Details for: PDE4C

Gene ID: 5143

Symbol: PDE4C

Ensembl ID: ENSG00000105650

Description: phosphodiesterase 4C

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 86.2129
    Cell Significance Index: -13.4100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 53.1061
    Cell Significance Index: -13.4700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 10.8844
    Cell Significance Index: -13.4200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 4.4273
    Cell Significance Index: -11.8600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.8184
    Cell Significance Index: 26.2100
  • Cell Name: helper T cell (CL0000912)
    Fold Change: 0.5792
    Cell Significance Index: 8.2300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.3480
    Cell Significance Index: 40.5500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.3147
    Cell Significance Index: 90.5600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2967
    Cell Significance Index: 59.5200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.2575
    Cell Significance Index: 6.6200
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: 0.2123
    Cell Significance Index: 2.8300
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.2032
    Cell Significance Index: 3.2600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1314
    Cell Significance Index: 71.7500
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.1212
    Cell Significance Index: 1.0300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1147
    Cell Significance Index: 21.8300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1053
    Cell Significance Index: 3.7000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1034
    Cell Significance Index: 13.2600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0855
    Cell Significance Index: 30.6700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0817
    Cell Significance Index: 1.4000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0607
    Cell Significance Index: 7.4600
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.0556
    Cell Significance Index: 0.8400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0472
    Cell Significance Index: 2.8400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0438
    Cell Significance Index: 0.9600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0276
    Cell Significance Index: 24.9500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0042
    Cell Significance Index: 0.1200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0016
    Cell Significance Index: 0.1600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0011
    Cell Significance Index: -0.7900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0050
    Cell Significance Index: -0.9100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0050
    Cell Significance Index: -0.1400
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.0060
    Cell Significance Index: -0.0900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.0113
    Cell Significance Index: -1.2300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.0124
    Cell Significance Index: -2.0200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0164
    Cell Significance Index: -12.1700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0201
    Cell Significance Index: -11.3400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0219
    Cell Significance Index: -13.6900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0256
    Cell Significance Index: -3.5200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0432
    Cell Significance Index: -1.0800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0440
    Cell Significance Index: -2.0500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0560
    Cell Significance Index: -3.8700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0645
    Cell Significance Index: -13.5800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0651
    Cell Significance Index: -1.2700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0732
    Cell Significance Index: -3.3200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0786
    Cell Significance Index: -8.0300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0789
    Cell Significance Index: -1.7100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0803
    Cell Significance Index: -13.7200
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0827
    Cell Significance Index: -1.2200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0828
    Cell Significance Index: -12.0400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0830
    Cell Significance Index: -2.2600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0859
    Cell Significance Index: -1.2300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0877
    Cell Significance Index: -6.7300
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.0886
    Cell Significance Index: -0.6000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0978
    Cell Significance Index: -4.6000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1010
    Cell Significance Index: -6.2100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1039
    Cell Significance Index: -11.9000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1284
    Cell Significance Index: -6.7400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1289
    Cell Significance Index: -7.9000
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.1300
    Cell Significance Index: -2.1900
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.1468
    Cell Significance Index: -2.1400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1521
    Cell Significance Index: -7.9000
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.1634
    Cell Significance Index: -1.7800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1756
    Cell Significance Index: -6.6500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1805
    Cell Significance Index: -3.7500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1958
    Cell Significance Index: -8.6600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1975
    Cell Significance Index: -6.9200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1985
    Cell Significance Index: -6.5000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2106
