Details for: POU6F1

Gene ID: 5463

Symbol: POU6F1

Ensembl ID: ENSG00000184271

Description: POU class 6 homeobox 1

Associated with

  • Brain development
    (GO:0007420)
  • Chromatin
    (GO:0000785)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna-binding transcription repressor activity, rna polymerase ii-specific
    (GO:0001227)
  • Heart development
    (GO:0007507)
  • Muscle organ development
    (GO:0007517)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Nucleus
    (GO:0005634)
  • Protein binding
    (GO:0005515)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Sequence-specific dna binding
    (GO:0043565)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 119.6437
    Cell Significance Index: -18.6100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 73.5481
    Cell Significance Index: -18.6600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 15.1100
    Cell Significance Index: -18.6300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 4.4311
    Cell Significance Index: -13.6100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.2585
    Cell Significance Index: -9.3200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.9625
    Cell Significance Index: 193.0700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.6345
    Cell Significance Index: 227.5800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.5037
    Cell Significance Index: 22.2800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.4679
    Cell Significance Index: 17.7200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.4546
    Cell Significance Index: 314.4000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4268
    Cell Significance Index: 81.2300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.3381
    Cell Significance Index: 8.6900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2392
    Cell Significance Index: 23.6600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.2381
    Cell Significance Index: 14.6400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2381
    Cell Significance Index: 214.9800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1128
    Cell Significance Index: 18.3400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1079
    Cell Significance Index: 6.8000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1057
    Cell Significance Index: 20.9700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0934
    Cell Significance Index: 2.6900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.0863
    Cell Significance Index: 2.0700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0671
    Cell Significance Index: 1.1500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.0412
    Cell Significance Index: 0.8100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.0283
    Cell Significance Index: 3.0800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0253
    Cell Significance Index: 47.6100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0204
    Cell Significance Index: 9.2500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0097
    Cell Significance Index: 1.2400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0086
    Cell Significance Index: 13.2800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0064
    Cell Significance Index: 1.1500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0052
    Cell Significance Index: 0.1300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0052
    Cell Significance Index: 9.5600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0020
    Cell Significance Index: 1.2800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0013
    Cell Significance Index: -1.8300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0023
    Cell Significance Index: -0.0800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0026
    Cell Significance Index: -0.1600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0119
    Cell Significance Index: -5.2700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0195
    Cell Significance Index: -14.2900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0243
    Cell Significance Index: -18.4000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0256
    Cell Significance Index: -0.5600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0257
    Cell Significance Index: -19.0400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0285
    Cell Significance Index: -4.1500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0300
    Cell Significance Index: -1.3600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0303
    Cell Significance Index: -16.5600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0312
    Cell Significance Index: -19.4800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0320
    Cell Significance Index: -2.4600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0340
    Cell Significance Index: -19.1500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0503
    Cell Significance Index: -6.1800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0530
    Cell Significance Index: -15.2400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0572
    Cell Significance Index: -9.7700
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0632
    Cell Significance Index: -1.3100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0664
    Cell Significance Index: -3.4600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0664
    Cell Significance Index: -4.5900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0664
    Cell Significance Index: -9.1200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0806
    Cell Significance Index: -3.7600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0807
    Cell Significance Index: -9.4000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0905
    Cell Significance Index: -1.9600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1005
    Cell Significance Index: -21.1800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1016
    Cell Significance Index: -2.8400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1061
    Cell Significance Index: -10.8400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.1163
    Cell Significance Index: -6.9800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1253
    Cell Significance Index: -16.1900
