Details for: PRPSAP2
Gene ID: 5636
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: PRPSAP2
Ensembl ID: ENSG00000141127
Description: phosphoribosyl pyrophosphate synthetase associated protein 2
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 10.27rCSI 30.62%PRS 67.73
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CSI 5.86rCSI 8.01%PRS 47.76
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CSI 5.26rCSI 16.93%PRS 44.45
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CSI 4.74rCSI 12.05%PRS 41.16
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CSI 4.71rCSI 8.15%PRS 36.11
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CSI 4.53rCSI 8%PRS 28.77
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CSI 4.35rCSI 9.25%PRS 48.9
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CSI 3.62rCSI 4.18%PRS 35.57
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CSI 3.42rCSI 2.46%PRS 58.12
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CSI 3.4rCSI 3.34%PRS 47.52
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CSI 3.38rCSI 2.35%PRS 53.79
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CSI 3.36rCSI 2.82%PRS 62.52
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CSI 3.33rCSI 7.46%PRS 30.47
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CSI 3.25rCSI 3.41%PRS 47.93
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CSI 3.19rCSI 12.85%PRS 43.64
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CSI 3.03rCSI 4.14%PRS 41.4
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CSI 2.95rCSI 2.21%PRS 59.69
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CSI 2.78rCSI 3.34%PRS 43.3
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CSI 2.6rCSI 4.26%PRS 36.08
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CSI 2.57rCSI 3.43%PRS 53.55
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CSI 2.53rCSI 1.92%PRS 56.46
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CSI 2.52rCSI 3.7%PRS 41.05
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CSI 2.52rCSI 2.32%PRS 46.04
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CSI 2.49rCSI 3.53%PRS 42.17
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CSI 2.42rCSI 2.38%PRS 60.51
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CSI 2.42rCSI 1.9%PRS 51.56
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CSI 2.39rCSI 1.41%PRS 60.37
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CSI 2.37rCSI 1.65%PRS 58.02
-
CSI 2.3rCSI 2.02%PRS 50.08
-
CSI 2.27rCSI 3.37%PRS 47.62
-
CSI 2.26rCSI 1.87%PRS 43.68
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CSI 2.25rCSI 2.87%PRS 50.52
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CSI 2.21rCSI 1.63%PRS 38.76
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CSI 2.17rCSI 5.5%PRS 35.91
-
CSI 2.13rCSI 1.89%PRS 44.09
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CSI 2.13rCSI 6.28%PRS 49.07
-
CSI 2.12rCSI 4.85%PRS 44.56
-
CSI 2.11rCSI 15.53%PRS 33.4
-
CSI 2.08rCSI 2.84%PRS 54.77
-
CSI 2.07rCSI 1.54%PRS 58.39
-
CSI 2.04rCSI 5.33%PRS 44.24
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CSI 2.04rCSI 5.45%PRS 38.22
-
CSI 2.03rCSI 1.35%PRS 48.92
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CSI 2.02rCSI 1.36%PRS 55.56
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CSI 2.01rCSI 1.4%PRS 46.91
-
CSI 2rCSI 2.04%PRS 58.3
-
CSI 1.97rCSI 1.48%PRS 48.63
