Details for: C3orf18

Gene ID: 51161

Symbol: C3orf18

Ensembl ID: ENSG00000088543

Description: chromosome 3 open reading frame 18

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 41.0170
    Cell Significance Index: -6.3800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 24.6803
    Cell Significance Index: -6.2600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 2.2696
    Cell Significance Index: -6.0800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 1.6269
    Cell Significance Index: -6.4200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 1.4130
    Cell Significance Index: -4.3400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.9374
    Cell Significance Index: 59.0800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.7947
    Cell Significance Index: 11.3800
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.4881
    Cell Significance Index: 3.0200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3193
    Cell Significance Index: 60.7600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.2850
    Cell Significance Index: 82.0000
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.2647
    Cell Significance Index: 3.1600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.2384
    Cell Significance Index: 5.2200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.2131
    Cell Significance Index: 11.1900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1740
    Cell Significance Index: 17.2100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1674
    Cell Significance Index: 33.5900
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.1596
    Cell Significance Index: 2.5600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1401
    Cell Significance Index: 126.4800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1222
    Cell Significance Index: 9.3800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.1194
    Cell Significance Index: 2.5000
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.1013
    Cell Significance Index: 1.6100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0904
    Cell Significance Index: 14.7000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0718
    Cell Significance Index: 9.2100
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.0680
    Cell Significance Index: 1.1200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.0617
    Cell Significance Index: 6.7200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0583
    Cell Significance Index: 8.0100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0538
    Cell Significance Index: 19.2800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0353
    Cell Significance Index: 0.5900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0330
    Cell Significance Index: 6.5400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0272
    Cell Significance Index: 1.2700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0263
    Cell Significance Index: 0.5600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0251
    Cell Significance Index: 0.4300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0227
    Cell Significance Index: 1.0100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0216
    Cell Significance Index: 0.7600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0143
    Cell Significance Index: 0.5400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0123
    Cell Significance Index: 23.1700
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.0112
    Cell Significance Index: 0.2400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0106
    Cell Significance Index: 1.2300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0097
    Cell Significance Index: 0.5800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0083
    Cell Significance Index: 0.1800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0051
    Cell Significance Index: 2.2500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0041
    Cell Significance Index: 0.2900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.0036
    Cell Significance Index: 0.1300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0012
    Cell Significance Index: 2.1600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0006
    Cell Significance Index: 0.3600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0003
    Cell Significance Index: -0.4300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0007
    Cell Significance Index: -0.3400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0022
    Cell Significance Index: -1.5900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0026
    Cell Significance Index: -3.5900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0033
    Cell Significance Index: -0.4800
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.0052
    Cell Significance Index: -0.0400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0053
    Cell Significance Index: -2.8900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0066
    Cell Significance Index: -4.8900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0069
    Cell Significance Index: -0.2000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0074
    Cell Significance Index: -5.5900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0080
    Cell Significance Index: -0.2000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0081
    Cell Significance Index: -4.5600
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.0095
    Cell Significance Index: -0.0800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0104
    Cell Significance Index: -6.5000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0109
    Cell Significance Index: -0.6700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0117
    Cell Significance Index: -2.1100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0129
    Cell Significance Index: -2.2100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0147
    Cell Significance Index: -0.9000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0152
    Cell Significance Index: -0.6900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0164
    Cell Significance Index: -1.8800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0191
    Cell Significance Index: -1.9500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0215
    Cell Significance Index: -0.5800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0220
    Cell Significance Index: -0.6500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0298
    Cell Significance Index: -3.6700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0300
    Cell Significance Index: -6.3200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0323
    Cell Significance Index: -0.6700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0332
    Cell Significance Index: -2.3500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0353
    Cell Significance Index: -0.7500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0359
    Cell Significance Index: -4.6400
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0366
    Cell Significance Index: -0.5400
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.0390
    Cell Significance Index: -0.5000
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0395
    Cell Significance Index: -0.4300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0399
    Cell Significance Index: -1.0500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0431
    Cell Significance Index: -1.3800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0497
    Cell Significance Index: -5.8600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0528
    Cell Significance Index: -2.7500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0558
    Cell Significance Index: -4.1600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0560
    Cell Significance Index: -5.8300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0567
    Cell Significance Index: -3.1800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0644
    Cell Significance Index: -5.1000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0732
    Cell Significance Index: -4.9200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0803
    Cell Significance Index: -2.1900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0814
    Cell Significance Index: -5.2500
  • Cell Name: urothelial cell (CL0000731)
    Fold Change: -0.0860
    Cell Significance Index: -0.6000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0877
    Cell Significance Index: -4.1200
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.0941
    Cell Significance Index: -0.8000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0984
    Cell Significance Index: -2.3600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1004
    Cell Significance Index: -2.5800
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.1018
    Cell Significance Index: -0.8400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1115
    Cell Significance Index: -3.9100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1134
    Cell Significance Index: -3.1700
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.1157
    Cell Significance Index: -2.0000
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1163
    Cell Significance Index: -2.3000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1174
    Cell Significance Index: -3.7400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1179
    Cell Significance Index: -3.8600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1184
    Cell Significance Index: -3.3800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** The C3orf18 gene is a non-coding gene, meaning it does not encode a protein that is directly involved in the synthesis of a specific protein. Instead, it is thought to play a regulatory role in the expression of other genes. The gene is specifically expressed in various cell types, including hematopoietic cells, T cells, and regulatory T cells, which suggests its involvement in immune system function. The expression patterns of C3orf18 are unique, with a high level of expression in polychromatophilic erythroblasts, a type of immature red blood cell. This suggests that the C3orf18 gene may play a role in the development and maturation of red blood cells. **Pathways and Functions** The C3orf18 gene is involved in several cellular pathways, including membrane-related functions. The gene is enriched in pathways related to cell signaling, including the phosphatidylinositol 3-kinase (PI3K) pathway and the mitogen-activated protein kinase (MAPK) pathway. These pathways are involved in various cellular processes, including cell proliferation, differentiation, and survival. The C3orf18 gene is also involved in the regulation of gene expression, particularly in the context of immune cell development and function. One of the most significant pathways associated with C3orf18 is the regulation of T cell development and function. The gene is specifically expressed in CD8+ alpha-beta+ T cells, a type of cytotoxic T cell, and regulatory T cells, which are essential for maintaining immune tolerance. The C3orf18 gene is thought to play a role in the regulation of T cell receptor signaling and the development of T cell subsets. **Clinical Significance** The C3orf18 gene has significant clinical implications, particularly in the context of immune system disorders. The gene's expression in hematopoietic cells and immune cells suggests that it may play a role in the development and maintenance of immune system function. Abnormal expression of C3orf18 has been implicated in several diseases, including autoimmune disorders, such as multiple sclerosis and type 1 diabetes, as well as cancer. Furthermore, the C3orf18 gene has been identified as a potential therapeutic target for the treatment of immune system disorders. The gene's involvement in T cell development and function makes it an attractive target for the development of immunotherapies, such as checkpoint inhibitors, which can modulate T cell activity and improve immune responses. In conclusion, the C3orf18 gene is a complex and multifunctional gene that plays a significant role in immune system function. Its unique expression patterns and involvement in various cellular pathways make it an attractive target for further research and potential therapeutic applications. As our understanding of the C3orf18 gene continues to evolve, it is likely that we will uncover new insights into its role in human health and disease.

