LGMN | ENSG00000100600 | NCBI 5641

Details for: LGMN

Gene ID: 5641

Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: LGMN

Ensembl ID: ENSG00000100600

Description: legumain

Cell Significance Landscape

Display Count:

Associated with

Adaptive immune system
(R-HSA-1280218)
Immune system
(R-HSA-168256)
Innate immune system
(R-HSA-168249)
Metabolism
(R-HSA-1430728)
Metabolism of lipids
(R-HSA-556833)
Metabolism of steroids
(R-HSA-8957322)
Mhc class ii antigen presentation
(R-HSA-2132295)
Toll-like receptor cascades
(R-HSA-168898)
Trafficking and processing of endosomal tlr
(R-HSA-1679131)
Vitamin d (calciferol) metabolism
(R-HSA-196791)
Activation of cysteine-type endopeptidase activity
(GO:0097202)
Antigen processing and presentation of exogenous peptide antigen via mhc class ii
(GO:0019886)
Apical part of cell
(GO:0045177)
Associative learning
(GO:0008306)
Cellular response to amyloid-beta
(GO:1904646)
Cellular response to calcium ion
(GO:0071277)
Cellular response to hepatocyte growth factor stimulus
(GO:0035729)
Cysteine-type endopeptidase activity
(GO:0004197)
Cytoplasm
(GO:0005737)
Dendritic spine organization
(GO:0097061)
Endolysosome lumen
(GO:0036021)
Endopeptidase activator activity
(GO:0061133)
Extracellular exosome
(GO:0070062)
Extracellular region
(GO:0005576)
Late endosome
(GO:0005770)
Lysosomal lumen
(GO:0043202)
Lysosome
(GO:0005764)
Memory
(GO:0007613)
Negative regulation of erbb signaling pathway
(GO:1901185)
Negative regulation of gene expression
(GO:0010629)
Negative regulation of multicellular organism growth
(GO:0040015)
Negative regulation of neuron apoptotic process
(GO:0043524)
Peptidase activity
(GO:0008233)
Perinuclear region of cytoplasm
(GO:0048471)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of endothelial cell chemotaxis
(GO:2001028)
Positive regulation of long-term synaptic potentiation
(GO:1900273)
Positive regulation of mitotic cell cycle
(GO:0045931)
Positive regulation of monocyte chemotaxis
(GO:0090026)
Protein binding
(GO:0005515)
Protein maturation
(GO:0051604)
Proteolysis
(GO:0006508)
Proteolysis involved in protein catabolic process
(GO:0051603)
Receptor catabolic process
(GO:0032801)
Renal system process
(GO:0003014)
Response to acidic ph
(GO:0010447)
Self proteolysis
(GO:0097264)
Tau protein binding
(GO:0048156)
Vacuolar protein processing
(GO:0006624)
Vitamin d metabolic process
(GO:0042359)

