Details for: PRKX
Gene ID: 5613
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: PRKX
Ensembl ID: ENSG00000183943
Description: protein kinase cAMP-dependent X-linked catalytic subunit
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
-
CSI 17.38rCSI 28.46%PRS 39.76
-
CSI 16.4rCSI 34.71%PRS 69.76
-
CSI 9.98rCSI 43.92%PRS 42.31
-
CSI 7.97rCSI 47.74%PRS 61.87
-
CSI 7.93rCSI 16.3%PRS 42.56
-
CSI 5.48rCSI 4.26%PRS 67.65
-
CSI 4.99rCSI 7.78%PRS 76.81
-
CSI 4.88rCSI 4.7%PRS 49.97
-
CSI 4.81rCSI 7.79%PRS 47.64
-
CSI 4.59rCSI 5.72%PRS 60.88
-
CSI 4.51rCSI 12.7%PRS 48.42
-
CSI 3.61rCSI 3.04%PRS 67.32
-
CSI 3.48rCSI 13.54%PRS 70.49
-
CSI 3.16rCSI 2.92%PRS 70.4
-
CSI 3.16rCSI 2.74%PRS 53.92
-
CSI 3.14rCSI 2.18%PRS 59.43
-
CSI 3.09rCSI 7.13%PRS 40.35
-
CSI 3.05rCSI 3.69%PRS 42.43
-
CSI 3.04rCSI 6.48%PRS 52.25
-
CSI 3.02rCSI 2.42%PRS 71.42
-
CSI 3.01rCSI 2.29%PRS 61.85
-
CSI 3rCSI 5.84%PRS 51.9
-
CSI 2.98rCSI 2.75%PRS 50.65
-
CSI 2.86rCSI 4.37%PRS 59.17
-
CSI 2.8rCSI 2.75%PRS 65.68
-
CSI 2.64rCSI 10.06%PRS 42.02
-
CSI 2.63rCSI 1.97%PRS 80.75
-
CSI 2.62rCSI 2.12%PRS 59.7
-
CSI 2.62rCSI 1.88%PRS 63.36
-
CSI 2.57rCSI 1.91%PRS 42.74
-
CSI 2.56rCSI 3.63%PRS 46.24
-
CSI 2.56rCSI 2.75%PRS 47.86
-
CSI 2.54rCSI 1.77%PRS 63.46
-
CSI 2.51rCSI 5.74%PRS 49.09
-
CSI 2.5rCSI 12%PRS 48.46
-
CSI 2.46rCSI 2.16%PRS 59.77
-
CSI 2.43rCSI 2.53%PRS 50.19
-
CSI 2.42rCSI 3.3%PRS 76.87
-
CSI 2.41rCSI 3.31%PRS 70.43
-
CSI 2.35rCSI 1.75%PRS 67.81
-
CSI 2.33rCSI 7.79%PRS 36.78
-
CSI 2.32rCSI 1.79%PRS 48.9
-
CSI 2.31rCSI 1.73%PRS 64.8
-
CSI 2.29rCSI 4.37%PRS 66.53
-
CSI 2.28rCSI 3.64%PRS 53.65
-
CSI 2.24rCSI 5.79%PRS 45.39
-
CSI 2.23rCSI 1.76%PRS 37.1
-
CSI 2.19rCSI 1.74%PRS 72.33
-
CSI 2.17rCSI 2.21%PRS 63.28
-
CSI 2.16rCSI 4.78%PRS 37.25
-
CSI 2.16rCSI 5.7%PRS 57.78
-
CSI 2.11rCSI 1.59%PRS 53.79
-
CSI 2.11rCSI 4.24%PRS 39.23
-
CSI 2.09rCSI 4.69%PRS 68.93
-
CSI 2.07rCSI 4.46%PRS 75.62
-
CSI 2.03rCSI 1.37%PRS 61.28
-
CSI 2.02rCSI 1.84%PRS 64.59
-
CSI 2.01rCSI 1.77%PRS 38.51
-
CSI 1.99rCSI 4.13%PRS 47.28
-
CSI 1.99rCSI 1.39%PRS 51.92
-
CSI 1.98rCSI 1.17%PRS 66.07
-
CSI 1.97rCSI 1.46%PRS 63.23
-
CSI 1.93rCSI 2.58%PRS 58.24
