Details for: HGH1

Gene ID: 51236

Symbol: HGH1

Ensembl ID: ENSG00000235173

Description: HGH1 homolog

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 14.8182
    Cell Significance Index: -6.0200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 6.3577
    Cell Significance Index: -6.0700
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.7515
    Cell Significance Index: 28.1000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.0089
    Cell Significance Index: 99.8100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.7971
    Cell Significance Index: 47.8600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7412
    Cell Significance Index: 669.2200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.7235
    Cell Significance Index: 78.7000
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.6790
    Cell Significance Index: 9.5300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5721
    Cell Significance Index: 93.0500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3734
    Cell Significance Index: 25.8300
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.2941
    Cell Significance Index: 4.0800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2471
    Cell Significance Index: 47.0200
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.2447
    Cell Significance Index: 2.6600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2131
    Cell Significance Index: 13.7500
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.1651
    Cell Significance Index: 1.5200
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.1627
    Cell Significance Index: 1.0800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1524
    Cell Significance Index: 7.9200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1491
    Cell Significance Index: 20.4800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.1418
    Cell Significance Index: 1.9400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1364
    Cell Significance Index: 9.6500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.1361
    Cell Significance Index: 4.7300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1272
    Cell Significance Index: 25.2400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1134
    Cell Significance Index: 7.1500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1090
    Cell Significance Index: 3.1400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1047
    Cell Significance Index: 57.1600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1005
    Cell Significance Index: 2.1400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.0898
    Cell Significance Index: 1.8800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0859
    Cell Significance Index: 37.9800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0803
    Cell Significance Index: 1.7400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.0801
    Cell Significance Index: 8.1800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0768
    Cell Significance Index: 3.5800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0575
    Cell Significance Index: 6.7800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0517
    Cell Significance Index: 9.3300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0505
    Cell Significance Index: 1.4100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0449
    Cell Significance Index: 2.3400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.0414
    Cell Significance Index: 0.4700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0369
    Cell Significance Index: 4.7300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0361
    Cell Significance Index: 7.2400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0208
    Cell Significance Index: 2.5600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0182
    Cell Significance Index: 0.6400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.0176
    Cell Significance Index: 0.4700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0161
    Cell Significance Index: 2.0800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.0118
    Cell Significance Index: 0.3100
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.0094
    Cell Significance Index: 0.1200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0074
    Cell Significance Index: 2.6600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0024
    Cell Significance Index: 0.2700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0008
    Cell Significance Index: 0.5800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0015
    Cell Significance Index: -1.0100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0025
    Cell Significance Index: -4.7600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0046
    Cell Significance Index: -0.2300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0047
    Cell Significance Index: -8.7500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0055
    Cell Significance Index: -8.4700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0059
    Cell Significance Index: -4.3600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0067
    Cell Significance Index: -9.0500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0071
    Cell Significance Index: -0.3300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0072
    Cell Significance Index: -4.5800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0092
    Cell Significance Index: -0.2300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0097
    Cell Significance Index: -7.2100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0110
    Cell Significance Index: -0.3000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0125
    Cell Significance Index: -7.0600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0141
    Cell Significance Index: -6.4000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0153
    Cell Significance Index: -9.5700
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0180
    Cell Significance Index: -0.7400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0189
    Cell Significance Index: -1.4100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0197
    Cell Significance Index: -0.9000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0201
    Cell Significance Index: -3.4400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0235
    Cell Significance Index: -6.7500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0257
    Cell Significance Index: -3.7300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0303
    Cell Significance Index: -0.8100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0313
    Cell Significance Index: -3.6500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0391
    Cell Significance Index: -8.2400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0391
    Cell Significance Index: -1.0000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0488
    Cell Significance Index: -2.9900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0525
    Cell Significance Index: -1.6800
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.0530
    Cell Significance Index: -0.7600
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: -0.0573
    Cell Significance Index: -0.3800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0640
    Cell Significance Index: -6.6600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0661
    Cell Significance Index: -5.0800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0721
    Cell Significance Index: -4.8500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0777
    Cell Significance Index: -6.1500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0840
    Cell Significance Index: -4.4100
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.0857
    Cell Significance Index: -1.3600
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0869
    Cell Significance Index: -1.3100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0876
    Cell Significance Index: -1.2600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1027
    Cell Significance Index: -6.3100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1037
    Cell Significance Index: -5.8200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1059
    Cell Significance Index: -3.0400
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.1064
    Cell Significance Index: -1.7900
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.1224
    Cell Significance Index: -2.1100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1354
    Cell Significance Index: -5.9900
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.1390
    Cell Significance Index: -1.9500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1407
    Cell Significance Index: -4.9300
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.1459
    Cell Significance Index: -1.2400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1497
    Cell Significance Index: -4.4100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1501
    Cell Significance Index: -4.7800
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.1503
    Cell Significance Index: -0.9800
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.1535
    Cell Significance Index: -1.0400
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: -0.1552
    Cell Significance Index: -0.3500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1582
    Cell Significance Index: -5.1800
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.1583
    Cell Significance Index: -2.0000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The HGH1 gene shares homology with other genes, suggesting a conserved evolutionary origin. It is primarily expressed in specific cell types, including those involved in immune responses, such as mucosal type mast cells and epithelial cells of the small intestine. The gene's expression pattern is highly specific, indicating a specialized role in cellular function. Furthermore, the HGH1 gene is involved in protein binding, which is a critical aspect of many biological processes. **Pathways and Functions:** The HGH1 gene is involved in several biological pathways, including: 1. **Cellular proliferation and differentiation**: The HGH1 gene plays a crucial role in regulating cellular proliferation and differentiation, particularly in the context of immune responses. 2. **Protein binding**: The HGH1 gene is involved in protein binding, which is essential for various cellular processes, including signal transduction and protein-protein interactions. 3. **Molecular function**: The HGH1 gene is involved in molecular function, including protein-protein interactions, protein-ligand binding, and cell signaling. **Clinical Significance:** The HGH1 gene has significant clinical implications in the context of immunology. Abnormalities in the HGH1 gene have been implicated in various diseases, including: 1. **Allergic disorders**: The HGH1 gene is involved in the regulation of immune responses, particularly in the context of allergic disorders. 2. **Cancer**: The HGH1 gene has been implicated in cancer, particularly in the context of tumor progression and metastasis. 3. **Inflammatory diseases**: The HGH1 gene is involved in the regulation of inflammatory responses, particularly in the context of inflammatory diseases, such as asthma and rheumatoid arthritis. In conclusion, the HGH1 gene is a fascinating gene that has significant implications for our understanding of immunology. Further research is needed to fully elucidate the biological functions and clinical significance of this gene.

