Details for: LGMN

Gene ID: 5641

Symbol: LGMN

Ensembl ID: ENSG00000100600

Description: legumain

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 309.0419
    Cell Significance Index: -48.0700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 189.0844
    Cell Significance Index: -47.9600
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 121.2290
    Cell Significance Index: -49.9400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 106.5458
    Cell Significance Index: -43.2900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 106.0212
    Cell Significance Index: -50.0600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 45.4834
    Cell Significance Index: -43.4300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 38.9876
    Cell Significance Index: -48.0700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 18.6488
    Cell Significance Index: -49.9600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 12.1793
    Cell Significance Index: -48.0600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 10.4999
    Cell Significance Index: -32.2500
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 6.6909
    Cell Significance Index: 54.5600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.9327
    Cell Significance Index: 100.4000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.3039
    Cell Significance Index: 78.2800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.2760
    Cell Significance Index: 163.5700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.2266
    Cell Significance Index: 11.3000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.1072
    Cell Significance Index: 604.6900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9599
    Cell Significance Index: 156.1300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.9524
    Cell Significance Index: 25.4300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.9166
    Cell Significance Index: 183.8700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.8873
    Cell Significance Index: 159.9600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.8844
    Cell Significance Index: 96.2000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.7193
    Cell Significance Index: 20.6200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6895
    Cell Significance Index: 68.2100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6727
    Cell Significance Index: 607.4000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.5493
    Cell Significance Index: 11.9000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4902
    Cell Significance Index: 97.2800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4389
    Cell Significance Index: 30.3500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3586
    Cell Significance Index: 128.6200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.2951
    Cell Significance Index: 21.9900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2733
    Cell Significance Index: 33.6000
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.2721
    Cell Significance Index: 4.2100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.2638
    Cell Significance Index: 20.2400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1931
    Cell Significance Index: 24.9500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1657
    Cell Significance Index: 73.2700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.1382
    Cell Significance Index: 104.5700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1348
    Cell Significance Index: 93.2300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1228
    Cell Significance Index: 16.8600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1116
    Cell Significance Index: 21.2400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1109
    Cell Significance Index: 5.1700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1105
    Cell Significance Index: 5.0100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0358
    Cell Significance Index: 6.1200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0310
    Cell Significance Index: 1.0900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0046
    Cell Significance Index: 8.6900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0098
    Cell Significance Index: -6.1000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0138
    Cell Significance Index: -1.4100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0192
    Cell Significance Index: -29.6000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0210
    Cell Significance Index: -15.5500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0240
    Cell Significance Index: -44.2800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0318
    Cell Significance Index: -23.3500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0403
    Cell Significance Index: -54.7800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0426
    Cell Significance Index: -2.0000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0435
    Cell Significance Index: -27.6400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0695
    Cell Significance Index: -39.2200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0737
    Cell Significance Index: -10.7200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0750
    Cell Significance Index: -34.0400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1255
    Cell Significance Index: -2.4500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1330
    Cell Significance Index: -28.0200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1361
    Cell Significance Index: -39.1700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1497
    Cell Significance Index: -17.4500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1603
    Cell Significance Index: -18.9100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1782
    Cell Significance Index: -20.3400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1945
    Cell Significance Index: -22.2900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2357
    Cell Significance Index: -7.5500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2482
    Cell Significance Index: -12.9300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2677
    Cell Significance Index: -18.9300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.2917
    Cell Significance Index: -8.4100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2961
    Cell Significance Index: -19.9100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3077