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1371
    Cell Significance Index: -2.7100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1441
    Cell Significance Index: -16.9900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1463
    Cell Significance Index: -16.7600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1483
    Cell Significance Index: -15.4400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1512
    Cell Significance Index: -3.2100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1642
    Cell Significance Index: -9.2200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1814
    Cell Significance Index: -5.8100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1851
    Cell Significance Index: -9.7200
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1934
    Cell Significance Index: -2.7700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1950
    Cell Significance Index: -13.7900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2057
    Cell Significance Index: -16.2900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2135
    Cell Significance Index: -15.9100
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.2187
    Cell Significance Index: -3.1400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2315
    Cell Significance Index: -10.8800
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.2421
    Cell Significance Index: -4.8600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2610
    Cell Significance Index: -16.8400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2789
    Cell Significance Index: -18.7500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2927
    Cell Significance Index: -15.2100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3074
    Cell Significance Index: -9.7900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.3093
    Cell Significance Index: -4.2200
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.3230
    Cell Significance Index: -6.9100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3369
    Cell Significance Index: -11.0300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.3444
    Cell Significance Index: -7.3400
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.3498
    Cell Significance Index: -15.2100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3699
    Cell Significance Index: -12.9600
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.3724
    Cell Significance Index: -9.2900
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.3777
    Cell Significance Index: -8.1600
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.3882
    Cell Significance Index: -2.6300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.4045
    Cell Significance Index: -10.8400
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.4118
    Cell Significance Index: -7.1200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.4140
    Cell Significance Index: -11.2700
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.4321
    Cell Significance Index: -6.1400
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.4337
    Cell Significance Index: -5.1700
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.4365
    Cell Significance Index: -9.1100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.4539
    Cell Significance Index: -12.1200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.4547
    Cell Significance Index: -15.8000
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.4639
    Cell Significance Index: -6.6700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.4696
    Cell Significance Index: -13.4600
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.4709
    Cell Significance Index: -5.1300
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.4991
    Cell Significance Index: -6.0500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **POU Domain:** The POU6F1 gene belongs to the POU domain family of transcription factors, which are characterized by the presence of a POU domain, a conserved DNA-binding motif. 2. **Transcriptional Regulation:** POU6F1 regulates the expression of target genes by binding to specific DNA sequences, thereby influencing the transcriptional activity of RNA polymerase II. 3. **Neural Development:** POU6F1 is specifically expressed in neural populations, including GABAergic cortical interneurons, and plays a critical role in their development and function. 4. **Cell Type-Specific Expression:** POU6F1 is expressed in various neuronal populations, including near-projecting glutamatergic cortical neurons, chandelier neurons, and L2/3-6 intratelencephalic projecting glutamatergic neurons. **Pathways and Functions:** 1. **Brain Development:** POU6F1 regulates the development of the brain by controlling the expression of genes essential for neural development, particularly in the context of cortical interneurons. 2. **Chromatin Remodeling:** POU6F1 interacts with chromatin remodeling complexes to regulate the structure and function of chromatin, thereby influencing gene expression. 3. **Transcriptional Repression:** POU6F1 acts as a transcriptional repressor, inhibiting the expression of genes that are not essential for neural development. 4. **RNA Polymerase II-Specific Regulation:** POU6F1 regulates the activity of RNA polymerase II, a key enzyme involved in the transcription of protein-coding genes. **Clinical Significance:** 1. **Neurodevelopmental Disorders:** Alterations in POU6F1 expression have been linked to neurodevelopmental disorders, such as epilepsy and autism spectrum disorder. 2. **Cortical Interneuron Dysfunction:** POU6F1 deficiency or dysfunction has been associated with cortical interneuron dysfunction, leading to impaired neural circuit function. 3. **Therapeutic Target:** POU6F1 has emerged as a potential therapeutic target for the treatment of neurodevelopmental disorders, particularly those involving cortical interneuron dysfunction. In conclusion, the POU6F1 gene is a crucial regulator of neural development and function, particularly in the context of cortical interneurons. Further research is necessary to fully elucidate the mechanisms by which POU6F1 regulates neural development and to explore its potential as a therapeutic target for neurodevelopmental disorders.

