Details for: PKIB

Gene ID: 5570

Symbol: PKIB

Ensembl ID: ENSG00000135549

Description: cAMP-dependent protein kinase inhibitor beta

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 120.8652
    Cell Significance Index: -18.8000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 74.3169
    Cell Significance Index: -18.8500
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 54.9706
    Cell Significance Index: -22.6500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 45.9807
    Cell Significance Index: -18.6800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 19.5760
    Cell Significance Index: -18.6900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 15.2560
    Cell Significance Index: -18.8100
  • Cell Name: colon endothelial cell (CL1001572)
    Fold Change: 12.7028
    Cell Significance Index: 9.7000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 9.1493
    Cell Significance Index: 244.3000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 7.7412
    Cell Significance Index: -20.7400
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 6.0073
    Cell Significance Index: 36.9700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 4.5448
    Cell Significance Index: 206.0000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 3.9927
    Cell Significance Index: 251.6500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 3.2263
    Cell Significance Index: 55.2900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 1.9419
    Cell Significance Index: -4.2500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.8012
    Cell Significance Index: 134.2400
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 1.2650
    Cell Significance Index: 15.0800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.2236
    Cell Significance Index: 73.4600
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.1702
    Cell Significance Index: 15.0700
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.9634
    Cell Significance Index: 14.4400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8362
    Cell Significance Index: 755.0600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.7855
    Cell Significance Index: 25.1600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6968
    Cell Significance Index: 68.9300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.5717
    Cell Significance Index: 113.4600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5552
    Cell Significance Index: 90.3000
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.5142
    Cell Significance Index: 7.3200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4560
    Cell Significance Index: 31.5400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.3636
    Cell Significance Index: 9.7300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.3470
    Cell Significance Index: 16.3100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3278
    Cell Significance Index: 62.3800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.2973
    Cell Significance Index: 10.4500
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.2456
    Cell Significance Index: 3.8000
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.2149
    Cell Significance Index: 2.2300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1777
    Cell Significance Index: 3.8500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1509
    Cell Significance Index: 19.5000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.1468
    Cell Significance Index: 7.7100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1463
    Cell Significance Index: 24.9900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1176
    Cell Significance Index: 23.5900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1155
    Cell Significance Index: 20.8200
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.1078
    Cell Significance Index: 0.6700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1060
    Cell Significance Index: 38.0200
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: 0.0818
    Cell Significance Index: 1.0200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0660
    Cell Significance Index: 4.6700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0553
    Cell Significance Index: 35.1100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0551
    Cell Significance Index: 38.0900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0483
    Cell Significance Index: 90.9000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0437
    Cell Significance Index: 1.2200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0343
    Cell Significance Index: 1.6000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0263
    Cell Significance Index: 3.8300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0258
    Cell Significance Index: 11.4100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0232
    Cell Significance Index: 42.7200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0188
    Cell Significance Index: 0.9800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0165
    Cell Significance Index: 0.4800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0113
    Cell Significance Index: 0.2400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0092
    Cell Significance Index: 0.4800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0079
    Cell Significance Index: 12.1000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0023
    Cell Significance Index: -1.7000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0044
    Cell Significance Index: -0.5400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0079
    Cell Significance Index: -4.9100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0086
    Cell Significance Index: -1.8200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0095
    Cell Significance Index: -0.9700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0115
    Cell Significance Index: -15.6700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0184
    Cell Significance Index: -10.3800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0252
    Cell Significance Index: -19.0400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0258
    Cell Significance Index: -18.9100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0388
    Cell Significance Index: -0.5300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0426
    Cell Significance Index: -19.3300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0441
    Cell Significance Index: -5.1500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0491