    Cell Significance Index: -5.1500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.3464
    Cell Significance Index: -7.2500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.4026
    Cell Significance Index: -11.2500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4245
    Cell Significance Index: -44.2000
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.4893
    Cell Significance Index: -3.0400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4927
    Cell Significance Index: -25.8700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.5301
    Cell Significance Index: -34.2000
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.5328
    Cell Significance Index: -9.4200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5571
    Cell Significance Index: -44.1200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.5642
    Cell Significance Index: -35.5600
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.6149
    Cell Significance Index: -6.3700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.6247
    Cell Significance Index: -27.6300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.6402
    Cell Significance Index: -16.3600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.6492
    Cell Significance Index: -36.4300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.6575
    Cell Significance Index: -17.2900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.6973
    Cell Significance Index: -19.9000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.6989
    Cell Significance Index: -42.8500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.7125
    Cell Significance Index: -19.0600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.7372
    Cell Significance Index: -18.9500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.7629
    Cell Significance Index: -26.5100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.7738
    Cell Significance Index: -29.3000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.8406
    Cell Significance Index: -51.6700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.9038
    Cell Significance Index: -24.6000
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.9131
    Cell Significance Index: -19.3800
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.9389
    Cell Significance Index: -11.1900
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.9475
    Cell Significance Index: -6.4200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.9601
    Cell Significance Index: -28.2800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.9699
    Cell Significance Index: -13.8900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.9830
    Cell Significance Index: -20.9400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -1.0105
    Cell Significance Index: -33.0900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -1.1228
    Cell Significance Index: -35.7600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -1.1528
    Cell Significance Index: -40.3900
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -1.1571
    Cell Significance Index: -22.8800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** Legumain is a cysteine-type endopeptidase with a molecular weight of approximately 40 kDa. It is a member of the papain superfamily, which is characterized by the presence of a cysteine residue in the active site. Legumain has a broad substrate specificity, allowing it to cleave a wide range of proteins, including immunoglobulins, antigens, and other proteins involved in cellular processes. The enzyme is also known for its ability to undergo self-proteolysis, which is essential for its activation and regulation. **Pathways and Functions** Legumain is involved in various cellular pathways, including: 1. **Activation of cysteine-type endopeptidase activity**: Legumain is responsible for activating cysteine-type endopeptidase activity, which is essential for protein breakdown and peptide generation. 2. **Antigen processing and presentation via MHC class II**: Legumain is involved in the processing and presentation of exogenous peptide antigens via MHC class II molecules, which is essential for immune responses. 3. **Protein maturation**: Legumain is involved in the maturation of proteins, including the breakdown of precursor proteins into mature forms. 4. **Proteolysis**: Legumain is involved in various proteolytic processes, including the breakdown of proteins into smaller peptides and the regulation of protein stability. 5. **Cellular response to amyloid-beta**: Legumain is involved in the regulation of cellular responses to amyloid-beta, a protein associated with neurodegenerative diseases. Legumain's functions are essential for various cellular processes, including: 1. **Immune responses**: Legumain is involved in the processing and presentation of antigens, which is essential for immune responses. 2. **Cellular proliferation**: Legumain is involved in the regulation of cellular proliferation, including the breakdown of proteins involved in cell cycle progression. 3. **Protein metabolism**: Legumain is involved in the regulation of protein metabolism, including the breakdown of proteins and the generation of peptides. 4. **Neurodegenerative diseases**: Legumain is involved in the regulation of cellular responses to amyloid-beta, which is associated with neurodegenerative diseases. **Clinical Significance** Legumain's dysregulation has been implicated in various diseases, including: 1. **Autoimmune disorders**: Legumain's dysregulation has been implicated in autoimmune disorders, including rheumatoid arthritis and lupus. 2. **Neurodegenerative diseases**: Legumain's dysregulation has been implicated in neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. 3. **Cancer**: Legumain's dysregulation has been implicated in cancer, including the breakdown of tumor suppressor proteins and the generation of peptides involved in tumor growth. 4. **Immunodeficiency disorders**: Legumain's dysregulation has been implicated in immunodeficiency disorders, including the breakdown of proteins involved in immune responses. In conclusion, legumain is a cysteine-type endopeptidase that plays a crucial role in various cellular processes, including antigen processing and presentation, protein maturation, and proteolysis. Its dysregulation has been implicated in various diseases, including autoimmune disorders, neurodegenerative diseases, cancer, and immunodeficiency disorders. Further research is needed to fully understand the functions of legumain and its role in human disease.

