Details for: TRIM17

Gene ID: 51127

Symbol: TRIM17

Ensembl ID: ENSG00000162931

Description: tripartite motif containing 17

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 16.8741
    Cell Significance Index: -4.2800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 9.7229
    Cell Significance Index: -3.9500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 4.1477
    Cell Significance Index: -3.9600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 3.4876
    Cell Significance Index: -4.3000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 1.5811
    Cell Significance Index: 96.9400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.3254
    Cell Significance Index: 28.7200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.0787
    Cell Significance Index: 34.5500
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.6380
    Cell Significance Index: 5.7900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.5725
    Cell Significance Index: 21.6800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.5320
    Cell Significance Index: 23.5300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5020
    Cell Significance Index: 95.5400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3156
    Cell Significance Index: 31.2200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2719
    Cell Significance Index: 54.5400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2633
    Cell Significance Index: 237.7100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.2477
    Cell Significance Index: 5.2800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2322
    Cell Significance Index: 12.0600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1769
    Cell Significance Index: 19.2400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.1727
    Cell Significance Index: 3.3700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1668
    Cell Significance Index: 27.1400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1443
    Cell Significance Index: 8.6600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1277
    Cell Significance Index: 25.3400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.1209
    Cell Significance Index: 3.4500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.1162
    Cell Significance Index: 7.8100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.1123
    Cell Significance Index: 2.4600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1070
    Cell Significance Index: 74.0100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0932
    Cell Significance Index: 4.7100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0902
    Cell Significance Index: 1.2300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0805
    Cell Significance Index: 1.3800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0794
    Cell Significance Index: 5.4900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.0755
    Cell Significance Index: 0.7000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0443
    Cell Significance Index: 7.9800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0435
    Cell Significance Index: 15.6200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0265
    Cell Significance Index: 0.5500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0196
    Cell Significance Index: 0.8900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0153
    Cell Significance Index: 0.8600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0148
    Cell Significance Index: 0.5200
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.0137
    Cell Significance Index: 0.2200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0107
    Cell Significance Index: 1.2500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0107
    Cell Significance Index: 0.5000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0078
    Cell Significance Index: 0.4800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0071
    Cell Significance Index: 13.1700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0070
    Cell Significance Index: 13.1400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0067
    Cell Significance Index: 10.3100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0059
    Cell Significance Index: 0.1700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0039
    Cell Significance Index: 5.2500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0025
    Cell Significance Index: 0.3600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0001
    Cell Significance Index: -0.0300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0003
    Cell Significance Index: -0.0400
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0005
    Cell Significance Index: -0.0200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0010
    Cell Significance Index: -0.5600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0047
    Cell Significance Index: -2.9900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0056
    Cell Significance Index: -0.1400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0057
    Cell Significance Index: -4.2400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0059
    Cell Significance Index: -2.6600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0059
    Cell Significance Index: -4.3000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0062
    Cell Significance Index: -0.7600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0062
    Cell Significance Index: -4.6800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0062
    Cell Significance Index: -0.8500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0070
    Cell Significance Index: -3.9700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0117
    Cell Significance Index: -3.3700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0126
    Cell Significance Index: -0.8900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0187
    Cell Significance Index: -0.5100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0223
    Cell Significance Index: -3.8000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0225
    Cell Significance Index: -2.9100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0227
    Cell Significance Index: -4.7900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0235
    Cell Significance Index: -2.6900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0249
    Cell Significance Index: -1.9100
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0273
    Cell Significance Index: -0.8700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0311
    Cell Significance Index: -3.1800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0340
    Cell Significance Index: -4.0200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0377
    Cell Significance Index: -1.3100
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.0378
    Cell Significance Index: -0.6000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0394
    Cell Significance Index: -4.1000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0399
    Cell Significance Index: -1.2700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0496
    Cell Significance Index: -0.7100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0525
    Cell Significance Index: -1.7200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0559
    Cell Significance Index: -4.4300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0586
    Cell Significance Index: -4.3700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0602
    Cell Significance Index: -3.1600
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.0612
    Cell Significance Index: -0.5200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0648
    Cell Significance Index: -1.8100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0679
    Cell Significance Index: -3.1900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0713
    Cell Significance Index: -2.1000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0724
    Cell Significance Index: -4.6700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0726
    Cell Significance Index: -3.7800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0739
    Cell Significance Index: -2.5900
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0863
    Cell Significance Index: -0.9400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0884
    Cell Significance Index: -2.3700
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0936
    Cell Significance Index: -1.4100
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0938
    Cell Significance Index: -2.3400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0955
    Cell Significance Index: -2.2900
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0991
    Cell Significance Index: -2.4000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1024
    Cell Significance Index: -3.7600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1056
    Cell Significance Index: -2.8200
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1061
    Cell Significance Index: -2.1300
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1152
    Cell Significance Index: -2.4900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1168
    Cell Significance Index: -3.4300
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1168
    Cell Significance Index: -2.3100
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.1192
    Cell Significance Index: -1.1300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1218
    Cell Significance Index: -3.1300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **E3 ubiquitin-protein ligase activity**: TRIM17 possesses E3 ubiquitin-protein ligase activity, which enables it to catalyze the transfer of ubiquitin molecules to specific target proteins, regulating their degradation, localization, and activity. 2. **Autophagy regulation**: TRIM17 is involved in the regulation of autophagy, a critical cellular process for maintaining protein homeostasis, recycling cellular components, and responding to stress. 3. **Cytokine signaling**: TRIM17 modulates cytokine signaling pathways, influencing immune responses, inflammation, and tissue homeostasis. 4. **Protein binding and ubiquitination**: TRIM17 interacts with various proteins, leading to their ubiquitination and subsequent degradation, which regulates protein turnover and cellular processes. **Pathways and Functions:** 1. **Autophagy pathway**: TRIM17 regulates autophagy by targeting key autophagy-related proteins, such as LC3 and ATG7, for ubiquitination and degradation. 2. **Cytokine signaling pathway**: TRIM17 modulates cytokine signaling by interacting with cytokine receptors, such as IL-12Rβ1, and influencing the activity of downstream signaling molecules. 3. **Protein degradation pathway**: TRIM17 regulates protein degradation by targeting proteins for ubiquitination and degradation, which maintains protein homeostasis and prevents protein accumulation. 4. **Regulation of gene expression**: TRIM17 regulates gene expression by interacting with transcription factors, such as NF-κB, and influencing the expression of target genes involved in immune responses and autophagy. **Clinical Significance:** 1. **Immune disorders**: TRIM17 dysregulation has been implicated in various immune disorders, including autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis, and infectious diseases, such as tuberculosis and HIV-1 infection. 2. **Cancer**: TRIM17 has been identified as a potential oncogene, contributing to cancer progression and metastasis by regulating autophagy and immune evasion. 3. **Neurological disorders**: TRIM17 has been implicated in neurological disorders, such as Alzheimer's disease and Parkinson's disease, where it regulates autophagy and protein degradation. 4. **Vaccine development**: TRIM17 has been identified as a potential target for vaccine development, as it plays a critical role in regulating immune responses and autophagy. In conclusion, TRIM17 is a multifaceted regulator of immune cell function, autophagy, and protein degradation. Its dysregulation has been implicated in various diseases, making it a promising target for therapeutic interventions and vaccine development. Further research is needed to fully elucidate the mechanisms of TRIM17 and its role in maintaining cellular homeostasis and responding to stress.

