MAPK9 | ENSG00000050748 | NCBI 5601

Details for: MAPK9

Gene ID: 5601

Symbol: MAPK9

Ensembl ID: ENSG00000050748

Description: mitogen-activated protein kinase 9

Associated with

Activation of the ap-1 family of transcription factors
(R-HSA-450341)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cytokine signaling in immune system
(R-HSA-1280215)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Fc epsilon receptor (fceri) signaling
(R-HSA-2454202)
Fceri mediated mapk activation
(R-HSA-2871796)
Immune system
(R-HSA-168256)
Innate immune system
(R-HSA-168249)
Interleukin-17 signaling
(R-HSA-448424)
Jnk (c-jun kinases) phosphorylation and activation mediated by activated human tak1
(R-HSA-450321)
Map kinase activation
(R-HSA-450294)
Mapk targets/ nuclear events mediated by map kinases
(R-HSA-450282)
Myd88 cascade initiated on plasma membrane
(R-HSA-975871)
Myd88 dependent cascade initiated on endosome
(R-HSA-975155)
Myd88-independent tlr4 cascade
(R-HSA-166166)
Myd88:mal(tirap) cascade initiated on plasma membrane
(R-HSA-166058)
Oxidative stress induced senescence
(R-HSA-2559580)
Signaling by alk fusions and activated point mutants
(R-HSA-9725370)
Signaling by alk in cancer
(R-HSA-9700206)
Signaling by interleukins
(R-HSA-449147)
Toll-like receptor cascades
(R-HSA-168898)
Toll like receptor 2 (tlr2) cascade
(R-HSA-181438)
Toll like receptor 3 (tlr3) cascade
(R-HSA-168164)
Toll like receptor 4 (tlr4) cascade
(R-HSA-166016)
Toll like receptor 5 (tlr5) cascade
(R-HSA-168176)
Toll like receptor 7/8 (tlr7/8) cascade
(R-HSA-168181)
Toll like receptor 9 (tlr9) cascade
(R-HSA-168138)
Toll like receptor 10 (tlr10) cascade
(R-HSA-168142)
Toll like receptor tlr1:tlr2 cascade
(R-HSA-168179)
Toll like receptor tlr6:tlr2 cascade
(R-HSA-168188)
Traf6 mediated induction of nfkb and map kinases upon tlr7/8 or 9 activation
(R-HSA-975138)
Trif (ticam1)-mediated tlr4 signaling
(R-HSA-937061)
Apoptotic signaling pathway
(GO:0097190)
Atp binding
(GO:0005524)
Cellular response to reactive oxygen species
(GO:0034614)
Cellular senescence
(GO:0090398)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Fc-epsilon receptor signaling pathway
(GO:0038095)
Inflammatory response to wounding
(GO:0090594)
Jnk cascade
(GO:0007254)
Jun kinase activity
(GO:0004705)
Mitochondrion
(GO:0005739)
Modulation of chemical synaptic transmission
(GO:0050804)
Nuclear speck
(GO:0016607)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Plasma membrane
(GO:0005886)
Positive regulation of apoptotic signaling pathway
(GO:2001235)
Positive regulation of cytokine production involved in inflammatory response
(GO:1900017)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of macrophage derived foam cell differentiation
(GO:0010744)
Positive regulation of podosome assembly
(GO:0071803)
Positive regulation of proteasomal ubiquitin-dependent protein catabolic process
(GO:0032436)
Positive regulation of protein ubiquitination
(GO:0031398)
Protein binding
(GO:0005515)
Protein localization to tricellular tight junction
(GO:0061833)
Protein phosphorylation
(GO:0006468)
Protein serine/threonine/tyrosine kinase activity
(GO:0004712)
Protein serine/threonine kinase activity
(GO:0004674)
Protein serine kinase activity
(GO:0106310)
Regulation of circadian rhythm
(GO:0042752)
Response to cadmium ion
(GO:0046686)
Rhythmic process
(GO:0048511)
Schaffer collateral - ca1 synapse
(GO:0098685)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 207.2066
Cell Significance Index: -32.2300
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 126.2797
Cell Significance Index: -32.0300
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 65.1804
Cell Significance Index: -26.4800
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 59.2941
Cell Significance Index: -30.5000
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 27.7876
Cell Significance Index: -26.5300
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 26.9109
Cell Significance Index: -33.1800
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 11.5534
Cell Significance Index: -30.9500
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 10.7864
Cell Significance Index: -33.1300
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 8.4515
Cell Significance Index: -33.3500
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 5.3916
Cell Significance Index: -11.8000
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.9591
Cell Significance Index: 392.9900
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 1.6708
Cell Significance Index: 271.7400
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 1.0859
Cell Significance Index: 118.1200
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 1.0411
Cell Significance Index: 121.3300
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 1.0229
Cell Significance Index: 366.9100
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.7659
Cell Significance Index: 151.9900
Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 0.7317
Cell Significance Index: 9.0800
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.6885
Cell Significance Index: 476.2000
Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: 0.6409
Cell Significance Index: 18.2900
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.6090