    Cell Significance Index: -4.4900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2168
    Cell Significance Index: -7.9600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2174
    Cell Significance Index: -12.2000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2195
    Cell Significance Index: -6.9900
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: -0.2241
    Cell Significance Index: -2.8700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2260
    Cell Significance Index: -4.7300
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.2329
    Cell Significance Index: -3.0500
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.2397
    Cell Significance Index: -5.9800
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.2473
    Cell Significance Index: -3.7000
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.2547
    Cell Significance Index: -1.5800
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.2564
    Cell Significance Index: -2.4400
  • Cell Name: tendon cell (CL0000388)
    Fold Change: -0.2574
    Cell Significance Index: -3.5000
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.2622
    Cell Significance Index: -6.5500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2851
    Cell Significance Index: -7.6400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.2878
    Cell Significance Index: -2.6500
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.3026
    Cell Significance Index: -6.0800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.3071
    Cell Significance Index: -4.1900
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.3078
    Cell Significance Index: -4.1500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.3127
    Cell Significance Index: -8.3500
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.3152
    Cell Significance Index: -6.8100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3209
    Cell Significance Index: -11.1500
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: -0.3220
    Cell Significance Index: -3.5200
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -0.3228
    Cell Significance Index: -3.4300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3243
    Cell Significance Index: -9.3000
  • Cell Name: stromal cell of endometrium (CL0002255)
    Fold Change: -0.3311
    Cell Significance Index: -4.7100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.3355
    Cell Significance Index: -7.1200
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.3363
    Cell Significance Index: -6.6500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.3363
    Cell Significance Index: -3.8200
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: -0.3374
    Cell Significance Index: -3.4900
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.3492
    Cell Significance Index: -3.3100
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.3497
    Cell Significance Index: -8.4700
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.3500
    Cell Significance Index: -7.3100
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: -0.3505
    Cell Significance Index: -3.2200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3568
    Cell Significance Index: -10.5100
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.3573
    Cell Significance Index: -8.5700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** PDE4C is a phosphodiesterase enzyme that specifically hydrolyzes cAMP and cGMP, two key second messengers in cellular signaling pathways. The enzyme is characterized by its high specificity for these nucleotides, with a high affinity for cAMP and a moderate affinity for cGMP. PDE4C is also notable for its ability to regulate the levels of cAMP and cGMP, which in turn modulate various cellular processes, including gene expression, cell proliferation, and differentiation. **Pathways and Functions:** PDE4C is involved in several signaling pathways, including: 1. **Camp-mediated signaling:** PDE4C regulates the levels of cAMP, which is a key second messenger in this pathway. cAMP activates protein kinase A (PKA), which in turn phosphorylates and activates various downstream targets, including transcription factors and ion channels. 2. **G alpha (i) and G alpha (s) signaling:** PDE4C is also involved in the regulation of G protein-coupled receptor (GPCR) signaling, specifically the G alpha (i) and G alpha (s) pathways. These pathways are involved in various cellular processes, including cell proliferation, differentiation, and survival. 3. **Opioid signaling:** PDE4C has been shown to regulate opioid signaling, which is involved in pain modulation and addiction. PDE4C's functions in these pathways are multifaceted, including: 1. **Gene expression regulation:** PDE4C regulates the expression of genes involved in various cellular processes, including immune response, cell proliferation, and differentiation. 2. **Cell signaling:** PDE4C modulates cell signaling pathways, including GPCR signaling, opioid signaling, and camp-mediated signaling. 3. **Immune regulation:** PDE4C is involved in the regulation of immune responses, including the activation of immune cells and the production of cytokines. **Clinical Significance:** PDE4C's dysregulation has been implicated in various diseases, including: 1. **Asthma:** PDE4C is overexpressed in the nasal mucosa of patients with asthma, suggesting a role in airway inflammation and hyperresponsiveness. 2. **Cardiovascular disease:** PDE4C has been shown to regulate blood pressure and cardiac function, suggesting a potential role in cardiovascular disease. 3. **Neurological disorders:** PDE4C dysregulation has been implicated in various neurological disorders, including Parkinson's disease, Alzheimer's disease, and multiple sclerosis. 4. **Cancer:** PDE4C has been shown to regulate cell proliferation and differentiation in cancer cells, suggesting a potential role in cancer development and progression. In conclusion, PDE4C is a multifunctional phosphodiesterase enzyme that plays a crucial role in various cellular processes, including immune regulation, signaling pathways, and gene expression. Its dysregulation has been implicated in various diseases, highlighting the need for further research into the role of PDE4C in human health and disease.

