Details for: ATP6V1H

Gene ID: 51606

Symbol: ATP6V1H

Ensembl ID: ENSG00000047249

Description: ATPase H+ transporting V1 subunit H

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 314.8280
    Cell Significance Index: -48.9700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 189.2026
    Cell Significance Index: -47.9900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 115.2243
    Cell Significance Index: -54.4000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 109.5242
    Cell Significance Index: -44.5000
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 98.8170
    Cell Significance Index: -50.8300
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 46.8137
    Cell Significance Index: -44.7000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 43.4647
    Cell Significance Index: -53.5900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 17.2622
    Cell Significance Index: -53.0200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 16.8187
    Cell Significance Index: -45.0600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 13.9165
    Cell Significance Index: -54.9200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 9.9288
    Cell Significance Index: -21.7300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 3.4537
    Cell Significance Index: 232.2300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 2.9677
    Cell Significance Index: 84.6900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.6979
    Cell Significance Index: 541.2000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 2.2689
    Cell Significance Index: 100.3600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 2.2286
    Cell Significance Index: 84.3900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.7626
    Cell Significance Index: 121.9000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.7305
    Cell Significance Index: 620.7200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.4536
    Cell Significance Index: 288.4800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.3106
    Cell Significance Index: 1183.4100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.1102
    Cell Significance Index: 58.2900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.9471
    Cell Significance Index: 25.2900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.8158
    Cell Significance Index: 147.0700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.7729
    Cell Significance Index: 84.0700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.7690
    Cell Significance Index: 94.5600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.7013
    Cell Significance Index: 19.6000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.6525
    Cell Significance Index: 39.1700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.6438
    Cell Significance Index: 445.3000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.6306
    Cell Significance Index: 48.4000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.5891
    Cell Significance Index: 321.7100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5700
    Cell Significance Index: 92.7100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4628
    Cell Significance Index: 45.7800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3383
    Cell Significance Index: 149.5800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3360
    Cell Significance Index: 17.4600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3309
    Cell Significance Index: 45.4400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.3293
    Cell Significance Index: 18.4800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.3220
    Cell Significance Index: 20.7800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.3093
    Cell Significance Index: 19.0100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.2998
    Cell Significance Index: 14.0900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2702
    Cell Significance Index: 17.0300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2554
    Cell Significance Index: 30.1200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.2213
    Cell Significance Index: 416.7700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.2109
    Cell Significance Index: 5.4200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.1899
    Cell Significance Index: 14.1500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1835
    Cell Significance Index: 3.9800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1674
    Cell Significance Index: 28.5800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1449
    Cell Significance Index: 18.7300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.1301
    Cell Significance Index: 2.2300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1143
    Cell Significance Index: 72.5900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1089
    Cell Significance Index: 13.9600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0892
    Cell Significance Index: 4.1600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0813
    Cell Significance Index: 36.9000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0694
    Cell Significance Index: 127.9800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0503
    Cell Significance Index: 77.4100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.0432
    Cell Significance Index: 0.5200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.0271
    Cell Significance Index: 20.0800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0159
    Cell Significance Index: 11.6600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0132
    Cell Significance Index: 2.5200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0131
    Cell Significance Index: 17.7900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0024
    Cell Significance Index: -0.0700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0169
    Cell Significance Index: -10.5700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0214
    Cell Significance Index: -3.1100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0321
