Details for: FAM53C

Gene ID: 51307

Symbol: FAM53C

Ensembl ID: ENSG00000120709

Description: family with sequence similarity 53 member C

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 182.7764
    Cell Significance Index: -28.4300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 107.3555
    Cell Significance Index: -27.2300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 65.8696
    Cell Significance Index: -26.7600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 58.5456
    Cell Significance Index: -30.1200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 28.2380
    Cell Significance Index: -26.9600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 24.1696
    Cell Significance Index: -29.8000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 9.9333
    Cell Significance Index: -26.6100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 7.9116
    Cell Significance Index: -24.3000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 7.7394
    Cell Significance Index: -30.5400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.6605
    Cell Significance Index: -10.2000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.6509
    Cell Significance Index: 22.5300
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.0278
    Cell Significance Index: 16.4900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.0190
    Cell Significance Index: 21.3300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.8969
    Cell Significance Index: 179.9200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.8722
    Cell Significance Index: 23.7400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.8472
    Cell Significance Index: 38.4000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.7205
    Cell Significance Index: 15.6100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.6606
    Cell Significance Index: 84.6800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.6285
    Cell Significance Index: 16.8400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.6203
    Cell Significance Index: 46.2300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5895
    Cell Significance Index: 95.8700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5657
    Cell Significance Index: 61.5300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.5291
    Cell Significance Index: 288.9400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.5169
    Cell Significance Index: 63.5600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.5081
    Cell Significance Index: 69.7800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.4877
    Cell Significance Index: 31.4700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.4845
    Cell Significance Index: 22.5900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4305
    Cell Significance Index: 154.4000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.4136
    Cell Significance Index: 19.4400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4070
    Cell Significance Index: 80.7800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3944
    Cell Significance Index: 71.1100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3904
    Cell Significance Index: 23.4400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.3602
    Cell Significance Index: 46.5300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3384
    Cell Significance Index: 9.7500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3084
    Cell Significance Index: 136.3700
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 0.2946
    Cell Significance Index: 3.1300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2922
    Cell Significance Index: 15.1800
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.2830
    Cell Significance Index: 4.2400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2668
    Cell Significance Index: 31.4600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.2590
    Cell Significance Index: 44.2200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.2532
    Cell Significance Index: 6.7600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2302
    Cell Significance Index: 15.9200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.2187
    Cell Significance Index: 7.6000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1657
    Cell Significance Index: 31.5400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1510
    Cell Significance Index: 14.9400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.1207
    Cell Significance Index: 6.3400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.1131
    Cell Significance Index: 12.9600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0762
    Cell Significance Index: 4.2700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0711
    Cell Significance Index: 1.1900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0680
    Cell Significance Index: 47.0600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0544
    Cell Significance Index: 1.9100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0367
    Cell Significance Index: 1.9100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.0353
    Cell Significance Index: 4.0300
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.0304
    Cell Significance Index: 0.3300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0174
    Cell Significance Index: 32.7500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0136
    Cell Significance Index: 1.0400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0029
    Cell Significance Index: 1.8400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0040
    Cell Significance Index: -7.3200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0046
    Cell Significance Index: -7.0300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0063
    Cell Significance Index: -0.3800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0076
    Cell Significance Index: -5.6100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0079
    Cell Significance Index: -10.7000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0105
    Cell Significance Index: -6.5700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0165
    Cell Significance Index: -7.5100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0176
    Cell Significance Index: -12.8900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0288
    Cell Significance Index: -21.8200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0291
    Cell Significance Index: -2.9700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0401
    Cell Significance Index: -22.5900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0479
    Cell Significance Index: -3.3900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0546
    Cell Significance Index: -0.9400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0704
    Cell Significance Index: -4.4400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0795
    Cell Significance Index: -16.7600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0802
    Cell Significance Index: -2.3000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0888
    Cell Significance Index: -25.5400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0960
    Cell Significance Index: -11.1900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1023
    Cell Significance Index: -6.8800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1066
    Cell Significance Index: -2.9800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1075
    Cell Significance Index: -15.6200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.1569
    Cell Significance Index: -1.8700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1587
    Cell Significance Index: -3.3800
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.1649
    Cell Significance Index: -1.3500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1898
    Cell Significance Index: -4.9900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1987
    Cell Significance Index: -5.6700
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.2229
    Cell Significance Index: -2.8700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2609
    Cell Significance Index: -11.5400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2801
    Cell Significance Index: -29.1600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3449
    Cell Significance Index: -13.0600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3494
    Cell Significance Index: -21.4200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3495
    Cell Significance Index: -11.2000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3569
    Cell Significance Index: -28.2700
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.4355
    Cell Significance Index: -2.6800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4733
    Cell Significance Index: -13.9400
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.4976
    Cell Significance Index: -6.9800
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.4989
    Cell Significance Index: -3.3800
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.4994
    Cell Significance Index: -5.1700
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.5043
    Cell Significance Index: -11.6500
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.5441
    Cell Significance Index: -5.0100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.5985
    Cell Significance Index: -19.0600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.6002
    Cell Significance Index: -19.6500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.6223
    Cell Significance Index: -14.9300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** FAM53C exhibits a distinct pattern of expression, with notable presence in polychromatophilic erythroblast, hematopoietic oligopotent progenitor cells, mucosal type mast cells, and various immune cells, including CD8-alpha-beta-positive intraepithelial T cells, CD8-positive alpha-beta regulatory T cells, and stromal cells of bone marrow. These findings suggest that FAM53C plays a role in the development and function of immune cells. The gene's involvement in nuclear processes, as indicated by its association with protein binding, protein import into the nucleus, and pathways related to the nucleus, further underscores its potential immunological significance. **Pathways and Functions:** FAM53C's involvement in nuclear processes and protein binding pathways suggests that it may participate in regulating gene expression, DNA repair, or cell cycle progression. The gene's expression in hematopoietic cells and immune cells implies that it may play a role in the development, function, or regulation of these cells. Furthermore, the presence of FAM53C in epithelial cells, such as ciliated cells of the bronchus and epidermal Langerhans cells, hints at its potential involvement in maintaining tissue homeostasis and immune surveillance. **Clinical Significance:** The identification of FAM53C as a gene of emerging immunological significance has far-reaching implications for our understanding of human immunology. The gene's expression in immune cells and its involvement in nuclear processes may contribute to the pathogenesis of various immune-related disorders, such as autoimmune diseases, cancer, and immunodeficiency syndromes. Additionally, the gene's expression in epithelial cells may play a role in maintaining tissue homeostasis and preventing infections. Further research is needed to elucidate the functional mechanisms underlying FAM53C's immunological significance and to explore its potential as a therapeutic target for immunological disorders. In conclusion, FAM53C is a gene of emerging immunological significance, with a unique expression profile and involvement in nuclear processes. Further research is necessary to uncover the functional mechanisms underlying its immunological significance and to explore its potential as a therapeutic target for immunological disorders.

