Details for: ZDHHC9

Gene ID: 51114

Symbol: ZDHHC9

Ensembl ID: ENSG00000188706

Description: zinc finger DHHC-type palmitoyltransferase 9

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 134.4304
    Cell Significance Index: -20.9100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 77.4315
    Cell Significance Index: -19.6400
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 54.1816
    Cell Significance Index: -22.3200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 44.9459
    Cell Significance Index: -21.2200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 44.7500
    Cell Significance Index: -18.1800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 19.0941
    Cell Significance Index: -18.2300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 17.1052
    Cell Significance Index: -21.0900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 7.9698
    Cell Significance Index: -21.3500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.3611
    Cell Significance Index: -21.1600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.6377
    Cell Significance Index: -10.1500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 2.4208
    Cell Significance Index: 282.1200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.8112
    Cell Significance Index: 51.9200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.5831
    Cell Significance Index: 95.0400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.2756
    Cell Significance Index: 138.7500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9387
    Cell Significance Index: 152.6700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7583
    Cell Significance Index: 684.7000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6783
    Cell Significance Index: 67.1000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.6775
    Cell Significance Index: 46.8600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.6412
    Cell Significance Index: 127.2600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.6035
    Cell Significance Index: 13.2200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.4439
    Cell Significance Index: 89.0400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4337
    Cell Significance Index: 236.8600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.4062
    Cell Significance Index: 8.8000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3852
    Cell Significance Index: 20.0100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.3567
    Cell Significance Index: 16.6300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3257
    Cell Significance Index: 14.7700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.2807
    Cell Significance Index: 3.8300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2722
    Cell Significance Index: 51.8000
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.2701
    Cell Significance Index: 1.8300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2520
    Cell Significance Index: 90.4000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2389
    Cell Significance Index: 29.3800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.2367
    Cell Significance Index: 40.4200
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.2146
    Cell Significance Index: 3.6200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1804
    Cell Significance Index: 32.5200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.1723
    Cell Significance Index: 4.6900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1707
    Cell Significance Index: 22.0600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1404
    Cell Significance Index: 6.6000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1180
    Cell Significance Index: 16.2000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1141
    Cell Significance Index: 50.4300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1007
    Cell Significance Index: 6.1900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0920
    Cell Significance Index: 2.6500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0879
    Cell Significance Index: 60.7800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0832
    Cell Significance Index: 6.2000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0698
    Cell Significance Index: 1.9500
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0609
    Cell Significance Index: 0.6300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0435
    Cell Significance Index: 32.9500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0169
    Cell Significance Index: 10.7600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0023
    Cell Significance Index: 0.0800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0015
    Cell Significance Index: 0.0400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0018
    Cell Significance Index: -0.1300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0033
    Cell Significance Index: -6.2100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0068
    Cell Significance Index: -5.0400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0071
    Cell Significance Index: -4.4300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0083
    Cell Significance Index: -12.8000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0085
    Cell Significance Index: -15.6700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0125
    Cell Significance Index: -16.9700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0209
    Cell Significance Index: -15.3500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0243
    Cell Significance Index: -0.5100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0253
    Cell Significance Index: -14.2600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0305
    Cell Significance Index: -0.5900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0350
    Cell Significance Index: -15.9000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0359
    Cell Significance Index: -2.7600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0379
    Cell Significance Index: -3.8700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0474
    Cell Significance Index: -13.6500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0561
    Cell Significance Index: -11.8100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0591
    Cell Significance Index: -7.5700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0703
    Cell Significance Index: -8.0500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0934
    Cell Significance Index: -13.5700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0939
    Cell Significance Index: -2.0000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0946
    Cell Significance Index: -3.0300
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1227
    Cell Significance Index: -14.0100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1548
    Cell Significance Index: -18.2500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1572
    Cell Significance Index: -3.9300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1594
    Cell Significance Index: -10.7200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1597
    Cell Significance Index: -10.3100
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.1604
    Cell Significance Index: -1.6600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1636
    Cell Significance Index: -8.5900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1897
    Cell Significance Index: -3.9700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1994
    Cell Significance Index: -20.7600
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.2060
    Cell Significance Index: -3.0400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.2096
    Cell Significance Index: -1.9300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2122
    Cell Significance Index: -11.9100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2448
    Cell Significance Index: -19.3900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2562
    Cell Significance Index: -16.1500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2798
    Cell Significance Index: -4.8000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2818
    Cell Significance Index: -7.4100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2825
    Cell Significance Index: -7.5700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2905
    Cell Significance Index: -12.8500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2962
    Cell Significance Index: -15.4300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2976
    Cell Significance Index: -10.3400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3073
    Cell Significance Index: -18.8400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.3094
    Cell Significance Index: -7.4200
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.3371
    Cell Significance Index: -5.6700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3555
    Cell Significance Index: -5.9500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3586
    Cell Significance Index: -13.5800
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.3831
    Cell Significance Index: -5.4900
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.3873
    Cell Significance Index: -2.3400
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.3899
    Cell Significance Index: -4.1800
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.3992
    Cell Significance Index: -7.0600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4291
    Cell Significance Index: -14.0500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Palmitoyltransferase activity:** ZDHHC9 is a palmitoyltransferase that catalyzes the transfer of a palmitoyl group to cysteine residues on target proteins, which is essential for protein stability, localization, and function. 2. **Protein targeting to membrane:** ZDHHC9 is involved in the palmitoylation of proteins that are targeted to the membrane, where they can interact with other proteins and regulate cellular processes. 3. **Signal transduction:** ZDHHC9 is involved in the regulation of signal transduction pathways, including the MAPK cascade and the Ras processing pathway. 4. **Expression in immune cells:** ZDHHC9 is highly expressed in various immune cells, including T cells, dendritic cells, and mast cells, suggesting its importance in immune function. **Pathways and Functions:** 1. **MAPK signaling pathway:** ZDHHC9 is involved in the regulation of the MAPK signaling pathway, which is critical for the regulation of immune responses, including the production of cytokines and the activation of immune cells. 2. **Ras processing pathway:** ZDHHC9 is involved in the regulation of the Ras processing pathway, which is critical for the regulation of cell growth, differentiation, and survival. 3. **Palmitoyltransferase activity:** ZDHHC9 is involved in the palmitoylation of proteins that are targeted to the membrane, where they can interact with other proteins and regulate cellular processes. 4. **Positive regulation of viral processes:** ZDHHC9 is involved in the positive regulation of viral processes, including the maturation of the SARS-CoV-2 spike protein, the regulation of the C-GAS/STING signaling pathway, and the regulation of the pyroptotic inflammatory response. **Clinical Significance:** 1. **SARS-CoV-2 infection:** ZDHHC9 has been implicated in the regulation of the SARS-CoV-2 infection process, including the maturation of the spike protein and the regulation of the C-GAS/STING signaling pathway. 2. **Immune response:** ZDHHC9 is involved in the regulation of the immune response to viral infections, including the production of cytokines and the activation of immune cells. 3. **Cancer therapy:** ZDHHC9 has been implicated in the regulation of cancer cell growth, differentiation, and survival, suggesting its potential as a target for cancer therapy. 4. **Neurological disorders:** ZDHHC9 has been implicated in the regulation of neurological disorders, including Alzheimer's disease and Parkinson's disease, suggesting its potential as a target for the treatment of these disorders. In conclusion, ZDHHC9 is a critical protein that plays a significant role in various cellular processes, including protein palmitoylation, protein targeting to membrane, and signal transduction. Its involvement in the regulation of the immune response and viral infection process highlights its potential as a therapeutic target for the treatment of viral infections and other diseases.