Genular Protein ID: 2233102933

Symbol: TRI17_HUMAN

Name: E3 ubiquitin-protein ligase TRIM17

UniProtKB Accession Codes:

Q9Y577 B4DVJ2 Q5VST8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 3 CTD 1 ChEBI 4 DMDM 1 DNASU 1 DisGeNET 1 EC 2 EMBL 5 Ensembl 4 ExpressionAtlas 1 GO 12 Gene3D 3 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 13 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 1 RefSeq 6 SIGNOR 1 SMART 4 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9792805

Title: Molecular cloning of a novel RING finger-B box-coiled coil (RBCC) protein, terf, expressed in the testis.

PubMed ID: 9792805

DOI: 10.1006/bbrc.1998.9502

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19358823

Title: TRIM44 interacts with and stabilizes terf, a TRIM ubiquitin E3 ligase.

PubMed ID: 19358823

DOI: 10.1016/j.bbrc.2009.04.010

PubMed ID: 22023800

Title: Terf/TRIM17 stimulates degradation of kinetochore protein ZWINT and regulates cell proliferation.

PubMed ID: 22023800

DOI: 10.1093/jb/mvr128

PubMed ID: 27562068

Title: TRIM17 contributes to autophagy of midbodies while actively sparing other targets from degradation.

PubMed ID: 27562068

DOI: 10.1242/jcs.190017

PubMed ID: 30042493

Title: TRIM17 and TRIM28 antagonistically regulate the ubiquitination and anti-apoptotic activity of BCL2A1.

PubMed ID: 30042493

DOI: 10.1038/s41418-018-0169-5

Sequence Information:

  • Length: 477
  • Mass: 54418
  • Checksum: ECA4010661ADD28A
  • Sequence:
    • MEAVELARKL QEEATCSICL DYFTDPVMTT CGHNFCRACI QLSWEKARGK KGRRKRKGSF 
PCPECREMSP QRNLLPNRLL TKVAEMAQQH PGLQKQDLCQ EHHEPLKLFC QKDQSPICVV 
CRESREHRLH RVLPAEEAVQ GYKLKLEEDM EYLREQITRT GNLQAREEQS LAEWQGKVKE 
RRERIVLEFE KMNLYLVEEE QRLLQALETE EEETASRLRE SVACLDRQGH SLELLLLQLE 
ERSTQGPLQM LQDMKEPLSR KNNVSVQCPE VAPPTRPRTV CRVPGQIEVL RGFLEDVVPD 
ATSAYPYLLL YESRQRRYLG SSPEGSGFCS KDRFVAYPCA VGQTAFSSGR HYWEVGMNIT 
GDALWALGVC RDNVSRKDRV PKCPENGFWV VQLSKGTKYL STFSALTPVM LMEPPSHMGI 
FLDFEAGEVS FYSVSDGSHL HTYSQATFPG PLQPFFCLGA PKSGQMVIST VTMWVKG

Genular Protein ID: 1022472800

Symbol: B3KP04_HUMAN

Name: N/A

UniProtKB Accession Codes:

B3KP04

Database IDs:

ARBA 3 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 2 CTD 1 DNASU 1 DisGeNET 1 EMBL 4 GO 5 Gene3D 2 InterPro 6 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 5 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 2 RefSeq 2 SMART 2 SUPFAM 2

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 262
  • Mass: 30705
  • Checksum: 92B8C61973E35371
  • Sequence:
    • MEAVELARKL QEEATCSICL DYFTDPVMTT CGHNFCRACI QLSWEKARGK KGRRKRKGSF 
PCPECREMSP QRNLLPNRLL TKVAEMAQQH PGLQKQDLCQ EHHEPLKLFC QKDQSPICVV 
CRESREHRLH RVLPAEEAVQ GYKLKLEEDM EYLREQITRT GNLQAREEQS LAEWQGKVKE 
RRERIVLEFE KMNLYLVEEE QRLLQALETE EEETASRLRE SVACLDRQGH SLELLLLQLE 
ERSTQGPLQM LQDMKEPLSR TT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.