Details for: NME8

Gene ID: 51314

Symbol: NME8

Ensembl ID: ENSG00000086288

Description: NME/NM23 family member 8

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 13.8223
    Cell Significance Index: -2.1500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 7.2543
    Cell Significance Index: -1.8400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 1.7681
    Cell Significance Index: -2.1800
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 1.2793
    Cell Significance Index: 5.8900
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.8572
    Cell Significance Index: 9.1200
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.5812
    Cell Significance Index: 4.9400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.4686
    Cell Significance Index: 6.7100
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.3270
    Cell Significance Index: 4.5900
  • Cell Name: trophoblast giant cell (CL0002488)
    Fold Change: 0.1624
    Cell Significance Index: 1.1700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0973
    Cell Significance Index: 11.3400
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.0704
    Cell Significance Index: 1.1600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0690
    Cell Significance Index: 3.2500
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.0404
    Cell Significance Index: 0.5100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0127
    Cell Significance Index: 8.8000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.0016
    Cell Significance Index: 0.0300
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.0010
    Cell Significance Index: 0.0200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0028
    Cell Significance Index: -2.0400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0029
    Cell Significance Index: -2.1300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0032
    Cell Significance Index: -2.4300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0034
    Cell Significance Index: -1.8800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0036
    Cell Significance Index: -2.0300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0043
    Cell Significance Index: -0.8600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0052
    Cell Significance Index: -2.3600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0055
    Cell Significance Index: -0.7000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0058
    Cell Significance Index: -1.6700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0085
    Cell Significance Index: -0.8700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0087
    Cell Significance Index: -0.4400
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0104
    Cell Significance Index: -0.1400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0119
    Cell Significance Index: -2.5000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0135
    Cell Significance Index: -1.8600
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0148
    Cell Significance Index: -0.6400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0157
    Cell Significance Index: -0.6400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0194
    Cell Significance Index: -0.5200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0206
    Cell Significance Index: -2.3600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0288
    Cell Significance Index: -1.7700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0321
    Cell Significance Index: -2.0700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0362
    Cell Significance Index: -1.6900
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0372
    Cell Significance Index: -0.9000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0380
    Cell Significance Index: -0.8000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0393
    Cell Significance Index: -2.0400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0440
    Cell Significance Index: -1.4000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0489
    Cell Significance Index: -1.6000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0496
    Cell Significance Index: -1.3500
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0528
    Cell Significance Index: -0.6900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0594
    Cell Significance Index: -2.0800
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0604
    Cell Significance Index: -1.1800
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0608
    Cell Significance Index: -0.9400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0609
    Cell Significance Index: -1.0400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0617
    Cell Significance Index: -1.3500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0631
    Cell Significance Index: -1.3400
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.0635
    Cell Significance Index: -0.9100
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0682
    Cell Significance Index: -0.9900
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0708
    Cell Significance Index: -1.4000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0708
    Cell Significance Index: -1.8900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0742
    Cell Significance Index: -1.8500
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0742
    Cell Significance Index: -1.4800
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.0747
    Cell Significance Index: -0.8800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0754
    Cell Significance Index: -2.0200
  • Cell Name: liver dendritic cell (CL2000055)
    Fold Change: -0.0796
    Cell Significance Index: -0.2100
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.0798
    Cell Significance Index: -1.2800
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0824
    Cell Significance Index: -1.7200
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0824
    Cell Significance Index: -1.4200
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0833
    Cell Significance Index: -1.8000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0833
    Cell Significance Index: -2.1900
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0842
    Cell Significance Index: -1.6900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0856
    Cell Significance Index: -1.6700
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0858
    Cell Significance Index: -2.0600
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0863
    Cell Significance Index: -2.2000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0875
    Cell Significance Index: -2.5700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0876
    Cell Significance Index: -2.5100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0896
    Cell Significance Index: -2.2900
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0896
    Cell Significance Index: -1.1400
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.0936
    Cell Significance Index: -1.0600
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: -0.0955
    Cell Significance Index: -0.9600
  • Cell Name: paneth cell (CL0000510)
    Fold Change: -0.0955
    Cell Significance Index: -0.9900
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0969
    Cell Significance Index: -1.4300
  • Cell Name: stromal cell of endometrium (CL0002255)
    Fold Change: -0.0970
    Cell Significance Index: -1.3800
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1000
    Cell Significance Index: -2.3100
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.1002
    Cell Significance Index: -1.2400
  • Cell Name: tendon cell (CL0000388)
    Fold Change: -0.1007
    Cell Significance Index: -1.3700
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.1008
    Cell Significance Index: -1.3400
  • Cell Name: pulmonary capillary endothelial cell (CL4028001)
    Fold Change: -0.1008
    Cell Significance Index: -1.3800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1012
    Cell Significance Index: -1.1500
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.1020
    Cell Significance Index: -1.3600
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.1031
    Cell Significance Index: -2.0300
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.1042
    Cell Significance Index: -0.9900
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.1046
    Cell Significance Index: -1.3200
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.1060
    Cell Significance Index: -1.6100
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.1070
    Cell Significance Index: -1.8500
  • Cell Name: immature NK T cell (CL0000914)
    Fold Change: -0.1094
    Cell Significance Index: -1.4000
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.1105
    Cell Significance Index: -1.7900
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.1112
    Cell Significance Index: -0.9900
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.1126
    Cell Significance Index: -1.3700
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.1148
    Cell Significance Index: -1.3500
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.1169
    Cell Significance Index: -1.7100
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.1173
    Cell Significance Index: -1.7100
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.1189
    Cell Significance Index: -1.6300
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.1193
    Cell Significance Index: -1.3000
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.1225
    Cell Significance Index: -1.9700
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.1229
    Cell Significance Index: -2.1000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** NME8 is a small, non-coding RNA gene that belongs to the NME/NM23 family of genes. It is characterized by its expression in various cell types, including polychromatophilic erythroblast, hematopoietic oligopotent progenitor cells, and epithelial cells of the kidney and stomach. The gene's protein product, TXND3_HUMAN, contains a thioredoxin domain, which is involved in redox reactions and the regulation of cellular redox status. **Pathways and Functions:** NME8's involvement in multiple cellular pathways highlights its importance in maintaining cellular homeostasis. Its functions include: 1. **3'-5' Exonuclease Activity**: NME8 has been shown to possess 3'-5' exonuclease activity, a crucial function in the degradation of RNA and the regulation of gene expression. 2. **Cell Differentiation**: NME8 is involved in the regulation of cell differentiation, particularly in the development of erythroblast cells and hematopoietic oligopotent progenitor cells. 3. **Cellular Response to Reactive Oxygen Species (ROS)**: The thioredoxin domain in NME8's protein product enables it to regulate redox reactions and protect cells from oxidative damage. 4. **Spermatogenesis**: NME8 is specifically expressed in spermatogenic cells, where it plays a critical role in the regulation of spermatogenesis and the development of spermatozoa. **Clinical Significance:** NME8's involvement in various cellular processes has significant implications for human health and disease. Abnormal expression of NME8 has been linked to: 1. **Cancer**: Altered expression of NME8 has been observed in various types of cancer, including leukemia, lymphoma, and breast cancer. 2. **Neurological Disorders**: NME8's role in neuronal development and function suggests that dysregulation of this gene may contribute to neurological disorders, such as Alzheimer's disease and Parkinson's disease. 3. **Reproductive Disorders**: NME8's involvement in spermatogenesis highlights its potential role in male infertility and reproductive disorders. In conclusion, NME8 is a multifaceted gene that plays a crucial role in various cellular processes, including cell differentiation, response to ROS, and spermatogenesis. Its involvement in multiple pathways and its expression in various cell types make it a valuable target for research into human health and disease. Further studies are needed to fully elucidate NME8's functions and its role in human disease.