Genular Protein ID: 787574455

Symbol: FA53C_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9NYF3 B2RDJ5 D3DQB9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CPTC 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 2 ExpressionAtlas 1 GO 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 2 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11087669

Title: cDNA cloning and genomic structure of three genes localized to human chromosome band 5q31 encoding potential nuclear proteins.

PubMed ID: 11087669

DOI: 10.1006/geno.2000.6345

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 392
  • Mass: 43091
  • Checksum: 28ED288D94D81073
  • Sequence:
    • MITLITEQLQ KQTLDELKCT RFSISLPLPD HADISNCGNS FQLVSEGASW RGLPHCSCAE 
FQDSLNFSYH PSGLSLHLRP PSRGNSPKEQ PFSQVLRPEP PDPEKLPVPP APPSKRHCRS 
LSVPVDLSRW QPVWRPAPSK LWTPIKHRGS GGGGGPQVPH QSPPKRVSSL RFLQAPSASS 
QCAPAHRPYS PPFFSLALAQ DSSRPCAASP QSGSWESDAE SLSPCPPQRR FSLSPSLGPQ 
ASRFLPSARS SPASSPELPW RPRGLRNLPR SRSQPCDLDA RKTGVKRRHE EDPRRLRPSL 
DFDKMNQKPY SGGLCLQETA REGSSISPPW FMACSPPPLS ASCSPTGGSS QVLSESEEEE 
EGAVRWGRQA LSKRTLCQRD FGDLDLNLIE EN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.