Details for: GSKIP

Gene ID: 51527

Symbol: GSKIP

Ensembl ID: ENSG00000100744

Description: GSK3B interacting protein

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 120.1901
    Cell Significance Index: -18.7000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 74.8295
    Cell Significance Index: -18.9800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 45.4638
    Cell Significance Index: -18.4700
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 33.3186
    Cell Significance Index: -22.3600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 19.4922
    Cell Significance Index: -18.6100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 15.6818
    Cell Significance Index: -19.3400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 5.4949
    Cell Significance Index: -14.7200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.2964
    Cell Significance Index: -20.9000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 4.4539
    Cell Significance Index: -13.6800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 4.0005
    Cell Significance Index: 252.1400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 2.8603
    Cell Significance Index: -6.2600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 2.3988
    Cell Significance Index: 279.5500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 2.3053
    Cell Significance Index: 27.4800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 2.2491
    Cell Significance Index: 244.6400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.6557
    Cell Significance Index: 22.5900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.3063
    Cell Significance Index: 28.3000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.0938
    Cell Significance Index: 16.3900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.0861
    Cell Significance Index: 980.6600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.7859
    Cell Significance Index: 35.6200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.7279
    Cell Significance Index: 37.8100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.5386
    Cell Significance Index: 14.6600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.5116
    Cell Significance Index: 279.4100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4850
    Cell Significance Index: 59.6400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.4767
    Cell Significance Index: 95.6300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.4302
    Cell Significance Index: 19.0300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3686
    Cell Significance Index: 70.1400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3678
    Cell Significance Index: 66.3100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.3100
    Cell Significance Index: 11.7400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.2941
    Cell Significance Index: 9.4200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.2866
    Cell Significance Index: 8.1800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.2390
    Cell Significance Index: 7.0400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2376
    Cell Significance Index: 105.0700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.2193
    Cell Significance Index: 4.6700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.2146
    Cell Significance Index: 5.7300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.2123
    Cell Significance Index: 15.8200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2120
    Cell Significance Index: 76.0300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1809
    Cell Significance Index: 35.9000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1651
    Cell Significance Index: 7.7000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.1548
    Cell Significance Index: 17.7400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.1212
    Cell Significance Index: 4.2100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1037
    Cell Significance Index: 71.7100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1014
    Cell Significance Index: 17.3100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0942
    Cell Significance Index: 11.1100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0921
    Cell Significance Index: 12.6500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0686
    Cell Significance Index: 8.8000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0588
    Cell Significance Index: 2.7700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0486
    Cell Significance Index: 3.2700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0478
    Cell Significance Index: 3.3800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0427
    Cell Significance Index: 4.2200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0401
    Cell Significance Index: 1.4100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0345
    Cell Significance Index: 4.4600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0297
    Cell Significance Index: 0.8600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.0296
    Cell Significance Index: 3.3800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.0191
    Cell Significance Index: 0.5600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0028
    Cell Significance Index: -2.0400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0064
    Cell Significance Index: -4.0100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0068
    Cell Significance Index: -12.8100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0096
    Cell Significance Index: -7.2600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0135
    Cell Significance Index: -24.9600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0137
    Cell Significance Index: -7.7200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0138
    Cell Significance Index: -8.7700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0138
    Cell Significance Index: -10.1000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0153
    Cell Significance Index: -23.5900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0179
    Cell Significance Index: -24.3300
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0227
    Cell Significance Index: -0.2400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0363
    Cell Significance Index: -16.4900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0512
    Cell Significance Index: -7.4400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0529
    Cell Significance Index: -5.4000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0532
    Cell Significance Index: -11.2100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0549
    Cell Significance Index: -1.5400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0589
    Cell Significance Index: -3.0900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0595
    Cell Significance Index: -17.1200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0609
    Cell Significance Index: -1.2800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0738
    Cell Significance Index: -4.1400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0863
    Cell Significance Index: -1.4500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1135
    Cell Significance Index: -3.0400
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.1258
    Cell Significance Index: -1.9100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1398
    Cell Significance Index: -9.0200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1703
    Cell Significance Index: -10.4700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1777
    Cell Significance Index: -13.6400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1954
    Cell Significance Index: -2.2200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1976
    Cell Significance Index: -20.5700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2053
    Cell Significance Index: -10.7000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2104
    Cell Significance Index: -16.6600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.2110
    Cell Significance Index: -14.5900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2164
    Cell Significance Index: -5.6900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2425
    Cell Significance Index: -14.8700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2443
    Cell Significance Index: -5.3500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2705
    Cell Significance Index: -6.9100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3295
    Cell Significance Index: -8.8200
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.3329
    Cell Significance Index: -2.7200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3345
    Cell Significance Index: -12.2800
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.3428
    Cell Significance Index: -4.8800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.3817
    Cell Significance Index: -3.5200
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.3895
    Cell Significance Index: -3.1100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4169
    Cell Significance Index: -13.6500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.4256
    Cell Significance Index: -14.9100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.4476
    Cell Significance Index: -14.2600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.4556
    Cell Significance Index: -11.7100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.4616
    Cell Significance Index: -13.2300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Interacting Protein of GSK3B**: GSKIP forms a complex with GSK3B, a critical kinase involved in Wnt signaling and glycogen synthesis. 2. **Regulation of Wnt Signaling**: GSKIP modulates the activity of GSK3B, influencing the canonical Wnt signaling pathway and its downstream effects. 3. **Negative Regulation of Protein Kinase Activity**: GSKIP inhibits the activity of protein kinases, including GSK3B, suggesting a role in regulating cellular signaling pathways. 4. **Positive Regulation of Canonical Wnt Signaling**: GSKIP promotes the activity of the canonical Wnt signaling pathway, indicating its potential role in promoting cell growth and survival. 5. **High Expression in Various Cell Types**: GSKIP is highly expressed in hematopoietic cells, epithelial cells, immune cells, and other cell types, highlighting its importance in tissue development and homeostasis. **Pathways and Functions:** 1. **Beta-catenin Binding**: GSKIP interacts with beta-catenin, a key component of the canonical Wnt signaling pathway, influencing its activity. 2. **Cytoplasmic Localization**: GSKIP regulates the localization of GSK3B and other kinases in the cytoplasm, affecting cellular signaling pathways. 3. **Intrinsic Apoptotic Signaling Pathway**: GSKIP modulates the activity of pro-apoptotic and anti-apoptotic proteins, influencing cell survival and death. 4. **Negative Regulation of Protein Kinase Activity**: GSKIP inhibits the activity of protein kinases, including GSK3B, regulating cellular signaling pathways. 5. **Positive Regulation of Canonical Wnt Signaling**: GSKIP promotes the activity of the canonical Wnt signaling pathway, influencing cell growth and survival. **Clinical Significance:** 1. **Cancer Therapy**: GSKIP's role in regulating Wnt signaling pathways makes it a potential target for cancer therapy, particularly in cancers driven by aberrant Wnt signaling. 2. **Immunological Disorders**: GSKIP's involvement in immune cell development and function suggests its potential role in immunological disorders, such as autoimmune diseases and immunodeficiency. 3. **Neurological Disorders**: GSKIP's expression in neuronal cells and its involvement in Wnt signaling pathways make it a potential target for neurological disorders, such as Alzheimer's disease and Parkinson's disease. 4. **Regenerative Medicine**: GSKIP's role in regulating cellular homeostasis and differentiation makes it a potential target for regenerative medicine, particularly in the development of tissues and organs. In conclusion, GSKIP is a multifunctional gene that plays a crucial role in regulating Wnt signaling pathways and maintaining cellular homeostasis. Its involvement in various cellular processes and its high expression in various cell types make it a potential target for cancer therapy, immunological disorders, neurological disorders, and regenerative medicine. Further research is necessary to fully elucidate the functions of GSKIP and its potential applications in human disease.