Genular Protein ID: 1498287372

Symbol: PDE4C_HUMAN

Name: DPDE1

UniProtKB Accession Codes:

Q08493 B3KTC4 Q9UN44 Q9UN45 Q9UN46 Q9UPJ6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CTD 1 ChEBI 23 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 11 DrugCentral 1 EC 1 EMBL 16 Ensembl 5 EvolutionaryTrace 1 ExpressionAtlas 1 GO 10 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 Reactome 2 RefSeq 5 Rhea 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7843419

Title: Molecular cloning and functional expression in yeast of a human cAMP-specific phosphodiesterase subtype (PDE IV-C).

PubMed ID: 7843419

DOI: 10.1016/0014-5793(94)01460-i

PubMed ID: 10574328

Title: Genomic organisation of the human cyclic AMP-specific phosphodiesterase PDE4C gene and its chromosomal localisation to 19p13.1, between RAB3A and JUND.

PubMed ID: 10574328

DOI: 10.1016/s0898-6568(99)00037-6

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 8413254

Title: A family of human phosphodiesterases homologous to the dunce learning and memory gene product of Drosophila melanogaster are potential targets for antidepressant drugs.

PubMed ID: 8413254

DOI: 10.1128/mcb.13.10.6558-6571.1993

PubMed ID: 17727341

Title: Structures of the four subfamilies of phosphodiesterase-4 provide insight into the selectivity of their inhibitors.

PubMed ID: 17727341

DOI: 10.1042/bj20070970

Sequence Information:

  • Length: 712
  • Mass: 79902
  • Checksum: 1932116C9CE0322C
  • Sequence:
    • MENLGVGEGA EACSRLSRSR GRHSMTRAPK HLWRQPRRPI RIQQRFYSDP DKSAGCRERD 
LSPRPELRKS RLSWPVSSCR RFDLENGLSC GRRALDPQSS PGLGRIMQAP VPHSQRRESF 
LYRSDSDYEL SPKAMSRNSS VASDLHGEDM IVTPFAQVLA SLRTVRSNVA ALARQQCLGA 
AKQGPVGNPS SSNQLPPAED TGQKLALETL DELDWCLDQL ETLQTRHSVG EMASNKFKRI 
LNRELTHLSE TSRSGNQVSE YISRTFLDQQ TEVELPKVTA EEAPQPMSRI SGLHGLCHSA 
SLSSATVPRF GVQTDQEEQL AKELEDTNKW GLDVFKVAEL SGNRPLTAII FSIFQERDLL 
KTFQIPADTL ATYLLMLEGH YHANVAYHNS LHAADVAQST HVLLATPALE AVFTDLEILA 
ALFASAIHDV DHPGVSNQFL INTNSELALM YNDASVLENH HLAVGFKLLQ AENCDIFQNL 
SAKQRLSLRR MVIDMVLATD MSKHMNLLAD LKTMVETKKV TSLGVLLLDN YSDRIQVLQN 
LVHCADLSNP TKPLPLYRQW TDRIMAEFFQ QGDRERESGL DISPMCDKHT ASVEKSQVGF 
IDYIAHPLWE TWADLVHPDA QDLLDTLEDN REWYQSKIPR SPSDLTNPER DGPDRFQFEL 
TLEEAEEEDE EEEEEGEETA LAKEALELPD TELLSPEAGP DPGDLPLDNQ RT

Genular Protein ID: 2241696067

Symbol: P78505_HUMAN

Name: N/A

UniProtKB Accession Codes:

P78505

Database IDs:

ARBA 6 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 14 DNASU 1 DisGeNET 1 EC 1 EMBL 2 GO 4 Gene3D 1 InterPro 6 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSR 3 PRINTS 1 PROSITE 3 PeptideAtlas 1 Pfam 2 PharmGKB 1 RefSeq 1 Rhea 2 RuleBase 1 SAM 1 SMART 1 SMR 1 SUPFAM 1 UniPathway 1

Citations:

PubMed ID: 9429761

Title: Molecular cloning and expression of a human phosphodiesterase 4C.

PubMed ID: 9429761

DOI: 10.1016/S0898-6568(97)00072-7

Sequence Information:

  • Length: 700
  • Mass: 77601
  • Checksum: B39732360C2E18A5
  • Sequence:
    • AVQKRSRAVG ARSSLHAVLA MQGPPAPAPV PGPGSPRGSP RGSPGLFRKL LVNQSIRLQR 
RFTVAHPLCF DLENGLSCGR RALDPQSSPG LGRIMQAPVP HSQRRESFLY RSDSDYELSP 
KAMSRNSSVA SDLHGEDMIV TPFAQVLASL RTVRSNVAAL ARQQCLGAAK QGPVGNPSSS 
NQLPPAEDTG QKLALETLDE LDWCLDQLET LQTRHSVGEM ASNKFKRILN RELTHLSETS 
RSGNQVSEYI SRTFLDQQTE VELPKVTAEE APQPMSRISG LHGLCHSASL SSATVPRFGV 
QTDQEEQLAK ELEDTNKWGL DVFKVAELSG NQPLTAIIFS IFQERDLLKT FQIPADTLAT 
YLLMLEGHYH ANVAYHNSLH AADVAQSTHV LLATPALEAV FTDLEILAAL FASAIHDVDH 
PGVSNQFLIN TNSELALMYN DASVLENHHL AVGFKLLQAE NCDIFQNLSA KQRLSLRRMV 
IDMVLATDMS KHMNLLADLK TMVETKKVTS LGVLLLDNYS DRIQVLQNLV HCADLSNPTK 
PLPLYRQWTD RIMAEFFQQG DRERESGLDI SPMCDKHTAS VEKSQVGFID YIAHPLWETW 
ADLVHPDAQD LLDTLEDNRE WYQSKIPRSP SDLTNPERDG PDRFQFELTL EEAEEEDEEE 
EEEGEETALA KEALELPDTE LLSPEAGPAP GDLPLDNQRT

Genular Protein ID: 4169677397

Symbol: Q7KYS4_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q7KYS4

Database IDs:

ARBA 6 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 14 DNASU 1 DisGeNET 1 EC 1 EMBL 2 GO 4 Gene3D 1 InterPro 6 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSR 3 PRINTS 1 PROSITE 3 PeptideAtlas 1 Pfam 2 PharmGKB 1 RefSeq 1 Rhea 2 RuleBase 1 SAM 1 SMART 1 SUPFAM 1 UniPathway 1

Citations:

PubMed ID: 9429761

Title: Molecular cloning and expression of a human phosphodiesterase 4C.

PubMed ID: 9429761

DOI: 10.1016/S0898-6568(97)00072-7

Sequence Information:

  • Length: 606
  • Mass: 67719
  • Checksum: AC14D9401F5CCDCE
  • Sequence:
    • MQAPVPHSQR RESFLYRSDS DYELSPKAMS RNSSVASDLH GEDMIVTPFA QVLASLRTVR 
SNVAALARQQ CLGAAKQGPV GNPSSSNQLP PAEDTGQKLA LETLDELDWC LDQLETLQTR 
HSVGEMASNK FKRILNRELT HLSETSRSGN QVSEYISRTF LDQQTEVELP KVTAEEAPQP 
MSRISGLHGL CHSASLSSAT VPRFGVQTDQ EEQLAKELED TNKWGLDVFK VAELSGNQPL 
TAIIFSIFQE RDLLKTFQIP ADTLATYLLM LEGHYHANVA YHNSLHAADV AQSTHVLLAT 
PALEAVFTDL EILAALFASA IHDVDHPGVS NQFLINTNSE LALMYNDASV LENHHLAVGF 
KLLQAENCDI FQNLSAKQRL SLRRMVIDMV LATDMSKHMN LLADLKTMVE TKKVTSLGVL 
LLDNYSDRIQ VLQNLVHCAD LSNPTKPLPL YRQWTDRIMA EFFQQGDRER ESGLDISPMC 
DKHTASVEKS QVGFIDYIAH PLWETWADLV HPDAQDLLDT LEDNREWYQS KIPRSPSDLT 
NPERDGPDRF QFELTLEEAE EEDEEEEEEG EETALAKEAL ELPDTELLSP EAGPAPGDLP 
LDNQRT

Genular Protein ID: 1344722962

Symbol: O43849_HUMAN

Name: N/A

UniProtKB Accession Codes:

O43849

Database IDs:

ARBA 6 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 14 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 1 EMBL 2 GO 4 Gene3D 1 InterPro 6 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSR 3 PRINTS 1 PROSITE 3 PeptideAtlas 1 Pfam 2 PharmGKB 1 RefSeq 1 Rhea 2 RuleBase 1 SAM 1 SMART 1 SUPFAM 1 UniPathway 1

Citations:

PubMed ID: 7843419

Title: Molecular cloning and functional expression in yeast of a human cAMP-specific phosphodiesterase subtype (PDE IV-C).

