Details for: PRKAB1

Gene ID: 5564

Symbol: PRKAB1

Ensembl ID: ENSG00000111725

Description: protein kinase AMP-activated non-catalytic subunit beta 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 50.1491
    Cell Significance Index: -12.7200
  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 41.6278
    Cell Significance Index: -6.4800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 32.1717
    Cell Significance Index: -13.0700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 31.1148
    Cell Significance Index: -14.6900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 13.8886
    Cell Significance Index: -13.2600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 10.7911
    Cell Significance Index: -13.3100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 4.5952
    Cell Significance Index: -12.3100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.6315
    Cell Significance Index: -14.3300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.1095
    Cell Significance Index: 66.6100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.9615
    Cell Significance Index: 104.5900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.8524
    Cell Significance Index: 11.6300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7750
    Cell Significance Index: 126.0400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7564
    Cell Significance Index: 682.9700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.7543
    Cell Significance Index: 87.9100
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.7314
    Cell Significance Index: 5.8400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.6104
    Cell Significance Index: 16.3600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.5913
    Cell Significance Index: 12.8100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.5656
    Cell Significance Index: 16.3000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.5319
    Cell Significance Index: 36.7900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.5300
    Cell Significance Index: 289.4600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4541
    Cell Significance Index: 20.5900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4141
    Cell Significance Index: 82.1800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3721
    Cell Significance Index: 74.6500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.3509
    Cell Significance Index: 51.0100
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.2886
    Cell Significance Index: 4.6300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2719
    Cell Significance Index: 32.0600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2707
    Cell Significance Index: 14.0600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2643
    Cell Significance Index: 16.6600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.2420
    Cell Significance Index: 8.4100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2158
    Cell Significance Index: 38.9000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.2061
    Cell Significance Index: 6.6000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2044
    Cell Significance Index: 20.2200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2022
    Cell Significance Index: 89.3900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1850
    Cell Significance Index: 13.0900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1716
    Cell Significance Index: 11.0700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.1514
    Cell Significance Index: 3.9800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.1371
    Cell Significance Index: 7.1400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1324
    Cell Significance Index: 18.1800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1280
    Cell Significance Index: 45.9300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.1249
    Cell Significance Index: 3.1900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0954
    Cell Significance Index: 4.4500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0910
    Cell Significance Index: 11.1900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0873
    Cell Significance Index: 1.8600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0733
    Cell Significance Index: 13.9400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0564
    Cell Significance Index: 39.0000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.0561
    Cell Significance Index: 0.8400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0494
    Cell Significance Index: 1.3800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0243
    Cell Significance Index: 3.1200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0188
    Cell Significance Index: 13.8200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0156
    Cell Significance Index: 1.1600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0136
    Cell Significance Index: 2.3300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0075
    Cell Significance Index: 5.6500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.0053
    Cell Significance Index: 0.1100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0036
    Cell Significance Index: 0.1900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.0016
    Cell Significance Index: 0.1600
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0010
    Cell Significance Index: 0.0100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0005
    Cell Significance Index: -0.3200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0025
    Cell Significance Index: -4.7800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0054
    Cell Significance Index: -8.3700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0056
    Cell Significance Index: -10.2400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0113
    Cell Significance Index: -15.3400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0159
    Cell Significance Index: -11.7800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0209
    Cell Significance Index: -9.4800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0225
    Cell Significance Index: -0.6000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0238
    Cell Significance Index: -13.4500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0256
    Cell Significance Index: -16.0100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0262
    Cell Significance Index: -3.3800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0292
    Cell Significance Index: -0.7300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0314
    Cell Significance Index: -1.4800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0324
    Cell Significance Index: -1.1400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0349
    Cell Significance Index: -2.6800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0367
    Cell Significance Index: -0.6200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0389
    Cell Significance Index: -1.0600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0409
    Cell Significance Index: -11.7800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0479
    Cell Significance Index: -1.2800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0717
    Cell Significance Index: -8.2200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0725
    Cell Significance Index: -4.0700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0754
    Cell Significance Index: -15.8900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0936
    Cell Significance Index: -2.7500
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: -0.0951
    Cell Significance Index: -0.5700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1010
    Cell Significance Index: -8.0000
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.1131
    Cell Significance Index: -1.2300
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.1214
    Cell Significance Index: -0.9900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1289
    Cell Significance Index: -8.6700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1295
    Cell Significance Index: -7.9600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1341
    Cell Significance Index: -13.9600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1491
    Cell Significance Index: -9.1400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1791
    Cell Significance Index: -7.9200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1981
    Cell Significance Index: -10.0100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2060
    Cell Significance Index: -7.8000
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.2483
    Cell Significance Index: -2.9600
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.2493
    Cell Significance Index: -4.4100
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.2610
    Cell Significance Index: -3.7400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2704
    Cell Significance Index: -6.9500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2869
    Cell Significance Index: -8.4500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2912
    Cell Significance Index: -10.2000
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.2946
    Cell Significance Index: -1.7800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.3040
    Cell Significance Index: -5.2100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3105
    Cell Significance Index: -9.8900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.3115
    Cell Significance Index: -6.4600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Subunit of AMPK:** PRKAB1 is a non-catalytic subunit of the AMPK complex, which is a crucial energy-sensing kinase that regulates cellular energy homeostasis. 2. **AMP-activated:** PRKAB1 is activated by AMP (adenosine monophosphate), a molecule that accumulates in response to low energy levels, thereby initiating various cellular responses to restore energy balance. 3. **Regulation of metabolic pathways:** PRKAB1 regulates various metabolic pathways, including fatty acid biosynthesis, autophagy, and mitochondrial biogenesis, to maintain cellular energy homeostasis. 4. **Phosphorylation-dependent regulation:** PRKAB1 is phosphorylated by AMPK, which modulates its activity and enhances its ability to regulate downstream targets. **Pathways and Functions:** PRKAB1 is involved in several cellular pathways, including: 1. **Activation of AMPK downstream of NMDARs:** PRKAB1 is activated by AMP, which triggers the activation of AMPK and subsequent regulation of downstream targets. 2. **Activation of NMDA receptors and postsynaptic events:** PRKAB1 is also involved in the regulation of NMDA receptors, which are critical for synaptic plasticity and learning. 3. **Regulation of PGC-1α by phosphorylation:** PRKAB1 phosphorylates and activates PGC-1α, a transcriptional coactivator that regulates genes involved in energy metabolism. 4. **Autophagy and lipophagy:** PRKAB1 regulates autophagy and lipophagy, processes that are essential for cellular degradation and recycling of damaged or dysfunctional components. 5. **Regulation of mTOR signaling:** PRKAB1 modulates the activity of mTOR, a key regulator of cellular growth and metabolism. **Clinical Significance:** Dysregulation of PRKAB1 has been implicated in various diseases, including: 1. **Type 2 diabetes:** PRKAB1 dysfunction has been linked to impaired insulin signaling and glucose metabolism. 2. **Metabolic syndrome:** PRKAB1 dysregulation contributes to the development of metabolic syndrome, a cluster of conditions that increase the risk of developing type 2 diabetes and cardiovascular disease. 3. **Neurodegenerative diseases:** PRKAB1 has been implicated in the pathogenesis of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. 4. **Cancer:** PRKAB1 dysregulation has been linked to cancer development and progression, highlighting the importance of PRKAB1 in maintaining cellular homeostasis. In conclusion, PRKAB1 is a crucial gene that plays a pivotal role in regulating cellular energy homeostasis, metabolism, and various cellular processes. Its dysregulation has been implicated in numerous diseases, underscoring the importance of PRKAB1 in maintaining cellular and organismal health. Further research is necessary to fully elucidate the mechanisms by which PRKAB1 regulates cellular processes and to develop therapeutic strategies targeting this gene.

