Details for: PRKX

Gene ID: 5613

Symbol: PRKX

Ensembl ID: ENSG00000183943

Description: protein kinase cAMP-dependent X-linked catalytic subunit

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 167.2182
    Cell Significance Index: -26.0100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 94.8576
    Cell Significance Index: -24.0600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 58.3128
    Cell Significance Index: -23.6900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 51.9066
    Cell Significance Index: -26.7000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 21.4931
    Cell Significance Index: -26.5000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 8.9702
    Cell Significance Index: -24.0300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 7.6934
    Cell Significance Index: -23.6300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.7941
    Cell Significance Index: -26.8100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 6.5110
    Cell Significance Index: -14.2500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 2.9510
    Cell Significance Index: 82.4700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 2.8467
    Cell Significance Index: 541.7400
  • Cell Name: peg cell (CL4033014)
    Fold Change: 2.4447
    Cell Significance Index: 56.4800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.1698
    Cell Significance Index: 15.9600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.9138
    Cell Significance Index: 54.8600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8610
    Cell Significance Index: 777.4600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.8545
    Cell Significance Index: 55.1300
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 0.8527
    Cell Significance Index: 9.0600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.7775
    Cell Significance Index: 84.5700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6362
    Cell Significance Index: 103.4700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.6282
    Cell Significance Index: 17.1000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.5746
    Cell Significance Index: 313.8100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.4958
    Cell Significance Index: 57.7800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.4856
    Cell Significance Index: 27.2500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.4482
    Cell Significance Index: 27.5500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3510
    Cell Significance Index: 24.2700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3382
    Cell Significance Index: 121.3000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3255
    Cell Significance Index: 40.0200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.3092
    Cell Significance Index: 7.7300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.3053
    Cell Significance Index: 14.3500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.2915
    Cell Significance Index: 8.5600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.2776
    Cell Significance Index: 79.8800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2740
    Cell Significance Index: 121.1500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2406
    Cell Significance Index: 47.7500
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.1975
    Cell Significance Index: 2.8400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1858
    Cell Significance Index: 18.3800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1689
    Cell Significance Index: 23.2000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.1114
    Cell Significance Index: 69.5600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1033
    Cell Significance Index: 18.6200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0959
    Cell Significance Index: 12.3900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0907
    Cell Significance Index: 62.7200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0734
    Cell Significance Index: 1.5900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0588
    Cell Significance Index: 43.0800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.0373
    Cell Significance Index: 0.6900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0131
    Cell Significance Index: 0.9300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0009
    Cell Significance Index: 1.6400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0067
    Cell Significance Index: -10.3900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0111
    Cell Significance Index: -2.2300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0120
    Cell Significance Index: -22.1200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0139
    Cell Significance Index: -0.4900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0190
    Cell Significance Index: -25.7900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0209
    Cell Significance Index: -15.4500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0231
    Cell Significance Index: -13.0100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0237
    Cell Significance Index: -3.4500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0265
    Cell Significance Index: -16.8400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0344
    Cell Significance Index: -26.0300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0388
    Cell Significance Index: -0.9300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0439
    Cell Significance Index: -19.9200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0468
    Cell Significance Index: -1.2500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0514
    Cell Significance Index: -5.2500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0579
    Cell Significance Index: -2.7000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0638
    Cell Significance Index: -10.8900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0658
    Cell Significance Index: -1.7600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0665
    Cell Significance Index: -7.8500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0671
