Details for: PRPSAP2

Gene ID: 5636

Symbol: PRPSAP2

Ensembl ID: ENSG00000141127

Description: phosphoribosyl pyrophosphate synthetase associated protein 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 187.8553
    Cell Significance Index: -29.2200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 109.7998
    Cell Significance Index: -27.8500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 66.5929
    Cell Significance Index: -31.4400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 66.1404
    Cell Significance Index: -26.8700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 24.9968
    Cell Significance Index: -30.8200
  • Cell Name: centroblast (CL0009112)
    Fold Change: 16.2104
    Cell Significance Index: 37.8200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 9.9744
    Cell Significance Index: -26.7200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 8.4716
    Cell Significance Index: -26.0200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 8.1005
    Cell Significance Index: -31.9700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 5.2911
    Cell Significance Index: -11.5800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 3.7826
    Cell Significance Index: 446.0800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.3577
    Cell Significance Index: 163.0500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.2812
    Cell Significance Index: 17.4800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.2205
    Cell Significance Index: 73.2700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.2111
    Cell Significance Index: 131.7400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.1500
    Cell Significance Index: 228.2300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.9394
    Cell Significance Index: 188.4400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.7701
    Cell Significance Index: 48.5400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.6926
    Cell Significance Index: 248.4200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.5719
    Cell Significance Index: 43.8900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.5594
    Cell Significance Index: 29.3700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.5373
    Cell Significance Index: 18.6700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.5034
    Cell Significance Index: 28.2500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.4855
    Cell Significance Index: 29.8400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.4630
    Cell Significance Index: 320.2200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4197
    Cell Significance Index: 79.8700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.4053
    Cell Significance Index: 26.1500
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.3824
    Cell Significance Index: 4.7400
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.3569
    Cell Significance Index: 4.2600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.3543
    Cell Significance Index: 23.8300
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.3515
    Cell Significance Index: 5.6400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2577
    Cell Significance Index: 7.4300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2574
    Cell Significance Index: 140.5600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2318
    Cell Significance Index: 41.7800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.2312
    Cell Significance Index: 6.4600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2290
    Cell Significance Index: 22.6600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2161
    Cell Significance Index: 29.6700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2130
    Cell Significance Index: 94.1800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2050
    Cell Significance Index: 25.2100
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.1926
    Cell Significance Index: 4.6200
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.1388
    Cell Significance Index: 1.0700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.1303
    Cell Significance Index: 3.3500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0972
    Cell Significance Index: 12.4600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0931
    Cell Significance Index: 4.2200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0917
    Cell Significance Index: 172.7200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0799
    Cell Significance Index: 1.3700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0747
    Cell Significance Index: 3.8800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0658
    Cell Significance Index: 3.0700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.0483
    Cell Significance Index: 1.0100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0429
    Cell Significance Index: 65.9700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0409
    Cell Significance Index: 55.6800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0405
    Cell Significance Index: 25.6900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0338
    Cell Significance Index: 62.3100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0228
    Cell Significance Index: 10.3700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0080
    Cell Significance Index: 0.2800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0069
    Cell Significance Index: 0.4900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0023
    Cell Significance Index: 0.0500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0042
    Cell Significance Index: -0.0900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0171
    Cell Significance Index: -12.9100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0177
    Cell Significance Index: -12.9800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0305
    Cell Significance Index: -4.4300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0321
    Cell Significance Index: -23.7600
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.0349
    Cell Significance Index: -0.7500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0449
    Cell Significance Index: -7.6600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0499
    Cell Significance Index: -28.1200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0511
    Cell Significance Index: -1.1200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0519
    Cell Significance Index: -6.7000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0565
    Cell Significance Index: -35.2800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0703
    Cell Significance Index: -7.1800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0809
    Cell Significance Index: -3.8000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0911
    Cell Significance Index: -1.5300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0930
    Cell Significance Index: -26.7700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1055
    Cell Significance Index: -12.2900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1163
    Cell Significance Index: -8.6700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1234
    Cell Significance Index: -3.3600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1375
    Cell Significance Index: -6.0800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1419
    Cell Significance Index: -3.7300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1672
    Cell Significance Index: -35.2100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1801
    Cell Significance Index: -6.8200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1992
    Cell Significance Index: -6.3800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2220
    Cell Significance Index: -25.4300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2336
    Cell Significance Index: -24.3200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2426
    Cell Significance Index: -6.5000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2702
    Cell Significance Index: -7.7100
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.2907
    Cell Significance Index: -3.1600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.3054
    Cell Significance Index: -8.9700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3277
    Cell Significance Index: -25.9500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.3401
    Cell Significance Index: -7.0600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.3543
    Cell Significance Index: -9.4600
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.4206
    Cell Significance Index: -6.2100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.4433
    Cell Significance Index: -23.0900
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.4623
    Cell Significance Index: -3.7700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.4672
    Cell Significance Index: -11.9400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5052
    Cell Significance Index: -30.9800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.5602
    Cell Significance Index: -18.3400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.5821
    Cell Significance Index: -18.5400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.6320
    Cell Significance Index: -16.9100
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.6575
    Cell Significance Index: -5.2500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.6620
    Cell Significance Index: -14.0500
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.6625
    Cell Significance Index: -13.3000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** PRPSAP2 is a small protein, with an estimated molecular weight of approximately 14 kDa. Its primary function is associated with the regulation of phosphoribosyl pyrophosphate (PRPP) synthetase activity, a crucial enzyme in the biosynthesis of purine nucleotides. The protein exhibits high expression levels in various cell types, including tonsil germinal center B cells, centroblasts, and pulmonary interstitial fibroblasts. Notably, PRPSAP2 is also expressed in the nervous system, where it may play a role in regulating neuronal function and development. **Pathways and Functions:** PRPSAP2 is involved in several key pathways, including: 1. **5-phosphoribose 1-diphosphate biosynthetic process**: PRPSAP2 regulates the activity of PRPP synthetase, which is essential for the biosynthesis of purine nucleotides. 2. **Purine nucleotide biosynthetic process**: PRPSAP2 is involved in the regulation of purine nucleotide synthesis, which is critical for DNA and RNA synthesis. 3. **Ribose phosphate diphosphokinase activity**: PRPSAP2 may also regulate the activity of ribose phosphate diphosphokinase, an enzyme involved in the biosynthesis of ribose-5-phosphate. 4. **Protein binding and regulation**: PRPSAP2 interacts with various proteins, including PRPP synthetase, and regulates their activity. **Clinical Significance:** PRPSAP2 has been identified as a significantly expressed protein in various tissues, including the nervous system. Its expression patterns and involvement in cellular processes suggest that PRPSAP2 may play a role in neurological disorders, such as Alzheimer's disease, Parkinson's disease, and multiple sclerosis. Additionally, PRPSAP2 may be involved in the regulation of immune responses, as it is expressed in tonsil germinal center B cells and centroblasts. **Implications and Future Directions:** Further research is necessary to fully elucidate the role of PRPSAP2 in human health and disease. Potential avenues for investigation include: 1. **Investigating the relationship between PRPSAP2 expression and neurological disorders**: Elucidating the mechanisms by which PRPSAP2 regulates purine nucleotide synthesis and ribose phosphate diphosphokinase activity may provide insights into the pathogenesis of neurological disorders. 2. **Exploring the role of PRPSAP2 in immune responses**: Investigating the interactions between PRPSAP2 and immune cells may reveal its potential as a therapeutic target for autoimmune diseases. 3. **Developing diagnostic biomarkers**: Identifying specific markers of PRPSAP2 expression may enable the development of diagnostic tools for neurological and autoimmune disorders. In conclusion, PRPSAP2 is a multifaceted protein with diverse expression patterns and involvement in various cellular processes. Further research is necessary to fully elucidate its role in human health and disease, but its potential implications in neurological disorders and immune responses make it an exciting area of investigation.

