Details for: CHST15

Gene ID: 51363

Symbol: CHST15

Ensembl ID: ENSG00000182022

Description: carbohydrate sulfotransferase 15

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 131.7945
    Cell Significance Index: -20.5000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 81.4529
    Cell Significance Index: -20.6600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 45.3161
    Cell Significance Index: -18.4100
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 42.1280
    Cell Significance Index: -21.6700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 16.6267
    Cell Significance Index: -20.5000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 7.3060
    Cell Significance Index: -22.4400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.2128
    Cell Significance Index: -20.5700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 2.9361
    Cell Significance Index: 129.8700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 2.8559
    Cell Significance Index: 71.3900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 2.7205
    Cell Significance Index: 103.0200
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.7911
    Cell Significance Index: 22.1600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.6108
    Cell Significance Index: 35.2700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.3475
    Cell Significance Index: 18.3900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.1736
    Cell Significance Index: 235.4200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.0753
    Cell Significance Index: 48.7400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.0589
    Cell Significance Index: 210.1500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.9647
    Cell Significance Index: 27.5300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.8952
    Cell Significance Index: 16.5500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.8153
    Cell Significance Index: 42.4700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.7070
    Cell Significance Index: 134.5400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.6765
    Cell Significance Index: 45.4900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.6094
    Cell Significance Index: 63.4500
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.5539
    Cell Significance Index: 11.8400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5076
    Cell Significance Index: 50.2200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5051
    Cell Significance Index: 456.1100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4134
    Cell Significance Index: 148.2900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.3821
    Cell Significance Index: 10.4000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.2165
    Cell Significance Index: 137.5100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.2069
    Cell Significance Index: 5.9300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1991
    Cell Significance Index: 374.9300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1252
    Cell Significance Index: 20.3700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1168
    Cell Significance Index: 63.8100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0597
    Cell Significance Index: 3.8500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0508
    Cell Significance Index: 35.1400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0493
    Cell Significance Index: 6.7700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.0480
    Cell Significance Index: 5.2300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0367
    Cell Significance Index: 4.5100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0352
    Cell Significance Index: 22.0000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0336
    Cell Significance Index: 15.2400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0077
    Cell Significance Index: 1.3900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0061
    Cell Significance Index: 9.3900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0029
    Cell Significance Index: -1.3000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0047
    Cell Significance Index: -8.6500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0125
    Cell Significance Index: -0.4400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0131
    Cell Significance Index: -9.7000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0148
    Cell Significance Index: -0.9100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0170
    Cell Significance Index: -23.1300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0224
    Cell Significance Index: -16.9300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0228
    Cell Significance Index: -12.8500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0256
    Cell Significance Index: -2.9300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0279
    Cell Significance Index: -20.4300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0280
    Cell Significance Index: -2.0900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0297
    Cell Significance Index: -0.8600
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0418
    Cell Significance Index: -0.8400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0504
    Cell Significance Index: -2.3500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0511
    Cell Significance Index: -10.7700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0521
    Cell Significance Index: -6.1400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0599
    Cell Significance Index: -10.2300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0610
    Cell Significance Index: -8.8600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0619
    Cell Significance Index: -17.8200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0724
    Cell Significance Index: -5.0100
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0900
    Cell Significance Index: -1.7800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0905
    Cell Significance Index: -10.5500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0954
    Cell Significance Index: -9.7400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1299
