Details for: SFMBT1

Gene ID: 51460

Symbol: SFMBT1

Ensembl ID: ENSG00000163935

Description: Scm like with four mbt domains 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 143.6238
    Cell Significance Index: -22.3400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 91.5853
    Cell Significance Index: -23.2300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 51.8298
    Cell Significance Index: -24.4700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 51.4453
    Cell Significance Index: -20.9000
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 36.4071
    Cell Significance Index: -24.4300
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 21.9012
    Cell Significance Index: -20.9100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 18.6868
    Cell Significance Index: -23.0400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 8.5857
    Cell Significance Index: -23.0000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 7.4769
    Cell Significance Index: -22.9700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.8907
    Cell Significance Index: -23.2500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 5.0672
    Cell Significance Index: -11.0900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.6529
    Cell Significance Index: 92.7500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.3423
    Cell Significance Index: 269.2700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.0942
    Cell Significance Index: 83.9700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.8660
    Cell Significance Index: 598.9500
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.8496
    Cell Significance Index: 18.1600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.8062
    Cell Significance Index: 30.5300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.7718
    Cell Significance Index: 34.1400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.7140
    Cell Significance Index: 15.6400
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.7059
    Cell Significance Index: 8.7600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.6935
    Cell Significance Index: 137.6300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.6492
    Cell Significance Index: 70.6200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.6476
    Cell Significance Index: 38.8800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.6263
    Cell Significance Index: 28.3900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.6145
    Cell Significance Index: 15.3600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6027
    Cell Significance Index: 98.0300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.5914
    Cell Significance Index: 212.1400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4439
    Cell Significance Index: 80.0200
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.3939
    Cell Significance Index: 3.9500
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 0.3489
    Cell Significance Index: 3.5200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3283
    Cell Significance Index: 9.4600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.2977
    Cell Significance Index: 18.3000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.2871
    Cell Significance Index: 33.4600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2856
    Cell Significance Index: 35.1200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.2598
    Cell Significance Index: 7.2600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.2474
    Cell Significance Index: 6.3600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2085
    Cell Significance Index: 20.6300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1723
    Cell Significance Index: 32.7900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1689
    Cell Significance Index: 3.6600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1433
    Cell Significance Index: 9.0300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.1278
    Cell Significance Index: 3.4300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1060
    Cell Significance Index: 7.3300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1047
    Cell Significance Index: 4.8800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.0892
    Cell Significance Index: 2.1400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0839
    Cell Significance Index: 9.8900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0830
    Cell Significance Index: 5.5800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0805
    Cell Significance Index: 13.7400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0741
    Cell Significance Index: 32.7600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0740
    Cell Significance Index: 2.6000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0468
    Cell Significance Index: 72.1000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0441
    Cell Significance Index: 83.1100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0374
    Cell Significance Index: 20.4200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0358
    Cell Significance Index: 48.7200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0324
    Cell Significance Index: 59.8000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0256
    Cell Significance Index: 16.2900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0126
    Cell Significance Index: 5.7100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0004
    Cell Significance Index: -0.0100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0071
    Cell Significance Index: -0.8100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0123
    Cell Significance Index: -9.1000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0163
    Cell Significance Index: -0.7700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0169
    Cell Significance Index: -10.5800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0198
    Cell Significance Index: -11.1800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0203
    Cell Significance Index: -14.8700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0235
    Cell Significance Index: -3.4200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0237
    Cell Significance Index: -1.2300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0251
    Cell Significance Index: -19.0300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0315
    Cell Significance Index: -0.5400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0594
    Cell Significance Index: -7.6800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0691
    Cell Significance Index: -14.5600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0692
    Cell Significance Index: -1.4400
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0713
    Cell Significance Index: -0.8500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0717
    Cell Significance Index: -20.6200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0812
    Cell Significance Index: -1.7300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0831
    Cell Significance Index: -6.1900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0843
    Cell Significance Index: -8.6100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0899
    Cell Significance Index: -12.3500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1087
    Cell Significance Index: -7.0100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1168
    Cell Significance Index: -14.9700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1253
    Cell Significance Index: -8.8600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1940
    Cell Significance Index: -20.2000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1987
    Cell Significance Index: -22.6800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2032
    Cell Significance Index: -2.9100
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.2037
    Cell Significance Index: -4.0900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2052
    Cell Significance Index: -2.8000
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2295
    Cell Significance Index: -4.8700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2406
    Cell Significance Index: -6.5500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2678
    Cell Significance Index: -21.2100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2709
    Cell Significance Index: -8.6800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2773
    Cell Significance Index: -14.5600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2778
    Cell Significance Index: -9.1000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3154
    Cell Significance Index: -10.9600
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.3198
    Cell Significance Index: -6.3200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3259
    Cell Significance Index: -10.3800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.3382
    Cell Significance Index: -9.6500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3746
    Cell Significance Index: -19.5100
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.3829
    Cell Significance Index: -6.4500
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.3844
    Cell Significance Index: -5.6800
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.3893
    Cell Significance Index: -8.4100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3932
    Cell Significance Index: -24.1100
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.4537
    Cell Significance Index: -3.7000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** The SFMBT1 protein, encoded by the ENSG00000163935 gene, possesses a unique combination of four MBT domains and a scm-like motif. The MBT domains are known to bind to methylated CpG sequences, which play a crucial role in epigenetic regulation. The scm-like motif, on the other hand, is thought to be involved in protein-protein interactions and may contribute to the protein's ability to regulate cellular processes. The presence of multiple MBT domains in SFMBT1 suggests a potential role in chromatin organization and regulation of gene expression. **Pathways and Functions** SFMBT1 is involved in a range of cellular processes, including: 1. **Cell Differentiation**: SFMBT1 plays a role in regulating cell differentiation, particularly in the development of hematopoietic cells. Studies have shown that SFMBT1 is expressed in polychromatophilic erythroblasts, a stage of erythrocyte development. 2. **Chromatin Organization**: SFMBT1 is involved in chromatin organization, which is essential for regulating gene expression. The protein's ability to bind to methylated CpG sequences and interact with chromatin-modifying enzymes suggests a role in maintaining chromatin structure and function. 3. **Negative Regulation of DNA-templated Transcription**: SFMBT1 acts as a transcriptional corepressor, regulating the expression of genes involved in DNA-templated transcription. This function is critical for maintaining the balance between gene expression and silencing. 4. **Spermatogenesis**: SFMBT1 is also involved in spermatogenesis, a process of cell differentiation and maturation in the testes. 5. **Chromatin Binding**: SFMBT1 interacts with chromatin-binding proteins, such as histone-modifying enzymes, to regulate chromatin structure and function. **Clinical Significance** The clinical significance of SFMBT1 is multifaceted and far-reaching. Dysregulation of SFMBT1 has been implicated in various diseases, including: 1. **Immunodeficiency Disorders**: SFMBT1 plays a critical role in the development and function of immune cells, such as T cells and B cells. Dysregulation of SFMBT1 may contribute to immunodeficiency disorders, such as immunodeficiency associated with CD8-alpha-beta-positive, alpha-beta intraepithelial T cells. 2. **Cancer**: SFMBT1's role in chromatin organization and regulation of gene expression makes it a potential target for cancer therapy. Dysregulation of SFMBT1 has been implicated in various types of cancer, including leukemia and lymphoma. 3. **Neurological Disorders**: SFMBT1's involvement in chromatin organization and regulation of gene expression suggests a potential role in neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, SFMBT1 is a gene of significant importance in cellular biology and immunology. Its unique combination of characteristics, including four MBT domains and a scm-like motif, suggests a multifaceted role in regulating cellular processes. Further research is needed to fully elucidate the clinical significance of SFMBT1 and its potential as a therapeutic target for various diseases.