-
CSI 1.92rCSI 7.2%PRS 42.26
-
CSI 1.9rCSI 5.95%PRS 36.84
-
CSI 1.88rCSI 3.31%PRS 32.18
-
CSI 1.87rCSI 1.69%PRS 46.49
-
CSI 1.86rCSI 2.38%PRS 47.6
-
CSI 1.85rCSI 5.47%PRS 53.74
-
CSI 1.85rCSI 2.23%PRS 57.82
-
CSI 1.84rCSI 2.25%PRS 57.49
-
CSI 1.84rCSI 1.39%PRS 63.07
-
CSI 1.84rCSI 3.15%PRS 70.23
-
CSI 1.79rCSI 2.44%PRS 62.29
-
CSI 1.78rCSI 2.3%PRS 34.16
-
CSI 1.78rCSI 2.09%PRS 65.76
-
CSI 1.74rCSI 1.44%PRS 51.1
-
CSI 1.71rCSI 3.84%PRS 33.92
-
CSI 1.7rCSI 2.32%PRS 42.58
-
CSI 1.67rCSI 2.56%PRS 49.82
-
CSI 1.65rCSI 3.12%PRS 82.36
-
CSI 1.64rCSI 1.96%PRS 33.01
-
CSI 1.61rCSI 1.56%PRS 40.29
-
CSI 1.61rCSI 3.53%PRS 53.85
-
CSI 1.6rCSI 6.45%PRS 48.08
-
CSI 1.59rCSI 4.14%PRS 48.7
-
CSI 1.57rCSI 1.95%PRS 31.49
-
CSI 1.56rCSI 1.44%PRS 57.85
-
CSI 1.56rCSI 1.8%PRS 43.72
-
CSI 1.55rCSI 4.45%PRS 68.49
-
CSI 1.52rCSI 2.75%PRS 75.19
-
CSI 1.52rCSI 13.09%PRS 48.77
-
CSI 1.51rCSI 2.21%PRS 48.1
-
CSI 1.5rCSI 2.98%PRS 48.16
-
CSI 1.49rCSI 2.04%PRS 44.97
-
CSI 1.47rCSI 2.16%PRS 52.97
-
CSI 1.46rCSI 1.92%PRS 63.26
-
CSI 1.4rCSI 1.58%PRS 66.53
-
CSI 1.37rCSI 1.75%PRS 54.42
-
CSI 1.35rCSI 1.17%PRS 59.93
-
CSI 0.2rCSI 1.0%PRS 61.1%
-
CSI 0.2rCSI 3.1%PRS 70.1%
-
CSI 0.4rCSI 1.9%PRS 61.4%
-
CSI 0.5rCSI 3.1%PRS 72.9%
-
CSI 0.6rCSI 0.9%PRS 47.5%
-
CSI 0.6rCSI 1.7%PRS 45.8%
-
CSI 0.7rCSI 1.0%PRS 57.6%
-
CSI 0.7rCSI 1.9%PRS 71.2%
-
CSI 0.8rCSI 1.9%PRS 78.7%
-
CSI 0.8rCSI 2.3%PRS 65.4%
-
CSI 0.9rCSI 3.3%PRS 69.6%
-
CSI 1.0rCSI 2.1%PRS 54.4%
-
CSI 1.1rCSI 1.6%PRS 50.3%
-
CSI 1.1rCSI 1.4%PRS 59.8%
-
CSI 1.1rCSI 2.7%PRS 64.0%
-
CSI 1.2rCSI 3.7%PRS 46.4%
-
CSI 1.2rCSI 3.1%PRS 41.8%
-
CSI 1.2rCSI 3.0%PRS 79.2%
-
CSI 1.2rCSI 2.9%PRS 44.6%
-
CSI 1.2rCSI 1.9%PRS 42.3%
-
CSI 1.2rCSI 2.1%PRS 40.2%
-
CSI 1.2rCSI 6.6%PRS 82.9%
-
CSI 1.3rCSI 3.1%PRS 51.1%
-
CSI 1.3rCSI 2.0%PRS 52.4%
-
CSI 1.3rCSI 2.6%PRS 68.2%
-
CSI 1.3rCSI 2.2%PRS 33.1%
-
CSI 1.3rCSI 1.1%PRS 50.6%
-
CSI 1.3rCSI 1.6%PRS 70.3%
-
CSI 1.4rCSI 1.2%PRS 59.9%
-
CSI 1.4rCSI 1.8%PRS 54.4%
-
CSI 1.4rCSI 1.6%PRS 66.5%
-
CSI 1.5rCSI 1.9%PRS 63.3%
-
CSI 1.5rCSI 2.2%PRS 53.0%
-
CSI 1.5rCSI 2.0%PRS 45.0%
-
CSI 1.5rCSI 3.0%PRS 48.2%
-
CSI 1.5rCSI 2.2%PRS 48.1%