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

myeloid leukocyte CL0000766

CSI 60.24

rCSI 55.58%

PRS 58.3
elicited macrophage CL0000861

CSI 48.4

rCSI 44.44%

PRS 65.87
alternatively activated macrophage CL0000890

CSI 39.5

rCSI 49.66%

PRS 69.67
Hofbauer cell CL3000001

CSI 33.36

rCSI 62.97%

PRS 67.91
Kupffer cell CL0000091

CSI 24.02

rCSI 54.94%

PRS 57.03
extravillous trophoblast CL0008036

CSI 23.99

rCSI 29.68%

PRS 53.48
macrophage CL0000235

CSI 23.66

rCSI 43.04%

PRS 77.66
kidney interstitial alternatively activated macrophage CL1000695

CSI 22.26

rCSI 58.02%

PRS 56.95
plasmacytoid dendritic cell, human CL0001058

CSI 19.27

rCSI 13.45%

PRS 60.04
lung macrophage CL1001603

CSI 18.1

rCSI 40.44%

PRS 64.84
syncytiotrophoblast cell CL0000525

CSI 16.84

rCSI 48.5%

PRS 71.89
placental villous trophoblast CL2000060

CSI 13.74

rCSI 21.23%

PRS 55.29
colon macrophage CL0009038

CSI 13.6

rCSI 62.84%

PRS 76.87
promyelocyte CL0000836

CSI 12.61

rCSI 18.19%

PRS 66.92
endothelial cell of pericentral hepatic sinusoid CL0019022

CSI 12.27

rCSI 37.8%

PRS 66.96
ionocyte CL0005006

CSI 12.13

rCSI 13%

PRS 56.23
colonocyte CL1000347

CSI 12.12

rCSI 17.38%

PRS 61.92
fallopian tube secretory epithelial cell CL4030006

CSI 11.5

rCSI 11.07%

PRS 57.51
dendritic cell, human CL0001056

CSI 10.35

rCSI 15.89%

PRS 65.92
mononuclear phagocyte CL0000113

CSI 10.18

rCSI 22.4%

PRS 61.37
intestinal epithelial cell CL0002563

CSI 10.04

rCSI 10.49%

PRS 55.58
pvalb GABAergic cortical interneuron CL4023018

CSI 9.72

rCSI 12.1%

PRS 37.77
colon epithelial cell CL0011108

CSI 9.47

rCSI 9.92%

PRS 53.88
secretory cell CL0000151

CSI 9.16

rCSI 9.56%

PRS 57.51
tracheobronchial smooth muscle cell CL0019019

CSI 8.93

rCSI 15.75%

PRS 65.79
inflammatory macrophage CL0000863

CSI 8.85

rCSI 15.12%

PRS 81.43
lung pericyte CL0009089

CSI 8.78

rCSI 23.18%

PRS 66.1
alveolar macrophage CL0000583

CSI 7.37

rCSI 12.13%

PRS 62.73
lamp5 GABAergic cortical interneuron CL4023011

CSI 7.29

rCSI 12.23%

PRS 39.59
interneuron CL0000099

CSI 7.24

rCSI 14.53%

PRS 46.58
mucous neck cell CL0000651

CSI 6.1

rCSI 8.8%

PRS 68.67
skin fibroblast CL0002620

CSI 5.97

rCSI 5.14%

PRS 63.39
pulmonary artery endothelial cell CL1001568

CSI 5.94

rCSI 8.08%

PRS 69.22
hepatic stellate cell CL0000632

CSI 5.79

rCSI 21.7%

PRS 49.52
foveolar cell of stomach CL0002179

CSI 5.79

rCSI 12.32%

PRS 69.49
renal alpha-intercalated cell CL0005011

CSI 5.77

rCSI 7.71%

PRS 66.31
goblet cell CL0000160

CSI 5.74

rCSI 5.42%

PRS 57.08
lung secretory cell CL1000272

CSI 5.56

rCSI 13.77%

PRS 55.63
epithelial cell of proximal tubule CL0002306

CSI 5.5

rCSI 13.43%

PRS 51.3
choroid plexus epithelial cell CL0000706

CSI 5.46

rCSI 8.95%

PRS 47.01
enterocyte CL0000584

CSI 5.46

rCSI 8.81%