Genular Protein ID: 2009566065

Symbol: PO6F1_HUMAN

Name: POU domain, class 6, transcription factor 1

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 7908264

Title: A human POU domain gene, mPOU, is expressed in developing brain and specific adult tissues.

PubMed ID: 7908264

DOI: 10.1111/j.1432-1033.1994.tb18676.x

PubMed ID: 8102789

Title: A novel POU domain protein which binds to the T-cell receptor beta enhancer.

PubMed ID: 8102789

DOI: 10.1128/mcb.13.9.5450-5460.1993

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 301
  • Mass: 32645
  • Checksum: 9C552BA84ABAB17A
  • Sequence:
  • MPGISSQILT NAQGQVIGTL PWVVNSASVA APAPAQSLQV QAVTPQLLLN AQGQVIATLA 
    SSPLPPPVAV RKPSTPESPA KSEVQPIQPT PTVPQPAVVI ASPAPAAKPS ASAPIPITCS 
    ETPTVSQLVS KPHTPSLDED GINLEEIREF AKNFKIRRLS LGLTQTQVGQ ALTATEGPAY 
    SQSAICRFEK LDITPKSAQK LKPVLEKWLN EAELRNQEGQ QNLMEFVGGE PSKKRKRRTS 
    FTPQAIEALN AYFEKNPLPT GQEITEIAKE LNYDREVVRV WFCNRRQTLK NTSKLNVFQI 
    P

Genular Protein ID: 1839441089

Symbol: B3KT91_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 301
  • Mass: 32673
  • Checksum: 834523B85DBAB17A
  • Sequence:
  • MPGISSQILT NAQGQVIGTL PWVVNSASVA APAPAQSLQV QAVTPQLLLN AQGQVIATLA 
    SSPLPPPVAV RKPSTPESPA KSEVQPIQPT PTVPQPAVVI ASPAPAAKPS ASAPIPITCS 
    ETPTVSQLVS KPHTPSLDED GINLEEIREF AKNFKIRRLS LGLTQTQVGQ ALTATEGPVY 
    SQSAICRFEK LDITPKSAQK LKPVLEKWLN EAELRNQEGQ QNLMEFVGGE PSKKRKRRTS 
    FTPQAIEALN AYFEKNPLPT GQEITEIAKE LNYDREVVRV WFCNRRQTLK NTSKLNVFQI 
    P

Genular Protein ID: 3388498677

Symbol: A0A1C7CYV8_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

Sequence Information:

  • Length: 611
  • Mass: 63068
  • Checksum: 4A64126561974CD3
  • Sequence:
  • MDPGAGSETS LTVNEQVIVM SGHETIRVLE VGVDAQLPAE EESKGLEGVA AEGSQSGDPA 
    EASQAAGEAG PDNLGSSAEA TVKSPPGIPP SPATAIATFS QAPSQPQASQ TLTPLAVQAA 
    PQVLTQENLA TVLTGVMVPA GAVTQPLLIP ISIAGQVAGQ QGLAVWTIPT ATVAALPGLT 
    AASPTGGVFK PPLAGLQAAA VLNTALPAPV QAAAPVQASS TAQPRPPAQP QTLFQTQPLL 
    QTTPAILPQP TAATAAAPTP KPVDTPPQIT VQPAGFAFSP GIISAASLGG QTQILGSLTT 
    APVITSAIPS MPGISSQILT NAQGQVIGTL PWVVNSASVA APAPAQSLQV QAVTPQLLLN 
    AQGQVIATLA SSPLPPPVAV RKPSTPESPA KSEVQPIQPT PTVPQPAVVI ASPAPAAKPS 
    ASAPIPITCS ETPTVSQLVS KPHTPSLDED GINLEEIREF AKNFKIRRLS LGLTQTQVGQ 
    ALTATEGPAY SQSAICRFEK LDITPKSAQK LKPVLEKWLN EAELRNQEGQ QNLMEFVGGE 
    PSKKRKRRTS FTPQAIEALN AYFEKNPLPT GQEITEIAKE LNYDREVVRV WFCNRRQTLK 
    NTSKLNVFQI P

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.