Details for: GET4

Gene ID: 51608

Symbol: GET4

Ensembl ID: ENSG00000239857

Description: guided entry of tail-anchored proteins factor 4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 36.4846
    Cell Significance Index: -5.6800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 22.8273
    Cell Significance Index: -5.7900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 17.3535
    Cell Significance Index: -7.0500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 7.6460
    Cell Significance Index: -7.3000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 4.6960
    Cell Significance Index: -5.7900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 2.7288
    Cell Significance Index: -7.3100
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.5072
    Cell Significance Index: 11.3800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 1.4749
    Cell Significance Index: -5.8200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.4281
    Cell Significance Index: 38.2700
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 1.3353
    Cell Significance Index: 18.7300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.9970
    Cell Significance Index: 29.2800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.8612
    Cell Significance Index: 44.8600
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.6284
    Cell Significance Index: 6.2000
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.4739
    Cell Significance Index: 2.3100
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.4302
    Cell Significance Index: 5.5100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4290
    Cell Significance Index: 12.3600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4078
    Cell Significance Index: 77.6100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.3962
    Cell Significance Index: 46.7200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2922
    Cell Significance Index: 6.3300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2835
    Cell Significance Index: 12.8500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2113
    Cell Significance Index: 20.9100
  • Cell Name: sebaceous gland cell (CL2000021)
    Fold Change: 0.2056
    Cell Significance Index: 0.2700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1823
    Cell Significance Index: 164.6300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1394
    Cell Significance Index: 8.3700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1312
    Cell Significance Index: 14.2700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1261
    Cell Significance Index: 20.5200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1171
    Cell Significance Index: 7.2000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.1038
    Cell Significance Index: 2.4900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.0869
    Cell Significance Index: 1.8200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0835
    Cell Significance Index: 57.7700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0799
    Cell Significance Index: 4.1500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0662
    Cell Significance Index: 4.5800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0513
    Cell Significance Index: 10.3000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0373
    Cell Significance Index: 1.3100
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 0.0270
    Cell Significance Index: 0.1600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0220
    Cell Significance Index: 3.9700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0197
    Cell Significance Index: 2.2900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0096
    Cell Significance Index: 3.4400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.0057
    Cell Significance Index: 0.1500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0050
    Cell Significance Index: 2.2100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0044
    Cell Significance Index: 0.1100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0039
    Cell Significance Index: 2.1400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0021
    Cell Significance Index: -3.1900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0026
    Cell Significance Index: -4.7700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0028
    Cell Significance Index: -5.3000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0031
    Cell Significance Index: -0.1600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0043
    Cell Significance Index: -5.8500
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.0048
    Cell Significance Index: -0.0300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0080
    Cell Significance Index: -5.9200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0085
    Cell Significance Index: -0.1800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0085
    Cell Significance Index: -6.4500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0095
    Cell Significance Index: -5.9100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0095
    Cell Significance Index: -1.2200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0096
    Cell Significance Index: -7.0300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0107
    Cell Significance Index: -6.0100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0121
    Cell Significance Index: -7.6900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0126
    Cell Significance Index: -0.1800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0142
    Cell Significance Index: -0.4000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0154
    Cell Significance Index: -7.0100
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0179
    Cell Significance Index: -0.2700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0193
    Cell Significance Index: -5.5500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0221
    Cell Significance Index: -3.0400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0243
    Cell Significance Index: -1.0000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0272
    Cell Significance Index: -2.7800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0288
    Cell Significance Index: -3.3000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0290
    Cell Significance Index: -4.9600
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.0294
    Cell Significance Index: -0.3200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0305
    Cell Significance Index: -1.4200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0309
    Cell Significance Index: -6.5100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0310
    Cell Significance Index: -3.8100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0335
    Cell Significance Index: -0.7100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0349
    Cell Significance Index: -6.9300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0351
    Cell Significance Index: -1.1500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0361
    Cell Significance Index: -1.1500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0380
    Cell Significance Index: -2.3300
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0386
    Cell Significance Index: -0.4000
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0446
    Cell Significance Index: -0.7500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0454
    Cell Significance Index: -0.6200
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: -0.0497
    Cell Significance Index: -0.4300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0525
    Cell Significance Index: -7.6300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0527
    Cell Significance Index: -6.8100
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0533
    Cell Significance Index: -1.3300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0540
    Cell Significance Index: -4.1500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0563
    Cell Significance Index: -5.8600
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0598
    Cell Significance Index: -1.2000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0601
    Cell Significance Index: -3.7900
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0606
    Cell Significance Index: -1.3100
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0622
    Cell Significance Index: -1.2300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0687
    Cell Significance Index: -2.4100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0731
    Cell Significance Index: -2.3400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0774
    Cell Significance Index: -1.4300
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.0802
    Cell Significance Index: -1.2000
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.0814
    Cell Significance Index: -1.1300
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.0823
    Cell Significance Index: -1.1800
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.0835
    Cell Significance Index: -0.5700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0856
    Cell Significance Index: -4.5000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0860
    Cell Significance Index: -2.3000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0868
    Cell Significance Index: -6.4700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0900
    Cell Significance Index: -5.0500
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: -0.0959
    Cell Significance Index: -0.2200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** GET4 is a gene that encodes a conserved protein, GET4_HUMAN, which is expressed in a wide range of cell types, including hematopoietic oligopotent progenitor cells, mucosal type mast cells, and stromal cells of bone marrow. The GET4 protein is characterized by its ability to interact with tail-anchored membrane proteins, facilitating their insertion into the ER membrane. This interaction is crucial for maintaining protein homeostasis and preventing ER stress. **Pathways and Functions:** GET4 is involved in several key pathways, including: 1. **ER insertion of tail-anchored proteins:** GET4 plays a crucial role in the insertion of TAPs into the ER membrane. This process is essential for the proper functioning of these proteins, which are involved in various cellular processes, including immune response and cell signaling. 2. **Protein-folding chaperone binding:** GET4 interacts with protein-folding chaperones, such as BiP and GRP78, to regulate protein folding and stability. 3. **Regulation of protein stability:** GET4 modulates the stability of TAPs by interacting with ubiquitin ligases and promoting their degradation. 4. **Cytosolic sequestering of protein:** GET4 can sequester proteins in the cytosol, preventing their interaction with the ER membrane and thereby regulating their activity. **Clinical Significance:** Dysregulation of GET4 has been implicated in various diseases, including: 1. **Immunodeficiency disorders:** GET4 mutations have been associated with immunodeficiency disorders, such as X-linked agammaglobulinemia. 2. **Cancer:** GET4 expression is altered in various types of cancer, including leukemia and lymphoma. 3. **Neurological disorders:** GET4 has been linked to neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, the GET4 gene is a complex and multifaceted player in the regulation of tail-anchored membrane proteins and protein homeostasis. Further research is needed to fully elucidate the mechanisms of GET4 and its role in various diseases. As an expert immunologist, I believe that a deeper understanding of GET4 will provide valuable insights into the development of novel therapeutic strategies for immunodeficiency disorders and other diseases associated with GET4 dysfunction.