Cell Significance Index: 16.2600
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 0.5836
Cell Significance Index: 22.1000
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 0.5699
Cell Significance Index: 25.2100
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.5476
Cell Significance Index: 33.6600
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.5218
Cell Significance Index: 94.0700
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.5158
Cell Significance Index: 35.6700
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 0.5067
Cell Significance Index: 34.0700
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.3622
Cell Significance Index: 44.5400
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.3252
Cell Significance Index: 18.2500
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.2906
Cell Significance Index: 158.6800
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.2795
Cell Significance Index: 13.0300
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.2566
Cell Significance Index: 13.3300
Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 0.2503
Cell Significance Index: 5.3500
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.2441
Cell Significance Index: 18.7400
Cell Name: cortical interneuron (CL0008031)
Fold Change: 0.2327
Cell Significance Index: 5.5800
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.2199
Cell Significance Index: 37.5500
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.1989
Cell Significance Index: 5.7300
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.1844
Cell Significance Index: 8.3600
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.1718
Cell Significance Index: 155.1000
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 0.1675
Cell Significance Index: 2.8700
Cell Name: Purkinje cell (CL0000121)
Fold Change: 0.1548
Cell Significance Index: 3.3900
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.1474
Cell Significance Index: 65.1900
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.1415
Cell Significance Index: 14.0000
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.1295
Cell Significance Index: 3.6200
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.0998
Cell Significance Index: 13.7000
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.0989
Cell Significance Index: 18.8300
Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.0774
Cell Significance Index: 4.0300
Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.0718
Cell Significance Index: 4.6400
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0711
Cell Significance Index: 2.5000
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0672
Cell Significance Index: 126.6200
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.0582
Cell Significance Index: 1.4600
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.0566
Cell Significance Index: 35.9200
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0512
Cell Significance Index: 78.8300
Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0353
Cell Significance Index: 65.0200
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.0337
Cell Significance Index: 15.2800
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.0268
Cell Significance Index: 0.5800
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.0054
Cell Significance Index: 0.3400
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0004
Cell Significance Index: -0.5200
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0101
Cell Significance Index: -7.5100
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0108
Cell Significance Index: -6.7600
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0191
Cell Significance Index: -14.0400
Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
Fold Change: -0.0232
Cell Significance Index: -0.3100
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0247
Cell Significance Index: -3.6000
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0304
Cell Significance Index: -23.0100
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0360
Cell Significance Index: -20.2900
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.0796
Cell Significance Index: -9.3900
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0804
Cell Significance Index: -16.9300
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.0944
Cell Significance Index: -4.4400
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0978
Cell Significance Index: -28.1300
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.1027
Cell Significance Index: -10.4900
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.1244
Cell Significance Index: -6.5300
Cell Name: odontoblast (CL0000060)
Fold Change: -0.1297
Cell Significance Index: -16.6300
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.1338
Cell Significance Index: -2.8500
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1342
Cell Significance Index: -15.3700
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.1702
Cell Significance Index: -3.5300
Cell Name: lactocyte (CL0002325)
Fold Change: -0.1730
Cell Significance Index: -22.3500
Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.2019
Cell Significance Index: -14.2800
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: -0.2074