Genular Protein ID: 71857104

Symbol: ZDHC9_HUMAN

Name: Palmitoyltransferase ZDHHC9

UniProtKB Accession Codes:

Q9Y397 B4F6G2 D3DTF9 Q59EK4 Q5JSW5 Q8WWS7 Q9BPY4 Q9NSP0 Q9NVL0 Q9NVR6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 4 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 16 EMDB 1 Ensembl 2 ExpressionAtlas 1 GO 17 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 2 Rhea 4 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 16193335

Title: Serological identification and bioinformatics analysis of immunogenic antigens in multiple myeloma.

PubMed ID: 16193335

DOI: 10.1007/s00262-005-0074-x

PubMed ID: 10810093

Title: Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics.

PubMed ID: 10810093

DOI: 10.1101/gr.10.5.703

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16000296

Title: DHHC9 and GCP16 constitute a human protein fatty acyltransferase with specificity for H- and N-Ras.

PubMed ID: 16000296

DOI: 10.1074/jbc.m504113200

PubMed ID: 27481942

Title: S-Palmitoylation of a Novel Site in the beta2-Adrenergic Receptor Associated with a Novel Intracellular Itinerary.

PubMed ID: 27481942

DOI: 10.1074/jbc.m116.725762

PubMed ID: 34599882

Title: S-acylation controls SARS-CoV-2 membrane lipid organization and enhances infectivity.

PubMed ID: 34599882

DOI: 10.1016/j.devcel.2021.09.016

PubMed ID: 37802025

Title: Targeting LYPLAL1-mediated cGAS depalmitoylation enhances the response to anti-tumor immunotherapy.

PubMed ID: 37802025

DOI: 10.1016/j.molcel.2023.09.007

PubMed ID: 38599239

Title: ROS-dependent S-palmitoylation activates cleaved and intact gasdermin D.

PubMed ID: 38599239

DOI: 10.1038/s41586-024-07373-5

PubMed ID: 38530158

Title: The palmitoylation of gasdermin D directs its membrane translocation and pore formation during pyroptosis.

PubMed ID: 38530158

DOI: 10.1126/sciimmunol.adn1452

PubMed ID: 17436253

Title: Mutations in ZDHHC9, which encodes a palmitoyltransferase of NRAS and HRAS, cause X-linked mental retardation associated with a Marfanoid habitus.

PubMed ID: 17436253

DOI: 10.1086/513609

PubMed ID: 19377476

Title: A systematic, large-scale resequencing screen of X-chromosome coding exons in mental retardation.

PubMed ID: 19377476

DOI: 10.1038/ng.367

Sequence Information:

  • Length: 364
  • Mass: 40916
  • Checksum: D1E97F3A93CC439F
  • Sequence:
    • MSVMVVRKKV TRKWEKLPGR NTFCCDGRVM MARQKGIFYL TLFLILGTCT LFFAFECRYL 
AVQLSPAIPV FAAMLFLFSM ATLLRTSFSD PGVIPRALPD EAAFIEMEIE ATNGAVPQGQ 
RPPPRIKNFQ INNQIVKLKY CYTCKIFRPP RASHCSICDN CVERFDHHCP WVGNCVGKRN 
YRYFYLFILS LSLLTIYVFA FNIVYVALKS LKIGFLETLK ETPGTVLEVL ICFFTLWSVV 
GLTGFHTFLV ALNQTTNEDI KGSWTGKNRV QNPYSHGNIV KNCCEVLCGP LPPSVLDRRG 
ILPLEESGSR PPSTQETSSS LLPQSPAPTE HLNSNEMPED SSTPEEMPPP EPPEPPQEAA 
EAEK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.