Details for: ANGPT4

Gene ID: 51378

Symbol: ANGPT4

Ensembl ID: ENSG00000101280

Description: angiopoietin 4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: keratocyte (CL0002363)
    Fold Change: 8.1356
    Cell Significance Index: 129.0700
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: 1.2017
    Cell Significance Index: 13.8400
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 1.0262
    Cell Significance Index: 8.6200
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.5813
    Cell Significance Index: 7.5100
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.5517
    Cell Significance Index: 17.4500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.4703
    Cell Significance Index: 6.7400
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.4072
    Cell Significance Index: 4.2200
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.1840
    Cell Significance Index: 1.6700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.1054
    Cell Significance Index: 3.9900
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.0600
    Cell Significance Index: 1.0600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0454
    Cell Significance Index: 5.8200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0287
    Cell Significance Index: 1.2700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0155
    Cell Significance Index: 0.3400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0076
    Cell Significance Index: 0.4800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0072
    Cell Significance Index: 1.2900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0064
    Cell Significance Index: 0.9300
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.0064
    Cell Significance Index: 0.0400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0048
    Cell Significance Index: 3.3500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0046
    Cell Significance Index: 8.6900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0028
    Cell Significance Index: 1.0200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0025
    Cell Significance Index: 0.5000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0000
    Cell Significance Index: 0.0300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0002
    Cell Significance Index: -0.0100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0008
    Cell Significance Index: -0.2400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0011
    Cell Significance Index: -2.1100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0015
    Cell Significance Index: -2.3300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0018
    Cell Significance Index: -2.3900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0025
    Cell Significance Index: -1.8500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0025
    Cell Significance Index: -1.8600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0032
    Cell Significance Index: -0.6400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0034
    Cell Significance Index: -1.9000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0036
    Cell Significance Index: -1.9500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0038
    Cell Significance Index: -1.7100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0053
    Cell Significance Index: -0.6200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0090
    Cell Significance Index: -1.8900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0097
    Cell Significance Index: -1.6600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0109
    Cell Significance Index: -1.2500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0116
    Cell Significance Index: -1.4300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0127
    Cell Significance Index: -1.7500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0133
    Cell Significance Index: -1.7200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0156
    Cell Significance Index: -1.5900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0158
    Cell Significance Index: -1.6500
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0217
    Cell Significance Index: -0.5400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0236
    Cell Significance Index: -1.5900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0247
    Cell Significance Index: -1.8400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0254
    Cell Significance Index: -1.5600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0262
    Cell Significance Index: -1.4700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0264
    Cell Significance Index: -2.0300
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0265
    Cell Significance Index: -0.6600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0267
    Cell Significance Index: -1.7200
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0282
    Cell Significance Index: -1.2200
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: -0.0282
    Cell Significance Index: -0.3200
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0307
    Cell Significance Index: -0.4500
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: -0.0326
    Cell Significance Index: -0.3400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0338
    Cell Significance Index: -1.7600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0345
    Cell Significance Index: -1.2100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0350
    Cell Significance Index: -1.6500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0381
    Cell Significance Index: -2.0000
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0423
    Cell Significance Index: -0.8500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0428
    Cell Significance Index: -1.4000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0431
    Cell Significance Index: -2.0100
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.0436
    Cell Significance Index: -0.4200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0445
    Cell Significance Index: -1.2700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0470
    Cell Significance Index: -1.2600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0483
    Cell Significance Index: -1.5400
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0501
    Cell Significance Index: -1.0200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0514
    Cell Significance Index: -1.5200
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0542
    Cell Significance Index: -0.7900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0551
    Cell Significance Index: -1.4700
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.0579
    Cell Significance Index: -0.8000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0590
    Cell Significance Index: -1.6900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0594
    Cell Significance Index: -2.1800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0606
    Cell Significance Index: -1.6200
  • Cell Name: basophil (CL0000767)
    Fold Change: -0.0619
    Cell Significance Index: -0.5700
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.0624
    Cell Significance Index: -0.5500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0643
    Cell Significance Index: -1.7500
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.0661
    Cell Significance Index: -0.8300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0671
    Cell Significance Index: -1.2400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0685
    Cell Significance Index: -1.7600
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0687
    Cell Significance Index: -1.1600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0695
    Cell Significance Index: -3.5100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0704
    Cell Significance Index: -1.8500
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0718
    Cell Significance Index: -1.8300
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0722
    Cell Significance Index: -1.4100
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.0738
    Cell Significance Index: -0.6800
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0749
    Cell Significance Index: -1.4800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0750
    Cell Significance Index: -1.5700
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0762
    Cell Significance Index: -1.4900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0763
    Cell Significance Index: -1.6200
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0780
    Cell Significance Index: -1.6900
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.0780
    Cell Significance Index: -0.9500
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0784
    Cell Significance Index: -1.9000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0784
    Cell Significance Index: -1.8800
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.0786
    Cell Significance Index: -0.9800
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0791
    Cell Significance Index: -0.7500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0805
    Cell Significance Index: -1.3800
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0812
    Cell Significance Index: -1.6200
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0822
    Cell Significance Index: -1.7200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0831
    Cell Significance Index: -1.3900
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0868
    Cell Significance Index: -1.5000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ANGPT4 is a secreted protein that belongs to the angiopoietin family, which consists of six members. ANGPT4 exhibits distinct structural and functional characteristics, including a distinctive C-terminal region with a hydrophobic motif, which enables it to interact with its receptor, Tie2. This interaction triggers a signaling cascade that regulates angiogenesis, cell migration, and proliferation. **Pathways and Functions:** ANGPT4's involvement in angiogenesis is primarily mediated by its interaction with the Tie2 receptor, which is a transmembrane receptor tyrosine kinase. This interaction triggers a signaling cascade that activates downstream pathways, including: 1. **Tie2 signaling pathway:** ANGPT4 binding to Tie2 activates the receptor's tyrosine kinase activity, leading to the phosphorylation of downstream targets, such as PI3K and AKT. 2. **Notch signaling pathway:** ANGPT4 also interacts with the Notch signaling pathway, which regulates cell fate decisions, proliferation, and differentiation. 3. **Cell surface interactions at the vascular wall:** ANGPT4's interaction with the vascular wall is mediated by its binding to heparan sulfate proteoglycans, which regulates cell migration and adhesion. 4. **Negative regulation of angiogenesis:** ANGPT4 also exhibits anti-angiogenic properties, inhibiting the formation of new blood vessels by suppressing the expression of pro-angiogenic factors. **Clinical Significance:** ANGPT4's involvement in angiogenesis and its regulatory functions make it a potential therapeutic target for various diseases, including: 1. **Cancer:** ANGPT4's role in tumor angiogenesis and metastasis makes it a promising target for cancer therapy. 2. **Vascular diseases:** ANGPT4's involvement in vascular remodeling and inflammation suggests its potential as a therapeutic target for cardiovascular diseases. 3. **Neurological disorders:** ANGPT4's interaction with the Notch signaling pathway and its role in neuronal development and maintenance make it a potential therapeutic target for neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, ANGPT4 is a multifunctional protein that plays a crucial role in angiogenesis and various cellular processes. Its regulatory functions make it a promising therapeutic target for various diseases, highlighting the need for further research into its mechanisms of action and potential applications.