    Cell Significance Index: -1.4600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0423
    Cell Significance Index: -31.9900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0682
    Cell Significance Index: -38.4500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0902
    Cell Significance Index: -9.2100
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.1018
    Cell Significance Index: -0.8300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1313
    Cell Significance Index: -27.6600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1609
    Cell Significance Index: -46.3000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1847
    Cell Significance Index: -21.5300
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1988
    Cell Significance Index: -22.6900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2106
    Cell Significance Index: -5.6400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2630
    Cell Significance Index: -18.6000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.2812
    Cell Significance Index: -9.8800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2869
    Cell Significance Index: -32.8700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2875
    Cell Significance Index: -7.8300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.3390
    Cell Significance Index: -8.1300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3464
    Cell Significance Index: -9.9300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3620
    Cell Significance Index: -12.5800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3690
    Cell Significance Index: -38.4200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.4199
    Cell Significance Index: -21.8700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.4475
    Cell Significance Index: -7.4900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4689
    Cell Significance Index: -37.1400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.4704
    Cell Significance Index: -10.3000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.4958
    Cell Significance Index: -10.5600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.5284
    Cell Significance Index: -13.5000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.5695
    Cell Significance Index: -7.7700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.6130
    Cell Significance Index: -13.0100
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.6282
    Cell Significance Index: -5.7900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.7437
    Cell Significance Index: -23.8200
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.7851
    Cell Significance Index: -9.7900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.8137
    Cell Significance Index: -21.4000
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.8372
    Cell Significance Index: -12.3600
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.8408
    Cell Significance Index: -8.0000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.8439
    Cell Significance Index: -27.6300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.8559
    Cell Significance Index: -27.2600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.8638
    Cell Significance Index: -52.9600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.8659
    Cell Significance Index: -25.4300
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.9123
    Cell Significance Index: -12.1700
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.9306
    Cell Significance Index: -18.4000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The ATP6V1H gene is a member of the V-ATPase family, which is composed of six subunits (A, B, C, D, E, and H). The H subunit is unique in that it is the only one that is not part of the V-ATPase complex and is instead associated with the endosomal and lysosomal membranes. The ATP6V1H gene is highly conserved across species, suggesting its essential role in maintaining cellular homeostasis. **Pathways and Functions:** The ATP6V1H gene is involved in various cellular processes, including: 1. **Endosomal and Lysosomal Acidification:** The ATP6V1H gene plays a critical role in acidifying the endosomal and lysosomal compartments, which is essential for the degradation and recycling of cellular waste and the processing of antigens for presentation to T-cells. 2. **Antigen Presentation:** The ATP6V1H gene is involved in the regulation of antigen presentation by modulating the activity of antigen-presenting cells (APCs), such as dendritic cells and macrophages. 3. **Phagocytosis:** The ATP6V1H gene is required for the acidification of phagosomes, which is essential for the killing of ingested pathogens. 4. **Autophagy:** The ATP6V1H gene is involved in the regulation of autophagy, a process by which cells recycle damaged or dysfunctional cellular components. 5. **Immune Response:** The ATP6V1H gene is required for the proper functioning of the immune response, including the activation of immune cells and the production of cytokines. **Clinical Significance:** Dysregulation of the ATP6V1H gene has been implicated in various diseases, including: 1. **Cancer:** The ATP6V1H gene has been shown to be overexpressed in certain types of cancer, including breast and lung cancer. 2. **Autoimmune Disorders:** The ATP6V1H gene has been implicated in autoimmune disorders, such as multiple sclerosis and rheumatoid arthritis. 3. **Infectious Diseases:** The ATP6V1H gene has been shown to be involved in the pathogenesis of infectious diseases, such as tuberculosis and HIV-1 infection. 4. **Neurodegenerative Diseases:** The ATP6V1H gene has been implicated in neurodegenerative diseases, such as Alzheimer's and Parkinson's disease. In conclusion, the ATP6V1H gene plays a crucial role in the regulation of endosomal and lysosomal acidification, antigen presentation, phagocytosis, autophagy, and the immune response. Dysregulation of the ATP6V1H gene has been implicated in various diseases, highlighting the importance of this gene in maintaining cellular homeostasis and immune function.