PubMed ID: 7843419

DOI: 10.1016/0014-5793(94)01460-I

PubMed ID: 9349724

Title: Multiple splice variants of phosphodiesterase PDE4C cloned from human lung and testis.

PubMed ID: 9349724

DOI: 10.1016/S0167-4781(97)00080-8

Sequence Information:

  • Length: 791
  • Mass: 88143
  • Checksum: 616F6606E39719B8
  • Sequence:
    • GTQAGLRSGA PSGHRQLLGV GPTLSPSSTF YRFSTSGADS SSLSPPLPAL GRTREQTLLG 
ARSRGRVLLP AIPDPFLWRM ENLGVGEGAE ACSRLSRSRG RHSMTRAPKH LWRQPRRPIR 
IQQRFYSDPD KSAGCRERDL SPRPELRKSR LSWPVSSCRR FDLENGLSCG RRALDPQSSP 
GLGRIMQAPV PHSQRRESFL YRSDSDYELS PKAMSRNSSV ASDLHGEDMI VTPFAQVLAS 
LRTVRSNVAA LARQQCLGAA KQGPVGNPSS SNQLPPAEDT GQKLALETLD ELDWCLDQLE 
TLQTRHSVGE MASNKFKRIL NRELTHLSET SRSGNQVSEY ISRTFLDQQT EVELPKVTAE 
EAPQPMSRIS GLHGLCHSAS LSSATVPRFG VQTDQEEQLA KELEDTNKWG LDVFKVAELS 
GNQPLTAIIF SIFQERDLLK TFQIPADTLA TYLLMLEGHY HANVAYHNSL HAADVAQSTH 
VLLATPALEA VFTDLEILAA LFASAIHDVD HPGVSNQFLI NTNSELALMY NDASVLENHH 
LAVGFKLLQA ENCDIFQNLS AKQRLSLRRM VIDMVLATDM SKHMNLLADL KTMVETKKVT 
SLGVLLLDNY SDRIQVLQNL VHCADLSNPT KPLPLYRQWT DRIMAEFFQQ GDRERESGLD 
ISPMCDKHTA SVEKSQVGFI DYIAHPLWET WADLVHPDAQ DLLDTLEDNR EWYQSKIPRS 
PSDLTNPERD GPDRFQFELT LEEAEEEDEE EEEEGEETAL AKEALELPDT ELLSPEAGPD 
PGDLPLDNQR T

Genular Protein ID: 1734066814

Symbol: Q32MM7_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q32MM7

Database IDs:

ARBA 6 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 14 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 1 EMBL 5 Ensembl 2 GO 4 Gene3D 1 GeneTree 1 HGNC 1 HOGENOM 1 InterPro 6 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSR 3 PRINTS 1 PROSITE 3 PeptideAtlas 1 Pfam 2 PharmGKB 1 Proteomes 2 ProteomicsDB 2 RefSeq 4 Rhea 2 RuleBase 1 SAM 1 SMART 1 SUPFAM 1 UCSC 1 UniPathway 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

Sequence Information:

  • Length: 481
  • Mass: 54159
  • Checksum: EB5D611C8D463AD4
  • Sequence:
    • MASNKFKRIL NRELTHLSET SRSGNQVSEY ISRTFLDQQT EVELPKVTAE EAPQPMSRIS 
GLHGLCHSAS LSSATVPRFG VQTDQEEQLA KELEDTNKWG LDVFKVAELS GNRPLTAIIF 
SIFQERDLLK TFQIPADTLA TYLLMLEGHY HANVAYHNSL HAADVAQSTH VLLATPALEA 
VFTDLEILAA LFASAIHDVD HPGVSNQFLI NTNSELALMY NDASVLENHH LAVGFKLLQA 
ENCDIFQNLS AKQRLSLRRM VIDMVLATDM SKHMNLLADL KTMVETKKVT SLGVLLLDNY 
SDRIQVLQNL VHCADLSNPT KPLPLYRQWT DRIMAEFFQQ GDRERESGLD ISPMCDKHTA 
SVEKSQVGFI DYIAHPLWET WADLVHPDAQ DLLDTLEDNR EWYQSKIPRS PSDLTNPERD 
GPDRFQFELT LEEAEEEDEE EEEEGEETAL AKEALELPDT ELLSPEAGPD PGDLPLDNQR 
T

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.