Details for: HSD17B14

Gene ID: 51171

Symbol: HSD17B14

Ensembl ID: ENSG00000087076

Description: hydroxysteroid 17-beta dehydrogenase 14

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 83.3198
    Cell Significance Index: -12.9600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 47.9610
    Cell Significance Index: -12.1700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 10.5113
    Cell Significance Index: -12.9600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.2868
    Cell Significance Index: -12.9700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 2.1668
    Cell Significance Index: 46.9400
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.9921
    Cell Significance Index: 31.9600
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 1.6961
    Cell Significance Index: 27.9500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.3756
    Cell Significance Index: 62.3500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.9284
    Cell Significance Index: 48.2300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.8516
    Cell Significance Index: 27.2800
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.7753
    Cell Significance Index: 6.1900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.6817
    Cell Significance Index: 35.7900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6489
    Cell Significance Index: 64.2000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5928
    Cell Significance Index: 112.8100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5830
    Cell Significance Index: 526.4000
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.5825
    Cell Significance Index: 4.7500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.5103
    Cell Significance Index: 101.2800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.4719
    Cell Significance Index: 12.6500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3573
    Cell Significance Index: 49.0700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3336
    Cell Significance Index: 66.9200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3247
    Cell Significance Index: 52.8000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2938
    Cell Significance Index: 31.9600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2817
    Cell Significance Index: 36.1100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2282
    Cell Significance Index: 81.8700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.2268
    Cell Significance Index: 4.8300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.2013
    Cell Significance Index: 125.6800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2003
    Cell Significance Index: 36.1100
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.1528
    Cell Significance Index: 1.8900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1466
    Cell Significance Index: 10.1400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1426
    Cell Significance Index: 8.5600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1425
    Cell Significance Index: 268.2800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.1042
    Cell Significance Index: 0.9600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.1019
    Cell Significance Index: 2.9200
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.0935
    Cell Significance Index: 1.1600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0824
    Cell Significance Index: 56.9700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0768
    Cell Significance Index: 9.4500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0666
    Cell Significance Index: 42.3200
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.0262
    Cell Significance Index: 0.2000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0117
    Cell Significance Index: 0.4100
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.0113
    Cell Significance Index: 0.1900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0097
    Cell Significance Index: 0.2800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0086
    Cell Significance Index: 1.0100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0069
    Cell Significance Index: 10.6200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0043
    Cell Significance Index: 7.9500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0035
    Cell Significance Index: 2.6800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.0025
    Cell Significance Index: 1.8300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0017
    Cell Significance Index: -0.7400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0035
    Cell Significance Index: -0.5100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0070
    Cell Significance Index: -5.1200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0077
    Cell Significance Index: -10.5300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0091
    Cell Significance Index: -0.9300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0100
    Cell Significance Index: -5.6500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0138
    Cell Significance Index: -7.5200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0143
    Cell Significance Index: -3.0200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0152
    Cell Significance Index: -6.9100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0152
    Cell Significance Index: -0.4000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0160
    Cell Significance Index: -0.8100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0207
    Cell Significance Index: -3.5300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0228
    Cell Significance Index: -1.0100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0278
    Cell Significance Index: -8.0000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0560
    Cell Significance Index: -2.1200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0612
    Cell Significance Index: -1.0300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0616
    Cell Significance Index: -7.9600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0628
    Cell Significance Index: -1.5700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0662
    Cell Significance Index: -1.1400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0724
    Cell Significance Index: -7.5400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0824
    Cell Significance Index: -9.4500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0897
    Cell Significance Index: -6.0300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0927
    Cell Significance Index: -7.3400
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.0927
    Cell Significance Index: -1.4700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0932
    Cell Significance Index: -1.9500
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0933
    Cell Significance Index: -10.6500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0963
    Cell Significance Index: -6.0700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0988
    Cell Significance Index: -2.7600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1051
    Cell Significance Index: -12.4000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1155
    Cell Significance Index: -8.8600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1245
    Cell Significance Index: -9.2800
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: -0.1282
    Cell Significance Index: -1.0600
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.1291
    Cell Significance Index: -1.6300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1339
    Cell Significance Index: -8.2100
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.1347
    Cell Significance Index: -1.6800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1529
    Cell Significance Index: -7.1300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1625
    Cell Significance Index: -3.3700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1664
    Cell Significance Index: -4.5300
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1666
    Cell Significance Index: -1.7300
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.1683
    Cell Significance Index: -2.9100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1811
    Cell Significance Index: -8.5100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1865
    Cell Significance Index: -5.9400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1900
    Cell Significance Index: -11.6800
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.1950
    Cell Significance Index: -3.2900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1962
    Cell Significance Index: -12.6600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1987
    Cell Significance Index: -11.1500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2145
    Cell Significance Index: -11.1800
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.2203
    Cell Significance Index: -3.0800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2251
    Cell Significance Index: -7.3700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2309
    Cell Significance Index: -8.0900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.2572
    Cell Significance Index: -6.4200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2572
    Cell Significance Index: -6.8800
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.2645
    Cell Significance Index: -2.0400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2798
    Cell Significance Index: -8.2400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** HSD17B14 is a cytosolic enzyme that belongs to the short-chain dehydrogenase/reductase superfamily. Its primary function is to catalyze the interconversion of 17-hydroxyprogesterone to 17-hydroxyestrone, a key step in the biosynthesis of estrogens. This enzyme is significantly expressed in various cell types, including polychromatophilic erythroblast, hematopoietic oligopotent progenitor cell, and stromal cell of bone marrow. Its expression is also found in epithelial cells of the pancreas, enterocytes of the large intestine, bladder urothelial cells, and Paneth cells of the small intestine. **Pathways and Functions:** HSD17B14 is involved in several metabolic pathways, including: 1. **Estrogen biosynthesis:** The enzyme plays a crucial role in the conversion of 17-hydroxyprogesterone to 17-hydroxyestrone, a precursor in the biosynthesis of estrogens. 2. **Steroid catabolic process:** HSD17B14 is also involved in the degradation of steroids, such as testosterone and estrogen. 3. **Metabolism of lipids and steroids:** The enzyme is involved in the regulation of lipid and steroid metabolism, which is essential for maintaining cellular homeostasis. 4. **Protein binding:** HSD17B14 interacts with various proteins, including chaperones and co-chaperones, to regulate enzyme activity. **Clinical Significance:** Dysregulation of HSD17B14 has been implicated in various diseases, including: 1. **Reproductive disorders:** Alterations in HSD17B14 expression have been linked to reproductive disorders, such as polycystic ovary syndrome (PCOS) and endometriosis. 2. **Cancer:** The enzyme has been found to be overexpressed in certain types of cancer, including breast and ovarian cancer. 3. **Autoimmune diseases:** HSD17B14 has been implicated in the pathogenesis of autoimmune diseases, such as multiple sclerosis and type 1 diabetes. In conclusion, HSD17B14 is a multifunctional enzyme that plays a crucial role in regulating steroid hormone metabolism, lipid, and steroid metabolism. Its dysregulation has been implicated in various diseases, highlighting the importance of understanding its mechanisms and functions in the context of human health and disease.