Genular Protein ID: 1868388370

Symbol: TXND3_HUMAN

Name: Thioredoxin domain-containing protein 3

UniProtKB Accession Codes:

Q8N427 Q9NZH1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 2 ExpressionAtlas 1 GO 16 Gene3D 2 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 2 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 11768308

Title: The human Nm23/nucleoside diphosphate kinases.

PubMed ID: 11768308

DOI: 10.1023/a:1005584929050

PubMed ID: 11737268

Title: Sptrx-2, a fusion protein composed of one thioredoxin and three tandemly repeated NDP-kinase domains is expressed in human testis germ cells.

PubMed ID: 11737268

DOI: 10.1046/j.1365-2443.2001.00484.x

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16313181

Title: Characterization of the 3' --> 5' exonuclease activity found in human nucleoside diphosphate kinase 1 (NDK1) and several of its homologues.

PubMed ID: 16313181

DOI: 10.1021/bi0515974

PubMed ID: 17360648

Title: A common variant in combination with a nonsense mutation in a member of the thioredoxin family causes primary ciliary dyskinesia.

PubMed ID: 17360648

DOI: 10.1073/pnas.0611405104

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 588
  • Mass: 67270
  • Checksum: 161A5101E06EE5A7
  • Sequence:
    • MASKKREVQL QTVINNQSLW DEMLQNKGLT VIDVYQAWCG PCRAMQPLFR KLKNELNEDE 
ILHFAVAEAD NIVTLQPFRD KCEPVFLFSV NGKIIEKIQG ANAPLVNKKV INLIDEERKI 
AAGEMARPQY PEIPLVDSDS EVSEESPCES VQELYSIAII KPDAVISKKV LEIKRKITKA 
GFIIEAEHKT VLTEEQVVNF YSRIADQCDF EEFVSFMTSG LSYILVVSQG SKHNPPSEET 
EPQTDTEPNE RSEDQPEVEA QVTPGMMKNK QDSLQEYLER QHLAQLCDIE EDAANVAKFM 
DAFFPDFKKM KSMKLEKTLA LLRPNLFHER KDDVLRIIKD EDFKILEQRQ VVLSEKEAQA 
LCKEYENEDY FNKLIENMTS GPSLALVLLR DNGLQYWKQL LGPRTVEEAI EYFPESLCAQ 
FAMDSLPVNQ LYGSDSLETA EREIQHFFPL QSTLGLIKPH ATSEQREQIL KIVKEAGFDL 
TQVKKMFLTP EQIEKIYPKV TGKDFYKDLL EMLSVGPSMV MILTKWNAVA EWRRLMGPTD 
PEEAKLLSPD SIRAQFGISK LKNIVHGASN AYEAKEVVNR LFEDPEEN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.