-
CSI 1.5rCSI 13.1%PRS 48.8%
-
CSI 1.5rCSI 2.8%PRS 75.2%
-
CSI 1.6rCSI 4.5%PRS 68.5%
-
CSI 1.6rCSI 1.8%PRS 43.7%
-
CSI 1.6rCSI 1.4%PRS 57.9%
-
CSI 1.6rCSI 2.0%PRS 31.5%
-
CSI 1.6rCSI 4.1%PRS 48.7%
-
CSI 1.6rCSI 6.5%PRS 48.1%
-
CSI 1.6rCSI 3.5%PRS 53.9%
-
CSI 1.6rCSI 1.6%PRS 40.3%
-
CSI 1.6rCSI 2.0%PRS 33.0%
-
CSI 1.7rCSI 3.1%PRS 82.4%
-
CSI 1.7rCSI 2.6%PRS 49.8%
-
CSI 1.7rCSI 2.3%PRS 42.6%
-
CSI 1.7rCSI 3.8%PRS 33.9%
-
CSI 1.7rCSI 1.4%PRS 51.1%
-
CSI 1.8rCSI 2.1%PRS 65.8%
-
CSI 1.8rCSI 2.3%PRS 34.2%
-
CSI 1.8rCSI 2.4%PRS 62.3%
-
CSI 1.8rCSI 3.2%PRS 70.2%
-
CSI 1.8rCSI 1.4%PRS 63.1%
-
CSI 1.8rCSI 2.3%PRS 57.5%
-
CSI 1.9rCSI 2.2%PRS 57.8%
-
CSI 1.9rCSI 5.5%PRS 53.7%
-
CSI 1.9rCSI 2.4%PRS 47.6%
-
CSI 1.9rCSI 1.7%PRS 46.5%
-
CSI 1.9rCSI 3.3%PRS 32.2%
-
CSI 1.9rCSI 6.0%PRS 36.8%
-
CSI 1.9rCSI 7.2%PRS 42.3%
-
CSI 1.9rCSI 2.6%PRS 58.2%
-
CSI 2.0rCSI 1.5%PRS 63.2%
-
CSI 2.0rCSI 1.2%PRS 66.1%
-
CSI 2.0rCSI 1.4%PRS 51.9%
-
CSI 2.0rCSI 4.1%PRS 47.3%
-
CSI 2.0rCSI 1.8%PRS 38.5%
-
CSI 2.0rCSI 1.8%PRS 64.6%
-
CSI 2.0rCSI 1.4%PRS 61.3%
-
CSI 2.1rCSI 4.5%PRS 75.6%
-
CSI 2.1rCSI 4.7%PRS 68.9%
-
CSI 2.1rCSI 4.2%PRS 39.2%
-
CSI 2.1rCSI 1.6%PRS 53.8%
-
CSI 2.2rCSI 5.7%PRS 57.8%
-
CSI 2.2rCSI 4.8%PRS 37.3%
-
CSI 2.2rCSI 2.2%PRS 63.3%
-
CSI 2.2rCSI 1.7%PRS 72.3%
-
CSI 2.2rCSI 1.8%PRS 37.1%
-
CSI 2.2rCSI 5.8%PRS 45.4%
-
CSI 2.3rCSI 3.6%PRS 53.7%
-
CSI 2.3rCSI 4.4%PRS 66.5%
-
CSI 2.3rCSI 1.7%PRS 64.8%
-
CSI 2.3rCSI 1.8%PRS 48.9%
-
CSI 2.3rCSI 7.8%PRS 36.8%
-
CSI 2.4rCSI 1.8%PRS 67.8%
-
CSI 2.4rCSI 3.3%PRS 70.4%
-
CSI 2.4rCSI 3.3%PRS 76.9%
-
CSI 2.4rCSI 2.5%PRS 50.2%
-
CSI 2.5rCSI 2.2%PRS 59.8%
-
CSI 2.5rCSI 12.0%PRS 48.5%
-
CSI 2.5rCSI 5.7%PRS 49.1%
-
CSI 2.5rCSI 1.8%PRS 63.5%
-
CSI 2.6rCSI 2.8%PRS 47.9%
-
CSI 2.6rCSI 3.6%PRS 46.2%
-
CSI 2.6rCSI 1.9%PRS 42.7%
-
CSI 2.6rCSI 1.9%PRS 63.4%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 2821844121
Symbol: PRKX_HUMAN
Name: cAMP-dependent protein kinase catalytic subunit PRKX
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 7633447
Title: The human protein kinase gene PKX1 on Xp22.3 displays Xp/Yp homology and is a site of chromosomal instability.