    Cell Significance Index: -8.6000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0673
    Cell Significance Index: -3.0500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0854
    Cell Significance Index: -17.9800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.1034
    Cell Significance Index: -2.9800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1272
    Cell Significance Index: -14.5700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1334
    Cell Significance Index: -2.8400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1502
    Cell Significance Index: -5.2200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1742
    Cell Significance Index: -2.9900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2001
    Cell Significance Index: -15.8500
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2155
    Cell Significance Index: -24.6000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2480
    Cell Significance Index: -25.8200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2633
    Cell Significance Index: -19.6200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2635
    Cell Significance Index: -5.7700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2660
    Cell Significance Index: -8.5200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2693
    Cell Significance Index: -14.0300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.2786
    Cell Significance Index: -5.7800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.3020
    Cell Significance Index: -23.1800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3057
    Cell Significance Index: -18.7400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.3107
    Cell Significance Index: -16.1400
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.3426
    Cell Significance Index: -5.3000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3688
    Cell Significance Index: -24.8000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.4068
    Cell Significance Index: -11.6600
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.4251
    Cell Significance Index: -6.1100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.4481
    Cell Significance Index: -28.2400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4752
    Cell Significance Index: -24.9500
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.4856
    Cell Significance Index: -5.0700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.5110
    Cell Significance Index: -18.7600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.5132
    Cell Significance Index: -13.1100
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.5513
    Cell Significance Index: -11.7900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.5552
    Cell Significance Index: -24.5600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.5715
    Cell Significance Index: -14.6900
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.5727
    Cell Significance Index: -4.6700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.5880
    Cell Significance Index: -8.4200
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.5947
    Cell Significance Index: -7.5100
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: -0.6117
    Cell Significance Index: -5.4300
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.6140
    Cell Significance Index: -12.1400
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.6167
    Cell Significance Index: -9.2400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** PRKX is a catalytic subunit of a protein kinase C (PKC) family, specifically a cAMP-dependent enzyme. It is X-linked, indicating its involvement in genetic disorders. PRKX is highly expressed in various cell types, including glandular epithelial cells, neural progenitor cells, and immune cells such as decidual natural killer cells and GABAergic neurons. **Pathways and Functions:** PRKX is involved in numerous signaling pathways, including: 1. **Activation of NMDA receptors and postsynaptic events**: PRKX regulates synaptic plasticity and learning by modulating NMDA receptor activity. 2. **Adora2b-mediated anti-inflammatory cytokines production**: PRKX interacts with Adora2b to produce anti-inflammatory cytokines, influencing immune responses. 3. **Angiogenesis**: PRKX is involved in endothelial cell migration and proliferation, promoting angiogenesis. 4. **Anti-inflammatory response favoring Leishmania parasite infection**: PRKX modulates the immune response to Leishmania parasites, allowing for parasite survival. 5. **Ca-dependent events**: PRKX regulates calcium-dependent signaling pathways, influencing cellular responses. PRKX functions as a protein kinase, phosphorylating and activating downstream targets, including: 1. **CREB1 phosphorylation**: PRKX phosphorylates CREB1, a transcription factor involved in various cellular processes. 2. **Peptidyl-serine phosphorylation**: PRKX phosphorylates serine residues on proteins, regulating their activity and localization. 3. **Pka-mediated phosphorylation of CREB**: PRKX interacts with Pka to phosphorylate CREB, enhancing its activity. **Clinical Significance:** PRKX's involvement in various diseases and disorders highlights its clinical significance: 1. **Leishmaniasis**: PRKX's anti-inflammatory response favoring Leishmania parasite infection may contribute to the disease's pathogenesis. 2. **Neurological disorders**: PRKX's role in synaptic plasticity and learning suggests its involvement in neurological disorders such as Alzheimer's disease and Parkinson's disease. 3. **Cancer**: PRKX's regulation of cell migration and proliferation may contribute to cancer development and progression. 4. **Immune disorders**: PRKX's involvement in immune response modulation may influence the development of autoimmune diseases. In conclusion, PRKX is a complex gene with far-reaching implications in immune regulation, cellular signaling, and disease mechanisms. Further research is necessary to fully elucidate PRKX's functions and its role in various diseases, ultimately informing the development of novel therapeutic strategies.