Cell Significance Index: -1.9100
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.2444
Cell Significance Index: -27.9000
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.2492
Cell Significance Index: -5.2900
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.2560
Cell Significance Index: -26.6600
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.2784
Cell Significance Index: -20.7500
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.3152
Cell Significance Index: -4.3000
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.3274
Cell Significance Index: -25.9300
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.3591
Cell Significance Index: -11.5000
Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -0.3899
Cell Significance Index: -7.7100
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.4362
Cell Significance Index: -14.2800
Cell Name: OFF midget ganglion cell (CL4033047)
Fold Change: -0.4419
Cell Significance Index: -5.5100
Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -0.4423
Cell Significance Index: -8.8800
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.4503
Cell Significance Index: -14.3400
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.4523
Cell Significance Index: -12.3100
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.4773
Cell Significance Index: -12.7900
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.5562
Cell Significance Index: -34.1000
Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: -0.5670
Cell Significance Index: -12.2500
Cell Name: ON midget ganglion cell (CL4033046)
Fold Change: -0.5673
Cell Significance Index: -7.1600
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.5989
Cell Significance Index: -16.0200
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.5991
Cell Significance Index: -15.4000
Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -0.6323
Cell Significance Index: -9.3400
Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.6407
Cell Significance Index: -9.1800
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.6451
Cell Significance Index: -22.6000
Cell Name: hippocampal interneuron (CL1001569)
Fold Change: -0.6662
Cell Significance Index: -8.6400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** MAPK9 is a serine/threonine kinase that belongs to the MAPK family, which consists of three main branches: JNK (c-Jun N-terminal kinases), p38 (p38 mitogen-activated protein kinases), and ERK (extracellular signal-regulated kinases). MAPK9 is specifically activated by stress signals, such as reactive oxygen species (ROS), and is involved in the regulation of various cellular processes, including: * Apoptosis: MAPK9 is involved in the regulation of apoptotic signaling pathways, particularly in the context of oxidative stress. * Inflammation: MAPK9 is activated by inflammatory signals, such as those generated by Toll-like receptors (TLRs) and interleukins (ILs). * Immune system function: MAPK9 is involved in the regulation of immune responses, including the production of cytokines and the activation of immune cells. * Synaptic transmission: MAPK9 is involved in the regulation of synaptic transmission, particularly in the context of neuronal activity. **Pathways and Functions** MAPK9 is involved in several signaling pathways, including: * Apoptotic signaling pathway: MAPK9 is activated by stress signals and is involved in the regulation of apoptotic pathways. * Cytokine signaling pathway: MAPK9 is activated by inflammatory signals, such as those generated by TLRs and ILs. * Immune system signaling pathway: MAPK9 is involved in the regulation of immune responses, including the production of cytokines and the activation of immune cells. * Toll-like receptor signaling pathway: MAPK9 is activated by TLRs and is involved in the regulation of inflammatory responses. * JNK cascade: MAPK9 is involved in the regulation of the JNK cascade, which is activated by stress signals. **Clinical Significance** MAPK9 has been implicated in several diseases, including: * Neurodegenerative disorders: MAPK9 has been implicated in the regulation of synaptic transmission and apoptosis in neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease. * Inflammatory conditions: MAPK9 has been implicated in the regulation of inflammatory responses in conditions such as rheumatoid arthritis and multiple sclerosis. * Cancer: MAPK9 has been implicated in the regulation of cancer cell survival and proliferation. * Neurodevelopmental disorders: MAPK9 has been implicated in the regulation of neuronal development and function in neurodevelopmental disorders, such as autism spectrum disorder. In conclusion, MAPK9 is a crucial component of the MAPK signaling pathway, which plays a vital role in regulating various cellular processes, including cell proliferation, differentiation, survival, and apoptosis. Its dysregulation has been implicated in several diseases, including neurodegenerative disorders, inflammatory conditions, and cancer. Further research is needed to fully understand the role of MAPK9 in human disease and to develop potential therapeutic strategies.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Mitogen-activated protein kinase 9
D7R525_HUMAN

