Details for: TMEM138

Gene ID: 51524

Symbol: TMEM138

Ensembl ID: ENSG00000149483

Description: transmembrane protein 138

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 95.4706
    Cell Significance Index: -14.8500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 64.2635
    Cell Significance Index: -16.3000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 42.4362
    Cell Significance Index: -17.2400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 40.6039
    Cell Significance Index: -19.1700
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 37.0539
    Cell Significance Index: -19.0600
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 28.6727
    Cell Significance Index: -19.2400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 17.8792
    Cell Significance Index: -17.0700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 14.6883
    Cell Significance Index: -18.1100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 5.3269
    Cell Significance Index: -14.2700
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 4.9360
    Cell Significance Index: 58.8400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.7491
    Cell Significance Index: -18.7400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 4.6124
    Cell Significance Index: 290.7100
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 3.2490
    Cell Significance Index: 52.1300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 2.9974
    Cell Significance Index: -6.5600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.2765
    Cell Significance Index: 34.2100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.1939
    Cell Significance Index: 194.1700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.9266
    Cell Significance Index: 55.6300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.5762
    Cell Significance Index: 40.7500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.4891
    Cell Significance Index: 13.0600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4415
    Cell Significance Index: 30.5300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4227
    Cell Significance Index: 21.9600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.4216
    Cell Significance Index: 49.1300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3971
    Cell Significance Index: 54.5300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.3865
    Cell Significance Index: 10.8000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.3758
    Cell Significance Index: 10.2300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3215
    Cell Significance Index: 290.3300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3062
    Cell Significance Index: 55.2000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.3016
    Cell Significance Index: 35.5700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2768
    Cell Significance Index: 34.0400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2739
    Cell Significance Index: 149.5800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2643
    Cell Significance Index: 17.0500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2339
    Cell Significance Index: 103.4100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2256
    Cell Significance Index: 45.2500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2208
    Cell Significance Index: 21.8400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.2200
    Cell Significance Index: 6.4600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1927
    Cell Significance Index: 8.7400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1859
    Cell Significance Index: 35.3800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1811
    Cell Significance Index: 35.9400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1724
    Cell Significance Index: 4.3100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1536
    Cell Significance Index: 19.6900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1426
    Cell Significance Index: 3.0900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1175
    Cell Significance Index: 20.0700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1111
    Cell Significance Index: 39.8400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0894
    Cell Significance Index: 1.2200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0869
    Cell Significance Index: 4.0500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0842
    Cell Significance Index: 58.2200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.0570
    Cell Significance Index: 1.9800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0301
    Cell Significance Index: 2.2500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0230
    Cell Significance Index: 1.0800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0189
    Cell Significance Index: 35.5700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0162
    Cell Significance Index: 0.8500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0113
    Cell Significance Index: 1.4600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0043
    Cell Significance Index: 7.9200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0003
    Cell Significance Index: -0.0100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0004
    Cell Significance Index: -0.5700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0027
    Cell Significance Index: -0.0700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0029
    Cell Significance Index: -2.1400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0031
    Cell Significance Index: -2.3100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0043
    Cell Significance Index: -2.4100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0054
    Cell Significance Index: -3.3900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0060
    Cell Significance Index: -0.1000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0062
    Cell Significance Index: -3.9200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0071
    Cell Significance Index: -9.7000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0124
    Cell Significance Index: -9.0900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0162
    Cell Significance Index: -1.6500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0188
    Cell Significance Index: -1.4400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0231
    Cell Significance Index: -10.4700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0269
    Cell Significance Index: -1.5100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0330
    Cell Significance Index: -4.8000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0383
    Cell Significance Index: -8.0700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0418
    Cell Significance Index: -0.8900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0425
    Cell Significance Index: -0.7800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0443
    Cell Significance Index: -1.1900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0531
    Cell Significance Index: -15.2900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0568
    Cell Significance Index: -6.5100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0576
    Cell Significance Index: -6.5800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0595
    Cell Significance Index: -2.0900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1225
    Cell Significance Index: -3.1300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1259
    Cell Significance Index: -3.6100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1285
    Cell Significance Index: -2.6900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1511
    Cell Significance Index: -9.2900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1628
    Cell Significance Index: -16.9500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1709
    Cell Significance Index: -10.4800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1847
    Cell Significance Index: -9.6200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1972
    Cell Significance Index: -13.2600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2201
    Cell Significance Index: -9.7400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2221
    Cell Significance Index: -17.5900
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.2257
    Cell Significance Index: -3.5800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2612
    Cell Significance Index: -9.8900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.2641
    Cell Significance Index: -3.0000
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: -0.2651
    Cell Significance Index: -1.6400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3136
    Cell Significance Index: -8.0600
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.3283
    Cell Significance Index: -4.9200
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.3580
    Cell Significance Index: -8.2700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3614
    Cell Significance Index: -11.5100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3748
    Cell Significance Index: -12.2700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.3855
    Cell Significance Index: -3.5500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3942
    Cell Significance Index: -13.8100
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.3965
    Cell Significance Index: -4.3100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4047
    Cell Significance Index: -11.9200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Transmembrane protein**: TMEM138 is a transmembrane protein, characterized by its presence of hydrophobic amino acid stretches at the N- and C-termini, which facilitate its integration into cell membranes. 2. **Expression in diverse cell types**: TMEM138 is expressed in a wide range of cell types, including hematopoietic cells, epithelial cells, and immune cells, highlighting its multifunctional role in cellular homeostasis. 3. **Cilium-related pathways**: TMEM138 is involved in cilium formation and function, suggesting its role in regulating cellular signaling and transport processes. 4. **Vacuolar membrane development**: TMEM138 is also implicated in the development of vacuolar membranes, which are essential for cellular homeostasis and immune regulation. **Pathways and Functions:** 1. **Cilium assembly and function**: TMEM138 plays a crucial role in the assembly and regulation of cilia, which are essential for cellular signaling, transport, and immune responses. 2. **Vacuolar membrane development**: TMEM138 is involved in the development of vacuolar membranes, which are critical for cellular homeostasis, protein degradation, and immune regulation. 3. **Immune cell regulation**: TMEM138 is expressed in immune cells, including hematopoietic cells, epithelial cells, and immune cells, suggesting its role in regulating immune responses and maintaining cellular homeostasis. 4. **Cellular signaling and transport**: TMEM138 is involved in regulating cellular signaling and transport processes, particularly in the context of cilium assembly and function. **Clinical Significance:** 1. **Respiratory disorders**: TMEM138 dysfunction has been implicated in respiratory disorders, such as primary ciliary dyskinesia (PCD), which is characterized by recurrent respiratory infections and infertility. 2. **Immunological disorders**: TMEM138 has been linked to immunological disorders, including autoimmune diseases and allergies, which may be related to its role in regulating immune cell function and homeostasis. 3. **Cancer**: TMEM138 has been identified as a potential oncogene, with its expression and activity implicated in cancer progression and metastasis. 4. **Neurological disorders**: TMEM138 has been implicated in neurological disorders, including neurodegenerative diseases, which may be related to its role in regulating cellular signaling and transport processes. In conclusion, TMEM138 is a multifunctional protein that plays a crucial role in regulating cellular homeostasis, immune responses, and cilium assembly and function. Its involvement in various cellular processes underscores its importance in maintaining health and preventing disease. Further research is necessary to fully elucidate the role of TMEM138 in human health and disease.