Genular Protein ID: 3371374694

Symbol: CC018_HUMAN

Name: Uncharacterized protein C3orf18

UniProtKB Accession Codes:

Q9UK00 C9JNP0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 4 ExpressionAtlas 1 GO 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 RefSeq 6 SMR 1 STRING 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 162
  • Mass: 17468
  • Checksum: D5B5DEFFE0E06D6E
  • Sequence:
    • MNSRTASARG WFSSRPPTSE SDLEPATDGP ASETTTLSPE ATTFNDTRIP DAAGGTAGVG 
TMLLSFGIIT VIGLAVALVL YIRKKKRLEK LRHQLMPMYN FDPTEEQDEL EQELLEHGRD 
AASVQAATSV QAMQGKTTLP SQGPLQRPSR LVFTDVANAI HA

Genular Protein ID: 1971249950

Symbol: Q6ZP18_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q6ZP18

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 NCBI Taxonomy 1 OrthoDB 1 RefSeq 4 SAM 1

Sequence Information:

  • Length: 160
  • Mass: 17363
  • Checksum: 206DCA6BD25B5693
  • Sequence:
    • MELKLSSMQG CQEKGNSHPG SIHTTEGPGG LPATHPWQPD VTGAKLGWEL RGKEVGEWKW 
KDAAPPDLPR GLMHVHECAH GQTCACPSTA GRMRLSTLAP PSKSTSTPWY VVEHQGRLSS 
LPSIFRDCRE EGSTHSTVPL STALFHWAHL LLKTAPCLGL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.