Genular Protein ID: 3906693880

Symbol: MK09_HUMAN

Name: Mitogen-activated protein kinase 9

UniProtKB Accession Codes:

P45984 A8K0S3 B5BU66 B5M0B4 D3DWQ8 D3DWQ9 Q15708 Q15710 Q15711 Q8N5C5

Database IDs:

Citations:

PubMed ID: 7969172

Title: Signal transduction by tumor necrosis factor mediated by JNK protein kinases.

PubMed ID: 7969172

DOI: 10.1128/mcb.14.12.8376-8384.1994

PubMed ID: 8001819

Title: JNK2 contains a specificity-determining region responsible for efficient c-Jun binding and phosphorylation.

PubMed ID: 8001819

DOI: 10.1101/gad.8.24.2996

PubMed ID: 8654373

Title: Selective interaction of JNK protein kinase isoforms with transcription factors.

PubMed ID: 8654373

DOI: 10.1002/j.1460-2075.1996.tb00636.x

PubMed ID: 21110917

Title: Molecular cloning and characterization of novel human JNK2 (MAPK9) transcript variants that show different stimulation activities on AP-1.

PubMed ID: 21110917

DOI: 10.5483/bmbrep.2010.43.11.738

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 19054851

Title: Human protein factory for converting the transcriptome into an in vitro-expressed proteome.

PubMed ID: 19054851

DOI: 10.1038/nmeth.1273

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10376527

Title: Role of the ATFa/JNK2 complex in Jun activation.

PubMed ID: 10376527

DOI: 10.1038/sj.onc.1202723

PubMed ID: 11062067

Title: Synergistic activation of stress-activated protein kinase 1/c-Jun N-terminal kinase (SAPK1/JNK) isoforms by mitogen-activated protein kinase kinase 4 (MKK4) and MKK7.

PubMed ID: 11062067

DOI: 10.1042/bj3520145

PubMed ID: 15693750

Title: Characterization of a novel human sperm-associated antigen 9 (SPAG9) having structural homology with c-Jun N-terminal kinase-interacting protein.

PubMed ID: 15693750

DOI: 10.1042/bj20041577

PubMed ID: 15805466

Title: The nucleolus as a stress sensor: JNK2 inactivates the transcription factor TIF-IA and down-regulates rRNA synthesis.

PubMed ID: 15805466

DOI: 10.1101/gad.333205

PubMed ID: 17875713

Title: Nuclear factor of activated T3 is a negative regulator of Ras-JNK1/2-AP-1 induced cell transformation.

PubMed ID: 17875713

DOI: 10.1158/0008-5472.can-06-4788

PubMed ID: 17189706

Title: The CARMA1-Bcl10 signaling complex selectively regulates JNK2 kinase in the T cell receptor-signaling pathway.

PubMed ID: 17189706

DOI: 10.1016/j.immuni.2006.11.008

PubMed ID: 17525747

Title: Cooperation between JNK1 and JNK2 in activation of p53 apoptotic pathway.

PubMed ID: 17525747

DOI: 10.1038/sj.onc.1210526

PubMed ID: 19290929

Title: CARMA1-mediated NF-kappaB and JNK activation in lymphocytes.

PubMed ID: 19290929

DOI: 10.1111/j.1600-065x.2008.00749.x

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19675674

Title: GSK3beta is involved in JNK2-mediated beta-catenin inhibition.

PubMed ID: 19675674

DOI: 10.1371/journal.pone.0006640

PubMed ID: 20595622

Title: c-Jun NH2-terminal kinase-2 mediates osmotic stress-induced tight junction disruption in the intestinal epithelium.