Genular Protein ID: 2394776706

Symbol: TM138_HUMAN

Name: Transmembrane protein 138

UniProtKB Accession Codes:

Q9NPI0 A6NGA7 B4E044 Q5JPE1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 5 ExpressionAtlas 1 GO 3 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 2 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 11042152

Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.

PubMed ID: 11042152

DOI: 10.1101/gr.140200

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 22282472

Title: Evolutionarily assembled cis-regulatory module at a human ciliopathy locus.

PubMed ID: 22282472

DOI: 10.1126/science.1213506

Sequence Information:

  • Length: 162
  • Mass: 19262
  • Checksum: 31D76DD5C95333DE
  • Sequence:
    • MLQTSNYSLV LSLQFLLLSY DLFVNSFSEL LQKTPVIQLV LFIIQDIAVL FNIIIIFLMF 
FNTFVFQAGL VNLLFHKFKG TIILTAVYFA LSISLHVWVM NLRWKNSNSF IWTDGLQMLF 
VFQRLAAVLY CYFYKRTAVR LGDPHFYQDS LWLRKEFMQV RR

Genular Protein ID: 3147177209

Symbol: J3QSZ6_HUMAN

Name: N/A

UniProtKB Accession Codes:

J3QSZ6

Database IDs:

ARBA 11 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GO 1 GeneTree 1 HGNC 1 InterPro 1 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 2 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 1 SMR 1 UCSC 1 VEuPathDB 1 iPTMnet 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

Sequence Information:

  • Length: 104
  • Mass: 12573
  • Checksum: 8D0FE9FA35DD7DE4
  • Sequence:
    • MFFNTFVFQA GLVNLLFHKF KGTIILTAVY FALSISLHVW VMNLRWKNSN SFIWTDGLQM 
LFVFQRLAAV LYCYFYKRTA VRLGDPHFYQ DSLWLRKEFM QVRR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.