Details for: PPP2R5B
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 75.7336
Cell Significance Index: -11.7800 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 63.7115
Cell Significance Index: -16.1600 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 33.3040
Cell Significance Index: -13.5300 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 14.2237
Cell Significance Index: -13.5800 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 12.0686
Cell Significance Index: -14.8800 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 5.8383
Cell Significance Index: -15.6400 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 4.1459
Cell Significance Index: -16.3600 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: 1.5902
Cell Significance Index: 83.4900 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.7689
Cell Significance Index: 10.4900 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.6984
Cell Significance Index: 36.3800 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.6322
Cell Significance Index: 570.7900 - Cell Name: decidual cell (CL2000002)
Fold Change: 0.5934
Cell Significance Index: 9.5200 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 0.5853
Cell Significance Index: 10.0300 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.5520
Cell Significance Index: 110.7400 - Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 0.4108
Cell Significance Index: 5.1000 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.3998
Cell Significance Index: 76.0800 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.3935
Cell Significance Index: 141.1500 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.3901
Cell Significance Index: 11.2400 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.3741
Cell Significance Index: 60.8500 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.3169
Cell Significance Index: 219.2100 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.3115
Cell Significance Index: 33.8800 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.2813
Cell Significance Index: 12.7500 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.2599
Cell Significance Index: 16.3800 - Cell Name: Purkinje cell (CL0000121)
Fold Change: 0.2069
Cell Significance Index: 4.5300 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.2027
Cell Significance Index: 20.0500 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.1940
Cell Significance Index: 5.2800 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.1684
Cell Significance Index: 8.7500 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.1501
Cell Significance Index: 9.0100 - Cell Name: odontoblast (CL0000060)
Fold Change: 0.1474
Cell Significance Index: 18.9000 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.1430
Cell Significance Index: 9.8900 - Cell Name: lactocyte (CL0002325)
Fold Change: 0.1326
Cell Significance Index: 17.1300 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.1181
Cell Significance Index: 4.1500 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.0977
Cell Significance Index: 17.6100 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.0973
Cell Significance Index: 5.9800 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.0612
Cell Significance Index: 2.8800 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.0568
Cell Significance Index: 6.9800 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.0491
Cell Significance Index: 26.8300 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.0476
Cell Significance Index: 3.5500 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.0470
Cell Significance Index: 3.6100 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.0464
Cell Significance Index: 9.2000 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.0346
Cell Significance Index: 4.7600 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.0341
Cell Significance Index: 15.0700 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.0255
Cell Significance Index: 4.3600 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.0231
Cell Significance Index: 1.0800 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0173
Cell Significance Index: 32.6000 - Cell Name: retinal rod cell (CL0000604)
Fold Change: 0.0168
Cell Significance Index: 0.2000 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0116
Cell Significance Index: 17.8000 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0114
Cell Significance Index: 20.9900 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 0.0049
Cell Significance Index: 0.3300 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.0041
Cell Significance Index: 5.5300 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.0009
Cell Significance Index: 0.5400 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0037
Cell Significance Index: -1.6600 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.0041
Cell Significance Index: -0.1800 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0053
Cell Significance Index: -3.2800 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0071
Cell Significance Index: -5.2300 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0143
Cell Significance Index: -10.4900 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0145
Cell Significance Index: -10.9700 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0171
Cell Significance Index: -9.6400 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.0304
Cell Significance Index: -1.1500 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0399
Cell Significance Index: -4.5700 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0407
