Details for: TRIM17

Gene ID: 51127

Gene Type:  Protein-coding  - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: TRIM17

Ensembl ID: ENSG00000162931

Description: tripartite motif containing 17

Selected Context(s):  Overall

Cell Significance Landscape

Contexts:

Associated with

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • fallopian tube secretory epithelial cell CL4030006
    CSI 2.82
    rCSI 2.72%
    PRS 98.83
  • ependymal cell CL0000065
    CSI 2.41
    rCSI 4.89%
    PRS 94.42
  • indirect pathway medium spiny neuron CL4023029
    CSI 0.41
    rCSI 9.85%
    PRS 94.98
  • direct pathway medium spiny neuron CL4023026
    CSI 0.38
    rCSI 9.08%
    PRS 95.18

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

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  • Node Color (Target Cell CSI, relative to current network):
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    • High
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    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary **[TRIM17](/details-gene/51127)** (Tripartite Motif Containing 17) is a protein-coding gene that encodes an E3 ubiquitin-protein ligase, a key class of enzymes that mediate the attachment of ubiquitin to substrate proteins, thereby regulating their function, localization, or degradation. Functional annotations link **[TRIM17](/details-gene/51127)** to fundamental cellular processes including [autophagy](/details-go/GO:0006914), the [innate immune response](/details-go/GO:0045087), and the regulation of gene expression and protein stability. Expression data highlights its highly specific and significant role in distinct cell populations, most notably [fallopian tube secretory epithelial cell](/details-cell/CL4030006) and [ependymal cell](/details-cell/CL0000065), suggesting specialized functions in both epithelial and central nervous system contexts. ## Cellular Roles and Expression Landscape The expression profile of **[TRIM17](/details-gene/51127)** indicates a highly specialized, rather than ubiquitous, role. **Overall**, its significance is most pronounced in a few distinct cell types, pointing towards context-specific functions. The highest significance index is observed in **[fallopian tube secretory epithelial cell](/details-cell/CL4030006)** (CSI: 2.82), suggesting a primary role in the female reproductive system, potentially related to mucosal defense or epithelial cell turnover. Following this, **[TRIM17](/details-gene/51127)** shows high significance in cells of the central nervous system, including **[ependymal cell](/details-cell/CL0000065)** (CSI: 2.41), which line the cerebral ventricles, and to a lesser extent, in both **[indirect pathway medium spiny neuron](/details-cell/CL4023029)** (CSI: 0.41) and **[direct pathway medium spiny neuron](/details-cell/CL4023026)** (CSI: 0.38). This pattern suggests that despite its annotated roles in systemic immunity, its primary physiological activity may be concentrated in specific epithelial and neural tissues. ## Pathways and Molecular Function As a member of the TRIM family, the core molecular function of **[TRIM17](/details-gene/51127)** is its [ubiquitin protein ligase activity](/details-go/GO:0061630). It acts as an E3 ligase, mediating the transfer of ubiquitin to target proteins, a function supported by its annotated roles in [protein autoubiquitination](/details-go/GO:0051865) and [protein binding](/details-go/GO:0005515). This enzymatic activity is the mechanistic basis for its involvement in several key biological processes. **[TRIM17](/details-gene/51127)** plays a role in selective [autophagy](/details-go/GO:0006914), where it has been shown to contribute to the degradation of midbodies while sparing other targets ([Link](https://doi.org/10.1242/jcs.190017)). Furthermore, it is implicated in regulating apoptosis and cell proliferation. It can antagonistically regulate the ubiquitination and stability of the anti-apoptotic protein BCL2A1 ([Link](https://doi.org/10.1038/s41418-018-0169-5)), and it stimulates the degradation of the kinetochore protein ZWINT to regulate cell proliferation ([Link](https://doi.org/10.1093/jb/mvr128)). Consistent with its role in cellular regulation, **[TRIM17](/details-gene/51127)** is annotated in pathways related to the [immune system](/details-pathway/R-HSA-168256), including [cytokine signaling](/details-pathway/R-HSA-1280215) and specifically [interferon gamma signaling](/details-pathway/R-HSA-877300). This suggests that even within its specific cellular niches like the fallopian tube epithelium, it may act as a modulator of local immune responses. ## Research Directions The discrepancy between the broad immune-related functional annotations of **[TRIM17](/details-gene/51127)** and its highly specific expression in non-immune cells presents several compelling avenues for future research. **Proposed Hypotheses:** 1. Given its high significance in [ependymal cell](/details-cell/CL0000065) and medium spiny neurons, **[TRIM17](/details-gene/51127)** may function as a key regulator of protein quality control in the central nervous system. Its E3 ligase activity could be essential for degrading misfolded or aggregated proteins, thereby preventing neurotoxicity in these long-lived cells. 2. The prominent expression of **[TRIM17](/details-gene/51127)** in [fallopian tube secretory epithelial cell](/details-cell/CL4030006) suggests it plays a role in mucosal immunity or tissue homeostasis. It may ubiquitinate key signaling proteins involved in the response to pathogens or regulate the apoptotic pathways necessary for the cyclical regeneration of the epithelial lining. **Experimental Approach:** To test the hypothesis that **[TRIM17](/details-gene/51127)** is critical for neuronal protein homeostasis, a targeted proteomics approach could be employed. Differentiated human neuronal cell lines (e.g., SH-SY5Y) with a CRISPR-Cas9-mediated knockout of **[TRIM17](/details-gene/51127)** could be subjected to proteotoxic stress (e.g., proteasome inhibition). Ubiquitin-remnant profiling (K-GG proteomics) could then be used to identify proteins that are differentially ubiquitinated in the absence of **[TRIM17](/details-gene/51127)**, revealing its direct and indirect substrates within the neuronal proteome. **Therapeutic Potential:** As an E3 ligase, **[TRIM17](/details-gene/51127)** belongs to a class of enzymes that are increasingly targeted for therapeutic intervention, for instance with molecular glue degraders or PROTACs. Its role appears pleiotropic; it can be pro-apoptotic by destabilizing BCL2A1 ([Link](https://doi.org/10.1038/s41418-018-0169-5)) but may also promote proliferation through other substrates ([Link](https://doi.org/10.1093/jb/mvr128)). Therefore, its suitability as a target would be highly context-dependent. **Activation** of **[TRIM17](/details-gene/51127)** could be a strategy in cancers that rely on BCL2A1 for survival. Conversely, **inhibition** might be beneficial in diseases characterized by excessive cell death or turnover in the specific tissues where it is highly expressed, such as certain neurodegenerative or reproductive disorders.