Genular Protein ID: 3357174800

Symbol: DHB14_HUMAN

Name: 17-beta-hydroxysteroid dehydrogenase DHRS10

UniProtKB Accession Codes:

Q9BPX1 Q9UKU3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 12 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 4 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 5 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 31 PDBsum 31 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 Rhea 4 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissLipids 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 10800688

Title: Short-chain dehydrogenases/reductases in retina.

PubMed ID: 10800688

DOI: 10.1016/s0076-6879(00)16736-9

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17067289

Title: Structural and biochemical characterization of human orphan DHRS10 reveals a novel cytosolic enzyme with steroid dehydrogenase activity.

PubMed ID: 17067289

DOI: 10.1042/bj20061319

Sequence Information:

  • Length: 270
  • Mass: 28317
  • Checksum: DAB68FB8CA422ABC
  • Sequence:
    • MATGTRYAGK VVVVTGGGRG IGAGIVRAFV NSGARVVICD KDESGGRALE QELPGAVFIL 
CDVTQEDDVK TLVSETIRRF GRLDCVVNNA GHHPPPQRPE ETSAQGFRQL LELNLLGTYT 
LTKLALPYLR KSQGNVINIS SLVGAIGQAQ AVPYVATKGA VTAMTKALAL DESPYGVRVN 
CISPGNIWTP LWEELAALMP DPRATIREGM LAQPLGRMGQ PAEVGAAAVF LASEANFCTG 
IELLVTGGAE LGYGCKASRS TPVDAPDIPS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.