    Cell Significance Index: -16.7800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1300
    Cell Significance Index: -4.1400
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.1300
    Cell Significance Index: -1.8700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1373
    Cell Significance Index: -15.6700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1435
    Cell Significance Index: -18.3900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1563
    Cell Significance Index: -9.5800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1648
    Cell Significance Index: -2.3600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2008
    Cell Significance Index: -11.2700
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.2181
    Cell Significance Index: -5.2300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2206
    Cell Significance Index: -16.9300
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: -0.2426
    Cell Significance Index: -1.9200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2577
    Cell Significance Index: -12.1100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2664
    Cell Significance Index: -18.8400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2752
    Cell Significance Index: -4.6100
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.2807
    Cell Significance Index: -3.6400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2960
    Cell Significance Index: -9.6900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.3180
    Cell Significance Index: -6.8900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.3238
    Cell Significance Index: -19.4400
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.3315
    Cell Significance Index: -8.2700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.3382
    Cell Significance Index: -17.5700
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: -0.3494
    Cell Significance Index: -2.6800
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.3681
    Cell Significance Index: -5.6000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3691
    Cell Significance Index: -12.9300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.3729
    Cell Significance Index: -10.4200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3935
    Cell Significance Index: -20.6600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.4408
    Cell Significance Index: -11.7900
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.4413
    Cell Significance Index: -19.1900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.4443
    Cell Significance Index: -15.4400
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.4792
    Cell Significance Index: -11.0700
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.5058
    Cell Significance Index: -7.2000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.5083
    Cell Significance Index: -18.6600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.5228
    Cell Significance Index: -11.1400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.5385
    Cell Significance Index: -11.4300
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.5401
    Cell Significance Index: -10.6300
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.5407
    Cell Significance Index: -7.9800
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.5649
    Cell Significance Index: -9.5200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Enzyme specificity:** CHST15 is highly specific for the sulfation of GalNAc residues, which is a hallmark of its enzymatic activity. 2. **Glycosaminoglycan metabolism:** CHST15 is involved in the biosynthesis of chondroitin sulfate and dermatan sulfate, which are critical components of the extracellular matrix and play roles in cell adhesion, signaling, and immune responses. 3. **Tissue distribution:** CHST15 is widely expressed in various tissues, including hematopoietic cells, epithelial cells, and neurons, highlighting its importance in multiple biological processes. 4. **Cellular localization:** CHST15 is primarily localized to the Golgi apparatus, where it can interact with other glycosyltransferases and enzymes involved in GAG biosynthesis. **Pathways and Functions:** 1. **Chondroitin sulfate/dermatan sulfate biosynthesis:** CHST15 is essential for the sulfation of GalNAc residues, which is a critical step in the formation of chondroitin sulfate and dermatan sulfate. 2. **Glycosaminoglycan metabolism:** CHST15 is involved in the catabolism and degradation of GAGs, which is essential for maintaining tissue homeostasis and immune function. 3. **Cell signaling and adhesion:** CHST15-derived GAGs play critical roles in cell signaling, adhesion, and migration, which are essential for development, tissue repair, and immune responses. 4. **Neurotransmission and synaptic plasticity:** CHST15 is involved in the biosynthesis of GAGs that regulate neurotransmission and synaptic plasticity in the brain. **Clinical Significance:** 1. **Cancer and tumor progression:** Altered expression of CHST15 has been linked to cancer progression and metastasis, suggesting its potential as a therapeutic target. 2. **Immune disorders:** CHST15 is involved in the regulation of immune responses, and alterations in its expression or function may contribute to immune disorders, such as autoimmune diseases and immunodeficiency. 3. **Neurological disorders:** CHST15 is involved in the regulation of neurotransmission and synaptic plasticity, and alterations in its expression or function may contribute to neurological disorders, such as Alzheimer's disease and Parkinson's disease. 4. **Glycosaminoglycan-related diseases:** CHST15 is involved in the biosynthesis and catabolism of GAGs, which play critical roles in maintaining tissue homeostasis. Alterations in CHST15 expression or function may contribute to GAG-related diseases, such as osteoarthritis and atherosclerosis. In conclusion, CHST15 is a critical enzyme involved in the biosynthesis and catabolism of glycosaminoglycans, and its dysregulation has been linked to various diseases, including cancer, immune disorders, and neurological disorders. Further research is needed to fully elucidate the role of CHST15 in human health and disease.