PubMed ID: 20595622

DOI: 10.1152/ajpgi.00265.2010

PubMed ID: 21364637

Title: JNK phosphorylates Yes-associated protein (YAP) to regulate apoptosis.

PubMed ID: 21364637

DOI: 10.1038/cddis.2010.7

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22441692

Title: JNK regulates the photic response of the mammalian circadian clock.

PubMed ID: 22441692

DOI: 10.1038/embor.2012.37

PubMed ID: 34048572

Title: Post-translational modification of RNA m6A demethylase ALKBH5 regulates ROS-induced DNA damage response.

PubMed ID: 34048572

DOI: 10.1093/nar/gkab415

PubMed ID: 18801372

Title: The crystal structure of JNK2 reveals conformational flexibility in the MAP kinase insert and indicates its involvement in the regulation of catalytic activity.

PubMed ID: 18801372

DOI: 10.1016/j.jmb.2008.08.086

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

PubMed ID: 28089251

Title: Mutations in MAPKBP1 cause juvenile or late-onset cilia-independent nephronophthisis.

PubMed ID: 28089251

DOI: 10.1016/j.ajhg.2016.12.011

PubMed ID: 28157543

Title:

PubMed ID: 28157543

DOI: 10.1016/j.ajhg.2017.01.025

Sequence Information:

Length: 424
Mass: 48139
Checksum: 9C15DA79981290AF
Sequence:

MSDSKCDSQF YSVQVADSTF TVLKRYQQLK PIGSGAQGIV CAAFDTVLGI NVAVKKLSRP 
FQNQTHAKRA YRELVLLKCV NHKNIISLLN VFTPQKTLEE FQDVYLVMEL MDANLCQVIH 
MELDHERMSY LLYQMLCGIK HLHSAGIIHR DLKPSNIVVK SDCTLKILDF GLARTACTNF 
MMTPYVVTRY YRAPEVILGM GYKENVDIWS VGCIMGELVK GCVIFQGTDH IDQWNKVIEQ 
LGTPSAEFMK KLQPTVRNYV ENRPKYPGIK FEELFPDWIF PSESERDKIK TSQARDLLSK 
MLVIDPDKRI SVDEALRHPY ITVWYDPAEA EAPPPQIYDA QLEEREHAIE EWKELIYKEV 
MDWEERSKNG VVKDQPSDAA VSSNATPSQS SSINDISSMS TEQTLASDTD SSLDASTGPL 
EGCR

Genular Protein ID: 1113547480

Symbol: D7R525_HUMAN

Name: N/A

UniProtKB Accession Codes:

D7R525

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.M800588-MCP200

PubMed ID: 21110917

Title: Molecular cloning and characterization of novel human JNK2 (MAPK9) transcript variants that show different stimulation activities on AP-1.

PubMed ID: 21110917

Sequence Information:

Length: 214
Mass: 24561
Checksum: 0D4FB7C173126E93
Sequence:

MSDSKCDSQF YSVQVADSTF TVLKRYQQLK PIGSGAQGIV CAAFDTVLGI NVAVKKLSRP 
FQNQTHAKRA YRELVLLKCV NHKNIISLLN VFTPQKTLEE FQDVYLVMEL MDANLCQVIH 
MELDHERMSY LLYQMLCGIK HLHSAGIIHR DLKPSNIVVK SDCTLKILDF GLARTACTNF 
MMTPYVVTRY YRAPEVILGM GYKENAIKYW TLWH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: MAPK9

Associated with

Cells (max top 100)

Other Information

Signal transduction by tumor necrosis factor mediated by JNK protein kinases. PubMed ID: 7969172

JNK2 contains a specificity-determining region responsible for efficient c-Jun binding and phosphorylation. PubMed ID: 8001819

Selective interaction of JNK protein kinase isoforms with transcription factors. PubMed ID: 8654373

Molecular cloning and characterization of novel human JNK2 (MAPK9) transcript variants that show different stimulation activities on AP-1. PubMed ID: 21110917