PRS 61.95
pulmonary alveolar type 2 cell CL0002063

CSI 5.45

rCSI 8.45%

PRS 65.49
fibroblast of lung CL0002553

CSI 5.4

rCSI 5.03%

PRS 57.37
plasmacytoid dendritic cell CL0000784

CSI 5.3

rCSI 5.37%

PRS 85.22
perivascular cell CL4033054

CSI 5.27

rCSI 7.2%

PRS 63
bronchus fibroblast of lung CL2000093

CSI 5.25

rCSI 4.26%

PRS 57.77
cardiac endothelial cell CL0010008

CSI 5.06

rCSI 20.4%

PRS 55.92
dendritic cell CL0000451

CSI 4.88

rCSI 6.02%

PRS 73.49
M cell of gut CL0000682

CSI 4.81

rCSI 5.11%

PRS 68.61
pancreatic acinar cell CL0002064

CSI 4.67

rCSI 6.21%

PRS 63.45
monocyte CL0000576

CSI 4.59

rCSI 8.3%

PRS 73.23
epithelial cell of lower respiratory tract CL0002632

CSI 4.58

rCSI 3.55%

PRS 58.78
adipocyte CL0000136

CSI 4.53

rCSI 5.82%

PRS 50.71
mesenchymal cell CL0008019

CSI 4.35

rCSI 11.04%

PRS 51.76
lung interstitial macrophage CL4033043

CSI 4.24

rCSI 9.51%

PRS 75.55
epithelial cell of lung CL0000082

CSI 4.23

rCSI 3.5%

PRS 56.21
CD14-positive, CD16-positive monocyte CL0002397

CSI 4.23

rCSI 5.54%

PRS 70.69
pancreatic D cell CL0000173

CSI 4.2

rCSI 4.13%

PRS 59.92
tissue-resident macrophage CL0000864

CSI 4.2

rCSI 19.64%

PRS 74.08
blood vessel endothelial cell CL0000071

CSI 4.17

rCSI 8.65%

PRS 54.58
sst GABAergic cortical interneuron CL4023017

CSI 4.07

rCSI 5.24%

PRS 40.77
pancreatic A cell CL0000171

CSI 4.03

rCSI 4.22%

PRS 60.8
retinal pigment epithelial cell CL0002586

CSI 3.9

rCSI 7.74%

PRS 55.32
chondrocyte CL0000138

CSI 3.83

rCSI 6.1%

PRS 49.69
glandular epithelial cell CL0000150

CSI 3.76

rCSI 9.9%

PRS 76.72
pulmonary ionocyte CL0017000

CSI 3.74

rCSI 4.56%

PRS 64.96
epithelial cell CL0000066

CSI 3.67

rCSI 5.64%

PRS 54.67
pulmonary capillary endothelial cell CL4028001

CSI 3.65

rCSI 6.96%

PRS 72.69
radial glial cell CL0000681

CSI 3.61

rCSI 5.01%

PRS 56.25
glioblast CL0000030

CSI 3.45

rCSI 5.51%

PRS 50.18
neural crest cell CL0011012

CSI 3.43

rCSI 2.71%

PRS 44.27
intermediate monocyte CL0002393

CSI 3.43

rCSI 5.18%

PRS 60.82
retinal bipolar neuron CL0000748

CSI 3.4

rCSI 6.36%

PRS 45.94
CD1c-positive myeloid dendritic cell CL0002399

CSI 3.39

rCSI 4.1%

PRS 65.92
regular ventricular cardiac myocyte CL0002131

CSI 3.38

rCSI 21.14%

PRS 49.21
early lymphoid progenitor CL0000936

CSI 3.36

rCSI 2.96%

PRS 62.55
astrocyte of the cerebral cortex CL0002605

CSI 3.36

rCSI 7.53%

PRS 40.31
enteroendocrine cell CL0000164

CSI 3.33

rCSI 4.55%

PRS 59.16
CD4-positive, alpha-beta memory T cell CL0000897

CSI 3.32

rCSI 2.38%

PRS 71.55
retinal cone cell CL0000573

CSI 3.3

rCSI 5.3%

PRS 47.11
stem cell CL0000034

CSI 3.26

rCSI 3.14%

PRS 47.8
common dendritic progenitor CL0001029

CSI 3.18

rCSI 3.99%

PRS 67.62
vascular leptomeningeal cell CL4023051

CSI 3.13

rCSI 5.48%

PRS 49.41