Genular Protein ID: 3431606156

Symbol: GSKIP_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9P0R6 B3KSZ0 Q9BST1 Q9NWK0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 5 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11042152

Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.

PubMed ID: 11042152

DOI: 10.1101/gr.140200

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16981698

Title: GSKIP is homologous to the axin GSK3beta interaction domain and functions as a negative regulator of GSK3beta.

PubMed ID: 16981698

DOI: 10.1021/bi061147r

PubMed ID: 19830702

Title: GSKIP, an inhibitor of GSK3beta, mediates the N-cadherin/beta-catenin pool in the differentiation of SH-SY5Y cells.

PubMed ID: 19830702

DOI: 10.1002/jcb.22362

PubMed ID: 20007971

Title: Glycogen synthase kinase 3beta interaction protein functions as an A-kinase anchoring protein.

PubMed ID: 20007971

DOI: 10.1074/jbc.m109.047944

PubMed ID: 25920809

Title: GSKIP- and GSK3-mediated anchoring strengthens cAMP/PKA/Drp1 axis signaling in the regulation of mitochondrial elongation.

PubMed ID: 25920809

DOI: 10.1016/j.bbamcr.2015.04.013

PubMed ID: 27484798

Title: The A-Kinase Anchoring Protein (AKAP) Glycogen Synthase Kinase 3beta Interaction Protein (GSKIP) Regulates beta-Catenin through Its Interactions with Both Protein Kinase A (PKA) and GSK3beta.

PubMed ID: 27484798

DOI: 10.1074/jbc.m116.738047

Sequence Information:

  • Length: 139
  • Mass: 15648
  • Checksum: A2D8BAF4B458B316
  • Sequence:
    • METDCNPMEL SSMSGFEEGS ELNGFEGTDM KDMRLEAEAV VNDVLFAVNN MFVSKSLRCA 
DDVAYINVET KERNRYCLEL TEAGLKVVGY AFDQVDDHLQ TPYHETVYSL LDTLSPAYRE 
AFGNALLQRL EALKRDGQS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.