Genular Protein ID: 1491327748

Symbol: CHSTF_HUMAN

Name: Carbohydrate sulfotransferase 15

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9754571

Title: hBRAG, a novel B cell lineage cDNA encoding a type II transmembrane glycoprotein potentially involved in the regulation of recombination activating gene 1 (RAG1).

PubMed ID: 9754571

DOI: 10.1002/(sici)1521-4141(199809)28:09<2839::aid-immu2839>3.0.co;2-6

PubMed ID: 11032940

Title: Structure, expression and mutational analysis of the hBRAG gene on 10q in the frequently deleted region in human endometrial cancer.

PubMed ID: 11032940

DOI: 10.3892/or.7.6.1339

PubMed ID: 11572857

Title: Human N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase cDNA is related to human B cell recombination activating gene-associated gene.

PubMed ID: 11572857

DOI: 10.1074/jbc.m104922200

PubMed ID: 9628581

Title: Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.

PubMed ID: 9628581

DOI: 10.1093/dnares/5.1.31

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10749872

Title: Characterization of the human B cell RAG-associated gene, hBRAG, as a B cell receptor signal-enhancing glycoprotein dimer that associates with phosphorylated proteins in resting B cells.

PubMed ID: 10749872

DOI: 10.1074/jbc.m001866200

PubMed ID: 12874280

Title: A unique nonreducing terminal modification of chondroitin sulfate by N-acetylgalactosamine 4-sulfate 6-o-sulfotransferase.

PubMed ID: 12874280

DOI: 10.1074/jbc.m306132200

PubMed ID: 16024005

Title: Synthesis of sulfated phenyl 2-acetamido-2-deoxy-D--D-galactopyranosides. 4-O-Sulfated phenyl 2-acetamido-2-deoxy-beta-D-galactopyranoside is a competitive acceptor that decreases sulfation of chondroitin sulfate by N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase.

PubMed ID: 16024005

DOI: 10.1016/j.carres.2005.06.010

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

Sequence Information:

  • Length: 561
  • Mass: 64926
  • Checksum: 74643A7CFF7F242D
  • Sequence:
  • MRHCINCCIQ LLPDGAHKQQ VNCQGGPHHG HQACPTCKGE NKILFRVDSK QMNLLAVLEV 
    RTEGNENWGG FLRFKKGKRC SLVFGLIIMT LVMASYILSG AHQELLISSP FHYGGFPSNP 
    SLMDSENPSD TKEHHHQSSV NNISYMKDYP SIKLIINSIT TRIEFTTRQL PDLEDLKKQE 
    LHMFSVIPNK FLPNSKSPCW YEEFSGQNTT DPYLTNSYVL YSKRFRSTFD ALRKAFWGHL 
    AHAHGKHFRL RCLPHFYIIG QPKCGTTDLY DRLRLHPEVK FSAIKEPHWW TRKRFGIVRL 
    RDGLRDRYPV EDYLDLFDLA AHQIHQGLQA SSAKEQSKMN TIIIGEASAS TMWDNNAWTF 
    FYDNSTDGEP PFLTQDFIHA FQPNARLIVM LRDPVERLYS DYLYFASSNK SADDFHEKVT 
    EALQLFENCM LDYSLRACVY NNTLNNAMPV RLQVGLYAVY LLDWLSVFDK QQFLILRLED 
    HASNVKYTMH KVFQFLNLGP LSEKQEALMT KSPASNARRP EDRNLGPMWP ITQKILRDFY 
    RPFNARLAQV LADEAFAWKT T

Genular Protein ID: 3373617644

Symbol: B4DH74_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 482
  • Mass: 55377
  • Checksum: E0BC9FA58D46CCE7
  • Sequence:
  • MRHCINCCIQ LLPDGAHKQQ VNCQGGPHHG HQACPTCKGE NKILFRVDSK QMNLLAVLEV 
    RTEGNENWGG FLRFKKGKRC SLVFGLIIMT LVMASYILSG AHQELLISSP FHYGGFPSNP 
    SLMDSENPSD TKEHHHQSSV NNISYMKDYP SIKLIINSIT TRIEFTTRQL PDLEDLKKQE 
    LHMFSVIPNK FLPNSKSPCW YEEFSGQNTT DPYLTNSYVL YSKRFRSTFD ALRKAFWGHL 
    AHAHGKHFRL RCLPHFYIIG QPKCGTTDLY DRLRLHPEVK FSAIKEPHWW TRKRFGIVRL 
    RDGLRDRYPV EDYLDLFDLA AHQIHQGLQA SSAKEQSKMN TIIIGEASAS TMWDNNAWTF 
    FYDNSTDGEP PFLTQDFIHA FQPNARLIVM LRDPVERLYS DYLYFASSNK SADDFHEKVT 
    EALQLFENCM LDYSLRACVY NNTLNNAMPV CTPPPVPPEL APGRRSWFVV IMQAALWVCV 
    SA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.