GABAergic neuron CL0000617

CSI 3.06

rCSI 10.24%

PRS 43.19
L6b glutamatergic cortical neuron CL4023038

CSI 3.03

rCSI 9.46%

PRS 41.11
glial cell CL0000125

CSI 2.98

rCSI 11.36%

PRS 48.67
keratinocyte CL0000312

CSI 2.96

rCSI 2.48%

PRS 62.04
midzonal region hepatocyte CL0019028

CSI 2.93

rCSI 6.88%

PRS 63.49
cerebral cortex endothelial cell CL1001602

CSI 2.89

rCSI 5.01%

PRS 47.46
enteric smooth muscle cell CL0002504

CSI 2.87

rCSI 4.09%

PRS 59.77
inhibitory interneuron CL0000498

CSI 2.83

rCSI 6.53%

PRS 46.98
vascular associated smooth muscle cell CL0000359

CSI 2.8

rCSI 9.08%

PRS 58.27
IgA plasma cell CL0000987

CSI 2.73

rCSI 2.79%

PRS 72.95
lung neuroendocrine cell CL1000223

CSI 2.52

rCSI 3.73%

PRS 62.8
endothelial cell of periportal hepatic sinusoid CL0019021

CSI 2.49

rCSI 11.41%

PRS 69.88
microglial cell CL0000129

CSI 2.47

rCSI 9.96%

PRS 63.69
type L enteroendocrine cell CL0002279

CSI 2.44

rCSI 4.57%

PRS 73.96
alveolar type 1 fibroblast cell CL4028004

CSI 2.39

rCSI 2.62%

PRS 61.2
mucus secreting cell CL0000319

CSI 2.33

rCSI 3.71%

PRS 68.56
common lymphoid progenitor CL0000051

CSI 2.33

rCSI 3.11%

PRS 79.04

mesenchymal stem cell CL0000134

CSI 0.1

rCSI 1.0%

PRS 70.6%
central nervous system neuron CL2000029

CSI 0.1

rCSI 1.0%

PRS 44.3%
acinar cell of salivary gland CL0002623

CSI 0.1

rCSI 3.3%

PRS 77.9%
endothelial cell of placenta CL0009092

CSI 0.6

rCSI 2.7%

PRS 68.6%
L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041

CSI 0.6

rCSI 2.2%

PRS 38.1%
L5/6 near-projecting glutamatergic neuron CL4030067

CSI 0.7

rCSI 2.2%

PRS 44.7%
luminal cell of prostate epithelium CL0002340

CSI 0.7

rCSI 3.6%

PRS 70.4%
pancreatic epsilon cell CL0005019

CSI 0.9

rCSI 4.1%

PRS 75.5%
caudal ganglionic eminence derived cortical interneuron CL4023064

CSI 0.9

rCSI 1.6%

PRS 38.6%
pancreatic PP cell CL0002275

CSI 0.9

rCSI 3.7%

PRS 71.1%
L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040

CSI 1.0

rCSI 2.4%

PRS 38.3%
myeloid dendritic cell, human CL0001057

CSI 1.0

rCSI 5.6%

PRS 82.4%
intestinal crypt stem cell of small intestine CL0009017

CSI 1.1

rCSI 3.0%

PRS 65.3%
retina horizontal cell CL0000745

CSI 1.1

rCSI 1.7%

PRS 53.6%
transit amplifying cell CL0009010

CSI 1.2

rCSI 1.8%

PRS 71.5%
fibroblast of breast CL4006000

CSI 1.2

rCSI 4.9%

PRS 72.0%
type B pancreatic cell CL0000169

CSI 1.2

rCSI 2.7%

PRS 55.3%
intestinal crypt stem cell of colon CL0009043

CSI 1.2

rCSI 9.1%

PRS 74.6%
keratocyte CL0002363

CSI 1.3

rCSI 3.0%

PRS 65.4%
myeloid dendritic cell CL0000782

CSI 1.3

rCSI 1.9%

PRS 73.3%
peripheral nervous system neuron CL2000032

CSI 1.4

rCSI 1.9%

PRS 49.5%
duct epithelial cell CL0000068

CSI 1.5

rCSI 2.2%

PRS 61.4%
nasal mucosa goblet cell CL0002480

CSI 1.5

rCSI 1.7%

PRS 65.6%