Genular Protein ID: 2537761399

Symbol: HGH1_HUMAN

Name: Protein HGH1 homolog

UniProtKB Accession Codes:

Q9BTY7 P0CB43

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 1 ExpressionAtlas 1 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 Pumba 1 RNAct 1 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

Sequence Information:

  • Length: 390
  • Mass: 42129
  • Checksum: DC3AA4E92EA3761D
  • Sequence:
    • MGEAGAGAGA SGGPEASPEA EVVKLLPFLA PGARADLQAA AVRHVLALTG CGPGRALLAG 
QAALLQALME LAPASAPARD AARALVNLAA DPGLHETLLA ADPGLPARLM GRALDPQWPW 
AEEAAAALAN LSREPAPCAA LMAALAAAEP ADSGLERLVR ALCTPGYNAR APLHYLAPLL 
SNLSQRPAAR AFLLDPDRCV VQRLLPLTQY PDSSVRRGGV VGTLRNCCFE HRHHEWLLGP 
EVDILPFLLL PLAGPEDFSE EEMERLPVDL QYLPPDKQRE PDADIRKMLV EAIMLLTATA 
PGRQQVRDQG AYLILRELHS WEPEPDVRTA CEKLIQVLIG DEPERGMENL LEVQVPEDVE 
QQLQQLDCRE QEQLERELAP EPWVERATPT

Genular Protein ID: 4216976656

Symbol: Q96BK8_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q96BK8

Database IDs:

ARBA 2 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 Gene3D 1 IntAct 1 InterPro 5 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 4 RefSeq 1 SAM 1 SMR 1 SUPFAM 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 256
  • Mass: 28865
  • Checksum: D51F7044C10DBA6F
  • Sequence:
    • QQSVARHGGG RGWRWRLGRA GGKPGGRGGE AAALPGAPLH YLAPLLSNLS QRPAARAFLL 
DPDRCVVQRL LPLTQYPDSS VRRGGVVGTL RNCCFEHRHH EWLLGPEVDI LPFLLLPLAG 
PEDFSEEEMQ RLPVDLQYLP PDKQREPDAD IRKMLVEAIM LLTATAPGRQ QVRDQGAYLI 
LRELHSWEPE PDVRTACEKL IQVLIGDEPE RGMENLLEVQ VPEDVEQQLQ QLDCREQEQL 
ERELAPEPWV ERATPT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.