Genular Protein ID: 2754665231

Symbol: ANGP4_HUMAN

Name: Angiopoietin-4

UniProtKB Accession Codes:

Q9Y264 B4E3J9 Q5TFF4 Q9H4Z4

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 1 GO 16 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 1 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 10218486

Title: Angiopoietin-3, a novel member of the angiopoietin family.

PubMed ID: 10218486

DOI: 10.1016/s0014-5793(99)00381-6

PubMed ID: 10051567

Title: Angiopoietins 3 and 4: diverging gene counterparts in mice and humans.

PubMed ID: 10051567

DOI: 10.1073/pnas.96.5.1904

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15284220

Title: Biological characterization of angiopoietin-3 and angiopoietin-4.

PubMed ID: 15284220

DOI: 10.1096/fj.03-1466com

PubMed ID: 19234476

Title: Control of vascular morphogenesis and homeostasis through the angiopoietin-Tie system.

PubMed ID: 19234476

DOI: 10.1038/nrm2639

Sequence Information:

  • Length: 503
  • Mass: 56849
  • Checksum: 79CE52F66B532340
  • Sequence:
    • MLSQLAMLQG SLLLVVATMS VAQQTRQEAD RGCETLVVQH GHCSYTFLLP KSEPCPPGPE 
VSRDSNTLQR ESLANPLHLG KLPTQQVKQL EQALQNNTQW LKKLERAIKT ILRSKLEQVQ 
QQMAQNQTAP MLELGTSLLN QTTAQIRKLT DMEAQLLNQT SRMDAQMPET FLSTNKLENQ 
LLLQRQKLQQ LQGQNSALEK RLQALETKQQ EELASILSKK AKLLNTLSRQ SAALTNIERG 
LRGVRHNSSL LQDQQHSLRQ LLVLLRHLVQ ERANASAPAF IMAGEQVFQD CAEIQRSGAS 
ASGVYTIQVS NATKPRKVFC DLQSSGGRWT LIQRRENGTV NFQRNWKDYK QGFGDPAGEH 
WLGNEVVHQL TRRAAYSLRV ELQDWEGHEA YAQYEHFHLG SENQLYRLSV VGYSGSAGRQ 
SSLVLQNTSF STLDSDNDHC LCKCAQVMSG GWWFDACGLS NLNGVYYHAP DNKYKMDGIR 
WHYFKGPSYS LRASRMMIRP LDI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.