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

Human protein factory for converting the transcriptome into an in vitro-expressed proteome. PubMed ID: 19054851

The DNA sequence and comparative analysis of human chromosome 5. PubMed ID: 15372022

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Role of the ATFa/JNK2 complex in Jun activation. PubMed ID: 10376527

Synergistic activation of stress-activated protein kinase 1/c-Jun N-terminal kinase (SAPK1/JNK) isoforms by mitogen-activated protein kinase kinase 4 (MKK4) and MKK7. PubMed ID: 11062067

Characterization of a novel human sperm-associated antigen 9 (SPAG9) having structural homology with c-Jun N-terminal kinase-interacting protein. PubMed ID: 15693750

The nucleolus as a stress sensor: JNK2 inactivates the transcription factor TIF-IA and down-regulates rRNA synthesis. PubMed ID: 15805466

Nuclear factor of activated T3 is a negative regulator of Ras-JNK1/2-AP-1 induced cell transformation. PubMed ID: 17875713

The CARMA1-Bcl10 signaling complex selectively regulates JNK2 kinase in the T cell receptor-signaling pathway. PubMed ID: 17189706

Cooperation between JNK1 and JNK2 in activation of p53 apoptotic pathway. PubMed ID: 17525747

CARMA1-mediated NF-kappaB and JNK activation in lymphocytes. PubMed ID: 19290929

Large-scale proteomics analysis of the human kinome. PubMed ID: 19369195

GSK3beta is involved in JNK2-mediated beta-catenin inhibition. PubMed ID: 19675674

c-Jun NH2-terminal kinase-2 mediates osmotic stress-induced tight junction disruption in the intestinal epithelium. PubMed ID: 20595622

JNK phosphorylates Yes-associated protein (YAP) to regulate apoptosis. PubMed ID: 21364637

Initial characterization of the human central proteome. PubMed ID: 21269460

JNK regulates the photic response of the mammalian circadian clock. PubMed ID: 22441692

Post-translational modification of RNA m6A demethylase ALKBH5 regulates ROS-induced DNA damage response. PubMed ID: 34048572

The crystal structure of JNK2 reveals conformational flexibility in the MAP kinase insert and indicates its involvement in the regulation of catalytic activity. PubMed ID: 18801372

Patterns of somatic mutation in human cancer genomes. PubMed ID: 17344846

Mutations in MAPKBP1 cause juvenile or late-onset cilia-independent nephronophthisis. PubMed ID: 28089251

PubMed ID: 28157543

Initial sequencing and analysis of the human genome. PubMed ID: 11237011

The DNA sequence and comparative analysis of human chromosome 5. PubMed ID: 15372022

Finishing the euchromatic sequence of the human genome. PubMed ID: 15496913

Large-scale proteomics analysis of the human kinome. PubMed ID: 19369195

Molecular cloning and characterization of novel human JNK2 (MAPK9) transcript variants that show different stimulation activities on AP-1. PubMed ID: 21110917

Database document:

PubMed ID: 7969172

PubMed ID: 8001819

PubMed ID: 8654373

PubMed ID: 21110917

PubMed ID: 14702039

PubMed ID: 19054851

PubMed ID: 15372022

PubMed ID: 15489334

PubMed ID: 10376527

PubMed ID: 11062067

PubMed ID: 15693750

PubMed ID: 15805466

PubMed ID: 17875713

PubMed ID: 17189706

PubMed ID: 17525747

PubMed ID: 19290929

PubMed ID: 19369195

PubMed ID: 19675674

PubMed ID: 20595622

PubMed ID: 21364637

PubMed ID: 21269460

PubMed ID: 22441692

PubMed ID: 34048572

PubMed ID: 18801372

PubMed ID: 17344846

PubMed ID: 28089251

PubMed ID: 11237011

PubMed ID: 15372022

PubMed ID: 15496913

PubMed ID: 19369195

PubMed ID: 21110917