Details for: PSG1

Gene ID: 5669

Symbol: PSG1

Ensembl ID: ENSG00000231924

Description: pregnancy specific beta-1-glycoprotein 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.7844
    Cell Significance Index: 19.0000
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.4834
    Cell Significance Index: 3.0400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.1424
    Cell Significance Index: 2.4400
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 0.0569
    Cell Significance Index: 0.5400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0427
    Cell Significance Index: 1.1400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0214
    Cell Significance Index: 4.3000
  • Cell Name: ionocyte (CL0005006)
    Fold Change: 0.0201
    Cell Significance Index: 0.2100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.0017
    Cell Significance Index: 0.5000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0004
    Cell Significance Index: 0.7800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0001
    Cell Significance Index: 0.0500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0002
    Cell Significance Index: -0.3600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0004
    Cell Significance Index: -0.6500
  • Cell Name: trophoblast giant cell (CL0002488)
    Fold Change: -0.0014
    Cell Significance Index: -0.0100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0015
    Cell Significance Index: -2.0200
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.0031
    Cell Significance Index: -0.0300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0046
    Cell Significance Index: -3.3900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0047
    Cell Significance Index: -2.9600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0069
    Cell Significance Index: -3.1200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0069
    Cell Significance Index: -3.9000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0074
    Cell Significance Index: -1.0100
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0085
    Cell Significance Index: -0.3700
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.0097
    Cell Significance Index: -0.0600
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0099
    Cell Significance Index: -0.1400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0159
    Cell Significance Index: -2.8600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0164
    Cell Significance Index: -3.2600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0180
    Cell Significance Index: -0.4900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0187
    Cell Significance Index: -3.9400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0198
    Cell Significance Index: -2.8800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0204
    Cell Significance Index: -3.4800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0246
    Cell Significance Index: -3.0300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0264
    Cell Significance Index: -3.0300
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0272
    Cell Significance Index: -0.6800
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.0277
    Cell Significance Index: -0.3000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0297
    Cell Significance Index: -3.0300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0306
    Cell Significance Index: -1.5400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0391
    Cell Significance Index: -2.6300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0396
    Cell Significance Index: -1.1400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0439
    Cell Significance Index: -2.7000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0460
    Cell Significance Index: -3.5300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0493
    Cell Significance Index: -2.1800
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0499
    Cell Significance Index: -0.6300
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0501
    Cell Significance Index: -0.6100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0556
    Cell Significance Index: -3.1200
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0556
    Cell Significance Index: -0.8200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0558
    Cell Significance Index: -1.0900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0589
    Cell Significance Index: -2.2300
  • Cell Name: pulmonary capillary endothelial cell (CL4028001)
    Fold Change: -0.0595
    Cell Significance Index: -0.8200
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0601
    Cell Significance Index: -2.4600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0660
    Cell Significance Index: -3.1000
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.0676
    Cell Significance Index: -0.6900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0689
    Cell Significance Index: -0.9400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0699
    Cell Significance Index: -3.6700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0708
    Cell Significance Index: -1.9800
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.0710
    Cell Significance Index: -0.9300
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.0723
    Cell Significance Index: -0.7500
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.0742
    Cell Significance Index: -1.1900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0762
    Cell Significance Index: -2.6700
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.0768
    Cell Significance Index: -0.7600
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.0791
    Cell Significance Index: -0.8500
  • Cell Name: secretory cell (CL0000151)
    Fold Change: -0.0822
    Cell Significance Index: -0.5700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0823
    Cell Significance Index: -2.1100
  • Cell Name: myelocyte (CL0002193)
    Fold Change: -0.0833
    Cell Significance Index: -0.8900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0835
    Cell Significance Index: -2.6600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0840