Genular Protein ID: 2012681460

Symbol: SMBT1_HUMAN

Name: Scm-like with four MBT domains protein 1

UniProtKB Accession Codes:

Q9UHJ3 Q402F7 Q96C73 Q9Y4Q9

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 5 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 1 ExpressionAtlas 1 GO 10 Gene3D 3 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 6 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10661410

Title: Processing of some antigens by the standard proteasome but not by the immunoproteasome results in poor presentation by dendritic cells.

PubMed ID: 10661410

DOI: 10.1016/s1074-7613(00)80163-6

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 17599839

Title: Human SFMBT is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3.

PubMed ID: 17599839

DOI: 10.1016/j.febslet.2007.06.025

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 23592795

Title: SFMBT1 functions with LSD1 to regulate expression of canonical histone genes and chromatin-related factors.

PubMed ID: 23592795

DOI: 10.1101/gad.210963.112

PubMed ID: 23349461

Title: Proteomic and functional analyses reveal the role of chromatin reader SFMBT1 in regulating epigenetic silencing and the myogenic gene program.

PubMed ID: 23349461

DOI: 10.1074/jbc.m112.429605

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

Sequence Information:

  • Length: 866
  • Mass: 98141
  • Checksum: DCE67BF35C413EB7
  • Sequence:
    • MNGEQQLDAD AGSGMEEVEL SWEDYLEETG STAVPYGSFK HVDTRLQNGF APGMKLEVAV 
RTDPETYWVA TVITTCEQLL LLRYDGYGED RRADFWCDIR KADLYPIGWC EQNKKTLEAP 
EGIRDKVSDW DEFLRQTLIG ACSPPVPLLE GLRNGRNPLD LIAPGSRLEC QAFQDSLSTW 
IVTVVENIGG RLKLRYEGLE SSDNYEHWLY YLDPFLHHVG WAAQQGYELQ PPSAIRHLKN 
EAEWQEILAK VKEEEEEPLP SYLFKDKQVI GIHTFSVNMK LEAVDPWSPF GISPATVVKV 
FDEKYFLVEM DDLRPENHAR RSFVCHADSP GIFPVQWSLK NGLHISPPPG YPSQDFDWAD 
YLKQCGAEAA PQRCFPPLIS EHEFKENMKL EAVNPILPEE VCVATITAVR GSYLWLQLEG 
SKKPIPECIV SVESMDIFPL GWCETNGHPL STPRRARVYK QRKIAVVQPE KQVPSSRTVH 
EGLRNQELNS TESVMINGKY CCPKIYFNHR CFSGPYLNKG RIAELPQCVG PGNCVLVLRE 
VLTLLINAAY KPSRVLRELQ LDKDSVWHGC GEVLKAKYKG KSYRATVEIV KTADRVTEFC 
RQTCIKLECC PNLFGPRMVL DKCSENCSVL TKTKYTHYYG KKKNKRIGRP PGGHSNLACA 
LKKASKRRKR RKNVFVHKKK RSSASVDNTP AGSPQGSGGE DEDDPDEGDD DSLSEGSTSE 
QQDELQEESE MSEKKSCSSS PTQSEISTSL PPDRQRRKRE LRTFSFSDDE NKPPSPKEIR 
IEVAERLHLD SNPLKWSVAD VVRFIRSTDC APLARIFLDQ EIDGQALLLL TLPTVQECMD 
LKLGPAIKLC HHIERIKFAF YEQFAN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.