Genular Protein ID: 2792921729

Symbol: VATH_HUMAN

Name: V-type proton ATPase subunit H

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9620685

Title: Interactions between HIV1 Nef and vacuolar ATPase facilitate the internalization of CD4.

PubMed ID: 9620685

DOI: 10.1016/s1074-7613(00)80569-5

PubMed ID: 10931946

Title: Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning.

PubMed ID: 10931946

DOI: 10.1073/pnas.160270997

PubMed ID: 10810093

Title: Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics.

PubMed ID: 10810093

DOI: 10.1101/gr.10.5.703

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12032142

Title: Subunit H of the V-ATPase binds to the medium chain of adaptor protein complex 2 and connects Nef to the endocytic machinery.

PubMed ID: 12032142

DOI: 10.1074/jbc.m200522200

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22087003

Title: Mycobacterium tuberculosis protein tyrosine phosphatase (PtpA) excludes host vacuolar-H+-ATPase to inhibit phagosome acidification.

PubMed ID: 22087003

DOI: 10.1073/pnas.1109201108

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25659576

Title: TM9SF4 is a novel V-ATPase-interacting protein that modulates tumor pH alterations associated with drug resistance and invasiveness of colon cancer cells.

PubMed ID: 25659576

DOI: 10.1038/onc.2014.437

PubMed ID: 33065002

Title: Structures of a Complete Human V-ATPase Reveal Mechanisms of Its Assembly.

PubMed ID: 33065002

DOI: 10.1016/j.molcel.2020.09.029

Sequence Information:

  • Length: 483
  • Mass: 55883
  • Checksum: EAE0457C538AC906
  • Sequence:
  • MTKMDIRGAV DAAVPTNIIA AKAAEVRANK VNWQSYLQGQ MISAEDCEFI QRFEMKRSPE 
    EKQEMLQTEG SQCAKTFINL MTHICKEQTV QYILTMVDDM LQENHQRVSI FFDYARCSKN 
    TAWPYFLPML NRQDPFTVHM AARIIAKLAA WGKELMEGSD LNYYFNWIKT QLSSQKLRGS 
    GVAVETGTVS SSDSSQYVQC VAGCLQLMLR VNEYRFAWVE ADGVNCIMGV LSNKCGFQLQ 
    YQMIFSIWLL AFSPQMCEHL RRYNIIPVLS DILQESVKEK VTRIILAAFR NFLEKSTERE 
    TRQEYALAMI QCKVLKQLEN LEQQKYDDED ISEDIKFLLE KLGESVQDLS SFDEYSSELK 
    SGRLEWSPVH KSEKFWRENA VRLNEKNYEL LKILTKLLEV SDDPQVLAVA AHDVGEYVRH 
    YPRGKRVIEQ LGGKQLVMNH MHHEDQQVRY NALLAVQKLM VHNWEYLGKQ LQSEQPQTAA 
    ARS

Genular Protein ID: 3023670961

Symbol: B3KUZ7_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 483
  • Mass: 55911
  • Checksum: EAF8D4FF75E17EF6
  • Sequence:
  • MTKMDIRGAV DAAVPTNIIA AKAAEVRANK VNWQSYLQGQ MISAEDCEFI QRFEMKRSPE 
    EKQEMLQTEG SQCAKTFINL MTHICKEQTV QYILTMVDDM LQENHQRVSI FFDYARCSKN 
    TAWPYFLPML NRQDPFTVHM AARIIAKLAA WGKELMEGSD LNYYFNWIKT QLSSQKLRGS 
    GVAVETGTVS SSDSSQYVQC VAGCLQLMLR VNEYRFAWVE ADGVNCIMGV LSNKCGFQLQ 
    YQMIFSIWLL AFSPQMCEHL RRYNIIPVLS DILQESVKEK VTRIILAAFR NFLEKSTERE 
    TRQEYALAMI QCKVLKQLEN LEQQKYDDED ISEDIRFLLE KLGESVQDLS SFDEYSSELK 
    SGRLEWSPVH KSEKFWRENA VRLNEKNYEL LKILTKLLEV SDDPQVLAVA AHDVGEYVRH 
    YPRGKRVIEQ LGGKQLVMNH MHHEDQQVRY NALLAVQKLM VHNWEYLGKQ LQSEQPQTAA 
    ARS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.