    Cell Significance Index: -2.7500
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0956
    Cell Significance Index: -1.3000
  • Cell Name: basophil mast progenitor cell (CL0002028)
    Fold Change: -0.0995
    Cell Significance Index: -0.8400
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.0995
    Cell Significance Index: -1.0300
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: -0.1002
    Cell Significance Index: -1.1600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1069
    Cell Significance Index: -3.1500
  • Cell Name: myoepithelial cell (CL0000185)
    Fold Change: -0.1075
    Cell Significance Index: -1.2200
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.1107
    Cell Significance Index: -2.7600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1124
    Cell Significance Index: -1.6100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1125
    Cell Significance Index: -3.2100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1130
    Cell Significance Index: -3.2400
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.1138
    Cell Significance Index: -1.8300
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: -0.1156
    Cell Significance Index: -0.8600
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.1160
    Cell Significance Index: -3.6700
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.1172
    Cell Significance Index: -1.7800
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.1177
    Cell Significance Index: -1.4900
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1190
    Cell Significance Index: -2.5700
  • Cell Name: mature T cell (CL0002419)
    Fold Change: -0.1195
    Cell Significance Index: -0.8600
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.1200
    Cell Significance Index: -1.4600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1224
    Cell Significance Index: -3.2800
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1227
    Cell Significance Index: -3.0600
  • Cell Name: megakaryocyte progenitor cell (CL0000553)
    Fold Change: -0.1252
    Cell Significance Index: -0.9000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1260
    Cell Significance Index: -2.7600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1263
    Cell Significance Index: -3.0300
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -0.1279
    Cell Significance Index: -1.6100
  • Cell Name: immature NK T cell (CL0000914)
    Fold Change: -0.1297
    Cell Significance Index: -1.6600
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1300
    Cell Significance Index: -2.6100
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1303
    Cell Significance Index: -3.3200
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.1320
    Cell Significance Index: -1.8500
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: -0.1329
    Cell Significance Index: -1.1800
  • Cell Name: group 3 innate lymphoid cell, human (CL0001078)
    Fold Change: -0.1334
    Cell Significance Index: -1.2500
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.1361
    Cell Significance Index: -1.1100
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.1362
    Cell Significance Index: -2.2900
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.1384
    Cell Significance Index: -1.6700
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.1395
    Cell Significance Index: -1.8300
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1406
    Cell Significance Index: -2.9900
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1431
    Cell Significance Index: -2.8300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Tissue-specific expression:** PSG1 is predominantly expressed in cells of the placenta, retina, and immune cells, such as plasma cells and goblet cells. This tissue-specific expression pattern highlights the gene's unique role in distinct cellular contexts. 2. **Glycoprotein structure:** PSG1 is a beta-1-glycoprotein, comprising a core protein backbone to which carbohydrate chains are attached. This glycoprotein structure confers specific binding properties, enabling PSG1 to interact with various cellular and molecular partners. 3. **Cell surface localization:** PSG1 is primarily localized to the cell surface, where it can engage with extracellular ligands, receptors, and signaling molecules, facilitating communication between cells. **Pathways and Functions:** 1. **Immune system regulation:** PSG1 is involved in the regulation of immune responses, modulating the activity of immune cells, such as plasma cells and macrophages. Its expression is upregulated during pregnancy, which may contribute to the immune tolerance observed in this period. 2. **Cell signaling:** PSG1 participates in various signaling pathways, including protein tyrosine kinase binding and cell surface interactions at the vascular wall. These interactions facilitate the transmission of signals between cells, influencing cellular behavior and function. 3. **Regulation of cellular interactions:** PSG1 modulates the adhesion and migration of cells, such as endothelial cells and trophoblasts, which are essential for tissue development and immune system function. **Clinical Significance:** 1. **Pregnancy-related disorders:** PSG1 has been implicated in the pathogenesis of pregnancy-related disorders, such as preeclampsia and gestational diabetes. Its dysregulation may contribute to the development of these conditions. 2. **Cancer and immune system disorders:** PSG1's involvement in immune regulation and cell signaling has also been linked to various cancers and immune system disorders, such as multiple sclerosis and rheumatoid arthritis. 3. **Neurological disorders:** The expression of PSG1 in retinal cells has sparked interest in its potential role in neurological disorders, such as retinal degeneration and glaucoma. In conclusion, PSG1 is a multifaceted gene that plays a critical role in immune regulation, cell signaling, and cellular interactions. Its dysregulation has been implicated in various diseases, highlighting the need for further research into the molecular mechanisms underlying PSG1's functions.