    Cell Significance Index: -6.7400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0512
    Cell Significance Index: -14.7300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0770
    Cell Significance Index: -9.8700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0876
    Cell Significance Index: -10.0400
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.0969
    Cell Significance Index: -0.9200
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.1012
    Cell Significance Index: -0.6600
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.1092
    Cell Significance Index: -0.6600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1178
    Cell Significance Index: -7.9200
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1358
    Cell Significance Index: -1.9500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1548
    Cell Significance Index: -9.4900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1551
    Cell Significance Index: -17.7100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1693
    Cell Significance Index: -17.6300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1725
    Cell Significance Index: -20.3400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2098
    Cell Significance Index: -16.1000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2195
    Cell Significance Index: -12.3200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2585
    Cell Significance Index: -20.4700
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: -0.2651
    Cell Significance Index: -2.7400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2672
    Cell Significance Index: -11.8200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2785
    Cell Significance Index: -5.9100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3050
    Cell Significance Index: -7.8400
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: -0.3056
    Cell Significance Index: -5.2500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3150
    Cell Significance Index: -19.3600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.3185
    Cell Significance Index: -9.0900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.3216
    Cell Significance Index: -8.0400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.3247
    Cell Significance Index: -20.9500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.3258
    Cell Significance Index: -6.8200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3399
    Cell Significance Index: -12.8700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.3497
    Cell Significance Index: -17.6700
  • Cell Name: trophoblast giant cell (CL0002488)
    Fold Change: -0.3539
    Cell Significance Index: -2.5500
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.3717
    Cell Significance Index: -7.3500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3719
    Cell Significance Index: -13.0300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.3929
    Cell Significance Index: -8.1500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** PKIB is a protein kinase inhibitor that specifically targets cAMP-dependent protein kinase (PKA), a key enzyme involved in numerous cellular signaling pathways. PKIB's inhibitory activity is crucial for regulating the PKA-mediated signaling cascade, thereby modulating various cellular processes. The gene's expression is highly tissue-specific, with significant expression in cells involved in immune responses, development, and tissue homeostasis. Notably, PKIB's role in telomere maintenance and regulation is a unique aspect of its function, highlighting the gene's importance in maintaining cellular integrity. **Pathways and Functions:** PKIB's involvement in various signaling pathways underscores its multifaceted role in cellular regulation. The primary pathways associated with PKIB include: 1. **Negative regulation of camp-dependent protein kinase activity**: PKIB inhibits PKA activity, thereby modulating the PKA-mediated signaling cascade. 2. **Positive regulation of telomerase activity**: PKIB enhances telomerase activity, promoting telomere length maintenance and preventing telomere shortening. 3. **Positive regulation of telomere capping**: PKIB contributes to the formation of telomere caps, protecting chromosomes from degradation. 4. **Positive regulation of telomere maintenance via telomerase**: PKIB's role in telomere maintenance is critical for ensuring the stability of telomeres. **Clinical Significance:** The PKIB gene's involvement in various cellular processes has significant implications for our understanding of human disease. Dysregulation of PKIB's activity has been implicated in several conditions, including: 1. **Immune disorders**: PKIB's role in regulating immune responses makes it a potential target for the treatment of immune-related disorders. 2. **Cancer**: PKIB's involvement in telomere maintenance and regulation may contribute to its role in cancer development and progression. 3. **Aging and age-related diseases**: PKIB's function in maintaining telomere length and stability may be critical in understanding the mechanisms underlying aging and age-related diseases. In conclusion, the PKIB gene's multifaceted role in regulating cellular processes, including immune responses, telomere maintenance, and cellular signaling, highlights its importance in maintaining cellular integrity and preventing disease. Further research into PKIB's function and dysregulation will provide valuable insights into the molecular mechanisms underlying human disease and the development of novel therapeutic strategies.

Genular Protein ID: 1901204747

Symbol: IPKB_HUMAN

Name: cAMP-dependent protein kinase inhibitor beta

UniProtKB Accession Codes:

Q9C010 B2RCK2 Q567T9 Q5T0Z7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 9 Ensembl 7 ExpressionAtlas 1 GO 6 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIRSF 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 14 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 10880337

Title: Cloning and mapping of human PKIB and PKIG, and comparison of tissue expression patterns of three members of the protein kinase inhibitor family, including PKIA.

PubMed ID: 10880337

DOI: 10.1042/0264-6021:3490403

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 78
  • Mass: 8468
  • Checksum: CA4AE267B9ECCD81
  • Sequence:
    • MRTDSSKMTD VESGVANFAS SARAGRRNAL PDIQSSAATD GTSDLPLKLE ALSVKEDAKE 
KDEKTTQDQL EKPQNEEK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.