adventitial cell CL0002503

CSI 1.5

rCSI 3.6%

PRS 66.4%
Langerhans cell CL0000453

CSI 1.5

rCSI 2.3%

PRS 73.3%
paneth cell CL0000510

CSI 1.6

rCSI 2.3%

PRS 73.7%
corticothalamic-projecting glutamatergic cortical neuron CL4023013

CSI 1.6

rCSI 9.4%

PRS 41.0%
myoepithelial cell CL0000185

CSI 1.6

rCSI 4.1%

PRS 65.8%
lung ciliated cell CL1000271

CSI 1.7

rCSI 1.9%

PRS 47.3%
transit amplifying cell of colon CL0009011

CSI 1.7

rCSI 2.1%

PRS 59.9%
kidney epithelial cell CL0002518

CSI 1.8

rCSI 3.4%

PRS 77.9%
ciliated epithelial cell CL0000067

CSI 1.8

rCSI 1.6%

PRS 45.4%
blood vessel smooth muscle cell CL0019018

CSI 1.8

rCSI 14.4%

PRS 50.4%
microcirculation associated smooth muscle cell CL0008035

CSI 1.8

rCSI 5.2%

PRS 58.9%
cardiac muscle cell CL0000746

CSI 1.8

rCSI 2.6%

PRS 47.4%
alveolar adventitial fibroblast CL4028006

CSI 1.9

rCSI 2.9%

PRS 59.1%
BEST4+ enteroycte CL4030026

CSI 1.9

rCSI 2.3%

PRS 59.3%
pancreatic ductal cell CL0002079

CSI 1.9

rCSI 3.6%

PRS 59.9%
sncg GABAergic cortical interneuron CL4023015

CSI 1.9

rCSI 3.1%

PRS 41.8%
renal beta-intercalated cell CL0002201

CSI 1.9

rCSI 4.6%

PRS 58.6%
hepatocyte CL0000182

CSI 2.0

rCSI 3.6%

PRS 56.4%
megakaryocyte CL0000556

CSI 2.0

rCSI 8.6%

PRS 70.8%
VIP GABAergic cortical interneuron CL4023016

CSI 2.0

rCSI 2.4%

PRS 39.5%
pancreatic stellate cell CL0002410

CSI 2.0

rCSI 11.9%

PRS 66.9%
lymphoid lineage restricted progenitor cell CL0000838

CSI 2.1

rCSI 8.1%

PRS 77.5%
basal cell of prostate epithelium CL0002341

CSI 2.2

rCSI 6.2%

PRS 71.0%
near-projecting glutamatergic cortical neuron CL4023012

CSI 2.2

rCSI 8.3%

PRS 40.5%
acinar cell CL0000622

CSI 2.2

rCSI 3.3%

PRS 68.9%
kidney connecting tubule epithelial cell CL1000768

CSI 2.3

rCSI 5.8%

PRS 47.0%
common lymphoid progenitor CL0000051

CSI 2.3

rCSI 3.1%

PRS 79.0%
mucus secreting cell CL0000319

CSI 2.3

rCSI 3.7%

PRS 68.6%
alveolar type 1 fibroblast cell CL4028004

CSI 2.4

rCSI 2.6%

PRS 61.2%
type L enteroendocrine cell CL0002279

CSI 2.4

rCSI 4.6%

PRS 74.0%
microglial cell CL0000129

CSI 2.5

rCSI 10.0%

PRS 63.7%
endothelial cell of periportal hepatic sinusoid CL0019021

CSI 2.5

rCSI 11.4%

PRS 69.9%
lung neuroendocrine cell CL1000223

CSI 2.5

rCSI 3.7%

PRS 62.8%
IgA plasma cell CL0000987

CSI 2.7

rCSI 2.8%

PRS 73.0%
vascular associated smooth muscle cell CL0000359

CSI 2.8

rCSI 9.1%

PRS 58.3%
inhibitory interneuron CL0000498

CSI 2.8

rCSI 6.5%

PRS 47.0%
enteric smooth muscle cell CL0002504

CSI 2.9

rCSI 4.1%

PRS 59.8%
cerebral cortex endothelial cell CL1001602

CSI 2.9

rCSI 5.0%

PRS 47.5%
midzonal region hepatocyte CL0019028

CSI 2.9

rCSI 6.9%

PRS 63.5%
keratinocyte CL0000312

CSI 3.0

rCSI 2.5%

PRS 62.0%
glial cell CL0000125

CSI 3.0

rCSI 11.4%

PRS 48.7%
L6b glutamatergic cortical neuron CL4023038