Genular Protein ID: 3739057836

Symbol: PSG1_HUMAN

Name: Pregnancy-specific beta-1-glycoprotein 1

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 3260773

Title: The human pregnancy-specific beta 1-glycoprotein (PS beta G) and the carcinoembryonic antigen (CEA)-related proteins are members of the same multigene family.

PubMed ID: 3260773

DOI: 10.1016/0006-291x(88)90660-2

PubMed ID: 3180995

Title: Characterization of cDNA encoding human pregnancy-specific beta 1-glycoprotein from placenta and extraplacental tissues and their comparison with carcinoembryonic antigen.

PubMed ID: 3180995

DOI: 10.1089/dna.1.1988.7.545

PubMed ID: 2735907

Title: Carcinoembryonic antigen gene family: molecular cloning of cDNA for a PS-beta-G/FL-NCA glycoprotein with a novel domain arrangement.

PubMed ID: 2735907

DOI: 10.1016/0006-291x(89)92631-4

PubMed ID: 2783133

Title: cDNA cloning demonstrates the expression of pregnancy-specific glycoprotein genes, a subgroup of the carcinoembryonic antigen gene family, in fetal liver.

PubMed ID: 2783133

DOI: 10.1016/0006-291x(89)91105-4

PubMed ID: 2377620

Title: Linkage of two human pregnancy-specific beta 1-glycoprotein genes: one is associated with hydatidiform mole.

PubMed ID: 2377620

DOI: 10.1073/pnas.87.15.5822

PubMed ID: 3257488

Title: Isolation and characterization of complementary DNAs encoding human pregnancy-specific beta 1-glycoprotein.

PubMed ID: 3257488

DOI: 10.1016/s0021-9258(19)77983-6

PubMed ID: 2541441

Title: Molecular cloning and expression of cDNA for a carcinoembryonic antigen-related fetal liver glycoprotein.

PubMed ID: 2541441

DOI: 10.1073/pnas.86.9.3332

PubMed ID: 2350345

Title: Carcinoembryonic antigen gene family members in submandibular salivary gland: demonstration of pregnancy-specific glycoproteins by cDNA cloning.

PubMed ID: 2350345

DOI: 10.1016/0006-291x(90)91455-2

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 419
  • Mass: 47223
  • Checksum: 5E9855162F0C796D
  • Sequence:
  • MGTLSAPPCT QRIKWKGLLL TASLLNFWNL PTTAQVTIEA EPTKVSEGKD VLLLVHNLPQ 
    NLTGYIWYKG QMRDLYHYIT SYVVDGEIII YGPAYSGRET AYSNASLLIQ NVTREDAGSY 
    TLHIIKGDDG TRGVTGRFTF TLHLETPKPS ISSSNLNPRE TMEAVSLTCD PETPDASYLW 
    WMNGQSLPMT HSLKLSETNR TLFLLGVTKY TAGPYECEIR NPVSASRSDP VTLNLLPKLP 
    KPYITINNLN PRENKDVLNF TCEPKSENYT YIWWLNGQSL PVSPRVKRPI ENRILILPSV 
    TRNETGPYQC EIRDRYGGIR SDPVTLNVLY GPDLPRIYPS FTYYRSGEVL YLSCSADSNP 
    PAQYSWTINE KFQLPGQKLF IRHITTKHSG LYVCSVRNSA TGKESSKSMT VEVSDWTVP

Genular Protein ID: 3307982995

Symbol: G5E9F7_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

Sequence Information:

  • Length: 326
  • Mass: 36926
  • Checksum: 354142BDDC9ED1C1
  • Sequence:
  • MGTLSAPPCT QRIKWKGLLL TASLLNFWNL PTTAQVTIEA EPTKVSEGKD VLLLVHNLPQ 
    NLTGYIWYKG QMRDLYHYIT SYVVDGEIII YGPAYSGRET AYSNASLLIQ NVTREDAGSY 
    TLHIIKGDDG TRGVTGRFTF TLHPKLPKPY ITINNLNPRE NKDVLNFTCE PKSENYTYIW 
    WLNGQSLPVS PRVKRPIENR ILILPSVTRN ETGPYQCEIR DRYGGIRSDP VTLNVLYGPD 
    LPRIYPSFTY YRSGEVLYLS CSADSNPPAQ YSWTINEKFQ LPGQKLFIRH ITTKHSGLYV 
    CSVRNSATGK ESSKSMTVEV SDWTVP

Genular Protein ID: 2767699584

Symbol: O75238_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

Sequence Information:

  • Length: 333
  • Mass: 37033
  • Checksum: 5B73191A3ABAC9A5
  • Sequence:
  • MGTLSAPPCT QRIKWKGLLL TASLLNFWNL PTTAQVTIEA EPTKVSEGKD VLLLVHNLPQ 
    NLTGYIWYKG QMRDLYHYIT SYVVDGEIII YGPAYSGRET AYSNASLLIQ NVTREDAGSY 
    TLHIIKGDDG TRGVTGRFTF TLHLETPKPS ISSSNLNPRE TMEAVSLTCD PETPDASYLW 
    WMNGQSLPMT HSLKLSETNR TLFLLGVTKY TAGPYECEIR NPVSASRSDP VTLNLLHGPD 
    LPRIYPSFTY YRSGEVLYLS CSADSNPPAQ YSWTINEKFQ LPGQKLFIRH ITTKHSGLYV 
    CSVRNSATGK ESSKSMTVEV SGKWIPASLA IGF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.