K protein kinase has been implicated in various cardiac and gastrointestinal diseases, including: 1. **Cardiac Arrhythmias:** TNNI3K has been shown to play a crucial role in regulating cardiac conduction, and mutations in the TNNI3K gene have been associated with cardiac arrhythmias. 2. **Cardiac Muscle Contraction:** TNNI3K has been shown to play a crucial role in regulating cardiac muscle contraction, and mutations in the TNNI3K gene have been associated with cardiac muscle contraction disorders. 3. **Gastrointestinal Diseases:** TNNI3K has been shown to play a crucial role in regulating intestinal cell function, and mutations in the TNNI3K gene have been associated with gastrointestinal diseases, including inflammatory bowel disease. In conclusion, the TNNI3K protein kinase is a critical regulator of cardiac conduction and muscle contraction, and its dysregulation has been implicated in various cardiac and gastrointestinal diseases. Further research is needed to fully understand the role of TNNI3K in human disease and to develop effective therapeutic strategies for the treatment of these diseases.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.