Genular Protein ID: 2045524281

Symbol: KPRB_HUMAN

Name: Phosphoribosyl pyrophosphate synthase-associated protein 2

UniProtKB Accession Codes:

O60256 B4E1M8 B4E329 B7ZKZ1 E7EMY2 Q6IAS2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 10 Ensembl 5 EvolutionaryTrace 1 ExpressionAtlas 1 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 RefSeq 17 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9545573

Title: Molecular cloning of a human cDNA for the 41-kDa phosphoribosylpyrophosphate synthetase-associated protein.

PubMed ID: 9545573

DOI: 10.1016/s0167-4781(97)00217-0

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 369
  • Mass: 40926
  • Checksum: 12A0E46BD4AC55BF
  • Sequence:
    • MFCVTPPELE TKMNITKGGL VLFSANSNSS CMELSKKIAE RLGVEMGKVQ VYQEPNRETR 
VQIQESVRGK DVFIIQTVSK DVNTTIMELL IMVYACKTSC AKSIIGVIPY FPYSKQCKMR 
KRGSIVSKLL ASMMCKAGLT HLITMDLHQK EIQGFFNIPV DNLRASPFLL QYIQEEIPDY 
RNAVIVAKSP ASAKRAQSFA ERLRLGIAVI HGEAQDAESD LVDGRHSPPM VRSVAAIHPS 
LEIPMLIPKE KPPITVVGDV GGRIAIIVDD IIDDVDSFLA AAETLKERGA YKIFVMATHG 
LLSSDAPRRI EESAIDEVVV TNTIPHEVQK LQCPKIKTVD ISMILSEAIR RIHNGESMSY 
LFRNIGLDD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.