Details for: PPP2R5B

Gene ID: 5526

Symbol: PPP2R5B

Ensembl ID: ENSG00000068971

Description: protein phosphatase 2 regulatory subunit B'beta

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 75.7336
    Cell Significance Index: -11.7800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 63.7115
    Cell Significance Index: -16.1600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 33.3040
    Cell Significance Index: -13.5300
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 14.2237
    Cell Significance Index: -13.5800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 12.0686
    Cell Significance Index: -14.8800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 5.8383
    Cell Significance Index: -15.6400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.1459
    Cell Significance Index: -16.3600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.5902
    Cell Significance Index: 83.4900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.7689
    Cell Significance Index: 10.4900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.6984
    Cell Significance Index: 36.3800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6322
    Cell Significance Index: 570.7900
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.5934
    Cell Significance Index: 9.5200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.5853
    Cell Significance Index: 10.0300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.5520
    Cell Significance Index: 110.7400
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.4108
    Cell Significance Index: 5.1000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3998
    Cell Significance Index: 76.0800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3935
    Cell Significance Index: 141.1500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3901
    Cell Significance Index: 11.2400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3741
    Cell Significance Index: 60.8500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.3169
    Cell Significance Index: 219.2100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3115
    Cell Significance Index: 33.8800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2813
    Cell Significance Index: 12.7500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2599
    Cell Significance Index: 16.3800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.2069
    Cell Significance Index: 4.5300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2027
    Cell Significance Index: 20.0500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.1940
    Cell Significance Index: 5.2800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1684
    Cell Significance Index: 8.7500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1501
    Cell Significance Index: 9.0100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1474
    Cell Significance Index: 18.9000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1430
    Cell Significance Index: 9.8900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1326
    Cell Significance Index: 17.1300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1181
    Cell Significance Index: 4.1500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0977
    Cell Significance Index: 17.6100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0973
    Cell Significance Index: 5.9800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0612
    Cell Significance Index: 2.8800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0568
    Cell Significance Index: 6.9800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0491
    Cell Significance Index: 26.8300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0476
    Cell Significance Index: 3.5500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0470
    Cell Significance Index: 3.6100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0464
    Cell Significance Index: 9.2000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0346
    Cell Significance Index: 4.7600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0341
    Cell Significance Index: 15.0700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0255
    Cell Significance Index: 4.3600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0231
    Cell Significance Index: 1.0800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0173
    Cell Significance Index: 32.6000
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.0168
    Cell Significance Index: 0.2000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0116
    Cell Significance Index: 17.8000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0114
    Cell Significance Index: 20.9900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0049
    Cell Significance Index: 0.3300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0041
    Cell Significance Index: 5.5300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0009
    Cell Significance Index: 0.5400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0037
    Cell Significance Index: -1.6600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0041
    Cell Significance Index: -0.1800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0053
    Cell Significance Index: -3.2800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0071
    Cell Significance Index: -5.2300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0143
    Cell Significance Index: -10.4900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0145
    Cell Significance Index: -10.9700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0171
    Cell Significance Index: -9.6400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0304
    Cell Significance Index: -1.1500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0399
    Cell Significance Index: -4.5700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0407
    Cell Significance Index: -8.5800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0425
    Cell Significance Index: -4.3400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0451
    Cell Significance Index: -12.9700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0460
    Cell Significance Index: -5.4300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0649
    Cell Significance Index: -9.4300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0873
    Cell Significance Index: -2.4900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0900
    Cell Significance Index: -10.4900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0930
    Cell Significance Index: -1.9800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0930
    Cell Significance Index: -2.6000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0936
    Cell Significance Index: -6.0400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1056
    Cell Significance Index: -7.4700
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1163
    Cell Significance Index: -2.7900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1213
    Cell Significance Index: -13.8500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1375
    Cell Significance Index: -14.3200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1376
    Cell Significance Index: -2.9800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1458
    Cell Significance Index: -8.1800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1564
    Cell Significance Index: -3.3200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1649
    Cell Significance Index: -3.4200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1783
    Cell Significance Index: -14.1200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1819
    Cell Significance Index: -3.0500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1852
    Cell Significance Index: -4.6300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1933
    Cell Significance Index: -6.1900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1974
    Cell Significance Index: -12.1100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.2203
    Cell Significance Index: -6.4700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2228
    Cell Significance Index: -3.1900
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.2234
    Cell Significance Index: -4.7800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2437
    Cell Significance Index: -7.9800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2526
    Cell Significance Index: -8.0500
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.2635
    Cell Significance Index: -5.2100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2684
    Cell Significance Index: -6.9000
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: -0.2690
    Cell Significance Index: -2.3700
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.2743
    Cell Significance Index: -4.1100
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.2894
    Cell Significance Index: -5.8100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3211
    Cell Significance Index: -11.2500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.3213
    Cell Significance Index: -8.6100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3283
    Cell Significance Index: -11.4100
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.3335
    Cell Significance Index: -8.3200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.3354
    Cell Significance Index: -7.0200
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.3360
    Cell Significance Index: -4.1900
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.3383
    Cell Significance Index: -4.8700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Isoform specificity**: PPP2R5B is one of the several isoforms of the PP2A regulatory subunit, with distinct tissue-specific expression patterns. 2. **Regulatory subunit function**: PPP2R5B acts as a regulatory subunit of PP2A, which is a serine/threonine phosphatase involved in dephosphorylation and protein regulation. 3. **Cellular localization**: PPP2R5B is predominantly localized in the cytosol, with some expression in the nucleus. 4. **Post-translational modifications**: PPP2R5B is subject to phosphorylation, which regulates its activity and interaction with PP2A. **Pathways and Functions:** 1. **Immune response**: PPP2R5B is involved in the regulation of immune cell function, including T-cell activation, cytokine production, and B-cell differentiation. 2. **Cell cycle regulation**: PPP2R5B regulates cell cycle progression by dephosphorylating and activating key cyclin-dependent kinases (CDKs) and cyclin partners. 3. **Signal transduction**: PPP2R5B is a key regulator of signal transduction pathways, including the Wnt/β-catenin pathway, MAPK/ERK pathway, and PI3K/AKT pathway. 4. **Cytoskeletal regulation**: PPP2R5B regulates cytoskeletal dynamics by dephosphorylating and activating key cytoskeletal proteins. **Clinical Significance:** 1. **Cancer**: Alterations in PPP2R5B expression and function have been implicated in various cancers, including colon, breast, and lung cancer. 2. **Autoimmune diseases**: PPP2R5B is involved in the regulation of immune cell function, making it a potential target for the treatment of autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. 3. **Neurological disorders**: PPP2R5B is implicated in the regulation of neuronal function and synaptic plasticity, making it a potential target for the treatment of neurological disorders, such as Alzheimer's disease and Parkinson's disease. 4. **Cardiovascular disease**: PPP2R5B is involved in the regulation of cardiac myocyte function and hypertrophy, making it a potential target for the treatment of cardiovascular disease. In conclusion, PPP2R5B is a critical regulatory subunit of PP2A involved in various cellular processes, including immune response, cell cycle regulation, and signal transduction. Its dysregulation has been implicated in various diseases, making it a potential target for therapeutic intervention. Further research is needed to fully elucidate the role of PPP2R5B in human disease and to develop effective therapeutic strategies.