Genular Protein ID: 602470077

Symbol: AAKB1_HUMAN

Name: 5'-AMP-activated protein kinase subunit beta-1

UniProtKB Accession Codes:

Q9Y478 Q9UBV0 Q9UE20 Q9UEX2 Q9Y6V8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CAZy 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 6 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 5 DrugCentral 1 EMBL 15 Ensembl 2 ExpressionAtlas 1 GO 14 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 12 PDBsum 12 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 8 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9224708

Title: AMP-activated protein kinase isoenzyme family: subunit structure and chromosomal location.

PubMed ID: 9224708

DOI: 10.1016/s0014-5793(97)00569-3

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17028174

Title: Folliculin encoded by the BHD gene interacts with a binding protein, FNIP1, and AMPK, and is involved in AMPK and mTOR signaling.

PubMed ID: 17028174

DOI: 10.1073/pnas.0603781103

PubMed ID: 18403135

Title: Identification and characterization of a novel folliculin-interacting protein FNIP2.

PubMed ID: 18403135

DOI: 10.1016/j.gene.2008.02.022

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21460634

Title: Ulk1-mediated phosphorylation of AMPK constitutes a negative regulatory feedback loop.

PubMed ID: 21460634

DOI: 10.4161/auto.7.7.15451

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 21680840

Title: AMPK is a direct adenylate charge-regulated protein kinase.

PubMed ID: 21680840

DOI: 10.1126/science.1200094

PubMed ID: 17307971

Title: AMP-activated protein kinase in metabolic control and insulin signaling.

PubMed ID: 17307971

DOI: 10.1161/01.res.0000256090.42690.05

PubMed ID: 17712357

Title: AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy.

PubMed ID: 17712357

DOI: 10.1038/nrm2249

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 270
  • Mass: 30382
  • Checksum: F0BCAA94D5BC15FC
  • Sequence:
    • MGNTSSERAA LERHGGHKTP RRDSSGGTKD GDRPKILMDS PEDADLFHSE EIKAPEKEEF 
LAWQHDLEVN DKAPAQARPT VFRWTGGGKE VYLSGSFNNW SKLPLTRSHN NFVAILDLPE 
GEHQYKFFVD GQWTHDPSEP IVTSQLGTVN NIIQVKKTDF EVFDALMVDS QKCSDVSELS 
SSPPGPYHQE PYVCKPEERF RAPPILPPHL LQVILNKDTG ISCDPALLPE PNHVMLNHLY 
ALSIKDGVMV LSATHRYKKK YVTTLLYKPI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.