Genular Protein ID: 2233102933

Symbol: TRI17_HUMAN

Name: E3 ubiquitin-protein ligase TRIM17

UniProtKB Accession Codes:

Q9Y577 B4DVJ2 Q5VST8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 3 CTD 1 ChEBI 4 DMDM 1 DNASU 1 DisGeNET 1 EC 2 EMBL 5 Ensembl 4 ExpressionAtlas 1 GO 12 Gene3D 3 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 13 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 1 RefSeq 6 SIGNOR 1 SMART 4 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9792805

Title: Molecular cloning of a novel RING finger-B box-coiled coil (RBCC) protein, terf, expressed in the testis.

PubMed ID: 9792805

DOI: 10.1006/bbrc.1998.9502

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19358823

Title: TRIM44 interacts with and stabilizes terf, a TRIM ubiquitin E3 ligase.

PubMed ID: 19358823

DOI: 10.1016/j.bbrc.2009.04.010

PubMed ID: 22023800

Title: Terf/TRIM17 stimulates degradation of kinetochore protein ZWINT and regulates cell proliferation.

PubMed ID: 22023800

DOI: 10.1093/jb/mvr128

PubMed ID: 27562068

Title: TRIM17 contributes to autophagy of midbodies while actively sparing other targets from degradation.

PubMed ID: 27562068

DOI: 10.1242/jcs.190017

PubMed ID: 30042493

Title: TRIM17 and TRIM28 antagonistically regulate the ubiquitination and anti-apoptotic activity of BCL2A1.

PubMed ID: 30042493

DOI: 10.1038/s41418-018-0169-5

Sequence Information:

  • Length: 477
  • Mass: 54418
  • Checksum: ECA4010661ADD28A
  • Sequence:
    • MEAVELARKL QEEATCSICL DYFTDPVMTT CGHNFCRACI QLSWEKARGK KGRRKRKGSF 
PCPECREMSP QRNLLPNRLL TKVAEMAQQH PGLQKQDLCQ EHHEPLKLFC QKDQSPICVV 
CRESREHRLH RVLPAEEAVQ GYKLKLEEDM EYLREQITRT GNLQAREEQS LAEWQGKVKE 
RRERIVLEFE KMNLYLVEEE QRLLQALETE EEETASRLRE SVACLDRQGH SLELLLLQLE 
ERSTQGPLQM LQDMKEPLSR KNNVSVQCPE VAPPTRPRTV CRVPGQIEVL RGFLEDVVPD 
ATSAYPYLLL YESRQRRYLG SSPEGSGFCS KDRFVAYPCA VGQTAFSSGR HYWEVGMNIT 
GDALWALGVC RDNVSRKDRV PKCPENGFWV VQLSKGTKYL STFSALTPVM LMEPPSHMGI 
FLDFEAGEVS FYSVSDGSHL HTYSQATFPG PLQPFFCLGA PKSGQMVIST VTMWVKG

Genular Protein ID: 1022472800

Symbol: B3KP04_HUMAN

Name: N/A

UniProtKB Accession Codes:

B3KP04

Database IDs:

ARBA 3 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 2 CTD 1 DNASU 1 DisGeNET 1 EMBL 4 GO 5 Gene3D 2 InterPro 6 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 5 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 2 RefSeq 2 SMART 2 SUPFAM 2

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 262
  • Mass: 30705
  • Checksum: 92B8C61973E35371
  • Sequence:
    • MEAVELARKL QEEATCSICL DYFTDPVMTT CGHNFCRACI QLSWEKARGK KGRRKRKGSF 
PCPECREMSP QRNLLPNRLL TKVAEMAQQH PGLQKQDLCQ EHHEPLKLFC QKDQSPICVV 
CRESREHRLH RVLPAEEAVQ GYKLKLEEDM EYLREQITRT GNLQAREEQS LAEWQGKVKE 
RRERIVLEFE KMNLYLVEEE QRLLQALETE EEETASRLRE SVACLDRQGH SLELLLLQLE 
ERSTQGPLQM LQDMKEPLSR TT