Cell Significance Index: -8.5800 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0425
Cell Significance Index: -4.3400 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0451
Cell Significance Index: -12.9700 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.0460
Cell Significance Index: -5.4300 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0649
Cell Significance Index: -9.4300 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.0873
Cell Significance Index: -2.4900 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.0900
Cell Significance Index: -10.4900 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.0930
Cell Significance Index: -1.9800 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.0930
Cell Significance Index: -2.6000 - Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.0936
Cell Significance Index: -6.0400 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.1056
Cell Significance Index: -7.4700 - Cell Name: cortical interneuron (CL0008031)
Fold Change: -0.1163
Cell Significance Index: -2.7900 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.1213
Cell Significance Index: -13.8500 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.1375
Cell Significance Index: -14.3200 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.1376
Cell Significance Index: -2.9800 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.1458
Cell Significance Index: -8.1800 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.1564
Cell Significance Index: -3.3200 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.1649
Cell Significance Index: -3.4200 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.1783
Cell Significance Index: -14.1200 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.1819
Cell Significance Index: -3.0500 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.1852
Cell Significance Index: -4.6300 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.1933
Cell Significance Index: -6.1900 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.1974
Cell Significance Index: -12.1100 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: -0.2203
Cell Significance Index: -6.4700 - Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.2228
Cell Significance Index: -3.1900 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: -0.2234
Cell Significance Index: -4.7800 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.2437
Cell Significance Index: -7.9800 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.2526
Cell Significance Index: -8.0500 - Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -0.2635
Cell Significance Index: -5.2100 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.2684
Cell Significance Index: -6.9000 - Cell Name: OFF-bipolar cell (CL0000750)
Fold Change: -0.2690
Cell Significance Index: -2.3700 - Cell Name: paneth cell of colon (CL0009009)
Fold Change: -0.2743
Cell Significance Index: -4.1100 - Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -0.2894
Cell Significance Index: -5.8100 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.3211
Cell Significance Index: -11.2500 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.3213
Cell Significance Index: -8.6100 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.3283
Cell Significance Index: -11.4100 - Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: -0.3335
Cell Significance Index: -8.3200 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.3354
Cell Significance Index: -7.0200 - Cell Name: OFF midget ganglion cell (CL4033047)
Fold Change: -0.3360
Cell Significance Index: -4.1900 - Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: -0.3383
Cell Significance Index: -4.8700
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 2079370237
Symbol: 2A5B_HUMAN
Name: Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 7592815
Title: Identification of a new family of protein phosphatase 2A regulatory subunits.
PubMed ID: 7592815
PubMed ID: 8694763
Title: The variable subunit associated with protein phosphatase 2A0 defines a novel multimember family of regulatory subunits.
PubMed ID: 8694763
DOI: 10.1042/bj3170187
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 8703017
Title: The B56 family of protein phosphatase 2A (PP2A) regulatory subunits encodes differentiation-induced phosphoproteins that target PP2A to both nucleus and cytoplasm.
PubMed ID: 8703017
PubMed ID: 16541025
Title: Shugoshin collaborates with protein phosphatase 2A to protect cohesin.
PubMed ID: 16541025
DOI: 10.1038/nature04663
PubMed ID: 21329884
Title: Clk2 and B56-beta mediate insulin-regulated assembly of the PP2A phosphatase holoenzyme complex on Akt.
PubMed ID: 21329884
PubMed ID: 23135275
Title: Selective proteasomal degradation of the B'beta subunit of protein phosphatase 2A by the E3 ubiquitin ligase adaptor Kelch-like 15.
PubMed ID: 23135275
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
Sequence Information:
- Length: 497
- Mass: 57393
- Checksum: 8BEF84F20A77982D
- Sequence:
METKLPPAST PTSPSSPGLS PVPPPDKVDG FSRRSLRRAR PRRSHSSSQF RYQSNQQELT PLPLLKDVPA SELHELLSRK LAQCGVMFDF LDCVADLKGK EVKRAALNEL VECVGSTRGV LIEPVYPDII RMISVNIFRT LPPSENPEFD PEEDEPNLEP SWPHLQLVYE FFLRFLESPD FQPSVAKRYV DQKFVLMLLE LFDSEDPRER EYLKTILHRV YGKFLGLRAY IRKQCNHIFL RFIYEFEHFN GVAELLEILG SIINGFALPL KTEHKQFLVR VLIPLHSVKS LSVFHAQLAY CVVQFLEKDA TLTEHVIRGL LKYWPKTCTQ KEVMFLGEME EILDVIEPSQ FVKIQEPLFK QVARCVSSPH FQVAERALYF WNNEYILSLI EDNCHTVLPA VFGTLYQVSK EHWNQTIVSL IYNVLKTFME MNGKLFDELT ASYKLEKQQE QQKAQERQEL WQGLEELRLR RLQGTQGAKE APLQRLTPQV AASGGQS
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.