Genular Protein ID: 2079370237

Symbol: 2A5B_HUMAN

Name: Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 7592815

Title: Identification of a new family of protein phosphatase 2A regulatory subunits.

PubMed ID: 7592815

DOI: 10.1074/jbc.270.44.26123

PubMed ID: 8694763

Title: The variable subunit associated with protein phosphatase 2A0 defines a novel multimember family of regulatory subunits.

PubMed ID: 8694763

DOI: 10.1042/bj3170187

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8703017

Title: The B56 family of protein phosphatase 2A (PP2A) regulatory subunits encodes differentiation-induced phosphoproteins that target PP2A to both nucleus and cytoplasm.

PubMed ID: 8703017

DOI: 10.1074/jbc.271.36.22081

PubMed ID: 16541025

Title: Shugoshin collaborates with protein phosphatase 2A to protect cohesin.

PubMed ID: 16541025

DOI: 10.1038/nature04663

PubMed ID: 21329884

Title: Clk2 and B56-beta mediate insulin-regulated assembly of the PP2A phosphatase holoenzyme complex on Akt.

PubMed ID: 21329884

DOI: 10.1016/j.molcel.2011.02.007

PubMed ID: 23135275

Title: Selective proteasomal degradation of the B'beta subunit of protein phosphatase 2A by the E3 ubiquitin ligase adaptor Kelch-like 15.

PubMed ID: 23135275

DOI: 10.1074/jbc.m112.420281

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

Sequence Information:

  • Length: 497
  • Mass: 57393
  • Checksum: 8BEF84F20A77982D
  • Sequence:
  • METKLPPAST PTSPSSPGLS PVPPPDKVDG FSRRSLRRAR PRRSHSSSQF RYQSNQQELT 
    PLPLLKDVPA SELHELLSRK LAQCGVMFDF LDCVADLKGK EVKRAALNEL VECVGSTRGV 
    LIEPVYPDII RMISVNIFRT LPPSENPEFD PEEDEPNLEP SWPHLQLVYE FFLRFLESPD 
    FQPSVAKRYV DQKFVLMLLE LFDSEDPRER EYLKTILHRV YGKFLGLRAY IRKQCNHIFL 
    RFIYEFEHFN GVAELLEILG SIINGFALPL KTEHKQFLVR VLIPLHSVKS LSVFHAQLAY 
    CVVQFLEKDA TLTEHVIRGL LKYWPKTCTQ KEVMFLGEME EILDVIEPSQ FVKIQEPLFK 
    QVARCVSSPH FQVAERALYF WNNEYILSLI EDNCHTVLPA VFGTLYQVSK EHWNQTIVSL 
    IYNVLKTFME MNGKLFDELT ASYKLEKQQE QQKAQERQEL WQGLEELRLR RLQGTQGAKE 
    APLQRLTPQV AASGGQS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.