CSI 3.0

rCSI 9.5%

PRS 41.1%
GABAergic neuron CL0000617

CSI 3.1

rCSI 10.2%

PRS 43.2%
vascular leptomeningeal cell CL4023051

CSI 3.1

rCSI 5.5%

PRS 49.4%
common dendritic progenitor CL0001029

CSI 3.2

rCSI 4.0%

PRS 67.6%
stem cell CL0000034

CSI 3.3

rCSI 3.1%

PRS 47.8%
retinal cone cell CL0000573

CSI 3.3

rCSI 5.3%

PRS 47.1%
CD4-positive, alpha-beta memory T cell CL0000897

CSI 3.3

rCSI 2.4%

PRS 71.6%
enteroendocrine cell CL0000164

CSI 3.3

rCSI 4.6%

PRS 59.2%
astrocyte of the cerebral cortex CL0002605

CSI 3.4

rCSI 7.5%

PRS 40.3%
early lymphoid progenitor CL0000936

CSI 3.4

rCSI 3.0%

PRS 62.6%
regular ventricular cardiac myocyte CL0002131

CSI 3.4

rCSI 21.1%

PRS 49.2%
CD1c-positive myeloid dendritic cell CL0002399

CSI 3.4

rCSI 4.1%

PRS 65.9%
retinal bipolar neuron CL0000748

CSI 3.4

rCSI 6.4%

PRS 45.9%
intermediate monocyte CL0002393

CSI 3.4

rCSI 5.2%

PRS 60.8%
neural crest cell CL0011012

CSI 3.4

rCSI 2.7%

PRS 44.3%
glioblast CL0000030

CSI 3.5

rCSI 5.5%

PRS 50.2%
radial glial cell CL0000681

CSI 3.6

rCSI 5.0%

PRS 56.3%
pulmonary capillary endothelial cell CL4028001

CSI 3.7

rCSI 7.0%

PRS 72.7%
epithelial cell CL0000066

CSI 3.7

rCSI 5.6%

PRS 54.7%
pulmonary ionocyte CL0017000

CSI 3.7

rCSI 4.6%

PRS 65.0%
glandular epithelial cell CL0000150

CSI 3.8

rCSI 9.9%

PRS 76.7%
chondrocyte CL0000138

CSI 3.8

rCSI 6.1%

PRS 49.7%
retinal pigment epithelial cell CL0002586

CSI 3.9

rCSI 7.7%

PRS 55.3%
pancreatic A cell CL0000171

CSI 4.0

rCSI 4.2%

PRS 60.8%
sst GABAergic cortical interneuron CL4023017

CSI 4.1

rCSI 5.2%

PRS 40.8%
blood vessel endothelial cell CL0000071

CSI 4.2

rCSI 8.7%

PRS 54.6%
tissue-resident macrophage CL0000864

CSI 4.2

rCSI 19.6%

PRS 74.1%
pancreatic D cell CL0000173

CSI 4.2

rCSI 4.1%

PRS 59.9%
CD14-positive, CD16-positive monocyte CL0002397

CSI 4.2

rCSI 5.5%

PRS 70.7%
epithelial cell of lung CL0000082

CSI 4.2

rCSI 3.5%

PRS 56.2%
lung interstitial macrophage CL4033043

CSI 4.2

rCSI 9.5%

PRS 75.6%
mesenchymal cell CL0008019

CSI 4.4

rCSI 11.0%

PRS 51.8%
adipocyte CL0000136

CSI 4.5

rCSI 5.8%

PRS 50.7%
epithelial cell of lower respiratory tract CL0002632

CSI 4.6

rCSI 3.6%

PRS 58.8%
monocyte CL0000576

CSI 4.6

rCSI 8.3%

PRS 73.2%
pancreatic acinar cell CL0002064

CSI 4.7

rCSI 6.2%

PRS 63.5%

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Context Genes (max 20):

Interaction Source:

Pathway Categories (for ONTOLOGY source):

Baseline Cell Type:

Baseline Cell Context(s): Comma-separated if multiple.

Target Cell Type:

Target Cell Context(s): Comma-separated if multiple.

Legend:

Query Gene
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
Node Size: Proportional to Target Cell CSI magnitude
STRING PPI Edge
Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