Genular Protein ID: 804660719

Symbol: LGMN_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q99538 O00123 Q86TV2 Q86TV3 Q9BTY1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 7 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 39 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 18 PDBsum 18 PIRSF 2 PRINTS 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 3 RefSeq 9 SABIO-RK 1 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9065484

Title: Cloning, isolation, and characterization of mammalian legumain, an asparaginyl endopeptidase.

PubMed ID: 9065484

DOI: 10.1074/jbc.272.12.8090

PubMed ID: 8893817

Title: Molecular cloning of a human cDNA encoding putative cysteine protease (PRSC1) and its chromosome assignment to 14q32.1.

PubMed ID: 8893817

DOI: 10.1159/000134397

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11085925

Title: Activation of human prolegumain by cleavage at a C-terminal asparagine residue.

PubMed ID: 11085925

DOI: 10.1042/bj3520327

PubMed ID: 9872320

Title: An asparaginyl endopeptidase processes a microbial antigen for class II MHC presentation.

PubMed ID: 9872320

DOI: 10.1038/25379

PubMed ID: 9821970

Title: Autocatalytic activation of human legumain at aspartic acid residues.

PubMed ID: 9821970

DOI: 10.1016/s0014-5793(98)01281-2

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 30425301

Title: Deficiency of the human cysteine protease inhibitor cystatin M/E causes hypotrichosis and dry skin.

PubMed ID: 30425301

DOI: 10.1038/s41436-018-0355-3

PubMed ID: 23776206

Title: Mechanistic and structural studies on legumain explain its zymogenicity, distinct activation pathways, and regulation.

PubMed ID: 23776206

DOI: 10.1073/pnas.1300686110

Sequence Information:

  • Length: 433
  • Mass: 49411
  • Checksum: 081AD2D0D584E72A
  • Sequence:
    • MVWKVAVFLS VALGIGAVPI DDPEDGGKHW VVIVAGSNGW YNYRHQADAC HAYQIIHRNG 
IPDEQIVVMM YDDIAYSEDN PTPGIVINRP NGTDVYQGVP KDYTGEDVTP QNFLAVLRGD 
AEAVKGIGSG KVLKSGPQDH VFIYFTDHGS TGILVFPNED LHVKDLNETI HYMYKHKMYR 
KMVFYIEACE SGSMMNHLPD NINVYATTAA NPRESSYACY YDEKRSTYLG DWYSVNWMED 
SDVEDLTKET LHKQYHLVKS HTNTSHVMQY GNKTISTMKV MQFQGMKRKA SSPVPLPPVT 
HLDLTPSPDV PLTIMKRKLM NTNDLEESRQ LTEEIQRHLD ARHLIEKSVR KIVSLLAASE 
AEVEQLLSER APLTGHSCYP EALLHFRTHC FNWHSPTYEY ALRHLYVLVN LCEKPYPLHR 
IKLSMDHVCL GHY

Genular Protein ID: 1513082579

Symbol: Q96CY7_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q96CY7

Database IDs:

ARBA 4 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 4 Gene3D 1 InterPro 3 MEROPS 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 2 PharmGKB 1 RefSeq 1

Sequence Information:

  • Length: 166
  • Mass: 19226
  • Checksum: 31B55ABE114AD0D7
  • Sequence:
    • MQYGNKTIST MKVMQFQGMK RKASSPVPLP PVTHLDLTPS PDVPLTIMKR KLMNTNDLEE 
SRQLTEEIQR HLDARHLIEK SVRKIVSLLA ASEAEVEQLL SERAPLTGHS CYPEALLHFR 
THCFNWHSPT YEYALRHLYV LVNLCEKPYP LHRIKLSMDH VCLGHY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.