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CSI 1.95rCSI 1.51%PRS 45.63
-
CSI 1.94rCSI 2.08%PRS 43.13
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CSI 1.93rCSI 4.4%PRS 38.68
-
CSI 1.88rCSI 2.51%PRS 67.57
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CSI 1.85rCSI 4.81%PRS 68.03
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CSI 1.84rCSI 1.52%PRS 46.08
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CSI 1.84rCSI 1.92%PRS 44.65
-
CSI 1.82rCSI 3.66%PRS 35.21
-
CSI 1.81rCSI 1.43%PRS 33.16
-
CSI 1.8rCSI 1.89%PRS 42.3
-
CSI 1.77rCSI 3.1%PRS 37.69
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CSI 1.76rCSI 2.18%PRS 41.1
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CSI 1.73rCSI 1.73%PRS 39.5
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CSI 1.68rCSI 1.36%PRS 45.75
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CSI 1.68rCSI 1.47%PRS 34.56
-
CSI 1.65rCSI 2.12%PRS 43.13
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CSI 1.64rCSI 1.58%PRS 36.02
-
CSI 1.63rCSI 2.6%PRS 38.34
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CSI 1.61rCSI 3.55%PRS 42.52
-
CSI 1.6rCSI 3.53%PRS 49.04
-
CSI 1.58rCSI 2.95%PRS 35.14
-
CSI 1.54rCSI 3.76%PRS 41.2
-
CSI 1.52rCSI 1.81%PRS 29.67
-
CSI 1.5rCSI 2.09%PRS 44.55
-
CSI 1.44rCSI 4.14%PRS 62.94
-
CSI 1.43rCSI 2.04%PRS 47.81
-
CSI 1.41rCSI 2.37%PRS 29.75
-
CSI 1.41rCSI 2.8%PRS 44.29
-
CSI 1.41rCSI 1.62%PRS 39.57
-
CSI 1.4rCSI 3.46%PRS 43.2
-
CSI 1.4rCSI 2.51%PRS 38.72
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CSI 1.37rCSI 3.1%PRS 50.47
-
CSI 1.37rCSI 1.6%PRS 48.78
-
CSI 1.36rCSI 1.75%PRS 30.64
-
CSI 1.35rCSI 2.38%PRS 43.48
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CSI 1.34rCSI 2.72%PRS 28.07
-
CSI 1.32rCSI 2.11%PRS 39.13
-
CSI 1.3rCSI 1.98%PRS 41.9
-
CSI 1.27rCSI 2.94%PRS 37
-
CSI 1.25rCSI 4.7%PRS 38.35
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CSI 1.23rCSI 1.98%PRS 36.04
-
CSI 1.2rCSI 3.09%PRS 41.39
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CSI 1.19rCSI 1.48%PRS 28.23
-
CSI 1.17rCSI 1.6%PRS 38.59
-
CSI 1.15rCSI 3.18%PRS 41.91
-
CSI 1.15rCSI 1.84%PRS 48.99
-
CSI 1.11rCSI 6.51%PRS 31.12
-
CSI 1.1rCSI 1.5%PRS 23.17
-
CSI 1.08rCSI 3.63%PRS 33.68
-
CSI 1.06rCSI 1.71%PRS 31.8
-
CSI 1.06rCSI 3.38%PRS 42.14
-
CSI 1.05rCSI 1.5%PRS 36.67
-
CSI 1.03rCSI 1.3%PRS 54.87
-
CSI 0.1rCSI 1.2%PRS 33.0%
-
CSI 0.2rCSI 4.6%PRS 29.2%
-
CSI 0.2rCSI 5.1%PRS 30.1%
-
CSI 0.4rCSI 1.2%PRS 33.2%
-
CSI 0.4rCSI 1.9%PRS 56.1%
-
CSI 0.4rCSI 1.2%PRS 36.7%
-
CSI 0.4rCSI 1.1%PRS 58.4%
-
CSI 0.5rCSI 1.9%PRS 30.6%
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CSI 0.5rCSI 2.7%PRS 59.7%
-
CSI 0.5rCSI 1.6%PRS 52.6%
-
CSI 0.6rCSI 1.8%PRS 30.9%
-
CSI 0.6rCSI 3.5%PRS 37.8%
-
CSI 0.6rCSI 3.6%PRS 55.9%
-
CSI 0.6rCSI 2.3%PRS 28.6%
-
CSI 0.7rCSI 2.9%PRS 43.9%
-
CSI 0.7rCSI 0.6%PRS 41.8%
-
CSI 0.7rCSI 1.7%PRS 28.9%
-
CSI 0.9rCSI 3.3%PRS 38.5%
-
CSI 0.9rCSI 3.9%PRS 42.8%
-
CSI 0.9rCSI 0.7%PRS 44.0%
-
CSI 1.0rCSI 1.4%PRS 50.2%
-
CSI 1.0rCSI 2.2%PRS 33.7%
-
CSI 1.0rCSI 2.7%PRS 44.7%
-
CSI 1.0rCSI 1.3%PRS 54.9%
-
CSI 1.1rCSI 1.5%PRS 36.7%
-
CSI 1.1rCSI 3.4%PRS 42.1%
-
CSI 1.1rCSI 1.7%PRS 31.8%
-
CSI 1.1rCSI 3.6%PRS 33.7%
-
CSI 1.1rCSI 1.5%PRS 23.2%
-
CSI 1.1rCSI 6.5%PRS 31.1%
-
CSI 1.2rCSI 1.8%PRS 49.0%
-
CSI 1.2rCSI 3.2%PRS 41.9%
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CSI 1.2rCSI 1.6%PRS 38.6%