PubMed ID: 7633447
DOI: 10.1093/hmg/4.5.869
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 9302280
Title: Abnormal XY interchange between a novel isolated protein kinase gene, PRKY, and its homologue, PRKX, accounts for one third of all (Y+)XX males and (Y-)XY females.
PubMed ID: 9302280
PubMed ID: 9860982
Title: A lineage-specific protein kinase crucial for myeloid maturation.
PubMed ID: 9860982
PubMed ID: 10026146
Title: PrKX is a novel catalytic subunit of the cAMP-dependent protein kinase regulated by the regulatory subunit type I.
PubMed ID: 10026146
PubMed ID: 12082174
Title: PRKX, a phylogenetically and functionally distinct cAMP-dependent protein kinase, activates renal epithelial cell migration and morphogenesis.
PubMed ID: 12082174
PubMed ID: 16236808
Title: Protein kinase X activates ureteric bud branching morphogenesis in developing mouse metanephric kidney.
PubMed ID: 16236808
PubMed ID: 15879576
Title: Profiles of PrKX expression in developmental mouse embryo and human tissues.
PubMed ID: 15879576
PubMed ID: 16491121
Title: Smad6 is a protein kinase X phosphorylation substrate and is required for HL-60 cell differentiation.
PubMed ID: 16491121
PubMed ID: 17980165
Title: Protein kinase X (PRKX) can rescue the effects of polycystic kidney disease-1 gene (PKD1) deficiency.
PubMed ID: 17980165
PubMed ID: 19367327
Title: Protein kinase-X interacts with Pin-1 and Polycystin-1 during mouse kidney development.
PubMed ID: 19367327
DOI: 10.1038/ki.2009.95
PubMed ID: 20819953
Title: Regulation of cAMP-dependent protein kinases: the human protein kinase X (PrKX) reveals the role of the catalytic subunit alphaH-alphaI loop.
PubMed ID: 20819953
PubMed ID: 21684272
Title: PRKX critically regulates endothelial cell proliferation, migration, and vascular-like structure formation.
PubMed ID: 21684272
PubMed ID: 22814378
Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
PubMed ID: 22814378
Sequence Information:
- Length: 358
- Mass: 40896
- Checksum: B603834E3541CB56
- Sequence:
MEAPGLAQAA AAESDSRKVA EETPDGAPAL CPSPEALSPE PPVYSLQDFD TLATVGTGTF GRVHLVKEKT AKHFFALKVM SIPDVIRLKQ EQHVHNEKSV LKEVSHPFLI RLFWTWHDER FLYMLMEYVP GGELFSYLRN RGRFSSTTGL FYSAEIICAI EYLHSKEIVY RDLKPENILL DRDGHIKLTD FGFAKKLVDR TWTLCGTPEY LAPEVIQSKG HGRAVDWWAL GILIFEMLSG FPPFFDDNPF GIYQKILAGK IDFPRHLDFH VKDLIKKLLV VDRTRRLGNM KNGANDVKHH RWFRSVDWEA VPQRKLKPPI VPKIAGDGDT SNFETYPEND WDTAAPVPQK DLEIFKNF