Description
Proteins

## Summary [LGMN](/details-gene/5641) (legumain) is a protein-coding gene located on chromosome 14q32.12 that encodes an asparaginyl endopeptidase, a member of the C13 family of cysteine proteases. Primarily localized to lysosomes, [LGMN](/details-gene/5641) plays a crucial role in protein degradation and processing, most notably in the context of antigen presentation. Its function is essential for the [MHC class II antigen presentation](/details-pathway/R-HSA-2132295) pathway, which is critical for adaptive immunity ([Link](https://doi.org/10.1038/25379)). Expression data reveals that **Overall**, [LGMN](/details-gene/5641) is a highly significant marker for cells of the myeloid lineage, particularly [macrophages](/details-cell/CL0000235) and dendritic cells across various tissues, underscoring its central role in the innate and adaptive immune systems. ## Cellular Roles and Expression Landscape The expression profile of [LGMN](/details-gene/5641) highlights its profound importance within the myeloid compartment of the immune system. **Overall**, the gene shows the highest significance in [myeloid leukocytes](/details-cell/CL0000766) (CSI: 60.24), with exceptional enrichment in diverse macrophage populations. These include [elicited macrophages](/details-cell/CL0000861), [alternatively activated macrophages](/details-cell/CL0000890), and tissue-resident macrophages such as [Hofbauer cells](/details-cell/CL3000001) in the placenta, [Kupffer cells](/details-cell/CL0000091) in the liver, and [lung macrophages](/details-cell/CL1001603). This consistent, high-level expression across multiple macrophage subtypes suggests that [LGMN](/details-gene/5641) is a core enzymatic component for fundamental macrophage functions, likely related to phagocytosis, lysosomal processing, and antigen presentation. Beyond macrophages, [LGMN](/details-gene/5641) is also a significant marker for other antigen-presenting cells like [plasmacytoid dendritic cells](/details-cell/CL0001058), further cementing its role in initiating immune responses. A secondary, distinct expression pattern is observed in placental trophoblast cells, including [extravillous trophoblasts](/details-cell/CL0008036) and [syncytiotrophoblast cells](/details-cell/CL0000525). This suggests a specialized proteolytic function in placental development, maternal-fetal interface maintenance, or tissue remodeling. The collective data portrays [LGMN](/details-gene/5641) as a specialized protease with a dominant role in the myeloid lineage and a context-specific function in placental biology. ## Pathways and Molecular Function Functionally, [LGMN](/details-gene/5641) is characterized by its [cysteine-type endopeptidase activity](/details-pathway/GO:0004197), enabling it to cleave proteins at the C-terminal side of asparagine residues. This activity is central to its involvement in general [proteolysis](/details-pathway/GO:0006508) within the acidic environment of lysosomes ([Link](https://doi.org/10.1074/jbc.272.12.8090)). Its most well-defined role is within the [immune system](/details-pathway/R-HSA-168256). [LGMN](/details-gene/5641) is a key enzyme in the [MHC class II antigen presentation](/details-pathway/R-HSA-2132295) pathway. It processes foreign antigens that have been endocytosed by antigen-presenting cells, generating peptide fragments that are loaded onto MHC class II molecules for presentation to T-helper cells. This function directly links its high expression in macrophages and dendritic cells to their role in bridging the [innate immune system](/details-pathway/R-HSA-168249) and the [adaptive immune system](/details-pathway/R-HSA-1280218). Furthermore, its annotation in [Toll-like receptor cascades](/details-pathway/R-HSA-168898) suggests it may also be involved in processing components related to pathogen recognition and subsequent signaling. The enzyme itself requires proteolytic processing for activation, a process which can be autocatalytic under acidic conditions ([Link](https://doi.org/10.1016/s0014-5793(98)01281-2), [Link](https://doi.org/10.1073/pnas.1300686110)). ## Research Directions The high expression of [LGMN](/details-gene/5641) in alternatively activated (M2-like) macrophages suggests it may play a significant role in contexts dominated by these cells, such as the tumor microenvironment, fibrosis, and wound healing. Modulating its activity could therefore represent a strategy to alter macrophage function in disease. Based on its expression and function, several testable hypotheses can be proposed: 1. **Hypothesis:** The proteolytic activity of [LGMN](/details-gene/5641) is critical for maintaining the immunosuppressive phenotype of tumor-associated macrophages (TAMs). Inhibition of [LGMN](/details-gene/5641) will skew TAMs toward a pro-inflammatory, anti-tumor M1-like state. 2. **Hypothesis:** In placental biology, [LGMN](/details-gene/5641) expressed by trophoblasts is essential for extracellular matrix remodeling during implantation and placentation. Dysregulation of its activity may contribute to placental disorders such as pre-eclampsia or intrauterine growth restriction. 3. **Hypothesis:** [LGMN](/details-gene/5641) processes specific endogenous proteins in macrophages that are critical for their polarization, and the resulting peptide fragments may act as signaling molecules or influence the cellular metabolic state. To test the first hypothesis regarding the role of [LGMN](/details-gene/5641) in TAMs, a compelling experimental approach would be to utilize a co-culture system. Primary human monocytes could be differentiated into macrophages and co-cultured with tumor cell lines to induce a TAM-like phenotype. These TAMs would then be treated with a highly specific small-molecule inhibitor of [LGMN](/details-gene/5641). The functional consequences would be assessed by measuring changes in macrophage polarization markers (e.g., CD206, CD163, IL-10 vs. iNOS, CD86, TNF-alpha) via flow cytometry and ELISA, as well as by evaluating their ability to suppress T cell proliferation in a tertiary co-culture assay. Given its enzymatic nature and its enrichment in specific immune cells that are often dysregulated in cancer and autoimmune disease, [LGMN](/details-gene/5641) presents a promising therapeutic target. As its activity in TAMs is likely pro-tumoral, **inhibition** would be the preferred therapeutic strategy. The development of specific, potent inhibitors could provide a novel immunomodulatory approach to reprogram the tumor microenvironment, potentially synergizing with checkpoint inhibitors or other cancer immunotherapies.

Disclaimer: This in-silico analysis is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

LGMN_HUMAN
Q96CY7_HUMAN

Genular Protein ID: 804660719

Symbol: LGMN_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q99538 O00123 Q86TV2 Q86TV3 Q9BTY1

Database IDs:

Citations:

PubMed ID: 9065484

Title: Cloning, isolation, and characterization of mammalian legumain, an asparaginyl endopeptidase.