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CSI 1.2rCSI 1.5%PRS 28.2%
-
CSI 1.2rCSI 3.1%PRS 41.4%
-
CSI 1.2rCSI 2.0%PRS 36.0%
-
CSI 1.3rCSI 4.7%PRS 38.4%
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CSI 1.3rCSI 2.9%PRS 37.0%
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CSI 1.3rCSI 2.0%PRS 41.9%
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CSI 1.3rCSI 2.1%PRS 39.1%
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CSI 1.3rCSI 2.7%PRS 28.1%
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CSI 1.4rCSI 2.4%PRS 43.5%
-
CSI 1.4rCSI 1.8%PRS 30.6%
-
CSI 1.4rCSI 1.6%PRS 48.8%
-
CSI 1.4rCSI 3.1%PRS 50.5%
-
CSI 1.4rCSI 2.5%PRS 38.7%
-
CSI 1.4rCSI 3.5%PRS 43.2%
-
CSI 1.4rCSI 1.6%PRS 39.6%
-
CSI 1.4rCSI 2.8%PRS 44.3%
-
CSI 1.4rCSI 2.4%PRS 29.8%
-
CSI 1.4rCSI 2.0%PRS 47.8%
-
CSI 1.4rCSI 4.1%PRS 62.9%
-
CSI 1.5rCSI 2.1%PRS 44.6%
-
CSI 1.5rCSI 1.8%PRS 29.7%
-
CSI 1.5rCSI 3.8%PRS 41.2%
-
CSI 1.6rCSI 3.0%PRS 35.1%
-
CSI 1.6rCSI 3.5%PRS 49.0%
-
CSI 1.6rCSI 3.6%PRS 42.5%
-
CSI 1.6rCSI 2.6%PRS 38.3%
-
CSI 1.6rCSI 1.6%PRS 36.0%
-
CSI 1.7rCSI 2.1%PRS 43.1%
-
CSI 1.7rCSI 1.5%PRS 34.6%
-
CSI 1.7rCSI 1.4%PRS 45.8%
-
CSI 1.7rCSI 1.7%PRS 39.5%
-
CSI 1.8rCSI 2.2%PRS 41.1%
-
CSI 1.8rCSI 3.1%PRS 37.7%
-
CSI 1.8rCSI 1.9%PRS 42.3%
-
CSI 1.8rCSI 1.4%PRS 33.2%
-
CSI 1.8rCSI 3.7%PRS 35.2%
-
CSI 1.8rCSI 1.9%PRS 44.7%
-
CSI 1.8rCSI 1.5%PRS 46.1%
-
CSI 1.9rCSI 4.8%PRS 68.0%
-
CSI 1.9rCSI 2.5%PRS 67.6%
-
CSI 1.9rCSI 4.4%PRS 38.7%
-
CSI 1.9rCSI 2.1%PRS 43.1%
-
CSI 2.0rCSI 1.5%PRS 45.6%
-
CSI 2.0rCSI 1.5%PRS 48.6%
-
CSI 2.0rCSI 2.0%PRS 58.3%
-
CSI 2.0rCSI 1.4%PRS 46.9%
-
CSI 2.0rCSI 1.4%PRS 55.6%
-
CSI 2.0rCSI 1.4%PRS 48.9%
-
CSI 2.0rCSI 5.5%PRS 38.2%
-
CSI 2.0rCSI 5.3%PRS 44.2%
-
CSI 2.1rCSI 1.5%PRS 58.4%
-
CSI 2.1rCSI 2.8%PRS 54.8%
-
CSI 2.1rCSI 15.5%PRS 33.4%
-
CSI 2.1rCSI 4.9%PRS 44.6%
-
CSI 2.1rCSI 6.3%PRS 49.1%
-
CSI 2.1rCSI 1.9%PRS 44.1%
-
CSI 2.2rCSI 5.5%PRS 35.9%
-
CSI 2.2rCSI 1.6%PRS 38.8%
-
CSI 2.3rCSI 2.9%PRS 50.5%
-
CSI 2.3rCSI 1.9%PRS 43.7%
-
CSI 2.3rCSI 3.4%PRS 47.6%
-
CSI 2.3rCSI 2.0%PRS 50.1%
-
CSI 2.4rCSI 1.7%PRS 58.0%
-
CSI 2.4rCSI 1.4%PRS 60.4%
-
CSI 2.4rCSI 1.9%PRS 51.6%
-
CSI 2.4rCSI 2.4%PRS 60.5%
-
CSI 2.5rCSI 3.5%PRS 42.2%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 2045524281
Symbol: KPRB_HUMAN
Name: Phosphoribosyl pyrophosphate synthase-associated protein 2
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9545573
Title: Molecular cloning of a human cDNA for the 41-kDa phosphoribosylpyrophosphate synthetase-associated protein.
PubMed ID: 9545573
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 16625196
Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.
PubMed ID: 16625196
DOI: 10.1038/nature04689
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 17081983
Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
PubMed ID: 17081983
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
Sequence Information:
- Length: 369
- Mass: 40926
- Checksum: 12A0E46BD4AC55BF
- Sequence:
MFCVTPPELE TKMNITKGGL VLFSANSNSS CMELSKKIAE RLGVEMGKVQ VYQEPNRETR VQIQESVRGK DVFIIQTVSK DVNTTIMELL IMVYACKTSC AKSIIGVIPY FPYSKQCKMR KRGSIVSKLL ASMMCKAGLT HLITMDLHQK EIQGFFNIPV DNLRASPFLL QYIQEEIPDY RNAVIVAKSP ASAKRAQSFA ERLRLGIAVI HGEAQDAESD LVDGRHSPPM VRSVAAIHPS LEIPMLIPKE KPPITVVGDV GGRIAIIVDD IIDDVDSFLA AAETLKERGA YKIFVMATHG LLSSDAPRRI EESAIDEVVV TNTIPHEVQK LQCPKIKTVD ISMILSEAIR RIHNGESMSY LFRNIGLDD