Genular Protein ID: 2821844121

Symbol: PRKX_HUMAN

Name: cAMP-dependent protein kinase catalytic subunit PRKX

UniProtKB Accession Codes:

P51817

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CPTAC 2 CTD 1 ChEBI 12 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugCentral 1 EC 3 EMBL 2 Ensembl 1 ExpressionAtlas 1 GO 20 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 4 RefSeq 1 Rhea 6 SABIO-RK 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7633447

Title: The human protein kinase gene PKX1 on Xp22.3 displays Xp/Yp homology and is a site of chromosomal instability.

PubMed ID: 7633447

DOI: 10.1093/hmg/4.5.869

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9302280

Title: Abnormal XY interchange between a novel isolated protein kinase gene, PRKY, and its homologue, PRKX, accounts for one third of all (Y+)XX males and (Y-)XY females.

PubMed ID: 9302280

DOI: 10.1093/hmg/6.11.1985

PubMed ID: 9860982

Title: A lineage-specific protein kinase crucial for myeloid maturation.

PubMed ID: 9860982

DOI: 10.1073/pnas.95.26.15412

PubMed ID: 10026146

Title: PrKX is a novel catalytic subunit of the cAMP-dependent protein kinase regulated by the regulatory subunit type I.

PubMed ID: 10026146

DOI: 10.1074/jbc.274.9.5370

PubMed ID: 12082174

Title: PRKX, a phylogenetically and functionally distinct cAMP-dependent protein kinase, activates renal epithelial cell migration and morphogenesis.

PubMed ID: 12082174

DOI: 10.1073/pnas.132051799

PubMed ID: 16236808

Title: Protein kinase X activates ureteric bud branching morphogenesis in developing mouse metanephric kidney.

PubMed ID: 16236808

DOI: 10.1681/asn.2005030240

PubMed ID: 15879576

Title: Profiles of PrKX expression in developmental mouse embryo and human tissues.

PubMed ID: 15879576

DOI: 10.1369/jhc.4a6568.2005

PubMed ID: 16491121

Title: Smad6 is a protein kinase X phosphorylation substrate and is required for HL-60 cell differentiation.

PubMed ID: 16491121

DOI: 10.1038/sj.onc.1209436

PubMed ID: 17980165

Title: Protein kinase X (PRKX) can rescue the effects of polycystic kidney disease-1 gene (PKD1) deficiency.

PubMed ID: 17980165

DOI: 10.1016/j.bbadis.2007.09.003

PubMed ID: 19367327

Title: Protein kinase-X interacts with Pin-1 and Polycystin-1 during mouse kidney development.

PubMed ID: 19367327

DOI: 10.1038/ki.2009.95

PubMed ID: 20819953

Title: Regulation of cAMP-dependent protein kinases: the human protein kinase X (PrKX) reveals the role of the catalytic subunit alphaH-alphaI loop.

PubMed ID: 20819953

DOI: 10.1074/jbc.m110.155150

PubMed ID: 21684272

Title: PRKX critically regulates endothelial cell proliferation, migration, and vascular-like structure formation.

PubMed ID: 21684272

DOI: 10.1016/j.ydbio.2011.05.673

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

Sequence Information:

  • Length: 358
  • Mass: 40896
  • Checksum: B603834E3541CB56
  • Sequence:
    • MEAPGLAQAA AAESDSRKVA EETPDGAPAL CPSPEALSPE PPVYSLQDFD TLATVGTGTF 
GRVHLVKEKT AKHFFALKVM SIPDVIRLKQ EQHVHNEKSV LKEVSHPFLI RLFWTWHDER 
FLYMLMEYVP GGELFSYLRN RGRFSSTTGL FYSAEIICAI EYLHSKEIVY RDLKPENILL 
DRDGHIKLTD FGFAKKLVDR TWTLCGTPEY LAPEVIQSKG HGRAVDWWAL GILIFEMLSG 
FPPFFDDNPF GIYQKILAGK IDFPRHLDFH VKDLIKKLLV VDRTRRLGNM KNGANDVKHH 
RWFRSVDWEA VPQRKLKPPI VPKIAGDGDT SNFETYPEND WDTAAPVPQK DLEIFKNF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.