PubMed ID: 9065484

DOI: 10.1074/jbc.272.12.8090

PubMed ID: 8893817

Title: Molecular cloning of a human cDNA encoding putative cysteine protease (PRSC1) and its chromosome assignment to 14q32.1.

PubMed ID: 8893817

DOI: 10.1159/000134397

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11085925

Title: Activation of human prolegumain by cleavage at a C-terminal asparagine residue.

PubMed ID: 11085925

DOI: 10.1042/bj3520327

PubMed ID: 9872320

Title: An asparaginyl endopeptidase processes a microbial antigen for class II MHC presentation.

PubMed ID: 9872320

DOI: 10.1038/25379

PubMed ID: 9821970

Title: Autocatalytic activation of human legumain at aspartic acid residues.

PubMed ID: 9821970

DOI: 10.1016/s0014-5793(98)01281-2

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 30425301

Title: Deficiency of the human cysteine protease inhibitor cystatin M/E causes hypotrichosis and dry skin.

PubMed ID: 30425301

DOI: 10.1038/s41436-018-0355-3

PubMed ID: 23776206

Title: Mechanistic and structural studies on legumain explain its zymogenicity, distinct activation pathways, and regulation.

PubMed ID: 23776206

DOI: 10.1073/pnas.1300686110

Sequence Information:

Length: 433
Mass: 49411
Checksum: 081AD2D0D584E72A
Sequence:

MVWKVAVFLS VALGIGAVPI DDPEDGGKHW VVIVAGSNGW YNYRHQADAC HAYQIIHRNG 
IPDEQIVVMM YDDIAYSEDN PTPGIVINRP NGTDVYQGVP KDYTGEDVTP QNFLAVLRGD 
AEAVKGIGSG KVLKSGPQDH VFIYFTDHGS TGILVFPNED LHVKDLNETI HYMYKHKMYR 
KMVFYIEACE SGSMMNHLPD NINVYATTAA NPRESSYACY YDEKRSTYLG DWYSVNWMED 
SDVEDLTKET LHKQYHLVKS HTNTSHVMQY GNKTISTMKV MQFQGMKRKA SSPVPLPPVT 
HLDLTPSPDV PLTIMKRKLM NTNDLEESRQ LTEEIQRHLD ARHLIEKSVR KIVSLLAASE 
AEVEQLLSER APLTGHSCYP EALLHFRTHC FNWHSPTYEY ALRHLYVLVN LCEKPYPLHR 
IKLSMDHVCL GHY

Genular Protein ID: 1513082579

Symbol: Q96CY7_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q96CY7

Database IDs:

Sequence Information:

Length: 166
Mass: 19226
Checksum: 31B55ABE114AD0D7
Sequence:

MQYGNKTIST MKVMQFQGMK RKASSPVPLP PVTHLDLTPS PDVPLTIMKR KLMNTNDLEE 
SRQLTEEIQR HLDARHLIEK SVRKIVSLLA ASEAEVEQLL SERAPLTGHS CYPEALLHFR 
THCFNWHSPT YEYALRHLYV LVNLCEKPYP LHRIKLSMDH VCLGHY

Details for: LGMN

Cell Significance Landscape

Associated with

Significant Cells

Network Configuration

Legend:

Other Information

Cloning, isolation, and characterization of mammalian legumain, an asparaginyl endopeptidase. PubMed ID: 9065484

Molecular cloning of a human cDNA encoding putative cysteine protease (PRSC1) and its chromosome assignment to 14q32.1. PubMed ID: 8893817

The DNA sequence and analysis of human chromosome 14. PubMed ID: 12508121

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Activation of human prolegumain by cleavage at a C-terminal asparagine residue. PubMed ID: 11085925

An asparaginyl endopeptidase processes a microbial antigen for class II MHC presentation. PubMed ID: 9872320

Autocatalytic activation of human legumain at aspartic acid residues. PubMed ID: 9821970

Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. PubMed ID: 19159218

Initial characterization of the human central proteome. PubMed ID: 21269460

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Deficiency of the human cysteine protease inhibitor cystatin M/E causes hypotrichosis and dry skin. PubMed ID: 30425301

Mechanistic and structural studies on legumain explain its zymogenicity, distinct activation pathways, and regulation. PubMed ID: 23776206