Genular Protein ID: 2997404854

Symbol: GET4_HUMAN

Name: Conserved edge-expressed protein

UniProtKB Accession Codes:

Q7L5D6 A4D2Q1 B3KNC7 Q9UFC9 Q9Y309

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 EMDB 3 Ensembl 2 ExpressionAtlas 1 GO 15 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 MoonDB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10810093

Title: Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics.

PubMed ID: 10810093

DOI: 10.1101/gr.10.5.703

PubMed ID: 18249086

Title: Genomic, evolutionary, and expression analyses of cee, an ancient gene involved in normal growth and development.

PubMed ID: 18249086

DOI: 10.1016/j.ygeno.2007.10.017

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 20676083

Title: A ribosome-associating factor chaperones tail-anchored membrane proteins.

PubMed ID: 20676083

DOI: 10.1038/nature09296

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21636303

Title: A ubiquitin ligase-associated chaperone holdase maintains polypeptides in soluble states for proteasome degradation.

PubMed ID: 21636303

DOI: 10.1016/j.molcel.2011.05.010

PubMed ID: 21743475

Title: Protein targeting and degradation are coupled for elimination of mislocalized proteins.

PubMed ID: 21743475

DOI: 10.1038/nature10181

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25535373

Title: Bag6 complex contains a minimal tail-anchor-targeting module and a mock BAG domain.

PubMed ID: 25535373

DOI: 10.1073/pnas.1402745112

PubMed ID: 28104892

Title: Mechanistic basis for a molecular triage reaction.

PubMed ID: 28104892

DOI: 10.1126/science.aah6130

PubMed ID: 32395830

Title: Mutations in GET4 disrupt the transmembrane domain recognition complex pathway.

PubMed ID: 32395830

DOI: 10.1002/jimd.12249

PubMed ID: 29042515

Title: Structural basis for regulation of the nucleo-cytoplasmic distribution of Bag6 by TRC35.

PubMed ID: 29042515

DOI: 10.1073/pnas.1702940114

Sequence Information:

  • Length: 327
  • Mass: 36504
  • Checksum: 4D6C4233181B0512
  • Sequence:
    • MAAAAAMAEQ ESARNGGRNR GGVQRVEGKL RASVEKGDYY EAHQMYRTLF FRYMSQSKHT 
EARELMYSGA LLFFSHGQQN SAADLSMLVL ESLEKAEVEV ADELLENLAK VFSLMDPNSP 
ERVTFVSRAL KWSSGGSGKL GHPRLHQLLA LTLWKEQNYC ESRYHFLHSA DGEGCANMLV 
EYSTSRGFRS EVDMFVAQAV LQFLCLKNKS SASVVFTTYT QKHPSIEDGP PFVEPLLNFI 
WFLLLAVDGG KLTVFTVLCE QYQPSLRRDP MYNEYLDRIG QLFFGVPPKQ TSSYGGLLGN 
LLTSLMGSSE QEDGEESPSD GSPIELD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.